| Identification, analysis of deleterious SNPs of the human GSR gene and their effects on the structure and functions of associated proteins and other diseases. | Identification, analysis of deleterious SNPs of the human GSR gene and their effects on the structure and functions of associated proteins and other diseases.
Vyas B, Bhowmik R, Akhter M, Ahmad FJ., Free PMC Article | 04/9/2022 |
| Evaluation of glutathione reductase activity in colon tissue of patients with irritable bowel syndrome. | Evaluation of glutathione reductase activity in colon tissue of patients with irritable bowel syndrome.
Lorestani S, Bahari A, Asadi M, Zahedi Avval F. | 01/1/2022 |
| MicroRNA-362-5p promotes the proliferation and inhibits apoptosis of trophoblast cells via targeting glutathione-disulfide reductase. | MicroRNA-362-5p promotes the proliferation and inhibits apoptosis of trophoblast cells via targeting glutathione-disulfide reductase.
Zhang C, Zhao D., Free PMC Article | 11/13/2021 |
| AMPKalpha1 is overexpressed in colorectal cancer (CRC) patient specimens and the high expression is correlated with poor survival. AMPKalpha1 maintains high level of reduced glutathione to keep redox homeostasis under stress conditions, thus promoting CRC cell survival. Mechanistically, AMPKalpha1 regulate the glutathione reductase (GSR) phosphorylation possibly through residue Thr507 which enhances its activity. | AMPKα1 confers survival advantage of colorectal cancer cells under metabolic stress by promoting redox balance through the regulation of glutathione reductase phosphorylation.
Wang YN, Lu YX, Liu J, Jin Y, Bi HC, Zhao Q, Liu ZX, Li YQ, Hu JJ, Sheng H, Jiang YM, Zhang C, Tian F, Chen Y, Pan ZZ, Chen G, Zeng ZL, Liu KY, Ogasawara M, Yun JP, Ju HQ, Feng JX, Xie D, Gao S, Jia WH, Kopetz S, Xu RH, Wang F., Free PMC Article | 06/20/2020 |
| It has been shown that acute aerobic exercise activates Nrf2 in young men, irrespective of training intensity, but that high-intensity exercise demonstrated a greater effect on increasing glutathione reductase activity which could indicate improved redox potential. | Effect of exercise intensity on Nrf2 signalling in young men.
Done AJ, Newell MJ, Traustadóttir T. | 04/21/2018 |
| GSR expression was higher in TMZ-resistant cells than in sensitive cells. GSR silencing in drug-resistant cells improved the sensitivity of cells to TMZ or cisplatin. Over-expression resulted in resistance. GSR partially prevented the oxidative stress caused by L-buthionine -sulfoximine. The action of GSR in drug resistance is associated with the modulation of redox homeostasis. High GSR correlated with lower survival. | Glutathione reductase mediates drug resistance in glioblastoma cells by regulating redox homeostasis.
Zhu Z, Du S, Du Y, Ren J, Ying G, Yan Z. | 01/6/2018 |
| Plasma glutathione reductase (GR) activity was correlated with erythrocyte GR activity and the erythrocyte reduced glutathione/glutathione disulfide ratio. A decrease in plasma GR activity was associated with an increase in mortality in septic shock. | Plasma glutathione reductase activity and prognosis of septic shock.
Kim JS, Kwon WY, Suh GJ, Kim KS, Jung YS, Kim SH, Lee SE. | 05/7/2016 |
| Glutathione reductase reduces mitochondrial protein mitoNEET [2Fe-2S] clusters. | Reduction of mitochondrial protein mitoNEET [2Fe-2S] clusters by human glutathione reductase.
Landry AP, Cheng Z, Ding H., Free PMC Article | 12/5/2015 |
| The recurrence of benign tumors of mammary gland occurred predominantly in women-carriers of mutant alleles with polymorphism rs8190924 of gene GSR and AA rs3763511of gene DKK4. | [MODERN METHODS OF PROGNOSTICATION OF THE RECURRENCES OCCURRENCE AFTER SURGICAL TREATMENT OF THE MAMMARY GLAND BENIGN TUMORS].
Usenko OY, Romak RP. | 10/10/2015 |
| GSR was the most significant single SNP association with systemic lupus erythematosus in African Americans. | Variable association of reactive intermediate genes with systemic lupus erythematosus in populations with different African ancestry.
Ramos PS, Oates JC, Kamen DL, Williams AH, Gaffney PM, Kelly JA, Kaufman KM, Kimberly RP, Niewold TB, Jacob CO, Tsao BP, Alarcón GS, Brown EE, Edberg JC, Petri MA, Ramsey-Goldman R, Reveille JD, Vilá LM, James JA, Guthridge JM, Merrill JT, Boackle SA, Freedman BI, Scofield RH, Stevens AM, Vyse TJ, Criswell LA, Moser KL, Alarcón-Riquelme ME, Langefeld CD, Harley JB, Gilkeson GS., Free PMC Article | 01/25/2014 |
| 1,25 (OH) vitamin D significantly upregulated expression of GCLC and GR and lowered secretion of IL-8 and MCP-1 in high-glucose exposed U937 monocytes. | Vitamin D upregulates glutamate cysteine ligase and glutathione reductase, and GSH formation, and decreases ROS and MCP-1 and IL-8 secretion in high-glucose exposed U937 monocytes.
Jain SK, Micinski D., Free PMC Article | 10/19/2013 |
| The results demonstrate for the first time that glutathione reductase gene polymorphisms are significantly associated with bone mineral density. | Antioxidant enzymes GSR, SOD1, SOD2, and CAT gene variants and bone mineral density values in postmenopausal women: a genetic association analysis.
Mlakar SJ, Osredkar J, Prezelj J, Marc J. | 07/14/2012 |
| Up-regulation of CAT and GR activity resulted in an increase in total antioxidant activity in A549 after exposure to B(a)P. | Comparative proteomic analysis of cellular response of human airway epithelial cells (A549) to benzo(a)pyrene.
Min L, He S, Chen Q, Peng F, Peng H, Xie M. | 09/10/2011 |
| Human eye lenses were dissected into discrete regions that were formed at different stages of life and assayed for activity of lactate dehydrogenase (LDH) and a particularly stable enzyme, glutathione reductase (GR). | Age-dependent denaturation of enzymes in the human lens: a paradigm for organismic aging?
Zhu X, Korlimbinis A, Truscott RJ. | 03/19/2011 |
| novel glutathione reductase alternative splice variants | Expression of glutathione reductase splice variants in human tissues.
Satoh N, Watanabe N, Kanda A, Sugaya-Fukasawa M, Hisatomi H. | 01/1/2011 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| GR deficiency and drug-induced GR inhibition may protect from malaria by inducing enhanced ring stage phagocytosis rather than by impairing parasite growth directly [case study] | Inherited glutathione reductase deficiency and Plasmodium falciparum malaria--a case study.
Gallo V, Schwarzer E, Rahlfs S, Schirmer RH, van Zwieten R, Roos D, Arese P, Becker K., Free PMC Article | 03/15/2010 |
| Data show that decreased activities of GPX1, increased activities of GR and CuZnSOD in women with depressive disorder. | Antioxidative enzymes and increased oxidative stress in depressive women.
Kodydková J, Vávrová L, Zeman M, Jirák R, Macásek J, Stanková B, Tvrzická E, Zák A. | 01/25/2010 |
| An increase in the activities of superoxide dismutase was observed in patients with active and silent celiac disease, while the activities of glutathione peroxidase and glutathione reductase and the glutathione content were significantly reduced. | Antioxidant status and lipid peroxidation in small intestinal mucosa of children with celiac disease.
Stojiljković V, Todorović A, Pejić S, Kasapović J, Saicić ZS, Radlović N, Pajović SB. | 01/25/2010 |
| higher glutathione reductase and total antioxidant capacity were found in end-stage renal disease patients than in controls | Glutathione, glutathione-related enzymes, and total antioxidant capacity in patients on maintenance dialysis.
Ahmadpoor P, Eftekhar E, Nourooz-Zadeh J, Servat H, Makhdoomi K, Ghafari A. | 01/21/2010 |
| Data report synchrotron-based cryocrystallographic studies of natural substrate complexes of the flavoenzyme human glutathione reductase at nominal resolutions between 1.1 and 0.95 A that reveal new aspects of its mechanism. | Catalytic cycle of human glutathione reductase near 1 A resolution.
Berkholz DS, Faber HR, Savvides SN, Karplus PA., Free PMC Article | 01/21/2010 |
| Inhibitory effects of several antibiotics on purified human erythrocyte glutathione reductase has been investigated. | Effects of some antibiotics on human erythrocyte glutathione reductase: an in vitro study.
Senturk M, Kufrevioglu OI, Ciftci M. | 01/21/2010 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Interactions between genes involved in the antioxidant defence system and breast cancer risk.
Oestergaard MZ, Tyrer J, Cebrian A, Shah M, Dunning AM, Ponder BA, Easton DF, Pharoah PD., Free PMC Article | 03/13/2008 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (9) articlesGenetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ. Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population.
Wang Y, Fu W, Xie F, Wang Y, Chu X, Wang H, Shen M, Wang Y, Wang Y, Sun W, Lei R, Yang L, Wu H, Foo J, Liu J, Jin L, Huang W. Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy.
Moyer AM, Sun Z, Batzler AJ, Li L, Schaid DJ, Yang P, Weinshilboum RM. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. Low 8-oxo-7,8-dihydro-2'-deoxyguanosine levels and influence of genetic background in an Andean population exposed to high levels of arsenic.
Engström KS, Vahter M, Lindh C, Teichert F, Singh R, Concha G, Nermell B, Farmer PB, Strömberg U, Broberg K. Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer.
Mavaddat N, Dunning AM, Ponder BA, Easton DF, Pharoah PD. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey.
Starr JM, Shiels PG, Harris SE, Pattie A, Pearce MS, Relton CL, Deary IJ. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.
Harris SE, Fox H, Wright AF, Hayward C, Starr JM, Whalley LJ, Deary IJ. Tagging single-nucleotide polymorphisms in antioxidant defense enzymes and susceptibility to breast cancer.
Cebrian A, Pharoah PD, Ahmed S, Smith PL, Luccarini C, Luben R, Redman K, Munday H, Easton DF, Dunning AM, Ponder BA. | 03/13/2008 |