| HIIT and MICT attenuate high-fat diet-induced hepatic lipid accumulation and ER stress via the PERK-ATF4-CHOP signaling pathway. | HIIT and MICT attenuate high-fat diet-induced hepatic lipid accumulation and ER stress via the PERK-ATF4-CHOP signaling pathway.
Yuan Z, Xiao-Wei L, Juan W, Xiu-Juan L, Nian-Yun Z, Lei S., Free PMC Article | 08/27/2022 |
| Changes in UPR-PERK pathway and muscle hypertrophy following resistance training and creatine supplementation in rats. | Changes in UPR-PERK pathway and muscle hypertrophy following resistance training and creatine supplementation in rats.
Nouri H, Sheikholeslami-Vatani D, Moloudi MR. | 08/7/2021 |
| Regulation of the cerebrovascular smooth muscle cell phenotype by mitochondrial oxidative injury and endoplasmic reticulum stress in simulated microgravity rats via the PERK-eIF2alpha-ATF4-CHOP pathway. | Regulation of the cerebrovascular smooth muscle cell phenotype by mitochondrial oxidative injury and endoplasmic reticulum stress in simulated microgravity rats via the PERK-eIF2α-ATF4-CHOP pathway.
Zhang R, Jiang M, Zhang J, Qiu Y, Li D, Li S, Liu J, Liu C, Fang Z, Cao F. | 01/9/2021 |
| High PEK expression is associated with reduced bone growth and shortened long bones. | Sirtuin-1 (SIRT1) stimulates growth-plate chondrogenesis by attenuating the PERK-eIF-2α-CHOP pathway in the unfolded protein response.
Kang X, Yang W, Wang R, Xie T, Li H, Feng D, Jin X, Sun H, Wu S., Free PMC Article | 01/19/2019 |
| These results suggest that the administration of Pien Tze Huang ameliorated the severity of alcoholic and high-fat diet rats possibly by inhibiting the Hcy-induced PERK/eIF2alpha pathway. | Pien Tze Huang ameliorates liver injury by inhibiting the PERK/eIF2α signaling pathway in alcohol and high-fat diet rats.
Yang Y, Chen Z, Deng L, Yu J, Wang K, Zhang X, Ji G, Li F. | 11/10/2018 |
| AS-IV may attenuate inflammatory responses by disrupting the crosstalk between autophagy and the PERK-eIF2alpha pathway and may be an ideal agent for treating inflammatory pulmonary diseases. | Astragaloside-IV Alleviates Heat-Induced Inflammation by Inhibiting Endoplasmic Reticulum Stress and Autophagy.
Dong Z, Zhou J, Zhang Y, Chen Y, Yang Z, Huang G, Chen Y, Yuan Z, Peng Y, Cao T. | 08/5/2017 |
| Pre-ischemia melatonin treatment alleviated acute neuronal injury after ischemic stroke by inhibiting endoplasmic reticulum stress-dependent autophagy via PERK and IRE1 signalings | Pre-ischemia melatonin treatment alleviated acute neuronal injury after ischemic stroke by inhibiting endoplasmic reticulum stress-dependent autophagy via PERK and IRE1 signalings.
Feng D, Wang B, Wang L, Abraham N, Tao K, Huang L, Shi W, Dong Y, Qu Y. | 07/1/2017 |
| these results confirmed that ER stress-mediated apoptosis contributes to the protection effects of naringenin against H/R injury, which is potentially involved in ATF6, IRE1alpha and PERK signaling activation. | Naringenin ameliorates hypoxia/reoxygenation-induced endoplasmic reticulum stress-mediated apoptosis in H9c2 myocardial cells: involvement in ATF6, IRE1α and PERK signaling activation.
Tang JY, Jin P, He Q, Lu LH, Ma JP, Gao WL, Bai HP, Yang J. | 02/18/2017 |
| Cirrhotic rats with diabetes showed higher intrahepatic ET-1 vasoresponsiveness than normoglycemic cirrhotic rats. This effect may be related, at least in part, to intrahepatic ETA R receptor and pERK over-expression. | Diabetes enhances the intrahepatic vascular response to endothelin-1 in cirrhotic rats: association with the ETA receptor and pERK up-regulation.
Lee JY, Lee FY, Huo TI, Wang SS, Huang HC, Lin HC, Chuang CL, Lee SD. | 10/31/2015 |
| Data suggest that down-regulation of PERK kinase-activating transcription factor 4 (ATF4)-tramscription factor CHOP pathway by Astragaloside IV (AS-IV) may be a strategy for the treatment of diabetic nephropathy (DN). | Down-regulation of PERK-ATF4-CHOP pathway by Astragaloside IV is associated with the inhibition of endoplasmic reticulum stress-induced podocyte apoptosis in diabetic rats.
Chen Y, Gui D, Chen J, He D, Luo Y, Wang N. | 09/26/2015 |
| Suggest role for PERK in modulating fluoride induced bone formation and bone resorption. | A role for PERK in the mechanism underlying fluoride-induced bone turnover.
Sun F, Li X, Yang C, Lv P, Li G, Xu H. | 12/20/2014 |
| PERK was activated in reactive oxygen species-mediated endoplasmic reticulum stress-induced apoptosis in a rat model of diabetic cardiomyopathy. PERK deletion in myocytes showed a protective effect against apoptosis induced by high-glucose incubation. | Protein kinase RNA-like endoplasmic reticulum kinase (PERK) signaling pathway plays a major role in reactive oxygen species (ROS)-mediated endoplasmic reticulum stress-induced apoptosis in diabetic cardiomyopathy.
Liu ZW, Zhu HT, Chen KL, Dong X, Wei J, Qiu C, Xue JH., Free PMC Article | 09/6/2014 |
| Autophagy induced by (125)I radiation was involved in endoplasmic reticulum stress and mainly dependent on PERK-eIF2alpha pathway. | Regulation of autophagy via PERK-eIF2α effectively relieve the radiation myelitis induced by iodine-125.
Yang Z, Xu Y, Xu L, Maccauro G, Rossi B, Chen Y, Li H, Zhang J, Sun H, Yang Y, Xu D, Liu X., Free PMC Article | 08/23/2014 |
| interplay between calcineurin and PERK regulates beta-cell Ca(2+) signaling and insulin secretion, and that loss of this interaction may have profound implications in insulin secretion defects associated with diabetes. | Insulin secretion and Ca2+ dynamics in β-cells are regulated by PERK (EIF2AK3) in concert with calcineurin.
Wang R, McGrath BC, Kopp RF, Roe MW, Tang X, Chen G, Cavener DR., Free PMC Article | 02/8/2014 |
| The number of PERK- and CHOP-positive cells is significantly higher in diabetic and high glucose-exposed retina cultures than in normal retinas. | Effect of neurotrophin-4 on endoplasmic reticulum stress-related neuronal apoptosis in diabetic and high glucose exposed rat retinas.
Oshitari T, Yoshida-Hata N, Yamamoto S. | 06/2/2012 |
| Activation of the PERK/eIF2a signaling pathway contributes to the occurrence and development of hepatocyte apoptosis in alcoholic liver injury. | [Role of PERK/eIF2a signaling pathway in hepatocyte apoptosis of alcoholic liver injury rats].
Han XH, Wang JY, Wang L, Zheng PY, Ji G. | 12/17/2011 |
| eukaryotic translation initiation factor 2 alpha kinase 3 (PERK) is activated following oxygen-glucose deprivation of rat cortical cells | Induction of ER stress in response to oxygen-glucose deprivation of cortical cultures involves the activation of the PERK and IRE-1 pathways and of caspase-12.
Badiola N, Penas C, Miñano-Molina A, Barneda-Zahonero B, Fadó R, Sánchez-Opazo G, Comella JX, Sabriá J, Zhu C, Blomgren K, Casas C, Rodríguez-Alvarez J., Free PMC Article | 11/5/2011 |
| A decrease in the ATP/energy status in response to a decrease in glucose results in SERCA pump inhibition, the efflux of Ca2+ from the ER, and the activation of PERK, which plays an important role in both pancreatic beta-cell function and survival. | PERK activation at low glucose concentration is mediated by SERCA pump inhibition and confers preemptive cytoprotection to pancreatic β-cells.
Moore CE, Omikorede O, Gomez E, Willars GB, Herbert TP., Free PMC Article | 08/6/2011 |
| Endoplasmic reticulum stress blunts cytokine-triggered activation of NF-kappaB, in part through PERK- and IRE1-mediated preferential induction of C/EBPbeta. | ER stress depresses NF-kappaB activation in mesangial cells through preferential induction of C/EBP beta.
Hayakawa K, Nakajima S, Hiramatsu N, Okamura M, Huang T, Saito Y, Tagawa Y, Tamai M, Takahashi S, Yao J, Kitamura M., Free PMC Article | 02/8/2010 |
| Dysregulation of endoplasmic reticulum chaperone/folding enzymes ERp72 and GRP78/BiP occurred early after ablation of PERK function | Acute ablation of PERK results in ER dysfunctions followed by reduced insulin secretion and cell proliferation.
Feng D, Wei J, Gupta S, McGrath BC, Cavener DR., Free PMC Article | 01/21/2010 |
| force-induced apoptosis depends on a novel function of PERK that occurs in addition to its canonical role in the unfolded protein response | Novel function of PERK as a mediator of force-induced apoptosis.
Mak BC, Wang Q, Laschinger C, Lee W, Ron D, Harding HP, Kaufman RJ, Scheuner D, Austin RC, McCulloch CA., Free PMC Article | 01/21/2010 |
| Translation mediated by the internal ribosome entry site of the cat-1 mRNA is regulated by glucose availability in a PERK kinase-dependent manner | Translation mediated by the internal ribosome entry site of the cat-1 mRNA is regulated by glucose availability in a PERK kinase-dependent manner.
Fernandez J, Bode B, Koromilas A, Diehl JA, Krukovets I, Snider MD, Hatzoglou M. | 01/21/2010 |
| Renal ischemia and reperfusion activates the eIF 2 alpha kinase PERK. | Renal ischemia and reperfusion activates the eIF 2 alpha kinase PERK.
Montie HL, Kayali F, Haezebrouck AJ, Rossi NF, Degracia DJ. | 01/21/2010 |