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    Aif1 allograft inflammatory factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29427, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Allograft inflammatory factor-1 enhances inflammation and oxidative stress via the NF-kappaB pathway of bladder urothelium in diabetic rat model.

    Allograft inflammatory factor-1 enhances inflammation and oxidative stress via the NF-κB pathway of bladder urothelium in diabetic rat model.
    Wu Q, Qin B, Wu X, Zhang M, Gan Z, Lan Y, Ma C, Fu W.

    12/22/2023
    Switching Rat Resident Macrophages from M1 to M2 Phenotype by Iba1 Silencing Has Analgesic Effects in SNL-Induced Neuropathic Pain.

    Switching Rat Resident Macrophages from M1 to M2 Phenotype by Iba1 Silencing Has Analgesic Effects in SNL-Induced Neuropathic Pain.
    Gheorghe RO, Grosu AV, Magercu M, Ghenghea MS, Zbarcea CE, Tanase A, Negres S, Filippi A, Chiritoiu G, Gherghiceanu M, Dinescu S, Gaina G, Sapunar D, Ristoiu V., Free PMC Article

    11/16/2023
    Neurotoxic and cardiotoxic effects of N-methyl-1-(naphthalen-2-yl)propan-2-amine (methamnetamine) and 1-phenyl-2-pyrrolidinylpentane (prolintane).

    Neurotoxic and cardiotoxic effects of N-methyl-1-(naphthalen-2-yl)propan-2-amine (methamnetamine) and 1-phenyl-2-pyrrolidinylpentane (prolintane).
    Jeong S, Yoon KS, Lee JM, Jo ES, Kim D, Choi SO.

    03/20/2023
    Histopathological evaluation of IBA-1, GFAP activity in the brain cortex of rats administered cadmium chloride.

    Histopathological evaluation of IBA-1, GFAP activity in the brain cortex of rats administered cadmium chloride.
    Gök E, Deveci E.

    08/6/2022
    Human Milk Oligosaccharide 2'-Fucosyllactose Induces Neuroprotection from Intracerebral Hemorrhage Stroke.

    Human Milk Oligosaccharide 2'-Fucosyllactose Induces Neuroprotection from Intracerebral Hemorrhage Stroke.
    Hung TW, Wu KJ, Wang YS, Bae EK, Song Y, Yoon J, Yu SJ., Free PMC Article

    10/23/2021
    The Crosstalk between Calcium Ions and Aldosterone Contributes to Inflammation, Apoptosis, and Calcification of VSMC via the AIF-1/NF-kappaB Pathway in Uremia.

    The Crosstalk between Calcium Ions and Aldosterone Contributes to Inflammation, Apoptosis, and Calcification of VSMC via the AIF-1/NF-κB Pathway in Uremia.
    Hao J, Tang J, Zhang L, Li X, Hao L., Free PMC Article

    09/11/2021
    Prenatal exposure to immune activation had a significant main effect on microglial IBA1 immunoreactivity in the corpus callosum.

    Late gestation immune activation increases IBA1-positive immunoreactivity levels in the corpus callosum of adult rat offspring.
    Duchatel RJ, Meehan CL, Harms LR, Michie PT, Bigland MJ, Smith DW, Walker FR, Jobling P, Hodgson DM, Tooney PA.

    01/26/2019
    lumbar disc herniation upregulates microglial Iba1 activity and CGRP expression in many adjacent and ipsilateral lumbar spinal segments

    Changes in the Expressions of Iba1 and Calcitonin Gene-Related Peptide in Adjacent Lumbar Spinal Segments after Lumbar Disc Herniation in a Rat Model.
    Cho HK, Ahn SH, Kim SY, Choi MJ, Hwang SJ, Cho YW., Free PMC Article

    10/8/2016
    Iba-1-immunoreactive microglia are activated and IFN-gamma and IL-1beta levels are increased in the hippocampal CA1 region and the dentate gyrus of aged, diabetic rats, indicating that chronic diabetes may accelerate aging processes in the hippocampus

    Activation of microglia and induction of pro-inflammatory cytokines in the hippocampus of type 2 diabetic rats.
    Hwang IK, Choi JH, Nam SM, Park OK, Yoo DY, Kim W, Yi SS, Won MH, Seong JK, Yoon YS.

    04/4/2015
    The responses suggest that depending on the type of lesion DRG Iba-1 (+) resident macrophages have different activation mechanisms, which are dissimilar to those in microglia.

    Activation profile of dorsal root ganglia Iba-1 (+) macrophages varies with the type of lesion in rats.
    Ton BH, Chen Q, Gaina G, Tucureanu C, Georgescu A, Strungaru C, Flonta ML, Sah D, Ristoiu V.

    12/6/2014
    AIF-1 was activated in warm and cold ischemia-reperfusion injury, and pretreatment with low-dose FK506 partly inhibited AIF-1 activation and reduced warm and cold IR injury.

    Allograft inflammatory factor-1 is up-regulated in warm and cold ischemia-reperfusion injury in rat liver and may be inhibited by FK506.
    Jiang W, Kong L, Wu X, Pu L, Wang X.

    01/15/2011
    Iba-1 protein was detected only in microglial cells, macrophages of brain meninges, supraependymal macrophages, superficial and stromal cells of the choroid plexus--all the cells possessing phagocytotic function.

    [Calcium-binding Iba-1/AIF-1 protein in rat brain cells].
    Kirik OV, Sukhorukova EG, Korzhevskiĭ DE.

    07/5/2010
    In a transient middle cerebral artery occlusion model of rats, a large ischemic lesion is formed where macrophage-like cells massively accumulate, many of which express a macrophage marker, Iba1

    Iba1(+)/NG2(+) macrophage-like cells expressing a variety of neuroprotective factors ameliorate ischemic damage of the brain.
    Smirkin A, Matsumoto H, Takahashi H, Inoue A, Tagawa M, Ohue S, Watanabe H, Yano H, Kumon Y, Ohnishi T, Tanaka J., Free PMC Article

    04/12/2010
    AIF-1 expression plays a key role in the development of neointimal hyperplasia. AIF-1 expression enhances the activation of p38 MAP kinase. AIF-1-enhanced proliferation is p38 kinase dependent, but AIF-1-enhanced VSMC migration is p38 independent.

    Inhibition of allograft inflammatory factor-1 expression reduces development of neointimal hyperplasia and p38 kinase activity.
    Sommerville LJ, Xing C, Kelemen SE, Eguchi S, Autieri MV., Free PMC Article

    01/21/2010
    Accumulation of macrophage-like cells expressing NG2 proteoglycan and Iba1 in ischemic core of rat brain after transient middle cerebral artery occlusion

    Accumulation of macrophage-like cells expressing NG2 proteoglycan and Iba1 in ischemic core of rat brain after transient middle cerebral artery occlusion.
    Matsumoto H, Kumon Y, Watanabe H, Ohnishi T, Shudou M, Chuai M, Imai Y, Takahashi H, Tanaka J.

    01/21/2010
    High levels of AIF-1 expression reflect aggressive liver allograft rejection and suggest a role for monitoring AIF-1 in peripheral blood leukocytes.

    Over-expression of AIF-1 in liver allografts and peripheral blood correlates with acute rejection after transplantation in rats.
    Nagakawa Y, Nomoto S, Kato Y, Montgomery RA, Williams GM, Klein AS, Sun Z.

    01/21/2010
    AIF-1 is a novel molecular component of podocytes and the upregulation of AIF-1 in an anti-GBM nephritis model may mainly be a consequence of its expression in infiltrating cells.

    Expression of allograft inflammatory factor-1 in kidneys: A novel molecular component of podocyte.
    Tsubata Y, Sakatsume M, Ogawa A, Alchi B, Kaneko Y, Kuroda T, Kawachi H, Narita I, Yamamoto T, Gejyo F.

    01/21/2010
    There is a functional interaction between AIF-1 and Rac2 in VSMC leading to Rac2 activation and a potential function for Rac2 in inflammation-driven VSMC response to injury.

    Cytokine expression and AIF-1-mediated activation of Rac2 in vascular smooth muscle cells: a role for Rac2 in VSMC activation.
    Tian Y, Autieri MV.

    01/21/2010
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