| IGFBP7 promotes endothelial cell repair in the recovery phase of acute lung injury. | IGFBP7 promotes endothelial cell repair in the recovery phase of acute lung injury.
He R, Feng B, Zhang Y, Li Y, Wang D, Yu L., Free PMC Article | 06/30/2024 |
| Structural insight into CD93 recognition by IGFBP7. | Structural insight into CD93 recognition by IGFBP7.
Xu Y, Sun Y, Zhu Y, Song G. | 03/14/2024 |
| METTL3-mediated m[6]A modification of IGFBP7-OT promotes osteoarthritis progression by regulating the DNMT1/DNMT3a-IGFBP7 axis. | METTL3-mediated m(6)A modification of IGFBP7-OT promotes osteoarthritis progression by regulating the DNMT1/DNMT3a-IGFBP7 axis.
Tang Y, Hong F, Ding S, Yang J, Zhang M, Ma Y, Zheng Q, Yang D, Jin Y, Ma C. | 10/12/2023 |
| Insulin-like growth factor binding protein 7 promotes acute kidney injury by alleviating poly ADP ribose polymerase 1 degradation. | Insulin-like growth factor binding protein 7 promotes acute kidney injury by alleviating poly ADP ribose polymerase 1 degradation.
Yu JT, Hu XW, Yang Q, Shan RR, Zhang Y, Dong ZH, Li HD, Wang JN, Li C, Xie SS, Dong YH, Ni WJ, Jiang L, Liu XQ, Wei B, Wen JG, Liu MM, Chen Q, Yang YR, Zhang GY, Zang HM, Jin J, Wu YG, Zhong X, Li J, Wang W, Meng XM. | 10/1/2022 |
| IGFBP7 aggravates sepsis-induced acute lung injury by activating the ERK1/2 pathway. | IGFBP7 aggravates sepsis-induced acute lung injury by activating the ERK1/2 pathway.
Xu Q, Wang J. | 07/24/2021 |
| Insulin-like growth factor binding protein 7 accelerates hepatic steatosis and insulin resistance in non-alcoholic fatty liver disease. | Insulin-like growth factor binding protein 7 accelerates hepatic steatosis and insulin resistance in non-alcoholic fatty liver disease.
Yan H, Li T, Wang Y, Li H, Xu J, Lu X. | 08/29/2020 |
| The mechanism may be that eleutheroside B can activate the insulin-like growth factor (IGF) pathway and its downstream pathway by downregulating the expression of IGFBP-7, thus promoting cell proliferation. Therefore, our results suggest that eleutheroside B is a potential drug for Acute kidney injury (AKI) treatment. | Eleutheroside B Protects against Acute Kidney Injury by Activating IGF Pathway.
Zang H, Yang Q, Li J., Free PMC Article | 03/14/2020 |
| IGFBP7 inhibited receptor activation of nuclear factor-kappaB (NF-kappaB) ligand (RANKL)-induced osteoclastogenesis. | IGFBP7 acts as a negative regulator of RANKL-induced osteoclastogenesis and oestrogen deficiency-induced bone loss.
Ye C, Hou W, Chen M, Lu J, Chen E, Tang L, Hang K, Ding Q, Li Y, Zhang W, He R., Free PMC Article | 03/7/2020 |
| IGFBP7 has a role in regulating sepsis-induced epithelial-mesenchymal transition through ERK1/2 signaling | IGFBP7 regulates sepsis-induced epithelial-mesenchymal transition through ERK1/2 signaling.
Wang X, Li Y, Zhao Z, Meng Y, Bian J, Bao R, Zhu K, Yang T. | 02/15/2020 |
| IGFBPrP1 promoted autophagy and contributed to hepatic stellate cell activation via mutual regulation between H19 and the PI3K/AKT/mTOR pathway. | IGFBPrP1 accelerates autophagy and activation of hepatic stellate cells via mutual regulation between H19 and PI3K/AKT/mTOR pathway.
Huang TJ, Ren JJ, Zhang QQ, Kong YY, Zhang HY, Guo XH, Fan HQ, Liu LX. | 01/18/2020 |
| Our findings define an immune component of the pleiotropic mechanisms through which IGFBP7 suppresses hepatocellular carcinoma | IGFBP7 Deletion Promotes Hepatocellular Carcinoma.
Akiel M, Guo C, Li X, Rajasekaran D, Mendoza RG, Robertson CL, Jariwala N, Yuan F, Subler MA, Windle J, Garcia DK, Lai Z, Chen HH, Chen Y, Giashuddin S, Fisher PB, Wang XY, Sarkar D., Free PMC Article | 09/30/2017 |
| Study shows that IGFBP7 contributes significantly to mesenchymal stromal cells (MSC)-mediated immune modulation, as is shown by decreasing ability of IGFBP7 knockdown in MSCs to restore proliferation and cytokine production in T-cells. | Mesenchymal Stromal Cells Mitigate Experimental Colitis via Insulin-like Growth Factor Binding Protein 7-mediated Immunosuppression.
Liao Y, Lei J, Liu M, Lin W, Hong D, Tuo Y, Jiang MH, Xia H, Wang M, Huang W, Xiang AP., Free PMC Article | 06/24/2017 |
| data suggest that IGFBP-7 was up regulated during EAE and inhibit the transition from OPCs to mature OLs, implying its use as a potential therapeutic target for the treatment of inflammatory demyelinating diseases | Insulin-like growth factor-binding protein 7 is up-regulated during EAE and inhibits the differentiation of oligodendrocyte precursor cells.
Tan W, Pu Y, Shao Q, Fang X, Han D, Zhao M, Cao L. | 08/22/2015 |
| Our data suggest that loss of Igfbp7 induces precocious involution possibly through diminished cell survival signals. | Loss of Igfbp7 causes precocious involution in lactating mouse mammary gland.
Chatterjee S, Bacopulos S, Yang W, Amemiya Y, Spyropoulos D, Raouf A, Seth A., Free PMC Article | 01/3/2015 |
| Angiomodulin is necessary for cardiac commitment of embryonic stem cells (ESCs) and its regulation depends on TAp63 isoform. | Angiomodulin is required for cardiogenesis of embryonic stem cells and is maintained by a feedback loop network of p63 and Activin-A.
Wolchinsky Z, Shivtiel S, Kouwenhoven EN, Putin D, Sprecher E, Zhou H, Rouleau M, Aberdam D. | 09/13/2014 |
| results show that Smarcb1 is required for transcriptional activation of Igfbp7 and show that re-introduction of Igfbp7 alone can hinder tumor development; results define a novel mechanism for Smarcb1-mediated tumorigenesis | Loss of IGFBP7 expression and persistent AKT activation contribute to SMARCB1/Snf5-mediated tumorigenesis.
Darr J, Klochendler A, Isaac S, Eden A. | 07/26/2014 |
| a model whereby IGFBP7 binds to unoccupied IGF1R and suppresses downstream signaling, thereby inhibiting protein synthesis, cell growth, and survival. | IGFBP7 binds to the IGF-1 receptor and blocks its activation by insulin-like growth factors.
Evdokimova V, Tognon CE, Benatar T, Yang W, Krutikov K, Pollak M, Sorensen PH, Seth A. | 05/25/2013 |
| IGFBP7 has a novel role in mouse uterus: it is regulating uterine receptivity through Th1/Th2 lymphocyte balance and decidualization. | A novel role of IGFBP7 in mouse uterus: regulating uterine receptivity through Th1/Th2 lymphocyte balance and decidualization.
Liu ZK, Wang RC, Han BC, Yang Y, Peng JP., Free PMC Article | 03/2/2013 |
| fear extinction-induced IGF2/IGFBP7 signalling promotes the survival of 17-19-day-old newborn hippocampal neurons | A hippocampal insulin-growth factor 2 pathway regulates the extinction of fear memories.
Agis-Balboa RC, Arcos-Diaz D, Wittnam J, Govindarajan N, Blom K, Burkhardt S, Haladyniak U, Agbemenyah HY, Zovoilis A, Salinas-Riester G, Opitz L, Sananbenesi F, Fischer A., Free PMC Article | 12/24/2011 |
| Results demonstrate that the vascular-specific marker angiomodulin (AGM) modulates vascular remodeling in part by temporizing the proangiogenic effects of VEGF-A. | Angiomodulin is a specific marker of vasculature and regulates vascular endothelial growth factor-A-dependent neoangiogenesis.
Hooper AT, Shmelkov SV, Gupta S, Milde T, Bambino K, Gillen K, Goetz M, Chavala S, Baljevic M, Murphy AJ, Valenzuela DM, Gale NW, Thurston G, Yancopoulos GD, Vahdat L, Evans T, Rafii S., Free PMC Article | 03/28/2011 |
| study showed that IGFBP-rP1 (IGFBP7) was expressed in dysregulated podocytes in a human immunodeficiency virus-associated nephropathy model and in immature podocytes in the developing kidney; conclude that IGFBP-rP1 may be a product of injured podocytes | Proteomic analysis identifies insulin-like growth factor-binding protein-related protein-1 as a podocyte product.
Matsumoto T, Hess S, Kajiyama H, Sakairi T, Saleem MA, Mathieson PW, Nojima Y, Kopp JB., Free PMC Article | 10/30/2010 |
| inhibition of Malignant melanoma growth is due to apoptosis and reduced expression of VEGF induced by pEGFC1-IGFBP7 | Intratumoral injection of pEGFC1-IGFBP7 inhibits malignant melanoma growth in C57BL/6J mice by inducing apoptosis and down-regulating VEGF expression.
Chen RY, Chen HX, Jian P, Xu L, Li J, Fan YM, Tu YT. | 06/28/2010 |
| IGFBP-7 can regulate glioma cell migration through the AKT-ERK pathway, thereby playing an important role in glioma growth and migration | Insulin-like growth factor binding protein 7 mediates glioma cell growth and migration.
Jiang W, Xiang C, Cazacu S, Brodie C, Mikkelsen T., Free PMC Article | 01/21/2010 |
| Mac25 interacts with the extracellular matrix proteins and glycosaminoglycans that are expressed in most blood vessels including high endothelial venules, as well as with chemokines implicated in regulation of lymphocyte trafficking, e.g., SLC and IP-10. | A high endothelial venule secretory protein, mac25/angiomodulin, interacts with multiple high endothelial venule-associated molecules including chemokines.
Nagakubo D, Murai T, Tanaka T, Usui T, Matsumoto M, Sekiguchi K, Miyasaka M. | 01/21/2010 |
| Proteolytic processing of mac25 modulates its insulin/IGF-1-dependent growth-stimulatory activity. | Proteolytic processing of IGFBP-related protein-1 (TAF/angiomodulin/mac25) modulates its biological activity.
Ahmed S, Yamamoto K, Sato Y, Ogawa T, Herrmann A, Higashi S, Miyazaki K. | 01/21/2010 |