| RP1-13D10.2 is a long noncoding RNA that regulates LDLR and may contribute to low-density lipoprotein cholesterol response to statin treatment. | RP1-13D10.2 Is a Novel Modulator of Statin-Induced Changes in Cholesterol.
Mitchel K, Theusch E, Cubitt C, Dosé AC, Stevens K, Naidoo D, Medina MW, Mitchel K, Theusch E, Cubitt C, Dosé AC, Stevens K, Naidoo D, Medina MW., Free PMC Articles: PMC4917428, PMC4917428 | 12/26/2023 |
| Effect of type 2 diabetes on the inducible degrader of LDL receptor. | Effect of type 2 diabetes on the inducible degrader of LDL receptor.
Lam S, Lui DTW, Shiu SWM, Wong Y, Tan KCB., Free PMC Article | 06/26/2023 |
| Mouse Spinal Cord Vascular Transcriptome Analysis Identifies CD9 and MYLIP as Injury-Induced Players. | Mouse Spinal Cord Vascular Transcriptome Analysis Identifies CD9 and MYLIP as Injury-Induced Players.
Martins I, Neves-Silva D, Ascensão-Ferreira M, Dias AF, Ribeiro D, Isidro AF, Quitéria R, Paramos-de-Carvalho D, Barbosa-Morais NL, Saúde L., Free PMC Article | 04/14/2023 |
| Genetic polymorphism of IDOL gene was associated with the susceptibility of coronary artery disease in Han population in Xinjiang, China. | Genetic polymorphism of IDOL gene was associated with the susceptibility of coronary artery disease in Han population in Xinjiang, China.
Adi D, Abuzhalihan J, Tao J, Wu Y, Wang YH, Liu F, Yang YN, Ma X, Li XM, Xie X, Fu ZY, Ma YT., Free PMC Article | 10/23/2021 |
| Identification of MYLIP gene and miRNA-802 involved in the growth and metastasis of cervical cancer cells. | Identification of MYLIP gene and miRNA-802 involved in the growth and metastasis of cervical cancer cells.
Ni M, Yan Q, Xue H, Du Y, Zhao S, Zhao Z. | 10/9/2021 |
| Novel associations of SNPs MYLIP rs3757354 and ABCA1 2230806 gene with early-onset-preeclampsia: A case-control candidate genetic study. | Novel associations of SNPs MYLIP rs3757354 and ABCA1 2230806 gene with early-onset-preeclampsia: A case-control candidate genetic study.
Wang H, Ma L, Pan X, Du Z, Chen Y. | 09/25/2021 |
| SUMOylation of the ubiquitin ligase IDOL decreases LDL receptor levels and is reversed by SENP1. | SUMOylation of the ubiquitin ligase IDOL decreases LDL receptor levels and is reversed by SENP1.
Wang JQ, Lin ZC, Li LL, Zhang SF, Li WH, Liu W, Song BL, Luo J., Free PMC Article | 08/28/2021 |
| IDOL gene variant is associated with hyperlipidemia in Han population in Xinjiang, China. | IDOL gene variant is associated with hyperlipidemia in Han population in Xinjiang, China.
Adi D, Abuzhalihan J, Wang YH, Baituola G, Wu Y, Xie X, Fu ZY, Yang YN, Ma X, Li XM, Chen BD, Liu F, Ma YT., Free PMC Article | 02/27/2021 |
| Structural analysis of the LDL receptor-interacting FERM domain in the E3 ubiquitin ligase IDOL reveals an obscured substrate-binding site. | Structural analysis of the LDL receptor-interacting FERM domain in the E3 ubiquitin ligase IDOL reveals an obscured substrate-binding site.
Martinelli L, Adamopoulos A, Johansson P, Wan PT, Gunnarsson J, Guo H, Boyd H, Zelcer N, Sixma TK., Free PMC Article | 02/6/2021 |
| IDOL(G51S) is a gain-of-function variant responsible for high LDL-C in both humans and mice. These results suggest that IDOL is a key player regulating cholesterol level in humans. | IDOL G51S Variant Is Associated With High Blood Cholesterol and Increases Low-Density Lipoprotein Receptor Degradation.
Adi D, Lu XY, Fu ZY, Wei J, Baituola G, Meng YJ, Zhou YX, Hu A, Wang JK, Lu XF, Wang Y, Song BL, Ma YT, Luo J. | 04/18/2020 |
| the effects caused by human inducible degrader of the low-density lipoprotein expression are LDLR- dependent given the unchanged plasma lipids in LAhB mice lacking low-density lipoprotein receptor | Stable liver-specific expression of human IDOL in humanized mice raises plasma cholesterol.
Ibrahim S, Somanathan S, Billheimer J, Wilson JM, Rader DJ., Free PMC Article | 12/31/2016 |
| The long noncoding RNA RP1-13D10.2 may contribute to LDL cholesterol levels in response to statins. | RP1-13D10.2 Is a Novel Modulator of Statin-Induced Changes in Cholesterol.
Mitchel K, Theusch E, Cubitt C, Dosé AC, Stevens K, Naidoo D, Medina MW, Mitchel K, Theusch E, Cubitt C, Dosé AC, Stevens K, Naidoo D, Medina MW., Free PMC Articles: PMC4917428, PMC4917428 | 12/16/2016 |
| Specifically, loss of IDOL increases LDLR distribution in the hepatic cell, and subsequently reduces serum LDL-C levels in dyslipidemic patients | IDOL, inducible degrader of low-density lipoprotein receptor, serves as a potential therapeutic target for dyslipidemia.
Zhang CP, Tian Y, Zhang M, Tuo QH, Chen JX, Liao DF. | 10/22/2016 |
| Data suggest inducible expression of IDOL is subject to robust, rapid regulation by process that is sensitive to deubiquitinase inhibition in human/mouse cell lines and primary human cells; transcriptional induction of IDOL leads to degradation of LDLR. | Deubiquitylase Inhibition Reveals Liver X Receptor-independent Transcriptional Regulation of the E3 Ubiquitin Ligase IDOL and Lipoprotein Uptake.
Nelson JK, Cook EC, Loregger A, Hoeksema MA, Scheij S, Kovacevic I, Hordijk PL, Ovaa H, Zelcer N., Free PMC Article | 08/6/2016 |
| Identify USP2 as a novel regulator of lipoprotein clearance owing to its ability to control ubiquitylation-dependent degradation of the LDLR by IDOL. | The Deubiquitylase USP2 Regulates the LDLR Pathway by Counteracting the E3-Ubiquitin Ligase IDOL.
Nelson JK, Sorrentino V, Avagliano Trezza R, Heride C, Urbe S, Distel B, Zelcer N. | 07/2/2016 |
| The study identified MARCH6 as a negative regulator of SREBP2-mediated transcription and described an unexpected E3 circuit functionally linking MARCH6 and IDOL to limit uptake of low-density lipoprotein via the LDLR pathway. | A MARCH6 and IDOL E3 Ubiquitin Ligase Circuit Uncouples Cholesterol Synthesis from Lipoprotein Uptake in Hepatocytes.
Loregger A, Cook EC, Nelson JK, Moeton M, Sharpe LJ, Engberg S, Karimova M, Lambert G, Brown AJ, Zelcer N., Free PMC Article | 05/21/2016 |
| IDOL N342S Variant, Atherosclerosis Progression and Cardiovascular Disorders in the Italian General Population. | IDOL N342S Variant, Atherosclerosis Progression and Cardiovascular Disorders in the Italian General Population.
Dhyani A, Tibolla G, Baragetti A, Garlaschelli K, Pellegatta F, Grigore L, Norata GD, Catapano AL., Free PMC Article | 04/16/2016 |
| Several lipid-related gene polymorphisms interact with overweight/obesity to modulate blood pressure levels. | Several lipid-related gene polymorphisms interact with overweight/obesity to modulate blood pressure levels.
Yin RX, Wu DF, Aung LHH, Yan TT, Cao XL, Long XJ, Miao L, Liu WY, Zhang L, Li M., Free PMC Article | 08/22/2015 |
| study indicates that MYLIP p.N342S might be a pharmacogenetic marker for lipid-lowering therapy in patients with FH. | The MYLIP p.N342S polymorphism is associated with response to lipid-lowering therapy in Brazilian patients with familial hypercholesterolemia.
Santos PC, Morgan AC, Jannes CE, Krieger JE, Santos RD, Pereira AC., Free PMC Article | 06/20/2015 |
| Liver-specific expression of dominant-active IDOL is associated with hypercholesterolemia and a marked elevation in atherosclerotic lesions in transgenic mice. | Transgenic expression of dominant-active IDOL in liver causes diet-induced hypercholesterolemia and atherosclerosis in mice.
Calkin AC, Lee SD, Kim J, Van Stijn CM, Wu XH, Lusis AJ, Hong C, Tangirala RI, Tontonoz P., Free PMC Article | 02/14/2015 |
| evidence for the existence of an LXR-IDOL-mediated internalization pathway for the LDLR that is distinct from that used for lipoprotein uptake | The LXR-IDOL axis defines a clathrin-, caveolae-, and dynamin-independent endocytic route for LDLR internalization and lysosomal degradation.
Sorrentino V, Nelson JK, Maspero E, Marques ARA, Scheer L, Polo S, Zelcer N., Free PMC Article | 03/1/2014 |
| Results show that IDOL contributes to variation in circulating levels of LDL-C. | Identification of a loss-of-function inducible degrader of the low-density lipoprotein receptor variant in individuals with low circulating low-density lipoprotein.
Sorrentino V, Fouchier SW, Motazacker MM, Nelson JK, Defesche JC, Dallinga-Thie GM, Kastelein JJ, Kees Hovingh G, Zelcer N. | 12/7/2013 |
| IDOL is recruited to plasma membrane by low-density lipoprotein receptor (LDLR), promotes LDLR internalization in the absence of clathrin or caveolae, and facilitates LDLR degradation by shuttling it into the multivesicular body protein-sorting pathway | IDOL stimulates clathrin-independent endocytosis and multivesicular body-mediated lysosomal degradation of the low-density lipoprotein receptor.
Scotti E, Calamai M, Goulbourne CN, Zhang L, Hong C, Lin RR, Choi J, Pilch PF, Fong LG, Zou P, Ting AY, Pavone FS, Young SG, Tontonoz P., Free PMC Article | 06/15/2013 |
| MYLIP rs3757354 SNP is associated with serum TC, HDL-C and ApoAI levels in the Bai Ku Yao and Han populations. But the association is different between the two ethnic groups. | Association of MYLIP rs3757354 SNP and several environmental factors with serum lipid levels in the Guangxi Bai Ku Yao and Han populations.
Yan TT, Yin RX, Li Q, Huang P, Zeng XN, Huang KK, Wu DF, Aung LH., Free PMC Article | 03/9/2013 |
| No association of the MYLIP rs9370867 genotypes with lipid profile, hemodynamic data, and coronary angiographic data was in a Brazilian population. | MYLIP p.N342S polymorphism is not associated with lipid profile in the Brazilian population.
Santos PC, Oliveira TG, Lemos PA, Mill JG, Krieger JE, Pereira AC., Free PMC Article | 01/26/2013 |