| The role of P2X4R in regulating CA1 hippocampal synaptic impairment in LPS-induced depression. | The role of P2X4R in regulating CA1 hippocampal synaptic impairment in LPS-induced depression.
Wei L, Yu X, Chen H, Du Y. | 09/18/2024 |
| Dorsal root ganglia P2X4 and P2X7 receptors contribute to diabetes-induced hyperalgesia and the downregulation of electroacupuncture on P2X4 and P2X7. | Dorsal root ganglia P2X4 and P2X7 receptors contribute to diabetes-induced hyperalgesia and the downregulation of electroacupuncture on P2X4 and P2X7.
Hu QQ, He XF, Ma YQ, Ma LQ, Qu SY, Wang HZ, Kang YR, Chen LH, Li X, Liu BY, Shao XM, Fang JF, Liang Y, Fang JQ, Jiang YL., Free PMC Article | 08/7/2023 |
| P2X4 receptors mediate induction of antioxidants, fibrogenic cytokines and ECM transcripts; in presence of replicating HCV in in vitro setting: An insight into role of P2X4 in fibrosis. | P2X4 receptors mediate induction of antioxidants, fibrogenic cytokines and ECM transcripts; in presence of replicating HCV in in vitro setting: An insight into role of P2X4 in fibrosis.
Manzoor S, Khalid M, Idrees M., Free PMC Article | 05/28/2022 |
| P2X4 Inhibition reduces microglia inflammation and apoptosis by NLRP3 and improves nervous system defects in rat brain trauma model. | P2X4 Inhibition reduces microglia inflammation and apoptosis by NLRP3 and improves nervous system defects in rat brain trauma model.
He W, Wang Q, Sha W, Wang L, Li D, Chen G. | 05/7/2022 |
| Enhanced expression of P2X4 purinoceptors in pyramidal neurons of the rat hippocampal CA1 region may be involved ischemia-reperfusion injury. | Enhanced expression of P2X4 purinoceptors in pyramidal neurons of the rat hippocampal CA1 region may be involved ischemia-reperfusion injury.
Xiang Z, Jiang X, Ji R, Yuan H., Free PMC Article | 02/19/2022 |
| P2X4 Receptors Mediate Ca(2+) Release from Lysosomes in Response to Stimulation of P2X7 and H1 Histamine Receptors. | P2X4 Receptors Mediate Ca(2+) Release from Lysosomes in Response to Stimulation of P2X7 and H(1) Histamine Receptors.
Tan SL, Barri M, Atakpa-Adaji P, Taylor CW, St John Smith E, Murrell-Lagnado RD., Free PMC Article | 10/30/2021 |
| Effect of electroacupuncture on the expression of P2 x 4, GABAA gamma 2 and long-term potentiation in spinal cord of rats with neuropathic pain. | Effect of electroacupuncture on the expression of P2 × 4, GABAA γ 2 and long-term potentiation in spinal cord of rats with neuropathic pain.
Zheng Y, Zhou Y, Wu Q, Yue J, Ying X, Li S, Lou X, Yang G, Tu W, Zhou K, Jiang S. | 10/2/2021 |
| Overexpression of Purinergic P2X4 Receptors in Hippocampus Rescues Memory Impairment in Rats with Type 2 Diabetes. | Overexpression of Purinergic P2X4 Receptors in Hippocampus Rescues Memory Impairment in Rats with Type 2 Diabetes.
Zhang PA, Sun Q, Li YC, Weng RX, Wu R, Zhang HH, Xu GY., Free PMC Article | 07/24/2021 |
| Activation of P2X4 receptors induces an increase in the area of the extracellular region and a decrease in receptor mobility. | Activation of P2X4 receptors induces an increase in the area of the extracellular region and a decrease in receptor mobility.
Bergler F, Fuentes C, Kadir MF, Navarrete C, Supple J, Barrera NP, Edwardson JM. | 06/5/2021 |
| P2X4 receptor in the dorsal horn contributes to BDNF/TrkB and AMPA receptor activation in the pathogenesis of remifentanil-induced postoperative hyperalgesia in rats. | P2X4 receptor in the dorsal horn contributes to BDNF/TrkB and AMPA receptor activation in the pathogenesis of remifentanil-induced postoperative hyperalgesia in rats.
Fu R, Li S, Li S, Gong X, Zhou G, Wang Y, Ding R, Zhu Z, Zhang L, Li Y. | 05/15/2021 |
| Electroacupuncture effects on the P2X4R pathway in microglia regulating the excitability of neurons in the substantia gelatinosa region of rats with spinal nerve ligation. | Electroacupuncture effects on the P2X4R pathway in microglia regulating the excitability of neurons in the substantia gelatinosa region of rats with spinal nerve ligation.
Zheng Y, Jia C, Jiang X, Chen J, Chen XL, Ying X, Wu J, Jiang M, Yang G, Tu W, Zhou K, Jiang S., Free PMC Article | 05/8/2021 |
| Overexpression of P2X4R in Schwann cells promotes motor and sensory recovery after nerve injury. | Overexpression of P2X4 receptor in Schwann cells promotes motor and sensory functional recovery and remyelination via BDNF secretion after nerve injury.
Su WF, Wu F, Jin ZH, Gu Y, Chen YT, Fei Y, Chen H, Wang YX, Xing LY, Zhao YY, Yuan Y, Tang X, Chen G. | 05/18/2019 |
| The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. | P2X4 receptor controls microglia activation and favors remyelination in autoimmune encephalitis.
Zabala A, Vazquez-Villoldo N, Rissiek B, Gejo J, Martin A, Palomino A, Perez-Samartín A, Pulagam KR, Lukowiak M, Capetillo-Zarate E, Llop J, Magnus T, Koch-Nolte F, Rassendren F, Matute C, Domercq M., Free PMC Article | 04/27/2019 |
| intrathecal or ganglionar (L5-DRG) administration of a novel P2X4R antagonist (PSB-15417) or intrathecal administration of oligodeoxynucleotides (ODN)-antisense against the P2X4R reversed diabetes-induced neuropathic mechanical hyperalgesia. The dorsal root ganglia of the diabetic neuropathic rats showed an increase in P2X4R expression. | Diabetes-induced Neuropathic Mechanical Hyperalgesia Depends on P2X4 Receptor Activation in Dorsal Root Ganglia.
Teixeira JM, Dos Santos GG, Neves AF, Athie MCP, Bonet IJM, Nishijima CM, Farias FH, Figueiredo JG, Hernandez-Olmos V, Alshaibani S, Tambeli CH, Müller CE, Parada CA. | 03/23/2019 |
| neuropathic pain is related to the expression of the P2X4 receptor in the L4-5 dorsal root ganglion | Microencapsulated olfactory ensheathing-cell transplantation reduces pain in rats by inhibiting P2X4 receptor overexpression in the dorsal root ganglion.
Zhang W, Liu Y, Yang B, Liu Z, Yu Q. | 03/2/2019 |
| The importance of this movement was confirmed by demonstrating that substitution introducing positive charge present in the CRH of the hP2X1R causes PPADS sensitivity at the normally insensitive rat P2X4R. This study provides a template for developing P2XR subtype selectivity based on the differences among the mammalian subunits around the orthosteric P2XR-binding site and the CRH. | Mapping the binding site of the P2X receptor antagonist PPADS reveals the importance of orthosteric site charge and the cysteine-rich head region.
Huo H, Fryatt AG, Farmer LK, Schmid R, Evans RJ., Free PMC Article | 02/16/2019 |
| Olfactory ensheathing cell transplantation inhibits P2X4 receptor overexpression in spinal cord injury rats with neuropathic pain. | Olfactory ensheathing cell transplantation inhibits P2X4 receptor overexpression in spinal cord injury rats with neuropathic pain.
Zheng Z, Du X, Zhang K, Wang X, Chen Y, Kuang N, Fan T, Sun B. | 03/31/2018 |
| Study found that spinal microglia were activated and that P2X4R was primarily expressed in spinal activated microglia during nicotine withdrawal (NTW). In addition, the P2X4R and BDNF expression levels in the spinal cord were upregulated during NTW. Furthermore, inhibition of microglial activation prevented thermal hyperalgesia and increased P2X4R and BDNF expression induced by NTW. | Spinal microglial P2X4 receptor-brain-derived neurotrophic factor signaling regulates nicotine withdrawal-induced hyperalgesia.
Zhang X, Xu P, Li C, Zhu W, Wu S, Yu A, Ding Y, Wang Q, Zhang Z. | 01/13/2018 |
| These results indicated that TLR4 and P2X4R pathways mediated IL-1beta synthesis and release in microglia followed chronic morphine. | Morphine enhances IL-1β release through toll-like receptor 4-mediated endocytic pathway in microglia.
Liang Y, Chu H, Jiang Y, Yuan L., Free PMC Article | 11/4/2017 |
| P2X4 and P2X6 proteins were expressed in a different way during rat small intestine development, showing a higher colocalization coefficient at age P30 in both intestine regions. Those results suggest that purinergic receptors may play a role in intestinal maturation, which is associated with age and intestinal region. | Differential gene expression patterns and colocalization of ATP-gated P2X6/P2X4 ion channels during rat small intestine ontogeny.
Padilla K, Gonzalez-Mendoza D, Berumen LC, Escobar JE, Miledi R, García-Alcocer G. | 05/27/2017 |
| work identified that in major arteries of rat cerebral circulation Vascular Smooth Muscle Cells express only P2X1 and P2X4 receptors subunits. | Molecular identification of P2X receptors in vascular smooth muscle cells from rat anterior, posterior, and basilar arteries.
Harhun MI, Sukhanova K, Gordienko D, Dyskina Y. | 09/17/2016 |
| The results suggest a role of PrP(C) in proteostasis, dysfunctions of which may be involved in the pathogenesis of neurodegenerative diseases such as TSE and Alzheimer's Disease. | The prion protein selectively binds to and modulates the content of purinergic receptor P2X4R.
Carneiro MV, Americo TA, Guimarães MZ, Linden R. | 08/13/2016 |
| Alanine scanning mutagenesis of the R203-L214 (dorsal fin) and the D280-N293 (left flipper) sequences of the rat P2X4 receptor showed that ATP potency/efficacy was reduced in 15 out of 26 alanine mutants. | Identification of functionally important residues of the rat P2X4 receptor by alanine scanning mutagenesis of the dorsal fin and left flipper domains.
Tvrdonova V, Rokic MB, Stojilkovic SS, Zemkova H., Free PMC Article | 12/19/2015 |
| ATP-binding-induced altered interdomain hydrophobic interactions and the concomitant coordinated motions of LF and DF domains are essential for the channel gating of P2X4. | Relative motions between left flipper and dorsal fin domains favour P2X4 receptor activation.
Zhao WS, Wang J, Ma XJ, Yang Y, Liu Y, Huang LD, Fan YZ, Cheng XY, Chen HZ, Wang R, Yu Y. | 11/21/2015 |
| Specific localization of the P2X4 receptor subunit was evaluated in mouse, rat and cat retinae using fluorescence immunohistochemistry and pre-embedding immuno-electron microscopy | Immunolocalization of the P2X4 receptor on neurons and glia in the mammalian retina.
Ho T, Vessey KA, Fletcher EL. | 06/20/2015 |