| Roles of eukaryotic elongation factor 2 kinase (eEF2K) in neuronal plasticity, cognition, and Alzheimer disease. | Roles of eukaryotic elongation factor 2 kinase (eEF2K) in neuronal plasticity, cognition, and Alzheimer disease.
Ma T., Free PMC Article | 07/10/2023 |
| Structure of the complex between calmodulin and a functional construct of eukaryotic elongation factor 2 kinase bound to an ATP-competitive inhibitor. | Structure of the complex between calmodulin and a functional construct of eukaryotic elongation factor 2 kinase bound to an ATP-competitive inhibitor.
Piserchio A, Isiorho EA, Dalby KN, Ghose R., Free PMC Article | 07/7/2023 |
| eEF2K promotes PD-L1 stabilization through inactivating GSK3beta in melanoma. | eEF2K promotes PD-L1 stabilization through inactivating GSK3β in melanoma.
Chen X, Wang K, Jiang S, Sun H, Che X, Zhang M, He J, Wen Y, Liao M, Li X, Zhou X, Song J, Ren X, Yi W, Yang J, Chen X, Yin M, Cheng Y., Free PMC Article | 07/23/2022 |
| miRNA-193b-5p Suppresses Pancreatic Cancer Cell Proliferation, Invasion, Epithelial Mesenchymal Transition, and Tumor Growth by Inhibiting eEF2K. | miRNA-193b-5p Suppresses Pancreatic Cancer Cell Proliferation, Invasion, Epithelial Mesenchymal Transition, and Tumor Growth by Inhibiting eEF2K.
Gurbuz N, Kahraman N, Sonmez HE, Mokhlis HA, Kosar PA, Ozpolat B. | 07/2/2022 |
| Novel regulation of the eEF2K/eEF2 pathway: prospects of 'PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD by suppressing eEF2 phosphorylation'. | Novel regulation of the eEF2K/eEF2 pathway: prospects of 'PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD by suppressing eEF2 phosphorylation'.
Shen Y, Han J, Zhang ZC., Free PMC Article | 02/19/2022 |
| eEF2K as a novel metastatic and prognostic biomarker in gastric cancer patients. | eEF2K as a novel metastatic and prognostic biomarker in gastric cancer patients.
Jiang M, Qi L, Jin K, Li L, Wu Y, Song D, Gan J, Huang M, Li Y, Song C. | 02/5/2022 |
| Targeting eukaryotic elongation factor-2 kinase suppresses the growth and peritoneal metastasis of ovarian cancer. | Targeting eukaryotic elongation factor-2 kinase suppresses the growth and peritoneal metastasis of ovarian cancer.
Erdogan MA, Ashour A, Yuca E, Gorgulu K, Ozpolat B. | 01/22/2022 |
| Structural dynamics of the complex of calmodulin with a minimal functional construct of eukaryotic elongation factor 2 kinase and the role of Thr348 autophosphorylation. | Structural dynamics of the complex of calmodulin with a minimal functional construct of eukaryotic elongation factor 2 kinase and the role of Thr348 autophosphorylation.
Piserchio A, Long K, Lee K, Kumar EA, Abzalimov R, Dalby KN, Ghose R., Free PMC Article | 12/25/2021 |
| Elongation factor eEF2 kinase and autophagy jointly promote survival of cancer cells. | Elongation factor eEF2 kinase and autophagy jointly promote survival of cancer cells.
Lenchine RV, Rao SR, Wang X, Fang DM, Proud CG. | 11/27/2021 |
| eEF2K enhances expression of PD-L1 by promoting the translation of its mRNA. | eEF2K enhances expression of PD-L1 by promoting the translation of its mRNA.
Wu Y, Xie J, Jin X, Lenchine RV, Wang X, Fang DM, Nassar ZD, Butler LM, Li J, Proud CG. | 03/13/2021 |
| This study determined the solution structure of a C-terminal fragment of eEF-2K, eEF-2K562-725 that encodes two alpha-helical repeats. | Solution Structure of the Carboxy-Terminal Tandem Repeat Domain of Eukaryotic Elongation Factor 2 Kinase and Its Role in Substrate Recognition.
Piserchio A, Will N, Giles DH, Hajredini F, Dalby KN, Ghose R., Free PMC Article | 06/20/2020 |
| Regulation of eEF2K mRNA abundance by TNFalpha Is dependent upon canonical NF-kappaB signaling and the p65 NF-kappaB subunit. | Repression of eEF2K transcription by NF-κB tunes translation elongation to inflammation and dsDNA-sensing.
Bianco C, Thompson L, Mohr I., Free PMC Article | 04/11/2020 |
| Knocking down eEF2K also led to a striking decrease in the phosphorylation of PI3K/Akt and STAT3, indicating inactivation of these tumorigenic pathways. Data suggest that eEF2K contributes to angiogenesis and tumor progression in HCC via SP1/KLF5-mediated VEGF expression, as well as the subsequent stimulation of PI3K/Akt and STAT3 signaling. | Eukaryotic elongation factor 2 kinase promotes angiogenesis in hepatocellular carcinoma via PI3K/Akt and STAT3.
Zhou Y, Li Y, Xu S, Lu J, Zhu Z, Chen S, Tan Y, He P, Xu J, Proud CG, Xie J, Shen K. | 02/8/2020 |
| Eukaryotic elongation factor-2 kinase mediates cross-talk between DFNA5-mediated pyroptosis and autophagy in doxorubicin-treated human melanoma cells. | Eukaryotic elongation factor-2 kinase regulates the cross-talk between autophagy and pyroptosis in doxorubicin-treated human melanoma cells in vitro.
Yu P, Wang HY, Tian M, Li AX, Chen XS, Wang XL, Zhang Y, Cheng Y., Free PMC Article | 02/8/2020 |
| findings indicate that eEF2K and HSPs closely cooperate to maintain proper proteostasis and suggest that concomitant inhibition of HSP90 and eEF2K could be a strategy to decrease cancer cell survival | Ablation of elongation factor 2 kinase enhances heat-shock protein 90 chaperone expression and protects cells under proteotoxic stress.
Xie J, Van Damme P, Fang D, Proud CG., Free PMC Article | 01/11/2020 |
| results link eEF2K/eEF2 signaling dysregulation to Alzheimer's disease pathophysiology and therefore offer a feasible therapeutic target. | Genetic reduction of eEF2 kinase alleviates pathophysiology in Alzheimer's disease model mice.
Beckelman BC, Yang W, Kasica NP, Zimmermann HR, Zhou X, Keene CD, Ryazanov AG, Ma T., Free PMC Article | 12/21/2019 |
| The functionality of eukaryotic translation elongation factor 2 (eEF2) is modulated by phosphorylation, eEF2 is simultaneously the molecular target of ADP-ribosylating toxins. | Interplay between reversible phosphorylation and irreversible ADP-ribosylation of eukaryotic translation elongation factor 2.
Mateus-Seidl R, Stahl S, Dengl S, Birzele F, Herrmuth H, Mayer K, Niederfellner G, Liu XF, Pastan I, Brinkmann U., Free PMC Article | 12/7/2019 |
| this study shows that eEF-2K expression is associated with poor patient survival and promotes proliferation, invasion and tumor growth of lung cancer | Elongation factor-2 kinase (eEF-2K) expression is associated with poor patient survival and promotes proliferation, invasion and tumor growth of lung cancer.
Bircan HA, Gurbuz N, Pataer A, Caner A, Kahraman N, Bayraktar E, Bayraktar R, Erdogan MA, Kabil N, Ozpolat B. | 09/14/2019 |
| The data of this study support the relevance of eEF2K in Parkinson disease, and of eEF2K inhibition in mitigating alpha synuclein induced oxidative stress and neuronal dysfunction. | Activity of translation regulator eukaryotic elongation factor-2 kinase is increased in Parkinson disease brain and its inhibition reduces alpha synuclein toxicity.
Jan A, Jansonius B, Delaidelli A, Bhanshali F, An YA, Ferreira N, Smits LM, Negri GL, Schwamborn JC, Jensen PH, Mackenzie IR, Taubert S, Sorensen PH., Free PMC Article | 06/8/2019 |
| Results suggest that the eukaryotic elongation factor-2 kinase (eEF-2 kinase) 3' untranslated regions (3'UTR) contains a functional target site for miR-449b in cancer cells. | eEF-2 Kinase-targeted miR-449b confers radiation sensitivity to cancer cells.
Ji C, Xu Q, Guo L, Wang X, Ren Y, Zhang H, Zhu W, Ming Z, Yuan Y, Ren X, Song J, Cheng Y, Yang J, Zhang Y. | 02/2/2019 |
| High levels of eEF2K expression were associated with invasive carcinoma and metastatic tumors. | Eukaryotic elongation factor 2 kinase upregulates the expression of proteins implicated in cell migration and cancer cell metastasis.
Xie J, Shen K, Lenchine RV, Gethings LA, Trim PJ, Snel MF, Zhou Y, Kenney JW, Kamei M, Kochetkova M, Wang X, Proud CG. | 01/12/2019 |
| that eukaryotic elongation factor 2 kinase might inhibit TGF-beta1-induced normal lung fibroblast (NHLF) proliferation and differentiation and activate NHLF cell apoptosis and autophagy through p38 MAPK signaling | Elongation factor-2 kinase acts downstream of p38 MAPK to regulate proliferation, apoptosis and autophagy in human lung fibroblasts.
Wang Y, Huang G, Wang Z, Qin H, Mo B, Wang C. | 11/17/2018 |
| Our study provides first evidence that TQ treatment inhibits cell proliferation, migration/invasion, and tumor growth, in part through the inhibition of eEF-2K signaling in Triple-negative breast cancer (TNBC) . Thus, our findings suggest that systemic TQ treatment may be used as a targeted therapeutic strategy for the inhibition of eEF-2K in TNBC tumor growth and progression. | Thymoquinone inhibits cell proliferation, migration, and invasion by regulating the elongation factor 2 kinase (eEF-2K) signaling axis in triple-negative breast cancer.
Kabil N, Bayraktar R, Kahraman N, Mokhlis HA, Calin GA, Lopez-Berestein G, Ozpolat B. | 10/27/2018 |
| The mechanism for Fluoxetine-induced autophagic cell death was associated with inhibition of eEF2K and activation of AMPK-mTOR-ULK complex axis. | Fluoxetine induces autophagic cell death via eEF2K-AMPK-mTOR-ULK complex axis in triple negative breast cancer.
Sun D, Zhu L, Zhao Y, Jiang Y, Chen L, Yu Y, Ouyang L., Free PMC Article | 03/31/2018 |
| This study provides new insights into the control of eEF2K by AMPK. | Direct and indirect activation of eukaryotic elongation factor 2 kinase by AMP-activated protein kinase.
Johanns M, Pyr Dit Ruys S, Houddane A, Vertommen D, Herinckx G, Hue L, Proud CG, Rider MH. | 03/10/2018 |