| Integrin alphavbeta5 which induces LSECs dysfunction, promoting hepatic sinusoidal capillarization regulates VN expression via ERK/FAK pathway under high glucose/ox-LDL | High glucose/ox-LDL induced hepatic sinusoidal capillarization via αvβ5/FAK/ERK signaling pathway.
Zhang Q, Yu J, Guo T, Tian L, Quan J, Lin W, Niu XE, Liu J. | 07/11/2020 |
| the effects on cardiac fibroblasts , isolated by spontaneously hypertensive rats (SHR), of integrin alphanubeta5 inhibition in myofibroblast differentiation. | Integrin ανβ5 in vitro inhibition limits pro-fibrotic response in cardiac fibroblasts of spontaneously hypertensive rats.
Perrucci GL, Barbagallo VA, Corlianò M, Tosi D, Santoro R, Nigro P, Poggio P, Bulfamante G, Lombardi F, Pompilio G., Free PMC Article | 06/22/2019 |
| findings demonstrate that, in SI-treated rats, oxidative stress activates STAT3 signaling which up-regulates miR-25 expression, in a very early stage. The increased miR-25 then inhibits ITGAV and PEDF expressions, resulting in RPE phagocytosis dysfunction and then RPE apoptosis and visual impairment as observed in patients with AMD. | miR-25 Mediates Retinal Degeneration Via Inhibiting ITGAV and PEDF in Rat.
Zhang J, Wang J, Zheng L, Wang M, Lu Y, Li Z, Lian C, Mao S, Hou X, Li S, Xu J, Tian H, Jin C, Gao F, Zhang J, Wang F, Li W, Lu L, Xu GT. | 03/30/2019 |
| These findings uncover a hitherto unrecognized role for hemichannels in the regulation of astrocyte migration via P2X7R transactivation induced by integrin-mediated ATP release. | Integrin-mediated transactivation of P2X7R via hemichannel-dependent ATP release stimulates astrocyte migration.
Alvarez A, Lagos-Cabré R, Kong M, Cárdenas A, Burgos-Bravo F, Schneider P, Quest AF, Leyton L. | 06/3/2017 |
| The membrane fraction of diabetic-derived fibroblasts showed a decrease of integrin subunits alpha5 and alphav, which was confirmed by immunocytochemistry assays. | Hyperglycemia reduces integrin subunits alpha v and alpha 5 on the surface of dermal fibroblasts contributing to deficient migration.
Almeida ME, Monteiro KS, Kato EE, Sampaio SC, Braga TT, Câmara NO, Lamers ML, Santos MF. | 02/18/2017 |
| These data support the hypothesis that IL-1beta was initially induced by hyperoxia; alphavbeta6 subsequently interacted with and activated TGF-beta1. | Interleukin-1β Promotes Epithelial-Derived Alveolar Elastogenesis via αvβ6 Integrin-Dependent TGF-β Activation.
Wang J, Bao L, Yu B, Liu Z, Han W, Deng C, Guo C. | 05/28/2016 |
| Gdf-5 induced the expression of the alpha5 sub-unit, while Bmp-7 induced the expression of the alphaV sub-unit. | Regulation of α5 and αV Integrin Expression by GDF-5 and BMP-7 in Chondrocyte Differentiation and Osteoarthritis.
Garciadiego-Cázares D, Aguirre-Sánchez HI, Abarca-Buis RF, Kouri JB, Velasquillo C, Ibarra C., Free PMC Article | 04/23/2016 |
| When administered after establishment of early pathophysiologic changes in renal function, the anti-integrin alphaVbeta3 antibody reversed the effects of diabetes normalizing albuminuria and profibrotic proteins in the kidney. | Blocking αVβ3 integrin ligand occupancy inhibits the progression of albuminuria in diabetic rats.
Maile LA, Gollahon K, Wai C, Dunbar P, Busby W, Clemmons D., Free PMC Article | 07/25/2015 |
| These results demonstrate that alphav beta3 integrin-mediated angiogenesis is critical for recovering fracture resistance after bone injury. | Antagonizing the αv β3 integrin inhibits angiogenesis and impairs woven but not lamellar bone formation induced by mechanical loading.
Tomlinson RE, Schmieder AH, Quirk JD, Lanza GM, Silva MJ., Free PMC Article | 04/25/2015 |
| both alphanu and beta1 integrins interfered with Abeta-induced neurotoxicity in hippocampal neurons and that this mechanism partially contributes to the activation of the Integrin-FAK signaling pathway. | αν and β1 Integrins mediate Aβ-induced neurotoxicity in hippocampal neurons via the FAK signaling pathway.
Han HY, Zhang JP, Ji SQ, Liang QM, Kang HC, Tang RH, Zhu SQ, Xue Z., Free PMC Article | 01/31/2015 |
| The possible functional roles of integrin alphavbeta5 in endothelial cells of the splenic sinus are discussed. | Integrin αvβ5 in endothelial cells of rat splenic sinus: an immunohistochemical and ultrastructural study.
Uehara K, Uehara A. | 11/22/2014 |
| The number of integrin alpha5- and alphav-positive cells markedly increased at day 3 and then gradually decreased, but was still elevated on day 14 after laser-induced choroidal neovascularization . | Mechanism for laser-induced neovascularization in rat choroid: accumulation of integrin α chain-positive cells and their ligands.
Nakajima T, Hirata M, Shearer TR, Azuma M., Free PMC Article | 10/4/2014 |
| ability of hTK gene-transduced EPCs can be enhanced in vitro, in which integrin alphavbeta3 plays a role in the process | Kallikrein gene-modified EPCs induce angiogenesis in rats with ischemic hindlimb and correlate with integrin αvβ3 expression.
Fu SS, Li FJ, Wang YY, You AB, Qie YL, Meng X, Li JR, Li BC, Zhang Y, Da Li Q., Free PMC Article | 05/17/2014 |
| These results show that fibrin promotes beta cell function, proliferation and survival via integrin alphavbeta3 interactions. | Fibrin improves beta (INS-1) cell function, proliferation and survival through integrin αvβ3.
Riopel M, Stuart W, Wang R. | 10/19/2013 |
| Integrin alphavbeta6 is strongly induced de novo in newly formed bile ducts because of cholangiocyte proliferation during ischemia-related biliary fibrogenesis after liver transplantation. | Role of integrin αvβ6 in the pathogenesis of ischemia-related biliary fibrosis after liver transplantation.
Chen G, Zhang L, Chen L, Wang H, Zhang Y, Bie P. | 07/20/2013 |
| The contribution of cyclic stretch to vascular smooth muscle cell-supported thrombin generation is driven by the integrin alpha(v)beta(3) signalling pathway. | Cyclic stretch-induced thrombin generation by rat vascular smooth muscle cells is mediated by the integrin αvβ3 pathway.
Mao X, Said R, Louis H, Max JP, Bourhim M, Challande P, Wahl D, Li Z, Regnault V, Lacolley P. | 04/27/2013 |
| alphavbeta3 integrin and nucleolin interact to regulate endothelial and glioma cell migration | Interplay between αvβ3 integrin and nucleolin regulates human endothelial and glioma cell migration.
Koutsioumpa M, Polytarchou C, Courty J, Zhang Y, Kieffer N, Mikelis C, Skandalis SS, Hellman U, Iliopoulos D, Papadimitriou E., Free PMC Article | 03/2/2013 |
| Lysophosphatidic acid signals through LPA2 receptors and Galphaq proteins of cultured proximal tubule cells to transactivate latent TGF-beta in a Rho/Rho-kinase and alphavbeta6 integrin-dependent manner. | Lysophosphatidic acid increases proximal tubule cell secretion of profibrotic cytokines PDGF-B and CTGF through LPA2- and Gαq-mediated Rho and αvβ6 integrin-dependent activation of TGF-β.
Geng H, Lan R, Singha PK, Gilchrist A, Weinreb PH, Violette SM, Weinberg JM, Saikumar P, Venkatachalam MA., Free PMC Article | 02/9/2013 |
| Authors conclude that MerTK activation via FAK and F-actin recruitment via Rac1 both require MFG-E8-ligated alphavbeta5 integrin. Both pathways are independently activated and required for clearance phagocytosis. | Essential diurnal Rac1 activation during retinal phagocytosis requires αvβ5 integrin but not tyrosine kinases focal adhesion kinase or Mer tyrosine kinase.
Mao Y, Finnemann SC., Free PMC Article | 08/4/2012 |
| Integrin alphavbeta6 is induced de novo in rodent and human liver fibrosis, where it is expressed on activated bile duct epithelia and (transitional) hepatocytes during fibrosis progression. | Integrin alphavbeta6 is a marker of the progression of biliary and portal liver fibrosis and a novel target for antifibrotic therapies.
Popov Y, Patsenker E, Stickel F, Zaks J, Bhaskar KR, Niedobitek G, Kolb A, Friess H, Schuppan D. | 12/9/2011 |
| Clustering of integrin alphaV-positive focal adhesions and upregulated alphav expression are observed in smooth muscle cells on tenascin C substrate. | Tenascin-C enhances crosstalk signaling of integrin αvβ3/PDGFR-β complex by SRC recruitment promoting PDGF-induced proliferation and migration in smooth muscle cells.
Ishigaki T, Imanaka-Yoshida K, Shimojo N, Matsushima S, Taki W, Yoshida T. | 10/15/2011 |
| tPA-mediated vasocontraction involves the coordinated interaction of LRP with integrin alphavbeta3. | LRP and alphavbeta3 mediate tPA activation of smooth muscle cells.
Akkawi S, Nassar T, Tarshis M, Cines DB, Higazi AA. | 10/4/2011 |
| Study is the first to demonstrate a functional link between alphavbeta3 integrin and P2X7 receptors, and to reveal an important, hitherto unanticipated, role for P2X7 in calcium-dependent signaling required for Thy-1-stimulated astrocyte adhesion. | ATP release due to Thy-1-integrin binding induces P2X7-mediated calcium entry required for focal adhesion formation.
Henríquez M, Herrera-Molina R, Valdivia A, Alvarez A, Kong M, Muñoz N, Eisner V, Jaimovich E, Schneider P, Quest AF, Leyton L., Free PMC Article | 09/24/2011 |
| Expressions of VEGF, integrin alphavbeta3, and TF in experimental choroidal neovascularization were found at the early, middle and late stage of CNV formation. | [Expression of integrin alphavbeta3, tissue factor, and vascular endothelial growth factor in experimental choroidal neovascularization].
Tang R, Long J, Chen B. | 05/21/2011 |
| the effect of LTB4 on vascular smooth muscle cell migration is modulated by integrin alphavbeta3 signaling activation | Leukotriene B4 mediates vascular smooth muscle cell migration through αvβ3 integrin transactivation.
Moraes J, Assreuy J, Canetti C, Barja-Fidalgo C. | 03/5/2011 |