| Enriched environment treatment promotes neurofunctional recovery by regulating the ALK5/Smad2/3/Gadd45beta signaling pathway in rats with cerebral ischemia /reperfusion injury. | Enriched environment treatment promotes neurofunctional recovery by regulating the ALK5/Smad2/3/Gadd45β signaling pathway in rats with cerebral ischemia /reperfusion injury.
Liu G, Xie C, Li J, Jiang X, Tang H, Li C, Zhang K. | 09/11/2024 |
| MicroRNA-499-5p inhibits transforming growth factor-beta1-induced Smad2 signaling pathway and suppresses fibroblast proliferation and collagen synthesis in rat by targeting TGFbeta-R1. | MicroRNA-499-5p inhibits transforming growth factor-β1-induced Smad2 signaling pathway and suppresses fibroblast proliferation and collagen synthesis in rat by targeting TGFβ-R1.
Zhao Q, Yang W, Li X, Yuan H, Guo J, Wang Y, Shan Z., Free PMC Article | 12/15/2023 |
| GDF11 Regulates PC12 Neural Stem Cells via ALK5-Dependent PI3K-Akt Signaling Pathway. | GDF11 Regulates PC12 Neural Stem Cells via ALK5-Dependent PI3K-Akt Signaling Pathway.
Wang Z, Jiang P, Liu F, Du X, Ma L, Ye S, Cao H, Sun P, Su N, Lin F, Zhang R, Li C., Free PMC Article | 11/5/2022 |
| Lung-restricted ALK5 inhibition avoids systemic toxicities associated with TGFbeta pathway inhibition. | Lung-restricted ALK5 inhibition avoids systemic toxicities associated with TGFβ pathway inhibition.
Maher JM, Zhang R, Palanisamy G, Perkins K, Liu L, Brassil P, McNamara A, Lo A, Hughes AD, Kanodia J, Kulyk S, Nikula KJ, Dengler HS, Scandurra A, Lua I, Harstad E. | 03/12/2022 |
| MicroRNA-210-5p alleviates cardiac fibrosis via targeting transforming growth factor-beta type I receptor in rats on high sodium chloride (NaCl)-based diet. | MicroRNA-210-5p alleviates cardiac fibrosis via targeting transforming growth factor-beta type I receptor in rats on high sodium chloride (NaCl)-based diet.
Zhao K, Mao Y, Ye X, Ma J, Sun L, Li P, Li Y. | 03/5/2022 |
| MicroRNA101 inhibits renal tubular epithelialtomesenchymal transition by targeting TGFbeta1 type I receptor. | MicroRNA‑101 inhibits renal tubular epithelial‑to‑mesenchymal transition by targeting TGF‑β1 type I receptor.
Wang Q, Tao Y, Xie H, Liu C, Liu P., Free PMC Article | 11/22/2021 |
| Application of ultrasound elastography for monitoring the effects of TbetaR1 shRNA therapy on hepatic fibrosis in a rat model. | Application of ultrasound elastography for monitoring the effects of TβR1 shRNA therapy on hepatic fibrosis in a rat model.
Shi X, Li J, Min B, Yang R, He C, Yang Y., Free PMC Article | 11/22/2021 |
| TGFbeta treatment aggravated hypoxia-induced BBB permeability but ALK5 or Furin blockade reversed injury-induced permeability changes. Thus during insult Furin compromises endothelial integrity by mediating the effects of TGFbeta. Targeting the Furin or ALK5 pathway may offer novel therapeutic strategies for improving BBB stability and CNS function during disease. | Furin inhibition prevents hypoxic and TGFβ-mediated blood-brain barrier disruption.
Baumann J, Huang SF, Gassmann M, Tsao CC, Ogunshola OO. | 07/4/2020 |
| The results suggest that the ALK5 signaling pathway plays a critical role in mediating neural plasticity and neurological function recovery via Gadd45b after cerebral ischemia. | ALK5 signaling pathway mediates neurogenesis and functional recovery after cerebral ischemia/reperfusion in rats via Gadd45b.
Zhang K, Zhang Q, Deng J, Li J, Li J, Wen L, Ma J, Li C., Free PMC Article | 05/16/2020 |
| High TGFBR1 expression is associated with cardiac hypertrophy. | miR-1-5p targets TGF-βR1 and is suppressed in the hypertrophying hearts of rats with pulmonary arterial hypertension.
Connolly M, Garfield BE, Crosby A, Morrell NW, Wort SJ, Kemp PR., Free PMC Article | 05/9/2020 |
| MiR-101a inhibited TGF-b signaling pathways by directly targeting TGFbr1, reducing Smad3 phosphorylation and inhibiting Tab3 promoter activity. Conversely TGF-beta inhibited promoter activity for both miR-101a and b. In vivo endogenous miR-101a expression was downregulated 2-day post-TAC returning to baseline by 14-day. | MicroRNA-101a suppresses fibrotic programming in isolated cardiac fibroblasts and in vivo fibrosis following trans-aortic constriction.
Zhou Y, Shiok TC, Richards AM, Wang P. | 09/14/2019 |
| a novel role for SREBP-1 as a cell surface retention factor for TbetaRI in mesangial cells, is reported. | Sterol Regulatory Element Binding Protein (SREBP)-1 is a novel regulator of the Transforming Growth Factor (TGF)-β receptor I (TβRI) through exosomal secretion.
Van Krieken R, Chen G, Gao B, Read J, Al Saleh HA, Li R, Al-Nedawi K, Krepinsky JC. | 12/2/2017 |
| exposure to hyperoxia altered the balance between TGF-beta-ALK1-Smad1/5 and TGF-beta-ALK5-Smad2/3 pathways in pulmonary endothelial cells, which may ultimately lead to the development of BPD. | Alteration of TGF-β-ALK-Smad signaling in hyperoxia-induced bronchopulmonary dysplasia model of newborn rats.
Jin M, Lee J, Lee KY, Jin Z, Pak JH, Kim HS. | 12/2/2017 |
| Studied the fibrotic actions of STAT3 suppression in endothelial cells (ECs); investigated TGF-beta1/ALK5/Smad4 signaling pathway participation; found signaling pathway involvement dependent on TGF-beta1 secretion, the ALK5 activation pathway, and Smad4 translocation into the nucleus.Conclude that suppressed STAT3 expression converts ECs into activated fibroblasts via TGF-beta1/ALK5/Smad4 signaling pathway. | Endothelial fibrosis induced by suppressed STAT3 expression mediated by signaling involving the TGF-β1/ALK5/Smad pathway.
Becerra A, Rojas M, Vallejos A, Villegas V, Pérez L, Cabello-Verrugio C, Simon F. | 09/16/2017 |
| the expression of Runx2, ALK5 and Smad3 were influenced by SB431542 treatment. In conclusion, this preliminary study indicated that fluoride regulated osteoblastic TGFb1 signaling in bone turnover and cells differentiation via ALK5. | Fluoride Regulate Osteoblastic Transforming Growth Factor-β1 Signaling by Mediating Recycling of the Type I Receptor ALK5.
Yang C, Wang Y, Xu H., Free PMC Article | 08/19/2017 |
| This study demonstrated that Transcutaneous auricular vagus nerve stimulation regulates expression of growth differentiation factor 11 and activin-like kinase 5 in cerebral ischemia/reperfusion rats. | Transcutaneous auricular vagus nerve stimulation regulates expression of growth differentiation factor 11 and activin-like kinase 5 in cerebral ischemia/reperfusion rats.
Ma J, Zhang L, He G, Tan X, Jin X, Li C. | 05/20/2017 |
| miR-22 acts as a novel negative regulator of angiotensin II-induced cardiac fibrosis by suppressing the expression of TGFbetaRI in the heart. | MiR-22 may Suppress Fibrogenesis by Targeting TGFβR I in Cardiac Fibroblasts.
Hong Y, Cao H, Wang Q, Ye J, Sui L, Feng J, Cai X, Song H, Zhang X, Chen X. | 02/18/2017 |
| The expressions of TGF-beta 1, TbetaRI, and TbetaRII in LPD and LPD + KA groups were significantly lower than those in NPD group and lower in LPD + KA group than those in LPD group | Effects of Low-Protein Diets Supplemented with Ketoacid on Expression of TGF-β and Its Receptors in Diabetic Rats.
Yang X, Yang M, Cheng M, Ma LB, Xie XC, Han S, Zhang B, Fei X, Wang M, Mei CL., Free PMC Article | 10/22/2016 |
| Overexpression of Alk-5 and silencing of Alk-1 led to a loss of the chondrocyte phenotype, proving that they are key regulators of chondrocyte mechanosensing. | The role of Alk-1 and Alk-5 in the mechanosensing of chondrocytes.
Sanz-Ramos P, Dotor J, Izal-Azcárate I., Free PMC Article | 08/29/2015 |
| Renal fibrosis resulting from excessive accumulation of extracellular matrix mainly driven by TGF-beta1 is dependent on the regulation of transforming growth factor receptor 1 expression by let-7b. | Transforming growth factor-β1-mediated renal fibrosis is dependent on the regulation of transforming growth factor receptor 1 expression by let-7b.
Wang B, Jha JC, Hagiwara S, McClelland AD, Jandeleit-Dahm K, Thomas MC, Cooper ME, Kantharidis P. | 10/4/2014 |
| cocaine self-administration resulted in an increase in TGF-beta R1 protein expression | Transforming growth factor beta receptor 1 is increased following abstinence from cocaine self-administration, but not cocaine sensitization.
Gancarz-Kausch AM, Schroeder GL, Panganiban C, Adank D, Humby MS, Kausch MA, Clark SD, Dietz DM., Free PMC Article | 09/6/2014 |
| Despite long-term obstruction injury, inhibition of TGF-betaRII and ALK5 core fucosylation ameliorated the progression of renal fibrosis, an effect independent of TGF-betaRII and ALK5 expression. | Inhibition of TGF-β1-receptor posttranslational core fucosylation attenuates rat renal interstitial fibrosis.
Shen N, Lin H, Wu T, Wang D, Wang W, Xie H, Zhang J, Feng Z. | 04/26/2014 |
| inhibiting ALK5 signaling in vitro antagonized the TGFbeta1-induced increase in astrocyte generation and antagonizing ALK5 signaling in vivo similarly inhibited astrogliogenesis within the SVZ during recovery from hypoxia-ischemia injury | TGFbeta1 stimulates the over-production of white matter astrocytes from precursors of the "brain marrow" in a rodent model of neonatal encephalopathy.
Bain JM, Ziegler A, Yang Z, Levison SW, Sen E., Free PMC Article | 02/11/2013 |
| These findings suggest that TGF-beta signaling via ALK5 plays a critical role in maintaining heart valve integrity. | Induction of heart valve lesions by small-molecule ALK5 inhibitors.
Anderton MJ, Mellor HR, Bell A, Sadler C, Pass M, Powell S, Steele SJ, Roberts RR, Heier A. | 02/18/2012 |
| TGF-beta1 caused apoptosis of pulmonary microvascular endothelial cell, an effect that was also dependent on ALK5 activity. | Transforming growth factor-beta1 causes pulmonary microvascular endothelial cell apoptosis via ALK5.
Lu Q, Patel B, Harrington EO, Rounds S., Free PMC Article | 12/14/2011 |