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    GSK3B glycogen synthase kinase 3 beta [ Homo sapiens (human) ]

    Gene ID: 2932, updated on 10-Oct-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Synergistic Effect between the APOE epsilon4 Allele with Genetic Variants of GSK3B and MAPT: Differential Profile between Refractory Epilepsy and Alzheimer Disease.

    Synergistic Effect between the APOE ε4 Allele with Genetic Variants of GSK3B and MAPT: Differential Profile between Refractory Epilepsy and Alzheimer Disease.
    Toral-Rios D, Pichardo-Rojas P, Ruiz-Sánchez E, Rosas-Carrasco Ó, Carvajal-García R, Gálvez-Coutiño DC, Martínez-Rodríguez NL, Rubio-Chávez AD, Alcántara-Flores M, López-Ramírez A, Martínez-Rosas AR, Ruiz-Chow ÁA, Alonso-Vanegas M, Campos-Peña V., Free PMC Article

    10/3/2024
    Structural and functional effects of phosphopriming and scaffolding in the kinase GSK-3beta.

    Structural and functional effects of phosphopriming and scaffolding in the kinase GSK-3β.
    Enos MD, Gavagan M, Jameson N, Zalatan JG, Weis WI.,

    09/13/2024
    GSK3: A potential target and pending issues for treatment of Alzheimer's disease.

    GSK3: A potential target and pending issues for treatment of Alzheimer's disease.
    Zhao J, Wei M, Guo M, Wang M, Niu H, Xu T, Zhou Y., Free PMC Article

    07/11/2024
    GSK3beta and UCHL3 govern RIPK4 homeostasis via deubiquitination to enhance tumor metastasis in ovarian cancer.

    GSK3β and UCHL3 govern RIPK4 homeostasis via deubiquitination to enhance tumor metastasis in ovarian cancer.
    Shan W, Peng W, Chen Y, Wang Y, Yu Q, Tian Y, Dou Y, Tu J, Huang X, Li X, Wang Z, Zhu Q, Chen J, Xia B.

    06/28/2024
    MiR-29a efficiently suppresses the generation of reactive oxygen species and alpha-synuclein in a cellular model of Parkinson's disease by potentially targeting GSK-3beta.

    MiR-29a efficiently suppresses the generation of reactive oxygen species and α-synuclein in a cellular model of Parkinson's disease by potentially targeting GSK-3β.
    Yang YL, Lin TK, Huang YH.

    05/30/2024
    Association of glycogen synthase kinase-3beta with cognitive impairment in type 2 diabetes patients: a six-year follow-up study.

    Association of glycogen synthase kinase-3β with cognitive impairment in type 2 diabetes patients: a six-year follow-up study.
    Wei W, Xu P, Li L, Mao H, Li N, Wang XQ, Wang L, Xu ZP, Zhao S., Free PMC Article

    05/8/2024
    NLRP3 Inflammasome Priming in the Retina of Diabetic Mice Requires REDD1-Dependent Activation of GSK3beta.

    NLRP3 Inflammasome Priming in the Retina of Diabetic Mice Requires REDD1-Dependent Activation of GSK3β.
    McCurry CM, Sunilkumar S, Subrahmanian SM, Yerlikaya EI, Toro AL, VanCleave AM, Stevens SA, Barber AJ, Sundstrom JM, Dennis MD., Free PMC Article

    04/2/2024
    Glutamine transporter SLC38A3 promotes breast cancer metastasis via Gsk3beta/beta-catenin/EMT pathway.

    Glutamine transporter SLC38A3 promotes breast cancer metastasis via Gsk3β/β-catenin/EMT pathway.
    Tan Z, Boyapati K, Tressler CM, Jenkinson NM, Glunde K.

    03/19/2024
    GSK3beta: A ray of hope for the treatment of diabetic kidney disease.

    GSK3β: A ray of hope for the treatment of diabetic kidney disease.
    Liang LL, He MF, Zhou PP, Pan SK, Liu DW, Liu ZS.

    03/8/2024
    Decreased ZMIZ1 suppresses melanogenesis in vitiligo by regulating mTOR/AKT/GSK-3beta-mediated glucose uptake.

    Decreased ZMIZ1 suppresses melanogenesis in vitiligo by regulating mTOR/AKT/GSK-3β-mediated glucose uptake.
    Lu W, Chen Z, Xu H, Shen Z, Wu Z, Li M.

    02/16/2024
    27-Hydroxycholesterol activates the GSK-3beta/beta-catenin signaling pathway resulting in intestinal fibrosis by inducing oxidative stress: effect of dietary interventions.

    27-Hydroxycholesterol activates the GSK-3β/β-catenin signaling pathway resulting in intestinal fibrosis by inducing oxidative stress: effect of dietary interventions.
    Xiao W, Hu C, Ni Y, Wang J, Jiao K, Zhou M, Li Z.

    02/16/2024
    Determining Structural Changes for Ligand Recognition between Human and Rat Phosphorylated BACE1 in Silico and Its Phosphorylation by GSK3beta at Thr252 by in Vitro Studies.

    Determining Structural Changes for Ligand Recognition between Human and Rat Phosphorylated BACE1 in Silico and Its Phosphorylation by GSK3β at Thr252 by in Vitro Studies.
    Velazquez Toledano J, Bello M, Correa Basurto J, Guerrero González I, Pacheco-Yépez J, Rosales Hernández MC.

    02/13/2024
    GSK-3beta as a Potential Coordinator of Anabolic and Catabolic Pathways in Hepatitis C Virus Insulin Resistance.

    GSK-3β as a Potential Coordinator of Anabolic and Catabolic Pathways in Hepatitis C Virus Insulin Resistance.
    Das GC, Hollinger FB., Free PMC Article

    02/13/2024
    GSK-3beta activation mediates apolipoprotein E4-associated cognitive impairment in type 2 diabetes mellitus: A multicenter, cross-sectional study.

    GSK-3β activation mediates apolipoprotein E4-associated cognitive impairment in type 2 diabetes mellitus: A multicenter, cross-sectional study.
    Gao Y, Yu H, Liu Y, Xu Z, He B, Liu H, Wang Y, Zhang Y, Liang Y, Yang Y, Zheng J, Wang JZ., Free PMC Article

    02/7/2024
    Intrarenal and Urinary Glycogen Synthase Kinase-3 Beta Levels in Diabetic and Nondiabetic Chronic Kidney Disease.

    Intrarenal and Urinary Glycogen Synthase Kinase-3 Beta Levels in Diabetic and Nondiabetic Chronic Kidney Disease.
    Zeng L, Ng JK, Fung WW, Chan GC, Chow KM, Szeto CC., Free PMC Article

    01/11/2024
    NRF1 knockdown alleviates lipopolysaccharide-induced pulmonary inflammatory injury by upregulating DKK3 and inhibiting the GSK-3beta/beta-catenin pathway.

    NRF1 knockdown alleviates lipopolysaccharide-induced pulmonary inflammatory injury by upregulating DKK3 and inhibiting the GSK-3β/β-catenin pathway.
    Kang L, Wang X, Wang J, Guo J, Zhang W, Lei R., Free PMC Article

    12/20/2023
    Phosphorylation of USP27X by GSK3beta maintains the stability and oncogenic functions of CBX2.

    Phosphorylation of USP27X by GSK3β maintains the stability and oncogenic functions of CBX2.
    Xing Y, Ba-Tu J, Dong C, Cao X, Li B, Jia X, Juan Y, Lv X, Zhang H, Qin N, Han W, Wang D, Qi X, Wang Y, Hao X, Zhang S, Du X, Wang H, Wang M., Free PMC Article

    12/4/2023
    Modulation of PI3K/Akt/GSK3beta signaling cascade through G protein-coupled receptor 55 (GPR55) activation: Prenatal lysophosphatidylinositol attenuates valproic acid-induced synaptic abnormalities and mitochondrial dysfunction.

    Modulation of PI3K/Akt/GSK3β signaling cascade through G protein-coupled receptor 55 (GPR55) activation: Prenatal lysophosphatidylinositol attenuates valproic acid-induced synaptic abnormalities and mitochondrial dysfunction.
    Ahmed S, Abir AH, Sharmin O, Khurshid N, Akter A, Nakshy NT, Hasan MM, Yesmine S, Rahman M.

    11/29/2023
    Transcriptional Regulation of the Human 5-HT1A Receptor Gene by Lithium: Role of Deaf1 and GSK3beta.

    Transcriptional Regulation of the Human 5-HT1A Receptor Gene by Lithium: Role of Deaf1 and GSK3β.
    Harkin EF, Nasrallah G, Le François B, Albert PR., Free PMC Article

    11/29/2023
    Interferon-gamma inducible protein 30 promotes the epithelial-mesenchymal transition-like phenotype and chemoresistance by activating EGFR/AKT/GSK3beta/beta-catenin pathway in glioma.

    Interferon-γ inducible protein 30 promotes the epithelial-mesenchymal transition-like phenotype and chemoresistance by activating EGFR/AKT/GSK3β/β-catenin pathway in glioma.
    Chen Y, Xu H, Yu P, Wang Q, Li S, Ji F, Wu C, Lan Q., Free PMC Article

    11/28/2023
    FUNDC2, a mitochondrial outer membrane protein, mediates triple-negative breast cancer progression via the AKT/GSK3beta/GLI1 pathway.

    FUNDC2, a mitochondrial outer membrane protein, mediates triple-negative breast cancer progression via the AKT/GSK3β/GLI1 pathway.
    Yin L, Cao R, Liu Z, Luo G, Li Y, Zhou X, Chen X, Wu Y, He J, Zu X, Shen Y., Free PMC Article

    11/22/2023
    Suspension state affects the stemness of breast cancer cells by regulating the glycogen synthase kinase-3beta.

    Suspension state affects the stemness of breast cancer cells by regulating the glycogen synthase kinase-3β.
    Chen L, Lv Y.

    11/16/2023
    Early growth response-1 is a new substrate of the GSK3beta-FBXW7 axis.

    Early growth response-1 is a new substrate of the GSK3β-FBXW7 axis.
    Yin L, Zhang J, Sun Y., Free PMC Article

    11/15/2023
    PCMT1 regulates the migration, invasion, and apoptosis of prostate cancer through modulating the PI3K/AKT/GSK-3beta pathway.

    PCMT1 regulates the migration, invasion, and apoptosis of prostate cancer through modulating the PI3K/AKT/GSK-3β pathway.
    Zhong J, Yuan C, Liu L, Du Y, Hui Y, Chen Z, Diao C, Yang R, Liu G, Liu X., Free PMC Article

    11/14/2023
    GSK3beta-driven SOX2 overexpression is a targetable vulnerability in esophageal squamous cell carcinoma.

    GSK3β-driven SOX2 overexpression is a targetable vulnerability in esophageal squamous cell carcinoma.
    Kang L, Liu Y, He J, Wang Y, Xue M, Wu X, Wang Z, Zhang Y, Chu M, Li J, Wei W, Li J, Li E, Liao L, Xiao J, Zhang R, Xu L, Wong J.

    10/24/2023
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