| Lectin-like Transcript-1 (LLT1) Expression in Oral Squamous Cell Carcinomas: Prognostic Significance and Relationship with the Tumor Immune Microenvironment. | Lectin-like Transcript-1 (LLT1) Expression in Oral Squamous Cell Carcinomas: Prognostic Significance and Relationship with the Tumor Immune Microenvironment.
de Vicente JC, Lequerica-Fernández P, Rodrigo JP, Rodríguez-Santamarta T, Blanco-Lorenzo V, Prieto-Fernández L, Corte-Torres D, Vallina A, Domínguez-Iglesias F, Álvarez-Teijeiro S, García-Pedrero JM., Free PMC Article | 05/16/2024 |
| Immune checkpoint CD161/LLT1-associated immunological landscape and diagnostic value in oral squamous cell carcinoma. | Immune checkpoint CD161/LLT1-associated immunological landscape and diagnostic value in oral squamous cell carcinoma.
Hu X, Dong Y, Xie S, Song Y, Yu C, He Y, Wang Z, Hu Q, Ni Y, Ding L., Free PMC Article | 03/20/2024 |
| SARS-CoV-2 infection impairs NK cell functions via activation of the LLT1-CD161 axis. | SARS-CoV-2 infection impairs NK cell functions via activation of the LLT1-CD161 axis.
Lenart M, Górecka M, Bochenek M, Barreto-Duran E, Szczepański A, Gałuszka-Bulaga A, Mazur-Panasiuk N, Węglarczyk K, Siwiec-Koźlik A, Korkosz M, Łabaj PP, Baj-Krzyworzeka M, Siedlar M, Pyrc K., Free PMC Article | 06/15/2023 |
| LLT1-CD161 Interaction in Cancer: Promises and Challenges. | LLT1-CD161 Interaction in Cancer: Promises and Challenges.
Braud VM, Meghraoui-Kheddar A, Elaldi R, Petti L, Germain C, Anjuère F., Free PMC Article | 04/2/2022 |
| Role of LLT1 and PCNA as Natural Killer Cell Immune Evasion Strategies of HCT 116 Cells. | Role of LLT1 and PCNA as Natural Killer Cell Immune Evasion Strategies of HCT 116 Cells.
Malaer JD, Mathew PA. | 12/19/2020 |
| Docetaxel suppresses immunotherapy efficacy of natural killer cells toward castration-resistant prostate cancer cells via altering androgen receptor-lectin-like transcript 1 signals. | Docetaxel suppresses immunotherapy efficacy of natural killer cells toward castration-resistant prostate cancer cells via altering androgen receptor-lectin-like transcript 1 signals.
Tang M, Gao S, Zhang L, Liu B, Li J, Wang Z, Zhang W. | 08/22/2020 |
| The authors identify Clec2d as a sensor for cell death through histone recognition and show that such interaction in macrophages shuttles histone-DNA complexes into endosomes to stimulate toll-like receptors. The consequent inflammation amplifies collateral tissue damage in a liver injury model. | Immune Sensing of Cell Death through Recognition of Histone Sequences by C-Type Lectin-Receptor-2d Causes Inflammation and Tissue Injury.
Lai JJ, Cruz FM, Rock KL., Free PMC Article | 02/8/2020 |
| LLT1 strong expression was a significant risk factor for nodal metastasis in patients with head and neck cutaneous squamous cell carcinoma (cSCC) and for cSCC specific mortality. Strong LLT1 expression is an independent predictor of nodal metastasis and poor disease-specific survival and it might be helpful for risk stratification of patients with cSCC. | Lectin-like transcript 1 (LLT1) expression is associated with nodal metastasis in patients with head and neck cutaneous squamous cell carcinoma.
Santos-Juanes J, Fernández-Vega I, Lorenzo-Herrero S, Sordo-Bahamonde C, Martínez-Camblor P, García-Pedrero JM, Vivanco B, Galache-Osuna C, Vazquez-Lopez F, Gonzalez S, Rodrigo JP. | 12/14/2019 |
| REVIEW: Biological and Clinical Significance of Human NKRP1A/LLT1 Receptor/Ligand Interactions | Biological and Clinical Significance of Human NKRP1A/LLT1 Receptor/Ligand Interactions.
Bialoszewska A, Malejczyk J. | 09/21/2019 |
| These results show that susceptibility of normal articular chondrocytes to lysis by NK cells is modulated by NKR-P1A/LLT1 interactions. Thus, NKR-P1A/LLT1 interaction might provide some novel target for therapeutic interventions in the course of pathological cartilage injury. | A Role of NKR-P1A (CD161) and Lectin-like Transcript 1 in Natural Cytotoxicity against Human Articular Chondrocytes.
Białoszewska A, Olkowska-Truchanowicz J, Bocian K, Osiecka-Iwan A, Czop A, Kieda C, Malejczyk J. | 09/1/2018 |
| Blocking LLT1-NKRP1A interaction will make prostate cancer cells susceptible to killing by NK cells, suggesting a therapeutic option for treatment of prostate cancer. | Overexpression of LLT1 (OCIL, CLEC2D) on prostate cancer cells inhibits NK cell-mediated killing through LLT1-NKRP1A (CD161) interaction.
Mathew SO, Chaudhary P, Powers SB, Vishwanatha JK, Mathew PA., Free PMC Article | 02/17/2018 |
| these data suggest that LLT1-CD161 interactions play a novel and important role in B cell maturation within the Germinal center in humans. | LLT1 and CD161 Expression in Human Germinal Centers Promotes B Cell Activation and CXCR4 Downregulation.
Llibre A, López-Macías C, Marafioti T, Mehta H, Partridge A, Kanzig C, Rivellese F, Galson JD, Walker LJ, Milne P, Phillips RE, Kelly DF, Freeman GJ, El Shikh ME, Klenerman P, Willberg CB., Free PMC Article | 08/6/2016 |
| In RA joints, LLT1 is expressed by cells of the monocyte/macrophage lineage. | Expression of Lectin-Like Transcript 1, the Ligand for CD161, in Rheumatoid Arthritis.
Chalan P, Bijzet J, Huitema MG, Kroesen BJ, Brouwer E, Boots AM., Free PMC Article | 04/16/2016 |
| The hexamer of glycosylated LLT1 consists of three classical dimers. The hexameric packing may indicate a possible mode of interaction of C-type lectin-like proteins in the glycosylated form. | Four crystal structures of human LLT1, a ligand of human NKR-P1, in varied glycosylation and oligomerization states.
Skálová T, Bláha J, Harlos K, Dušková J, Koval' T, Stránský J, Hašek J, Vaněk O, Dohnálek J., Free PMC Article | 12/5/2015 |
| One polymorphism in LLT1 was found to be associated with our Crohn's Disease population (P<0.034).Our Ulcerative Colitis cohort was not associated with the variation in LLT1 (P=0.33) | Single nucleotide polymorphisms in C-type lectin genes, clustered in the IBD2 and IBD6 susceptibility loci, may play a role in the pathogenesis of inflammatory bowel diseases.
Wolfkamp SC, Verstege MI, Vogels EW, Meisner S, Verseijden C, Stokkers PC, te Velde AA. | 12/8/2012 |
| LLT1 and CD161 have roles in modulating immune responses to pathogens; and interferon-gamma contributes to modulate immune responses | Induction of lectin-like transcript 1 (LLT1) protein cell surface expression by pathogens and interferon-γ contributes to modulate immune responses.
Germain C, Meier A, Jensen T, Knapnougel P, Poupon G, Lazzari A, Neisig A, Håkansson K, Dong T, Wagtmann N, Galsgaard ED, Spee P, Braud VM., Free PMC Article | 01/14/2012 |
| Molecular basis for LLT1 protein recognition by human CD161 protein (NKRP1A/KLRB1). | Molecular basis for LLT1 protein recognition by human CD161 protein (NKRP1A/KLRB1).
Kamishikiryo J, Fukuhara H, Okabe Y, Kuroki K, Maenaka K., Free PMC Article | 09/10/2011 |
| Data show that only CLEC2D isoform 1 (LLT1) is expressed on the cell surface. | Characterization of alternatively spliced transcript variants of CLEC2D gene.
Germain C, Bihl F, Zahn S, Poupon G, Dumaurier MJ, Rampanarivo HH, Padkjær SB, Spee P, Braud VM., Free PMC Article | 02/26/2011 |
| LLT1 used Src-PTK, p38 and ERK signalling pathways, but not PKC, PI3K or calcineurin pathways, to increase production of IFN-gamma by human natural killer cells. | LLT1-mediated activation of IFN-gamma production in human natural killer cells involves ERK signalling pathway.
Bambard ND, Mathew SO, Mathew PA. | 06/14/2010 |
| Women with a lysine (GG genotype) at position 19 of the OCIL protein displayed lower bone mineral density at femoral neck and at lumbar spine sites than women having an asparagine residue. | The Asn19Lys substitution in the osteoclast inhibitory lectin (OCIL) gene is associated with a reduction of bone mineral density in postmenopausal women.
Pineda B, Laporta P, Cano A, García-Pérez MA, Pineda B, Laporta P, Cano A, García-Pérez MA. | 01/21/2010 |
| Expression of LLT1 on activated dendritic cells and B cells suggests that it might regulate the cross-talk between NK cells and APCs | Functional consequences of interactions between human NKR-P1A and its ligand LLT1 expressed on activated dendritic cells and B cells.
Rosen DB, Cao W, Avery DT, Tangye SG, Liu YJ, Houchins JP, Lanier LL., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesPolymorphisms in CLEC16A and CIITA at 16p13 are associated with primary adrenal insufficiency.
Skinningsrud B, Husebye ES, Pearce SH, McDonald DO, Brandal K, Wolff AB, Løvås K, Egeland T, Undlien DE. The Asn19Lys substitution in the osteoclast inhibitory lectin (OCIL) gene is associated with a reduction of bone mineral density in postmenopausal women.
Pineda B, Laporta P, Cano A, García-Pérez MA, Pineda B, Laporta P, Cano A, García-Pérez MA. | 05/21/2008 |
| Engagement of CD161 on NK cells with LLT1 expressed on target cells inhibited NK cell-mediated cytotoxicity and IFN-gamma secretion. LLT1/CD161 interaction in the presence of a TCR signal enhanced IFN-gamma production by T cells | Cutting edge: lectin-like transcript 1 is a ligand for the CD161 receptor.
Aldemir H, Prod'homme V, Dumaurier MJ, Retiere C, Poupon G, Cazareth J, Bihl F, Braud VM. | 01/21/2010 |
| LLT1 induces Interferon Type II production by natural killer cells. | The LLT1 receptor induces IFN-gamma production by human natural killer cells.
Mathew PA, Chuang SS, Vaidya SV, Kumaresan PR, Boles KS, Pham HT. | 01/21/2010 |
| LLT1 on target cells can inhibit NK cytotoxicity via interactions with CD161. LLT1 activates NFAT-GFP reporter cells expressing a CD3zeta-CD161 chimeric receptor; reciprocally, reporter cells with a CD3zeta-LLT1 chimeric receptor are stimulated by CD161 | Cutting edge: lectin-like transcript-1 is a ligand for the inhibitory human NKR-P1A receptor.
Rosen DB, Bettadapura J, Alsharifi M, Mathew PA, Warren HS, Lanier LL. | 01/21/2010 |