A TBK1 variant causes autophagolysosomal and motoneuron pathology without neuroinflammation in mice.
Brenner D, Sieverding K, Srinidhi J, Zellner S, Secker C, Yilmaz R, Dyckow J, Amr S, Ponomarenko A, Tunaboylu E, Douahem Y, Schlag JS, Rodríguez Martínez L, Kislinger G, Niemann C, Nalbach K, Ruf WP, Uhl J, Hollenbeck J, Schirmer L, Catanese A, Lobsiger CS, Danzer KM, Yilmazer-Hanke D, Münch C, Koch P, Freischmidt A, Fetting M, Behrends C, Parlato R, Weishaupt JH., Free PMC Article

AZI2 mediates TBK1 activation at unresolved selective autophagy cargo receptor complexes with implications for CD8 T-cell infiltration in breast cancer.
Yeo SK, Haas M, Manupati K, Hao M, Yang F, Chen S, Guan JL., Free PMC Article

Optineurin provides a mitophagy contact site for TBK1 activation.
Yamano K, Sawada M, Kikuchi R, Nagataki K, Kojima W, Endo R, Kinefuchi H, Sugihara A, Fujino T, Watanabe A, Tanaka K, Hayashi G, Murakami H, Matsuda N., Free PMC Article

Kinome-wide siRNA screen identifies a DCLK2-TBK1 oncogenic signaling axis in clear cell renal cell carcinoma.
Hu L, Zhang Y, Guo L, Zhong H, Xie L, Zhou J, Liao C, Yao H, Fang J, Liu H, Zhang C, Zhang H, Zhu X, Luo M, von Kriegsheim A, Li B, Luo W, Zhang X, Chen X, Mendell JT, Xu L, Kapur P, Baldwin AS, Brugarolas J, Zhang Q.,

STING upregulation mediates ferroptosis and inflammatory response in lupus nephritis by upregulating TBK1 and activating NF-κB signal pathway.
Chen J, Chen P, Song Y, Wei J, Wu F, Sun J, Xu Z.

Activating STING/TBK1 suppresses tumor growth via degrading HPV16/18 E7 oncoproteins in cervical cancer.
Huang X, Huo L, Xiao B, Ouyang Y, Chen F, Li J, Zheng X, Wei D, Wu Y, Zhang R, Cao X, Kang T, Gao Y.,

Cutting Edge: STING Induces ACLY Activation and Metabolic Adaptations in Human Macrophages through TBK1.
Nickenig M, Mangan MSJ, Lee HE, Symeonidis K, Henne A, Kaiser R, Geißmar E, Garritsen H, Abdullah Z, Hiller K, Latz E, Lauterbach MA.

NAK-associated protein 1/NAP1 activates TBK1 to ensure accurate mitosis and cytokinesis.
Paul S, Sarraf SA, Nam KH, Zavar L, DeFoor N, Biswas SR, Fritsch LE, Yaron TM, Johnson JL, Huntsman EM, Cantley LC, Ordureau A, Pickrell AM., Free PMC Article

ATG4B antagonizes antiviral immunity by GABARAP-directed autophagic degradation of TBK1.
Xie W, Zhang C, Wang Z, Chen H, Gu T, Zhou T, Wu Y, Xia F, Li M, Wang J, Jiao R, Cui J, Jin S.,

CDK12 loss inhibits cell proliferation by regulating TBK1 in non-small cell lung cancer cells.
Liu X, Liu Y, Chai W, Yan M, Li H, Li J, Sun L, Cao Y, Liu Q, Sun Y, Pan H.

TBK1 variants in Chinese patients with amyotrophic lateral sclerosis: Genetic analysis and clinical features.
Zhao B, Jiang Q, Lin J, Wei Q, Li C, Hou Y, Cao B, Zhang L, Ou R, Liu K, Yang T, Xiao Y, Shang H.

An Updated Evolutionary and Structural Study of TBK1 Reveals Highly Conserved Motifs as Potential Pharmacological Targets in Neurodegenerative Diseases.
Papageorgiou L, Mangana E, Papakonstantinou E, Diakou I, Pierouli K, Dragoumani K, Bacopoulou F, Chrousos GP, Exarchos TP, Vlamos P, Eliopoulos E, Vlachakis D.

Serine/threonine kinase TBK1 promotes cholangiocarcinoma progression via direct regulation of β-catenin.
Gao CQ, Chu ZZ, Zhang D, Xiao Y, Zhou XY, Wu JR, Yuan H, Jiang YC, Chen D, Zhang JC, Yao N, Chen KY, Hong J., Free PMC Article

TBK1 promotes thyroid cancer progress by activating the PI3K/Akt/mTOR signaling pathway.
Jiang Q, Guan Y, Zheng J, Lu H., Free PMC Article

Increased IKKϵ protein stability ensures efficient type I interferon responses in conditions of TBK1 deficiency.
Wegner J, Hunkler C, Ciupka K, Hartmann G, Schlee M., Free PMC Article

Functional Characterization of a Familial ALS-Associated Missense TBK1 (p-Arg573Gly) Mutation in Patient-Derived Lymphoblasts.
Porras G, Ruiz S, Maestro I, Borrego-Hernández D, Redondo AG, Martínez A, Martín-Requero Á., Free PMC Article

TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.
Zhou J, Rasmussen NL, Olsvik HL, Akimov V, Hu Z, Evjen G, Kaeser-Pebernard S, Sankar DS, Roubaty C, Verlhac P, van de Beek N, Reggiori F, Abudu YP, Blagoev B, Lamark T, Johansen T, Dengjel J., Free PMC Article

Correlation of TBK1, AR, and other serum cancer-related biomarkers in breast cancer patients: An observational study.
Liu H, Li H, Zhang J, Meng Q, Ma L., Free PMC Article

TBK1 is part of a galectin 8 dependent membrane damage recognition complex and drives autophagy upon Adenovirus endosomal escape.
Pied N, Daussy CF, Denis Z, Ragues J, Faure M, Iggo R, Tschan MP, Roger B, Rayne F, Wodrich H., Free PMC Article

CXCL4 synergizes with TLR8 for TBK1-IRF5 activation, epigenomic remodeling and inflammatory response in human monocytes.
Yang C, Bachu M, Du Y, Brauner C, Yuan R, Ah Kioon MD, Chesi G, Barrat FJ, Ivashkiv LB., Free PMC Article

TBK1 Facilitates GLUT1-Dependent Glucose Consumption by suppressing mTORC1 Signaling in Colorectal Cancer Progression.
Zhou D, Yao Y, Zong L, Zhou G, Feng M, Chen J, Liu G, Chen G, Sun K, Yao H, Liu Y, Shi X, Zhang W, Shi B, Tai Q, Wu G, Sun L, Hu W, Zhu X, He S., Free PMC Article

TBK1 participates in glutaminolysis by mediating the phosphorylation of RIPK3 to promote endotoxin tolerance.
Pan L, Yang L, Yi Z, Zhang W, Gong J.

TBK1 haploinsufficiency results in changes in the K63-ubiquitination profiles in brain and fibroblasts from affected and presymptomatic mutation carriers.
Khoshnood B, Ullgren A, Laffita-Mesa J, Öijerstedt L, Patra K, Nennesmo I, Graff C., Free PMC Article

The role of TBK1 in cancer pathogenesis and anticancer immunity.
Runde AP, Mack R, S J PB, Zhang J., Free PMC Article

Specific association of TBK1 with the trans-Golgi network following STING stimulation.
Kemmoku H, Kuchitsu Y, Mukai K, Taguchi T., Free PMC Article