| G-Protein Signaling Modulator 2 as a Potential Biomarker in Colorectal Cancer: Integrative Analysis Using Genetic Profiling and Pan-Cancer Studies. | G-Protein Signaling Modulator 2 as a Potential Biomarker in Colorectal Cancer: Integrative Analysis Using Genetic Profiling and Pan-Cancer Studies.
Kadhim DJ, Azari H, Sokhangouy SK, Hassanian SM, Alshekarchi HI, Goshayeshi L, Goshayeshi L, Abbaszadegan MR, Khojasteh-Leylakoohi F, Khazaei M, Gataa IS, Peters GJ, A Ferns G, Batra J, Lam AK, Giovannetti E, Avan A., Free PMC Article | 05/16/2024 |
| Truncated isoforms of GPSM2 containing the GoLoco motif region promote CD4(+) T-cell migration in SLE. | Truncated isoforms of GPSM2 containing the GoLoco motif region promote CD4(+) T-cell migration in SLE.
Esser RL, Brück C, Thiele J, Golumba-Nagy V, Meyer A, Steinbach-Knödgen E, Yan S, Tho Pesch C, Stahl D, Schiller J, Kofler DM., Free PMC Article | 08/20/2022 |
| GPSM2 Serves as an Independent Prognostic Biomarker for Liver Cancer Survival. | GPSM2 Serves as an Independent Prognostic Biomarker for Liver Cancer Survival.
Yang D, Ji F, Li Y, Jiao Y, Fang X., Free PMC Article | 12/4/2021 |
| Loss of G-protein-signaling modulator 2 accelerates proliferation of lung adenocarcinoma via EGFR signaling pathway. | Loss of G-protein-signaling modulator 2 accelerates proliferation of lung adenocarcinoma via EGFR signaling pathway.
Deng M, Liu B, Zhang Z, Chen Y, Wang Y, Wang X, Lv Q, Yang X, Hou K, Che X, Qu X, Liu Y, Zhang Y, Hu X. | 12/5/2020 |
| Downregulation of GPSM2 is associated with primary resistance to paclitaxel in breast cancer. | Downregulation of GPSM2 is associated with primary resistance to paclitaxel in breast cancer.
Zhang Z, Li Z, Deng M, Liu B, Xin X, Zhao Z, Zhang Y, Lv Q., Free PMC Article | 09/26/2020 |
| LGN has a role in cell cortex recruitment of NuMA | Intramolecular interaction in LGN, an adaptor protein that regulates mitotic spindle orientation.
Takayanagi H, Hayase J, Kamakura S, Miyano K, Chishiki K, Yuzawa S, Sumimoto H., Free PMC Article | 06/27/2020 |
| Study reports the crystal structure of NuMA:LGN hetero-hexamers, and unveil their role in promoting the assembly of active cortical dynein/dynactin motors that are required in orchestrating oriented divisions in polarized cells. | Hexameric NuMA:LGN structures promote multivalent interactions required for planar epithelial divisions.
Pirovano L, Culurgioni S, Carminati M, Alfieri A, Monzani S, Cecatiello V, Gaddoni C, Rizzelli F, Foadi J, Pasqualato S, Mapelli M., Free PMC Article | 06/8/2019 |
| The results show how E-cadherin instructs the assembly of the LGN/NuMA complex at cell-cell contacts, and define a mechanism that couples cell division orientation to intercellular adhesion. | Cell division orientation is coupled to cell-cell adhesion by the E-cadherin/LGN complex.
Gloerich M, Bianchini JM, Siemers KA, Cohen DJ, Nelson WJ., Free PMC Article | 11/17/2018 |
| Endothelial flow mechanotransduction through the junctional complex is mediated by a specific pool of VE-cadherin that is phosphorylated on cytoplasmic tyrosine Y658 and bound to LGN. | VE-Cadherin Phosphorylation Regulates Endothelial Fluid Shear Stress Responses through the Polarity Protein LGN.
Conway DE, Coon BG, Budatha M, Arsenovic PT, Orsenigo F, Wessel F, Zhang J, Zhuang Z, Dejana E, Vestweber D, Schwartz MA., Free PMC Article | 07/21/2018 |
| In mammary stem cells, the asymmetric domain of Insc bound to LGN:Galphai(GDP) suffices to drive asymmetric fate, and reverts aberrant symmetric divisions induced by p53 loss. | Insc:LGN tetramers promote asymmetric divisions of mammary stem cells.
Culurgioni S, Mari S, Bonetti P, Gallini S, Bonetto G, Brennich M, Round A, Nicassio F, Mapelli M., Free PMC Article | 05/19/2018 |
| Data support the notion that the Galpha, but not Gbetagamma, arm of the Gi/o signalling is involved in TRPC4 activation and unveil new roles for RGS and LGN in fine-tuning TRPC4 activities. | Regulator of G-protein signalling and GoLoco proteins suppress TRPC4 channel function via acting at Gαi/o.
Jeon JP, Thakur DP, Tian JB, So I, Zhu MX., Free PMC Article | 05/20/2017 |
| high expression of G-protein signaling modulator 2 was involved in the pathological processes of hepatocellular carcinoma through activation of the phosphatidylinositol 3-kinase/protein kinase B signaling pathway, which may provide an attractive potential diagnostic biomarker and therapeutic target for treatment of hepatocellular carcinoma. | High expression of G-protein signaling modulator 2 in hepatocellular carcinoma facilitates tumor growth and metastasis by activating the PI3K/AKT signaling pathway.
He XQ, Zhang YF, Yu JJ, Gan YY, Han NN, Zhang MX, Ge W, Deng JJ, Zheng YF, Xu XM. | 04/8/2017 |
| A novel mutation (c.1093C > T; p.Arg365*) is described in a family with dizygotic twins with variable phenotype of Chudley-McCullough syndrome. | Chudley-McCullough Syndrome: Variable Clinical Picture in Twins with a Novel GPSM2 Mutation.
Koenigstein K, Gramsch C, Kolodziej M, Neubauer BA, Weber A, Lechner S, Hahn A. | 02/25/2017 |
| This mutation is predicted to abolish all four GoLoco domains in GPSM2 and this explains the bioinformatic prediction for this mutation to be functionally damaging. Full clinical and molecular accounts of the novel mutation are provided in this paper. | A novel nonsense GPSM2 mutation in a Yemeni family underlying Chudley-McCullough syndrome.
Hamzeh AR, Nair P, Mohamed M, Saif F, Tawfiq N, Al-Ali MT, Bastaki F. | 02/18/2017 |
| Kinocilium is essential for proper localization of Lgn, as well as Gai and aPKC, suggesting that cilium function plays a role in positioning of apical proteins critical for hearing. | The GPSM2/LGN GoLoco motifs are essential for hearing.
Bhonker Y, Abu-Rayyan A, Ushakov K, Amir-Zilberstein L, Shivatzki S, Yizhar-Barnea O, Elkan-Miller T, Tayeb-Fligelman E, Kim SM, Landau M, Kanaan M, Chen P, Matsuzaki F, Sprinzak D, Avraham KB., Free PMC Article | 10/22/2016 |
| This study determined the crystallographic structure of human Afadin in complex with LGN. | Concomitant binding of Afadin to LGN and F-actin directs planar spindle orientation.
Carminati M, Gallini S, Pirovano L, Alfieri A, Bisi S, Mapelli M. | 07/2/2016 |
| results fit a model whereby LGN influences interphase microtubule dynamics in endothelial cells to regulate migration, cell adhesion, and sprout extension, and reveal a novel non-mitotic role for LGN in sprouting angiogenesis | LGN Directs Interphase Endothelial Cell Behavior via the Microtubule Network.
Wright CE, Kushner EJ, Du Q, Bautch VL., Free PMC Article | 05/28/2016 |
| A crystal structure of Frmpd4-bound LGN in an oxidized form is also reported, although oxidation does not appear to strongly affect the interaction with Frmpd4. | Structural basis for the recognition of the scaffold protein Frmpd4/Preso1 by the TPR domain of the adaptor protein LGN.
Takayanagi H, Yuzawa S, Sumimoto H., Free PMC Article | 11/7/2015 |
| LGN is required for mitotic spindle rotation but not orientation maintenance. | Automated tracking of mitotic spindle pole positions shows that LGN is required for spindle rotation but not orientation maintenance.
Corrigan AM, Shrestha RL, Zulkipli I, Hiroi N, Liu Y, Tamura N, Yang B, Patel J, Funahashi A, Donald A, Draviam VM., Free PMC Article | 03/15/2014 |
| Hepatocyte Par1b defines lumen position in concert with the position of the astral microtubule anchoring complex LGN-NuMA to yield the distinct epithelial division phenotypes. | Par1b links lumen polarity with LGN-NuMA positioning for distinct epithelial cell division phenotypes.
Lázaro-Diéguez F, Cohen D, Fernandez D, Hodgson L, van Ijzendoorn SC, Müsch A., Free PMC Article | 12/14/2013 |
| one homozygous frameshift GPSM2 variants c.1473delG was identified in three Chudley-McCullough syndrome Dutch patients. | GPSM2 and Chudley-McCullough syndrome: a Dutch founder variant brought to North America.
Almomani R, Sun Y, Aten E, Hilhorst-Hofstee Y, Peeters-Scholte CM, van Haeringen A, Hendriks YM, den Dunnen JT, Breuning MH, Kriek M, Santen GW. | 11/30/2013 |
| Data indicate that dynein- and astral microtubule-mediated transport of Galphai/LGN/nuclear mitotic apparatus (NuMA) complex from cell cortex to spindle poles. | Evidence for dynein and astral microtubule-mediated cortical release and transport of Gαi/LGN/NuMA complex in mitotic cells.
Zheng Z, Wan Q, Liu J, Zhu H, Chu X, Du Q., Free PMC Article | 09/21/2013 |
| Studies indicate that the Inscuteable (Insc)and NuMA are mutually exclusive interactors of LGN. | On the inscrutable role of Inscuteable: structural basis and functional implications for the competitive binding of NuMA and Inscuteable to LGN.
Mapelli M, Gonzalez C., Free PMC Article | 06/29/2013 |
| Results show compound heterozygous mutations in the GPSM2 gene, in affected members of a family with Chudley-McCullough syndrome, co-segregate in the family as an autosomal recessive trait. | GPSM2 mutations in Chudley-McCullough syndrome.
Diaz-Horta O, Sirmaci A, Doherty D, Nance W, Arnos K, Pandya A, Tekin M., Free PMC Article | 06/22/2013 |
| Overexpression of LGN decreases the activity of cellular sGC, whereas knockdown of LGN mRNA and protein correlated with increased sGC activity | The G-protein regulator LGN modulates the activity of the NO receptor soluble guanylate cyclase.
Chauhan S, Jelen F, Sharina I, Martin E., Free PMC Article | 11/17/2012 |