| MTR4 adaptor PICT1 functions in two distinct steps during pre-rRNA processing. | MTR4 adaptor PICT1 functions in two distinct steps during pre-rRNA processing.
Miyao S, Saito K, Oshima R, Kawahara K, Nagahama M. | 12/10/2022 |
| PICT1 is critical for regulating the Rps27a-Mdm2-p53 pathway by microtubule polymerization inhibitor against cervical cancer. | PICT1 is critical for regulating the Rps27a-Mdm2-p53 pathway by microtubule polymerization inhibitor against cervical cancer.
Wang H, Zhao J, Yang J, Wan S, Fu Y, Wang X, Zhou T, Zhang Z, Shen J. | 12/4/2021 |
| Downregulation of NOP53 Ribosome Biogenesis Factor Leads to Abnormal Nuclear Division and Chromosomal Instability in Human Cervical Cancer Cells. | Downregulation of NOP53 Ribosome Biogenesis Factor Leads to Abnormal Nuclear Division and Chromosomal Instability in Human Cervical Cancer Cells.
Lee S, Ahn YM, Kim JY, Cho YE, Park JH. | 01/16/2021 |
| Germline variant p. Asp31His was present in all affected members in three families with familial non-medullary thyroid cancer. NOP53 is likely a low-penetrant gene implicated in FNMTC. | NOP53 as A Candidate Modifier Locus for Familial Non-Medullary Thyroid Cancer.
Orois A, Gara SK, Mora M, Halperin I, MartÃnez S, Alfayate R, Kebebew E, Oriola J., Free PMC Article | 03/14/2020 |
| Blocking cytoplasmic translocation of nucleolar protein NOP53 by deleting its nuclear export sequence abrogated its support of viral replication. Recombinant N3-T protein, containing NOP53 residues 330-432 and a human immunodeficiency virus-derived cell-penetrating Tat peptide, attenuated the expression of IFN-beta; and IFN-stimulated genes, as well as decreased the phosphorylation of interferon regulatory factor3. | Cytoplasmic Translocation of Nucleolar Protein NOP53 Promotes Viral Replication by Suppressing Host Defense.
Meng W, Han SC, Li CC, Dong HJ, Chang JY, Wang HR, Wang XJ., Free PMC Article | 10/6/2018 |
| The findings of this study suggest that disruption of PICT-1 protein expression and codon 389 polymorphism can contribute to the pathogenesis or neoplastic progression of endometrial cancer. | Abnormal Expression of PICT-1 and Its Codon 389 Polymorphism Is a Risk Factor for Human Endometrial Cancer.
Yoshimoto M, Tokuda A, Nishiwaki K, Sengoku K, Yaginuma Y. | 07/7/2018 |
| The study presented evidence that viral infection induced translocation of GLTSCR2 from nucleus to cytoplasm, and cytoplasmic translocation enabled GLTSCR2 to effectively attenuate IFN-beta and support viral replication; however, viral infection did not result in elevating GLTSCR2 in cells. | The nucleolar protein GLTSCR2 is required for efficient viral replication.
Wang P, Meng W, Han SC, Li CC, Wang XJ, Wang XJ., Free PMC Article | 06/30/2018 |
| PICT-1 triggers pro-death autophagy through inhibition of rRNA transcription and the inactivation of AKT/mTOR/p70S6K pathway in glioblastoma cells. | PICT-1 triggers a pro-death autophagy through inhibiting rRNA transcription and AKT/mTOR/p70S6K signaling pathway.
Chen H, Duo Y, Hu B, Wang Z, Zhang F, Tsai H, Zhang J, Zhou L, Wang L, Wang X, Huang L., Free PMC Article | 02/24/2018 |
| PICT-1 is a major nucleolar sensor of the DNA damage repair response and an important upstream regulator of p53 via the RPL11-MDM2-p53 pathway. | PICT-1 is a key nucleolar sensor in DNA damage response signaling that regulates apoptosis through the RPL11-MDM2-p53 pathway.
Chen H, Han L, Tsai H, Wang Z, Wu Y, Duo Y, Cao W, Chen L, Tan Z, Xu N, Huang X, Zhuang J, Huang L., Free PMC Article | 02/24/2018 |
| Codon 389 polymorphism in PICT-1 is a risk factor for uterine cervical cancers.PICT-1 counteracts HPV-induced p53 degradation. | The protein interacting with carboxyl terminus-1 codon 389 polymorphism impairs protein interacting with carboxyl terminus-1 function and is a risk factor for uterine cervical cancer.
Yoshimoto M, Tokuda A, Nishiwaki K, Sengoku K, Yaginuma Y. | 04/29/2017 |
| GLTSCR2 is a crucially involved in the positive regulation of telomerase and chromosome stability. | Role of GLTSCR2 in the regulation of telomerase activity and chromosome stability.
Kim JY, An YM, Park JH. | 04/8/2017 |
| The expression of GLTSCR2 was suppressed in renal cell carcinomas, accentuating the malignant phenotype. | Suppression of GLTSCR2 expression in renal cell carcinomas.
Cho YE, Lee HL, Lim SJ, Kim YW, Choe BK, Lee S, Park JH. | 11/12/2016 |
| GLTSCR2 is crucial for normal cellular function as well as for preventing the development or progression of cancer. The JNK-c-jun axis is indispensible for regulating the activities of GLTSCR2. | c-Jun N-terminal kinase regulates the nucleoplasmic translocation and stability of nucleolar GLTSCR2 protein.
Lee S, Cho YE, Kim YJ, Park JH. | 08/6/2016 |
| GLTSCR2 was an upstream negative regulator of the nucleophosmin (NPM)-MYC axis involved in controlling the transcriptional activity of MYC. GLTSCR2 may be a candidate for suppressing the growth of cancer cells stimulated by MYC hyperactivation. | The Nucleolar Protein GLTSCR2 Is an Upstream Negative Regulator of the Oncogenic Nucleophosmin-MYC Axis.
Kim JY, Cho YE, Park JH. | 06/11/2016 |
| Data show that tumor sppressor protein GLTSCR2 down-regulates total nucleophosmin (NPM) expression levels by decreasing its protein stability. | GLTSCR2 is an upstream negative regulator of nucleophosmin in cervical cancer.
Kim JY, Cho YE, An YM, Kim SH, Lee YG, Park JH, Lee S., Free PMC Article | 04/2/2016 |
| We demonstrated the GLTSCR2 expression decreased with the rise of the grade of cervical lesions; GLTSCR2 may play an important role in carcinogenesis of cervical cancer | The expression of GLTSCR2 in cervical intra-epithelial lesion and cancer.
Zhang J, Wang Q, Liu Y, Sun K, Zhang B, Jin Q, Chen J. | 06/20/2015 |
| These results suggest that PICT1 employs atypical proteasome-mediated degradation machinery to sense nucleolar stress within the nucleolus. | Nucleolar stress induces ubiquitination-independent proteasomal degradation of PICT1 protein.
Maehama T, Kawahara K, Nishio M, Suzuki A, Hanada K., Free PMC Article | 02/14/2015 |
| High PICT1 expression is associated with hepatocellular carcinoma. | Clinical significance of PICT1 in patients of hepatocellular carcinoma with wild-type TP53.
Ishibashi M, Kogo R, Shibata K, Ueo H, Uchi R, Matsumura T, Takano Y, Sawada G, Takahashi Y, Mima K, Kurashige J, Akiyoshi S, Iwaya T, Eguchi H, Sudo T, Sugimachi K, Suzuki A, Wakabayashi G, Mori M, Mimori K. | 08/30/2014 |
| GLTSCR2 is down-regulated in squamous cell carcinomas of the skin and UV light exposure decreases the stability of GLTSCR2 and sensitizes keratinocytes to DNA damage. | Expression of GLTSCR2/Pict-1 in squamous cell carcinomas of the skin.
Kim JY, Cho YE, Park JH, Lee S. | 07/19/2014 |
| Authors confirmed the interaction of PICT-1 with itself by direct yeast two-hybrid assay and also showed self-association of PICT-1 in mammalian cells by co-immunoprecipitation and fluorescence resonance energy transfer assays. | The nucleolar PICT-1/GLTSCR2 protein forms homo-oligomers.
Borodianskiy-Shteinberg T, Kalt I, Kipper S, Nachum N, Katz S, Pauker MH, Barda-Saad M, Gerber D, Sarid R. | 07/12/2014 |
| GLTCR2 may play a role in the tumorigenesis, progression and biological behavior in breast cancer. | Downregulation of GLTSCR2 expression is correlated with breast cancer progression.
Moon A, Lim SJ, Jo YH, Lee S, Kim JY, Lee J, Park JH. | 06/28/2014 |
| GLTSCR2 controls cellular proliferation and metabolism via the transcription factor Myc, and is induced by mitochondrial stress, suggesting it may constitute a significant component of the mitochondrial signaling pathway. | GLTSCR2/PICT1 links mitochondrial stress and Myc signaling.
Yoon JC, Ling AJ, Isik M, Lee DY, Steinbaugh MJ, Sack LM, Boduch AN, Blackwell TK, Sinclair DA, Elledge SJ., Free PMC Article | 05/10/2014 |
| Findings suggest that PICT1 has a crucial role in gastric cancer progression by regulating the MDM2-TP53 pathway through RPL11. | PICT1 regulates TP53 via RPL11 and is involved in gastric cancer progression.
Uchi R, Kogo R, Kawahara K, Sudo T, Yokobori T, Eguchi H, Sugimachi K, Maehama T, Mori M, Suzuki A, Komune S, Mimori K., Free PMC Article | 01/18/2014 |
| GLTSCR2 functions as a tumor suppressor in prostatic adenocarcinomas. | Down-regulation and aberrant cytoplasmic expression of GLTSCR2 in prostatic adenocarcinomas.
Kim JY, Cho YE, Kim GY, Lee HL, Lee S, Park JH. | 11/30/2013 |
| The glioma tumor-suppressor candidate region gene 2 (GLTSCR2)is as a new member of the nucleolus-nucleoplasmic axis for p53 regulation. | Nucleolar protein GLTSCR2 stabilizes p53 in response to ribosomal stresses.
Lee S, Kim JY, Kim YJ, Seok KO, Kim JH, Chang YJ, Kang HY, Park JH., Free PMC Article | 01/26/2013 |