| SERTAD1 initiates NLRP3-mediated inflammasome activation through restricting NLRP3 polyubiquitination. | SERTAD1 initiates NLRP3-mediated inflammasome activation through restricting NLRP3 polyubiquitination.
Ha J, Kim M, Park JS, Lee Y, Lee JY, Shin JC, Seo D, Park SS, You J, Jung SM, Kim HY, Mizuno S, Takahashi S, Kim SJ, Park SH. | 03/5/2024 |
| Inhibitory Role of TRIP-Br1/XIAP in Necroptosis under Nutrient/Serum Starvation. | Inhibitory Role of TRIP-Br1/XIAP in Necroptosis under Nutrient/Serum Starvation.
Sandag Z, Jung S, Quynh NTN, Myagmarjav D, Anh NH, Le DT, Lee BS, Mongre RK, Jo T, Lee M., Free PMC Article | 11/21/2020 |
| In human PCa tumor tissues, Sertad1 expression is positively correlated with AR expression and the Gleason score. Taken together, this report is the first to show that Sertad1 is a novel AR-LBD-binding protein, and DHT-liganded AR-LBD inhibits Sertad1 degradation. | Sertad1 promotes prostate cancer progression through binding androgen receptor ligand binding domain.
Hu B, Hu H, Yin M, Sun Z, Chen X, Li Y, Sun Z, Liu C, Li L, Qiu Y. | 04/27/2019 |
| Sertad1 could antagonize iASPP function by hindering its entrance into nuclei to interact with P53 in leukemic cells when iASPP was in the stage of overproduction. | Sertad1 antagonizes iASPP function by hindering its entrance into nuclei to interact with P53 in leukemic cells.
Qiu S, Liu S, Yu T, Yu J, Wang M, Rao Q, Xing H, Tang K, Mi Y, Wang J., Free PMC Article | 07/7/2018 |
| Here, the authors show that transcriptional regulator interacting with the PHD-bromodomain 1 (TRIP-Br1, Sertad1), a newly identified protein with poorly characterized functions, acts as an adaptor that bridges the interaction of multiple Adenylyl cyclase isoforms with X-linked inhibitor of apoptosis protein (XIAP), a RING-domain E3 ubiquitin ligase. | The complex of TRIP-Br1 and XIAP ubiquitinates and degrades multiple adenylyl cyclase isoforms.
Hu W, Yu X, Liu Z, Sun Y, Chen X, Yang X, Li X, Lam WK, Duan Y, Cao X, Steller H, Liu K, Huang P., Free PMC Article | 03/17/2018 |
| NEDD4-1 recognizes SERTA domain containing proline rich region of p34SEI-1. Residues of NEDD4-1 responsible for direct interaction with p34SEI-1 are identified by NMR titration experiments. | NMR uncovers direct interaction between human NEDD4-1 and p34(SEI-1).
Shrestha P, Yun JH, Ko YJ, Yeon KJ, Kim D, Lee H, Jin DH, Nam KY, Yoo HD, Lee W. | 08/19/2017 |
| SEI1 up-regulation induces genomic instability by inhibiting DNA damage response in ovarian cancer cells. | SEI1 induces genomic instability by inhibiting DNA damage response in ovarian cancer.
You J, Liu J, Bao Y, Wang L, Yu Y, Wang L, Wu D, Liu C, Wang N, Wang F, Wang F, Xu L, Tian X, Liang H, Gao Y, Guan R, Bai J, Meng X, Sun W, Guan XY, Zhang C, Fu S, Jin Y. | 08/12/2017 |
| Findings provide evidence that TRIP-Br1 functions as an oncogenic protein by providing cancer cells resistance to the hypoxia-induced cell death of breast cancer cells. | Inhibitory role of TRIP-Br1 oncoprotein in hypoxia-induced apoptosis in breast cancer cell lines.
Li C, Jung S, Yang Y, Kim KI, Lim JS, Cheon CI, Lee MS. | 03/11/2017 |
| TRIP-Br1 confers resistance to serum starvation-induced cell deaths by stabilizing the XIAP protein and inhibiting cellular ROS production. | TRIP-Br1 oncoprotein inhibits autophagy, apoptosis, and necroptosis under nutrient/serum-deprived condition.
Jung S, Li C, Duan J, Lee S, Kim K, Park Y, Yang Y, Kim KI, Lim JS, Cheon CI, Kang YS, Lee MS., Free PMC Article | 08/6/2016 |
| Data demonstrate that p34SEI-1 induces the activation of either AKT or ILK signaling on HER2/neu expression status. | Distinct regulatory effect of the p34SEI-1 oncoprotein on cancer metastasis in HER2/neu-positive and -negative cells.
Jung S, Ohk J, Jeong D, Li C, Lee S, Duan J, Kim C, Lim JS, Yang Y, Kim KI, Lee MS. | 01/17/2015 |
| High SERTAD1 expression is associated with breast cancer. | Oncogenic function of p34SEI-1 via NEDD4‑1‑mediated PTEN ubiquitination/degradation and activation of the PI3K/AKT pathway.
Jung S, Li C, Jeong D, Lee S, Ohk J, Park M, Han S, Duan J, Kim C, Yang Y, Kim KI, Lim JS, Kang YS, Lee MS. | 05/24/2014 |
| These results suggest that p34 (SEI-1) inhibits ROS-induced cell death through by indirectly inducing ubiquitination of ASK1. | p34 (SEI-1) inhibits ROS-induced cell death through suppression of ASK1.
Hong SW, Shin JS, Lee YM, Kim DG, Lee SY, Yoon DH, Jung SY, Hwang JJ, Lee SJ, Cho DH, Hong YS, Kim TW, Jin DH, Lee WK. | 01/28/2012 |
| study shows that the p34SE1-1 expression level was not changed after H2O2 treatment at either protein or transcriptional levels | Effect of PP2A on p34SEI-1 expression in response to ionizing radiation in MCF-7 human breast cancer cells.
Jung S, Jeong HK, Shin J, Lee MS. | 08/6/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | An integrative method for scoring candidate genes from association studies: application to warfarin dosing.
Tatonetti NP, Dudley JT, Sagreiya H, Butte AJ, Altman RB., Free PMC Article | 12/5/2010 |
| Translocation of small amount of NM23H1 into the nucleus induced by the overexpressions of SEI1/SET could increase the frequency of sister chromatid exchangein esophageal cancers. | Characterization of a novel mechanism of genomic instability involving the SEI1/SET/NM23H1 pathway in esophageal cancers.
Li Y, Nie CJ, Hu L, Qin Y, Liu HB, Zeng TT, Chen L, Fu L, Deng W, Chen SP, Jia WH, Zhang C, Xie D, Guan XY. | 08/30/2010 |
| interacts with low- and high-risk HPV11 and HPV16 E6 proteins in yeast, in vitro and in mammalian cell cultures | The human papillomavirus type 11 and 16 E6 proteins modulate the cell-cycle regulator and transcription cofactor TRIP-Br1.
Gupta S, Takhar PP, Degenkolbe R, Koh CH, Zimmermann H, Yang CM, Guan Sim K, Hsu SI, Bernard HU. | 01/21/2010 |
| p34SEI1 fragment 30-160 can bind, activate, and inhibit cyclin-dependent kinase CDK4; fragment 30-132 binds and activates but does not inhibit CDK4, while fragment 30-88 cannot bind, activate, or inhibit but retains LexA-mediated transactivation activity. | The nuclear protein p34SEI-1 regulates the kinase activity of cyclin-dependent kinase 4 in a concentration-dependent manner.
Li J, Melvin WS, Tsai MD, Muscarella P. | 01/21/2010 |
| p34SEI-1 strongly suppressed CREB-mediated transcription, and this suppression was overcome by excess amount of CBP | Regulation of CREB-mediated transcription by association of CDK4 binding protein p34SEI-1 with CBP.
Hirose T, Fujii R, Nakamura H, Aratani S, Fujita H, Nakazawa M, Nakamura K, Nishioka K, Nakajima T. | 01/21/2010 |
| p34(SEI-1) and p16(INK4A) have different roles in development of squamous cell carcinoma of the head and neck | Dissection of CDK4-binding and transactivation activities of p34(SEI-1) and comparison between functions of p34(SEI-1) and p16(INK4A).
Li J, Muscarella P, Joo SH, Knobloch TJ, Melvin WS, Weghorst CM, Tsai MD. | 01/21/2010 |