| ANT2 drives proinflammatory macrophage activation in obesity. | ANT2 drives proinflammatory macrophage activation in obesity.
Moon JS, da Cunha FF, Huh JY, Andreyev AY, Lee J, Mahata SK, Reis FC, Nasamran CA, Lee YS., Free PMC Article | 03/12/2022 |
| Differential Expression of ADP/ATP Carriers as a Biomarker of Metabolic Remodeling and Survival in Kidney Cancers. | Differential Expression of ADP/ATP Carriers as a Biomarker of Metabolic Remodeling and Survival in Kidney Cancers.
Trisolini L, Laera L, Favia M, Muscella A, Castegna A, Pesce V, Guerra L, De Grassi A, Volpicella M, Pierri CL., Free PMC Article | 06/26/2021 |
| ANT2 can be used as a marker of dedifferentiated pathology and aggressiveness of cancer. | Adenine Nucleotide Translocase 2 as an Enzyme Related to [(18)F] FDG Accumulation in Various Cancers.
Lee CH, Kim MJ, Lee HH, Paeng JC, Park YJ, Oh SW, Chai YJ, Kim YA, Cheon GJ, Kang KW, Youn H, Chung JK. | 05/16/2020 |
| Findings suggest that ANT2 overexpression contributes to EGFR-TKI resistance in non-small cell lung cancer. | Targeting Adenine Nucleotide Translocase-2 (ANT2) to Overcome Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor in Non-Small Cell Lung Cancer.
Jang JY, Kim YG, Nam SJ, Keam B, Kim TM, Jeon YK, Kim CW. | 07/1/2017 |
| Study found that ANT2 was upregulated in sorafenibresistant hepatocellular carcinoma Huh7 cell line and its overexpression promoted sorafenib resistance. | Upregulation of miR-137 reverses sorafenib resistance and cancer-initiating cell phenotypes by degrading ANT2 in hepatocellular carcinoma.
Lu AQ, Lv B, Qiu F, Wang XY, Cao XH. | 07/1/2017 |
| cancer cells require both hANT2 and hANT3, depending on their proliferation status: hANT2 when proliferation rates are high, and hANT3 when proliferation slows. | Changes in the expression of the human adenine nucleotide translocase isoforms condition cellular metabolic/proliferative status.
Gavaldà-Navarro A, Mampel T, Viñas O., Free PMC Article | 11/5/2016 |
| ANT2 shRNA downregulates miR-19a and miR-96 through the PI3K/Akt pathway and suppresses tumor growth in hepatocellular carcinoma cells. | ANT2 shRNA downregulates miR-19a and miR-96 through the PI3K/Akt pathway and suppresses tumor growth in hepatocellular carcinoma cells.
Baik SH, Lee J, Lee YS, Jang JY, Kim CW., Free PMC Article | 10/22/2016 |
| IFNgamma induces oxidative stress, DNA damage and tumor cell senescence via TGFbeta/SMAD signaling-dependent induction of Nox4 and suppression of ANT2 | IFNγ induces oxidative stress, DNA damage and tumor cell senescence via TGFβ/SMAD signaling-dependent induction of Nox4 and suppression of ANT2.
Hubackova S, Kucerova A, Michlits G, Kyjacova L, Reinis M, Korolov O, Bartek J, Hodny Z. | 07/30/2016 |
| TGF-beta-mediated suppression of ANT2 through NF1/Smad4 complexes contributes to oxidative stress and DNA damage during induction of cellular senescence. | TGF-β/NF1/Smad4-mediated suppression of ANT2 contributes to oxidative stress in cellular senescence.
Kretova M, Sabova L, Hodny Z, Bartek J, Kollarovic G, Nelson BD, Hubackova S, Luciakova K. | 07/25/2015 |
| Sirt4 regulates ATP levels via ANT2 and a feedback loop involving AMPK. | SIRT4 regulates ATP homeostasis and mediates a retrograde signaling via AMPK.
Ho L, Titus AS, Banerjee KK, George S, Lin W, Deota S, Saha AK, Nakamura K, Gut P, Verdin E, Kolthur-Seetharam U., Free PMC Article | 08/16/2014 |
| ANT2 suppression by shRNA may be able to exert anticancer effects in HCC further by restoring SOCS1 expression | ANT2 suppression by shRNA may be able to exert anticancer effects in HCC further by restoring SOCS1 expression.
Jang JY, Jeon YK, Lee CE, Kim CW. | 01/11/2014 |
| SLC25A5 is involved in memory formation or establishment, which could add mitochondrial processes to the wide array of pathways that regulate normal cognitive functions. | The mitochondrial solute carrier SLC25A5 at Xq24 is a novel candidate gene for non-syndromic intellectual disability.
Vandewalle J, Bauters M, Van Esch H, Belet S, Verbeeck J, Fieremans N, Holvoet M, Vento J, Spreiz A, Kotzot D, Haberlandt E, Rosenfeld J, Andrieux J, Delobel B, Dehouck MB, Devriendt K, Fryns JP, Marynen P, Goldstein A, Froyen G. | 11/16/2013 |
| miR-636 might function as a tumor suppressor miRNA affecting hepatocellular carcinoma (HCC) tumorigenesis via downregulation of Ras, and that ANT2 suppression by shRNA could exert an anticancer effect by restoring miR-636 expression in HCC. | ANT2 suppression by shRNA restores miR-636 expression, thereby downregulating Ras and inhibiting tumorigenesis of hepatocellular carcinoma.
Jang JY, Lee YS, Jeon YK, Lee K, Jang JJ, Kim CW., Free PMC Article | 10/26/2013 |
| Apigenin upregulates DR5 and enhances TRAIL induced apoptosis by binding and inhibiting ANT2. | Apigenin sensitizes prostate cancer cells to Apo2L/TRAIL by targeting adenine nucleotide translocase-2.
Oishi M, Iizumi Y, Taniguchi T, Goi W, Miki T, Sakai T., Free PMC Article | 08/31/2013 |
| Compares and contrasts all the known human SLC25A* genes and includes functional information. | The mitochondrial transporter family SLC25: identification, properties and physiopathology.
Palmieri F. | 07/2/2013 |
| The mammalian proteins MMS19, MIP18, and ANT2 are involved in cytoplasmic iron-sulfur cluster protein assembly. | The mammalian proteins MMS19, MIP18, and ANT2 are involved in cytoplasmic iron-sulfur cluster protein assembly.
van Wietmarschen N, Moradian A, Morin GB, Lansdorp PM, Uringa EJ., Free PMC Article | 03/2/2013 |
| In the context of ovarian cancer, the interaction between CKIepsilon and ANT2 mediates pathogenic signalling that is distinct from the canonical Wnt/beta-catenin pathway and is essential for cell proliferation and is clinically associated with poor survival. | Casein kinase I epsilon interacts with mitochondrial proteins for the growth and survival of human ovarian cancer cells.
Rodriguez N, Yang J, Hasselblatt K, Liu S, Zhou Y, Rauh-Hain JA, Ng SK, Choi PW, Fong WP, Agar NY, Welch WR, Berkowitz RS, Ng SW., Free PMC Article | 01/26/2013 |
| ANT2 is not pro-apoptotic and may therefore contribute to carcinogenesis. | Adenine nucleotide translocase 2 is a key mitochondrial protein in cancer metabolism.
Chevrollier A, Loiseau D, Reynier P, Stepien G. | 07/9/2011 |
| ANT2 shRNA treatment sensitized MCF7, T47 D, and BT474 cells to TRAIL-induced apoptosis by up-regulating the expression of TRAIL death receptors 4 and 5 (DR4 and DR5) and down-regulating the TRAIL decoy receptor 2 (DcR2). | Short-hairpin RNA-induced suppression of adenine nucleotide translocase-2 in breast cancer cells restores their susceptibility to TRAIL-induced apoptosis by activating JNK and modulating TRAIL receptor expression.
Jang JY, Jeon YK, Choi Y, Kim CW., Free PMC Article | 01/22/2011 |
| ANT2-specific RNA interference approach to inhibit ANT2 expression resulted in breast cancer cell growth arrest | Suppression of adenine nucleotide translocase-2 by vector-based siRNA in human breast cancer cells induces apoptosis and inhibits tumor growth in vitro and in vivo.
Jang JY, Choi Y, Jeon YK, Kim CW., Free PMC Article | 01/21/2010 |
| Growth-dependent repression of human adenine nucleotide translocator-2 (ANT2) transcription. | Growth-dependent repression of human adenine nucleotide translocator-2 (ANT2) transcription: evidence for the participation of Smad and Sp family proteins in the NF1-dependent repressor complex.
Luciakova K, Kollarovic G, Barath P, Nelson BD. | 01/21/2010 |
| enhanced binding of NF1 is a key step in the growth arrest repression of ANT2 transcription. | Repression of the human adenine nucleotide translocase-2 gene in growth-arrested human diploid cells: the role of nuclear factor-1.
Luciakova K, Barath P, Poliakova D, Persson A, Nelson BD. | 01/21/2010 |
| expression under hypoxic conditions alters cell cycle in cancer cells | ANT2 expression under hypoxic conditions produces opposite cell-cycle behavior in 143B and HepG2 cancer cells.
Chevrollier A, Loiseau D, Gautier F, Malthièry Y, Stepien G. | 01/21/2010 |
| ANT2 is able to restore growth on a nonfermentable carbon source of a yeast mutant strain lacking its three endogenous ANC. | The human mitochondrial ADP/ATP carriers: kinetic properties and biogenesis of wild-type and mutant proteins in the yeast S. cerevisiae.
De Marcos Lousa C, Trézéguet V, Dianoux AC, Brandolin G, Lauquin GJ. | 01/21/2010 |