| CARMA3: A potential therapeutic target in non-cancer diseases. | CARMA3: A potential therapeutic target in non-cancer diseases.
Gui Z, Zhang Y, Zhang A, Xia W, Jia Z., Free PMC Article | 01/14/2023 |
| CARMA3 Transcriptional Regulation of STMN1 by NF-kappaB Promotes Renal Cell Carcinoma Proliferation and Invasion. | CARMA3 Transcriptional Regulation of STMN1 by NF-κB Promotes Renal Cell Carcinoma Proliferation and Invasion.
Shi D, Zhang Z, Kong C., Free PMC Article | 12/18/2021 |
| Mutant CARD10 in a family with progressive immunodeficiency and autoimmunity. | Mutant CARD10 in a family with progressive immunodeficiency and autoimmunity.
Yang DH, Guo T, Yuan ZZ, Lei C, Ding SZ, Yang YF, Tan ZP, Luo H., Free PMC Article | 07/31/2021 |
| The circINTS4/miR-146b/CARMA3 axis promotes tumorigenesis in bladder cancer. | The circINTS4/miR-146b/CARMA3 axis promotes tumorigenesis in bladder cancer.
Zhang X, Liu X, Jing Z, Bi J, Li Z, Liu X, Li J, Li Z, Zhang Z, Kong C. | 05/15/2021 |
| CARD10 promotes the progression of renal cell carcinoma by regulating the NFkappaB signaling pathway. | CARD10 promotes the progression of renal cell carcinoma by regulating the NF‑κB signaling pathway.
Peng L, He K, Cao Z, Bi L, Yu D, Wang Q, Wang J., Free PMC Article | 11/21/2020 |
| Caspase recruitment domain family member 10 regulates carbamoyl phosphate synthase 1 and promotes cancer growth in bladder cancer cells. | Caspase recruitment domain family member 10 regulates carbamoyl phosphate synthase 1 and promotes cancer growth in bladder cancer cells.
Liu X, Zhang X, Bi J, Li Z, Zhang Z, Kong C., Free PMC Article | 09/26/2020 |
| Higher expression of CARMA3 in hepatocellular carcinoma (HCC) was relevant to poor prognostic survival. Down-regulation of CARMA3 inhibited proliferation and colony formation and induced apoptosis in HCC cell lines, while increasing its expression promoted tumorigenesis. | CARMA3/NF-κB signaling contributes to tumorigenesis of hepatocellular carcinoma and is inhibited by sodium aescinate.
Hou H, Li WX, Cui X, Zhou DC, Zhang B, Geng XP., Free PMC Article | 02/29/2020 |
| Card10 is expressed in granulocytes and is a direct target of CEBPE with functions extending to myeloid differentiation. | CARD10, a CEBPE target involved in granulocytic differentiation.
Shyamsunder P, Sankar H, Mayakonda A, Han L, Nordin HBM, Woon TW, Shanmugasundaram M, Dakle P, Madan V, Koeffler HP., Free PMC Article | 10/5/2019 |
| High CARMA3 expression is associated with Breast Cancer. | The CARMA3-Bcl10-MALT1 Signalosome Drives NFκB Activation and Promotes Aggressiveness in Angiotensin II Receptor-Positive Breast Cancer.
Ekambaram P, Lee JL, Hubel NE, Hu D, Yerneni S, Campbell PG, Pollock N, Klei LR, Concel VJ, Delekta PC, Chinnaiyan AM, Tomlins SA, Rhodes DR, Priedigkeit N, Lee AV, Oesterreich S, McAllister-Lucas LM, Lucas PC., Free PMC Article | 01/19/2019 |
| The results suggest that the involvement of CARMA3 in DNA damage-induced NF-kappaB is through the recruitment of TRAF6. | The CARMA3-BCL10-MALT1 (CBM) complex contributes to DNA damage-induced NF-κB activation and cell survival.
Zhang S, Pan D, Jia XM, Lin X, Zhao X., Free PMC Article | 07/21/2018 |
| Card10 polymorphisms may not be linked with psoriasis vulgaris in the southern Han Chinese population. | Lack of association between CARD10/CARMA3 tag SNPs and psoriasis vulgaris in the southern Chinese population.
Shi G, Zhang MF, Liao PY, Wang TT, Li SJ, Fan YM, Zhu KJ. | 04/15/2017 |
| Data indicate no association between caspase recruitment domain family, member 10 protein (CARD10) polymorphism rs6000782 and type 1 autoimmune hepatitis (AIH) in a Japanese population. | Lack of association between the CARD10 rs6000782 polymorphism and type 1 autoimmune hepatitis in a Japanese population.
Migita K, Jiuchi Y, Furukawa H, Nakamura M, Komori A, Yasunami M, Kozuru H, Abiru S, Yamasaki K, Nagaoka S, Hashimoto S, Bekki S, Yoshizawa K, Shimada M, Kouno H, Kamitsukasa H, Komatsu T, Hijioka T, Nakamuta M, Naganuma A, Yamashita H, Nishimura H, Ohta H, Nakamura Y, Ario K, Oohara Y, Sugi K, Tomizawa M, Sato T, Takahashi H, Muro T, Makita F, Mita E, Sakai H, Yatsuhashi H., Free PMC Article | 09/24/2016 |
| Findings indicate that CARMA3 may suppress the activation of the P38 MAPK signaling pathway to regulate invasion, migration and apoptosis of lung cancer cells by activating NF-small ka, CyrillicB (P65) in the nucleus. | CARMA3 regulates the invasion, migration, and apoptosis of non-small cell lung cancer cells by activating NF-кB and suppressing the P38 MAPK signaling pathway.
Xia ZX, Li ZX, Zhang M, Sun LM, Zhang QF, Qiu XS. | 09/10/2016 |
| The study identified the DEP domain-containing protein DEPDC7 as cellular binding partner of CARMA2 and CARMA3 proteins. | The Dishevelled, EGL-10 and pleckstrin (DEP) domain-containing protein DEPDC7 binds to CARMA2 and CARMA3 proteins, and regulates NF-κB activation.
D'Andrea EL, Ferravante A, Scudiero I, Zotti T, Reale C, Pizzulo M, De La Motte LR, De Maio C, Mazzone P, Telesio G, Vito P, Stilo R., Free PMC Article | 12/5/2015 |
| A novel mechanism of CARMA3 in lung cancer stemness and metastasis through the negative regulation of NME2 was identified. | CARMA3 Represses Metastasis Suppressor NME2 to Promote Lung Cancer Stemness and Metastasis.
Chang YW, Chiu CF, Lee KY, Hong CC, Wang YY, Cheng CC, Jan YH, Huang MS, Hsiao M, Ma JT, Su JL. | 09/12/2015 |
| CARMA3 regulates the ovarian cancer cell proliferation, cell cycle progression, and chemoresistance. | Overexpression of CARMA3 is associated with advanced tumor stage, cell cycle progression, and cisplatin resistance in human epithelial ovarian cancer.
Xie C, Han Y, Fu L, Li Q, Qiu X, Wang E. | 01/17/2015 |
| CARMA3 is overexpressed in pancreatic cancer and regulates malignant cell growth, invasion, and NF-kappaB signaling, which was dependent on its association with Bcl10. | CARMA3 is upregulated in human pancreatic carcinoma, and its depletion inhibits tumor proliferation, migration, and invasion.
Du S, Jia L, Zhang Y, Fang L, Zhang X, Fan Y. | 08/23/2014 |
| CARMA3 is overexpressed in bladder cancer and regulates malignant cell growth and NF-kappaB signaling. | Clinical significance and biological roles of CARMA3 in human bladder carcinoma.
Man X, He J, Kong C, Zhu Y, Zhang Z. | 06/28/2014 |
| Genetic variation within PARP1 and CARD10 was associated with rate of hippocampal neurodegeneration in APOE e3/e3 patients. | Whole-exome sequencing and imaging genetics identify functional variants for rate of change in hippocampal volume in mild cognitive impairment.
Nho K, Corneveaux JJ, Kim S, Lin H, Risacher SL, Shen L, Swaminathan S, Ramanan VK, Liu Y, Foroud T, Inlow MH, Siniard AL, Reiman RA, Aisen PS, Petersen RC, Green RC, Jack CR, Weiner MW, Baldwin CT, Lunetta K, Farrer LA, Multi-Institutional Research on Alzheimer Genetic Epidemiology (MIRAGE) Study, Furney SJ, Lovestone S, Simmons A, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Soininen H, AddNeuroMed Consortium, McDonald BC, Farlow MR, Ghetti B, Indiana Memory and Aging Study, Huentelman MJ, Saykin AJ, Alzheimer's Disease Neuroimaging Initiative (ADNI)., Free PMC Article | 05/3/2014 |
| CARD10 may be involved in hepatic carcinogenesis associated with hepatitis C in Egyptian patients. | Caspase recruitment domains. New potential markers for diagnosis of hepatocellular carcinoma associated with HCV in Egyptian patients.
Zekri AR, El-Kassas M, Saad Y, Bahnassy A, El-Din HK, Darweesh SK, Abdel Hafez H, Esmat G. | 04/26/2014 |
| overexpression of CARMA3 in human glioma and its correlation with tumor grade. | CARMA3 is overexpressed in human glioma and promotes cell invasion through MMP9 regulation in A172 cell line.
Feng X, Miao G, Han Y, Xu Y. | 03/29/2014 |
| Data show that CARMA3 may serve as a novel and prognostic marker for renal cell carcinoma (RCC) and play a role during the development and progression of the disease. | Evaluating the expression of CARMA3 as a prognostic tumor marker in renal cell carcinoma.
Wu GL, Yuan JL, Huang XD, Rong JF, Zhang LX, Liu YP, Wang FL. | 02/22/2014 |
| CARMA3 facilitates proliferation and inhibits apoptosis through nuclear factor-kappaB signaling. | CARMA3 overexpression accelerates cell proliferation and inhibits paclitaxel-induced apoptosis through NF-κB regulation in breast cancer cells.
Zhao T, Miao Z, Wang Z, Xu Y, Wu J, Liu X, You Y, Li J. | 11/30/2013 |
| miR-146a expression is up-regulated in a majority of gastric cancers where it targets CARD10 and COPS8, inhibiting GPCR-mediated activation of NF-kappaB. | microRNA-146a inhibits G protein-coupled receptor-mediated activation of NF-κB by targeting CARD10 and COPS8 in gastric cancer.
Crone SG, Jacobsen A, Federspiel B, Bardram L, Krogh A, Lund AH, Friis-Hansen L., Free PMC Article | 03/23/2013 |
| this study found that CARMA3 is overexpressed in colon cancers and contributes to malignant cell growth by facilitating cell cycle progression through NF-kappaB mediated upregulation of cyclin D1. | CARMA3 is overexpressed in colon cancer and regulates NF-κB activity and cyclin D1 expression.
Miao Z, Zhao T, Wang Z, Xu Y, Song Y, Wu J, Xu H. | 01/26/2013 |