| DNMT3L inhibits hepatocellular carcinoma progression through DNA methylation of CDO1: insights from big data to basic research. | DNMT3L inhibits hepatocellular carcinoma progression through DNA methylation of CDO1: insights from big data to basic research.
Yan X, Qi Y, Yao X, Zhou N, Ye X, Chen X., Free PMC Article | 02/7/2024 |
| Stable DNMT3L overexpression in SH-SY5Y neurons recreates a facet of the genome-wide Down syndrome DNA methylation signature. | Stable DNMT3L overexpression in SH-SY5Y neurons recreates a facet of the genome-wide Down syndrome DNA methylation signature.
Laufer BI, Gomez JA, Jianu JM, LaSalle JM., Free PMC Article | 01/22/2022 |
| Decoding the Genetic Alterations in Genes of DNMT Family (DNA Methyl-Transferase) and their Association with Head and Neck Squamous Cell Carcinoma. | Decoding the Genetic Alterations in Genes of DNMT Family (DNA Methyl-Transferase) and their Association with Head and Neck Squamous Cell Carcinoma.
Fathima T, Arumugam P, Girija As S, Priyadharsini JV., Free PMC Article | 09/4/2021 |
| EGR1 interacts with DNMT3L to inhibit the transcription of miR-195 and plays an anti-apoptotic role in the development of gastric cancer. | EGR1 interacts with DNMT3L to inhibit the transcription of miR-195 and plays an anti-apoptotic role in the development of gastric cancer.
Yang Y, Wu F, Zhang J, Sun R, Li F, Li Y, Chang S, Wang L, Wang X, Liu L, Huang C., Free PMC Article | 09/12/2020 |
| Nutrition and its DNA methylation influence cognitive decline. | Interaction of nutrition and genetics via DNMT3L-mediated DNA methylation determines cognitive decline.
Flitton M, Rielly N, Warman R, Warden D, Smith AD, Macdonald IA, Knight HM. | 07/13/2019 |
| DNMT3L overexpression is associated with Down syndrome. | Global hypermethylation in fetal cortex of Down syndrome due to DNMT3L overexpression.
Lu J, Mccarter M, Lian G, Esposito G, Capoccia E, Delli-Bovi LC, Hecht J, Sheen V., Free PMC Article | 08/19/2017 |
| the present study has demonstrated that variations in the DNMT3L gene do not contribute to stage I-II endometriosis-associated infertility. | Association between DNMT3L polymorphic variants and the risk of endometriosis-associated infertility.
Mostowska A, Szczepańska M, Wirstlein P, Skrzypczak J, Jagodziński PP. | 10/8/2016 |
| DNMT3L rs2070565 (genotype P = 0.007, allele P = 0.0026) confers an increased risk of developing schizophrenia at an early age in individuals with family history. | DNA methyl transferase (DNMT) gene polymorphisms could be a primary event in epigenetic susceptibility to schizophrenia.
Saradalekshmi KR, Neetha NV, Sathyan S, Nair IV, Nair CM, Banerjee M., Free PMC Article | 06/20/2015 |
| crystal structures of DNMT3A-DNMT3L (autoinhibitory form) and DNMT3A-DNMT3L-H3 (active form) complexes at 3.82 and 2.90 A resolution, respectively | Structural insight into autoinhibition and histone H3-induced activation of DNMT3A.
Guo X, Wang L, Li J, Ding Z, Xiao J, Yin X, He S, Shi P, Dong L, Li G, Tian C, Wang J, Cong Y, Xu Y. | 05/16/2015 |
| DNMT3L can address DNMT3A/B to specific sites by directly interacting with TFs that do not directly interact with DNMT3A/B | DNMT3L interacts with transcription factors to target DNMT3L/DNMT3B to specific DNA sequences: role of the DNMT3L/DNMT3B/p65-NFκB complex in the (de-)methylation of TRAF1.
Pacaud R, Sery Q, Oliver L, Vallette FM, Tost J, Cartron PF. | 04/4/2015 |
| CpG island encompassing the promoter and first exon of human DNMT3L gene is a PcG/TrX response element | The CpG island encompassing the promoter and first exon of human DNMT3L gene is a PcG/TrX response element (PRE).
Basu A, Dasari V, Mishra RK, Khosla S., Free PMC Article | 01/17/2015 |
| DNMT3L is one of the key players in de novo DNA methylation of imprinting control elements and retrotransposons, which occurs after genome-wide epigenetic erasure during germ cell development. (Review) | Functions of DNA methyltransferase 3-like in germ cells and beyond.
Liao HF, Tai KY, Chen WS, Cheng LC, Ho HN, Lin SP. | 02/23/2013 |
| SNP rs2070565, as well as haplotypes AAA and GAA, may be associated with male infertility; DNMT3L may contribute to azoospermia susceptibility in humans | Association between single-nucleotide polymorphisms of DNMT3L and infertility with azoospermia in Chinese men.
Huang JX, Scott MB, Pu XY, Zhou-Cun A. | 09/1/2012 |
| Genetic polymorphisms of DNMT3L involved in hypermethylation of chromosomal ends are associated with greater risk of developing ovarian endometriosis. | Genetic polymorphisms of DNMT3L involved in hypermethylation of chromosomal ends are associated with greater risk of developing ovarian endometriosis.
Borghese B, Santulli P, Héquet D, Pierre G, de Ziegler D, Vaiman D, Chapron C. | 08/11/2012 |
| mutation analysis of SYCP3, DNMT3L and MSH4 in patients with maturation arrest of spermatogenesis and couples with recurrent miscarriages. | Mutation analysis of three genes in patients with maturation arrest of spermatogenesis and couples with recurrent miscarriages.
Stouffs K, Vandermaelen D, Tournaye H, Liebaers I, Lissens W. | 05/7/2011 |
| This study offers insights into the manner by which DNA methylation patterns are deposited and reveals a new level of interplay between members of the de novo DNMT family. | DNMT3L modulates significant and distinct flanking sequence preference for DNA methylation by DNMT3A and DNMT3B in vivo.
Wienholz BL, Kareta MS, Moarefi AH, Gordon CA, Ginno PA, Chédin F., Free PMC Article | 01/8/2011 |
| Processive methylation is enhanced 3-fold in the presence of DNMT3L, an inactive homolog of DNMT3A, therefore providing a mechanism for the previously described DNMT3L activation of DNMT3A. | The inherent processivity of the human de novo methyltransferase 3A (DNMT3A) is enhanced by DNMT3L.
Holz-Schietinger C, Reich NO., Free PMC Article | 10/4/2010 |
| We have identified loss of methylation at the DNMT3L promoter in ocular surface squamous neoplasia cases. | Hypomethylation of the DNMT3L promoter in ocular surface squamous neoplasia.
Manderwad GP, Gokul G, Kannabiran C, Honavar SG, Khosla S, Vemuganti GK. | 08/30/2010 |
| DNMT3L is a novel marker and is essential for the growth of human embryonal carcinoma. | DNMT3L is a novel marker and is essential for the growth of human embryonal carcinoma.
Minami K, Chano T, Kawakami T, Ushida H, Kushima R, Okabe H, Okada Y, Okamoto K. | 08/23/2010 |
| DNMT3L exerts a major effect on the transcriptional regulation of a specific target gene, such as thymine DNA glycosylase | DNA methyltransferase 3-like affects promoter methylation of thymine DNA glycosylase independently of DNMT1 and DNMT3B in cancer cells.
Kim H, Park J, Jung Y, Song SH, Han SW, Oh DY, Im SA, Bang YJ, Kim TY. | 08/23/2010 |
| CG dinucleotide recognized by the Dnmt3a and Dnmt3L complex are distinctive at retroelements and imprinted domains. | CG dinucleotide periodicities recognized by the Dnmt3a-Dnmt3L complex are distinctive at retroelements and imprinted domains.
Glass JL, Fazzari MJ, Ferguson-Smith AC, Greally JM. | 03/29/2010 |
| Overexpression of DNMT3L, which functions by regulating the activity of DNMT3A and DNMT3B, increased cellular proliferation and anchorage-independent growth. | Reprogramming of HeLa cells upon DNMT3L overexpression mimics carcinogenesis.
Gokul G, Ramakrishna G, Khosla S. | 01/21/2010 |
| DNMT3L(R271Q) is impaired in its ability to stimulate de novo DNA methylation by DNMT3A. | A systematic search for DNA methyltransferase polymorphisms reveals a rare DNMT3L variant associated with subtelomeric hypomethylation.
El-Maarri O, Kareta MS, Mikeska T, Becker T, Diaz-Lacava A, Junen J, Nüsgen N, Behne F, Wienker T, Waha A, Oldenburg J, Chédin F, El-Maarri O, Kareta MS, Mikeska T, Becker T, Diaz-Lacava A, Junen J, Nüsgen N, Behne F, Wienker T, Waha A, Oldenburg J, Chédin F. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesHuman intelligence and polymorphisms in the DNA methyltransferase genes involved in epigenetic marking.
Haggarty P, Hoad G, Harris SE, Starr JM, Fox HC, Deary IJ, Whalley LJ. A systematic search for DNA methyltransferase polymorphisms reveals a rare DNMT3L variant associated with subtelomeric hypomethylation.
El-Maarri O, Kareta MS, Mikeska T, Becker T, Diaz-Lacava A, Junen J, Nüsgen N, Behne F, Wienker T, Waha A, Oldenburg J, Chédin F, El-Maarri O, Kareta MS, Mikeska T, Becker T, Diaz-Lacava A, Junen J, Nüsgen N, Behne F, Wienker T, Waha A, Oldenburg J, Chédin F. | 03/25/2009 |
| Observational study and meta-analysis of gene-disease association. (HuGE Navigator) | Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women.
Palmieri RT, Wilson MA, Iversen ES, Clyde MA, Calingaert B, Moorman PG, Poole C, Anderson AR, Anderson S, Anton-Culver H, Beesley J, Hogdall E, Brewster W, Carney ME, Chen X, Chenevix-Trench G, Chang-Claude J, Cunningham JM, Dicioccio RA, Doherty JA, Easton DF, Edlund CK, Gayther SA, Gentry-Maharaj A, Goode EL, Goodman MT, Kjaer SK, Hogdall CK, Hopkins MP, Jenison EL, Blaakaer J, Lurie G, McGuire V, Menon U, Moysich KB, Ness RB, Pearce CL, Pharoah PD, Pike MC, Ramus SJ, Rossing MA, Song H, Terada KY, Vandenberg D, Vierkant RA, Wang-Gohrke S, Webb PM, Whittemore AS, Wu AH, Ziogas A, Berchuck A, Schildkraut JM, Ovarian Cancer Association Consortium, Australian Cancer Study (Ovarian Cancer Group), Australian Ovarian Cancer Study Group., Free PMC Article | 01/11/2009 |