| Clinical physiology and pharmacology of GSTZ1/MAAI. | Clinical physiology and pharmacology of GSTZ1/MAAI.
Stacpoole PW. | 11/8/2023 |
| Glutathione S-transferase zeta 1 alters the HMGB1/GPX4 axis to drive ferroptosis in bladder cancer cells. | Glutathione S-transferase zeta 1 alters the HMGB1/GPX4 axis to drive ferroptosis in bladder cancer cells.
Zhu H, Chen Q, Zhang Y, Zhao L. | 03/16/2023 |
| GSTZ1 sensitizes hepatocellular carcinoma cells to sorafenib-induced ferroptosis via inhibition of NRF2/GPX4 axis. | GSTZ1 sensitizes hepatocellular carcinoma cells to sorafenib-induced ferroptosis via inhibition of NRF2/GPX4 axis.
Wang Q, Bin C, Xue Q, Gao Q, Huang A, Wang K, Tang N., Free PMC Article | 10/9/2021 |
| Age-Related Changes in miRNA Expression Influence GSTZ1 and Other Drug Metabolizing Enzymes. | Age-Related Changes in miRNA Expression Influence GSTZ1 and Other Drug Metabolizing Enzymes.
Jahn SC, Gay LA, Weaver CJ, Renne R, Langaee TY, Stacpoole PW, James MO., Free PMC Article | 09/11/2021 |
| GSTZ1-1 downregulates Wnt/beta-catenin signalling in hepatocellular carcinoma cells. | GSTZ1-1 downregulates Wnt/β-catenin signalling in hepatocellular carcinoma cells.
Lei C, Wang Q, Tang N, Wang K., Free PMC Article | 01/9/2021 |
| First clinical trial of dichloroacetate (DCA) in multiple myeloma patients revealed that GSTZ1 genotypes are correlated with drug concentrations, tolerability, and disease outcomes. Promoter GSTZ1 polymorphisms may be important determinants of DCA concentrations and neuropathy during chronic treatment. | GSTZ1 genotypes correlate with dichloroacetate pharmacokinetics and chronic side effects in multiple myeloma patients in a pilot phase 2 clinical trial.
Tian DD, Bennett SK, Coupland LA, Forwood K, Lwin Y, Pooryousef N, Tea I, Truong TT, Neeman T, Crispin P, D'Rozario J, Blackburn AC., Free PMC Article | 07/11/2020 |
| Study shows that GSTZ1 is markedly downregulated in hepatocellular carcinoma (HCC) thus predicting a poor prognosis. GSTZ1 deficiency induces oxidative stress, thus activating the KEAP1/NRF2 signaling pathway, which promotes HCC progression. | GSTZ1 deficiency promotes hepatocellular carcinoma proliferation via activation of the KEAP1/NRF2 pathway.
Li J, Wang Q, Yang Y, Lei C, Yang F, Liang L, Chen C, Xia J, Wang K, Tang N., Free PMC Article | 03/28/2020 |
| Results suggested that GSTZ1-1 is downregulated in hepatocellular carcinoma (HCC) and may serve as a prognostic marker. These data indicate an alternative oncogenic action of succinylacetone through activation of the NRF2/IGF1R axis by alkylation of KEAP1. | GSTZ1-1 Deficiency Activates NRF2/IGF1R Axis in HCC via Accumulation of Oncometabolite Succinylacetone.
Yang F, Li J, Deng H, Wang Y, Lei C, Wang Q, Xiang J, Liang L, Xia J, Pan X, Li X, Long Q, Chang L, Xu P, Huang A, Wang K, Tang N., Free PMC Article | 12/28/2019 |
| Some properties of cytosolic and mitochondrial GSTZ1 differed. | Age-Related Changes in Expression and Activity of Human Hepatic Mitochondrial Glutathione Transferase Zeta1.
Zhong G, James MO, Smeltz MG, Jahn SC, Langaee T, Simpson P, Stacpoole PW., Free PMC Article | 11/17/2018 |
| mild hypersuccinylacetonaemia (MHSA)can be caused by sequence variants in GSTZ1. Such individuals have thus far remained asymptomatic despite receiving no specific treatment. | Hypersuccinylacetonaemia and normal liver function in maleylacetoacetate isomerase deficiency.
Yang H, Al-Hertani W, Cyr D, Laframboise R, Parizeault G, Wang SP, Rossignol F, Berthier MT, Giguère Y, Waters PJ, Mitchell GA, Québec NTBC Study Group. | 11/4/2017 |
| rs7975 GG carriers had an increased risk of below-reference sperm motility | Interactions between CYP2E1, GSTZ1 and GSTT1 polymorphisms and exposure to drinking water trihalomethanes and their association with semen quality.
Yang P, Zeng Q, Cao WC, Wang YX, Huang Z, Li J, Liu C, Lu WQ. | 08/20/2016 |
| We conclude that the lower expression of GSTZ1 in Whites who possess the K carrier haplotype results in lower enzymatic activity and slower metabolism of DCA, compared with those who possess the non-K carrier haplotype | The influence of human GSTZ1 gene haplotype variations on GSTZ1 expression.
Langaee TY, Zhong G, Li W, Hamadeh I, Solayman MH, McDonough CW, Stacpoole PW, James MO., Free PMC Article | 12/26/2015 |
| Haplotype variations in glutathione transferase zeta 1 influence the kinetics and dynamics of chronic dichloroacetate in children | Haplotype variations in glutathione transferase zeta 1 influence the kinetics and dynamics of chronic dichloroacetate in children.
Shroads AL, Coats BS, McDonough CW, Langaee T, Stacpoole PW., Free PMC Article | 09/5/2015 |
| The data indicates no association between GSTZ1 genotypes and risk of gastric cancer. | Glutathione S-transferase Z1 (GSTZ1) gene polymorphism in gastric cancer: a preliminary study in a Turkish population.
Karakaş-Celik S, Aras N, Ateş C. | 07/12/2014 |
| Two SNPs, rs282070 located in intron 1 of the MAP3K7 gene, and rs2111699 located in intron 1 of the GSTZ1 gene, were significantly associated (after adjustment for multiple testing) with longevity in stage 2 | MAP3K7 and GSTZ1 are associated with human longevity: a two-stage case-control study using a multilocus genotyping.
Di Cianni F, Campa D, Tallaro F, Rizzato C, De Rango F, Barale R, Passarino G, Canzian F, Gemignani F, Montesanto A, Landi S, Rose G., Free PMC Article | 10/19/2013 |
| The ping-pong catalytic mechanism of Se-hGSTZ1-1 is similar to that of the natural GPX. | Characterization of selenium-containing glutathione transferase zeta1-1 with high GPX activity prepared in eukaryotic cells.
Yin L, Song J, Board PG, Yu Y, Han X, Wei J. | 08/31/2013 |
| Elucidation of the role of individual residues in the N-terminal, SSC motif of human GSTZ1. | Characterization of catalytic activity and structure of selenocysteine-containing hGSTZ1c-1c based on site-directed mutagenesis and computational analysis.
Yu Y, Song J, Song Y, Guo X, Han Y, Wei J. | 07/13/2013 |
| This study was performed on 228 BPD patients and 234 control subjects. Among early-onset patients, the variant alleles of Glu32Lys and G-1002A increased BPD susceptibility. | Association between three genetic polymorphisms of glutathione S-transferase Z1 (GSTZ1) and susceptibility to bipolar disorder.
Rezaei Z, Saadat I, Saadat M. | 03/23/2013 |
| e report for the first time the conversion of human glutathione transferase Zeta (hGSTZ1-1) into seleno-hGSTZ1-1 by means of genetic engineering in eukaryotes. | Expression of selenocysteine-containing glutathione S-transferase in eukaryote.
Liu H, Yin L, Board PG, Han X, Fan Z, Fang J, Lu Z, Zhang Y, Wei J. | 12/22/2012 |
| The present results indicate that the haplotype of "-1002A, 32Lys, 42Arg" (containing three variant alleles) of GSTZ1 have protective effect compared to the other haplotypes. | Genetic polymorphisms of glutathione S-transferase Z1 (GSTZ1) and susceptibility to preeclampsia.
Saadat M, Anvar Z, Namavar-Jahromi B, Saadat I. | 12/22/2012 |
| Our study did not support any association between susceptibility to exudative AMD (age-related macular degeneration) and polymorphisms of GSTZ1. | Susceptibility to exudative age-related macular degeneration and three genetic polymorphisms of glutathione S-transferase Z1 (GSTZ1).
Othman H, Saadat I, Farvardin-Jahromi M, Saadat M. | 07/28/2012 |
| Data suggest neonatal onset and age-related increase in GSTZ1 protein expression during liver development/growth. GSTZ1 haplotype influences activity with dichloroacetate but not protein expression. | Prenatal and postnatal expression of glutathione transferase ζ 1 in human liver and the roles of haplotype and subject age in determining activity with dichloroacetate.
Li W, Gu Y, James MO, Hines RN, Simpson P, Langaee T, Stacpoole PW., Free PMC Article | 05/19/2012 |
| polymorphisms of GSTZ1 showed strong linkage disequilibrium among cancer patients and control su | Susceptibility to breast cancer and three polymorphisms of GSTZ1.
Saadat I, Khalili M, Nafissi S, Omidvari S, Saadat M. | 04/21/2012 |
| Results describe the genotypic frequencies of glutathione S-transferase Z1 polymorphisms among an Iranian population. | Genetic polymorphisms of glutathione S-transferase Z1 in an Iranian population.
Nafissi S, Saadat I, Saadat M. | 10/22/2011 |
| The results of this study did not support the association between genetic polymorphisms of glutathione S-transferase Z1 (GSTZ1) and susceptibility to schizophrenia. | Association between three genetic polymorphisms of glutathione S-transferase Z1 (GSTZ1) and susceptibility to schizophrenia.
Nafissi S, Saadat I, Farrashbandi H, Saadat M. | 06/4/2011 |