| Sirtuin 6 Deacetylates Apoptosis-Associated Speck-Like Protein (ASC) to Inhibit Endothelial Cell Pyroptosis in Atherosclerosis. | Sirtuin 6 Deacetylates Apoptosis-Associated Speck-Like Protein (ASC) to Inhibit Endothelial Cell Pyroptosis in Atherosclerosis.
Huang J, Dong S, Wu Y, Yi H, Zhang W, Ai X. | 10/1/2024 |
| PYCARD gene polymorphisms and susceptibility to periodontal and coronary heart diseases. | PYCARD gene polymorphisms and susceptibility to periodontal and coronary heart diseases.
Daily ZA, Al-Ghurabi BH, Al-Qarakhli AM., Free PMC Article | 06/6/2024 |
| The Mechanism of Osteoprotegerin-Induced Osteoclast Pyroptosis In Vitro. | The Mechanism of Osteoprotegerin-Induced Osteoclast Pyroptosis In Vitro.
Zhu J, Ma Y, Wang J, Wang Y, Ali W, Zou H, Zhao H, Tong X, Song R, Liu Z., Free PMC Article | 01/28/2023 |
| The Inflammasome Activity of NLRP3 Is Independent of NEK7 in HEK293 Cells Co-Expressing ASC. | The Inflammasome Activity of NLRP3 Is Independent of NEK7 in HEK293 Cells Co-Expressing ASC.
Machtens DA, Bresch IP, Eberhage J, Reubold TF, Eschenburg S., Free PMC Article | 10/8/2022 |
| Salmonella enterica Serovar Typhimurium Induces NAIP/NLRC4- and NLRP3/ASC-Independent, Caspase-4-Dependent Inflammasome Activation in Human Intestinal Epithelial Cells. | Salmonella enterica Serovar Typhimurium Induces NAIP/NLRC4- and NLRP3/ASC-Independent, Caspase-4-Dependent Inflammasome Activation in Human Intestinal Epithelial Cells.
Naseer N, Zhang J, Bauer R, Constant DA, Nice TJ, Brodsky IE, Rauch I, Shin S., Free PMC Article | 07/30/2022 |
| Expression of a PYCARD/ASC variant lacking exon 2 in Japanese patients with palindromic rheumatism increases interleukin-1beta secretion. | Expression of a PYCARD/ASC variant lacking exon 2 in Japanese patients with palindromic rheumatism increases interleukin-1β secretion.
Suganuma Y, Tanaka H, Kawase A, Kishida A, Yamaguchi M, Yabuuchi A, Inoue K, Shiozawa S, Komai K. | 07/16/2022 |
| The central inflammasome adaptor protein ASC activates the inflammasome after transition from a soluble to an insoluble state. | The central inflammasome adaptor protein ASC activates the inflammasome after transition from a soluble to an insoluble state.
Prather ER, Gavrilin MA, Wewers MD., Free PMC Article | 07/2/2022 |
| Apoptosis-associated speck-like protein containing a CARD regulates the growth of pancreatic ductal adenocarcinoma. | Apoptosis-associated speck-like protein containing a CARD regulates the growth of pancreatic ductal adenocarcinoma.
Koizumi M, Watanabe T, Masumoto J, Sunago K, Imamura Y, Kanemitsu K, Kumagi T, Hiasa Y., Free PMC Article | 01/29/2022 |
| Characterizing the NLRP3 Inflammasome in Mood Disorders: Overview, Technical Development, and Measures of Peripheral Activation in Adolescent Patients. | Characterizing the NLRP3 Inflammasome in Mood Disorders: Overview, Technical Development, and Measures of Peripheral Activation in Adolescent Patients.
Zhou X, Fernando SM, Pan AY, Laposa R, Cullen KR, Klimes-Dougan B, Andreazza AC., Free PMC Article | 12/18/2021 |
| Aberrant Hypermethylation-Mediated Suppression of PYCARD Is Extremely Frequent in Prostate Cancer with Gleason Score >/= 7. | Aberrant Hypermethylation-Mediated Suppression of PYCARD Is Extremely Frequent in Prostate Cancer with Gleason Score ≥ 7.
Miyauchi T, Takahashi M, Mitsuzuka K, Saiki Y, Okubo T, Vertino PM, Goto A, Arai Y, Horii A, Fukushige S., Free PMC Article | 10/30/2021 |
| Overexpression of Limb Bud and Heart Alleviates Sepsis-Induced Acute Lung Injury via Inhibiting the NLRP3 Inflammasome. | Overexpression of Limb Bud and Heart Alleviates Sepsis-Induced Acute Lung Injury via Inhibiting the NLRP3 Inflammasome.
Wang Y, Shi Y, Zhang X, Fu J, Chen F., Free PMC Article | 09/11/2021 |
| cAbl Kinase Regulates Inflammasome Activation and Pyroptosis via ASC Phosphorylation. | cAbl Kinase Regulates Inflammasome Activation and Pyroptosis via ASC Phosphorylation.
Gavrilin MA, Prather ER, Vompe AD, McAndrew CC, Wewers MD., Free PMC Article | 08/7/2021 |
| DPP9 restrains NLRP1 activation. | DPP9 restrains NLRP1 activation.
Bauernfried S, Hornung V. | 06/26/2021 |
| Mechanism of inflammasome activation by SARS coronavirus 3a protein: abridged secondary publication. | Mechanism of inflammasome activation by SARS coronavirus 3a protein: abridged secondary publication.
Jin DY, Zheng BJ, Tang HMV. | 06/12/2021 |
| ASC modulates HIF-1alpha stability and induces cell mobility in OSCC. | ASC modulates HIF-1α stability and induces cell mobility in OSCC.
Wu CS, Chang IY, Hung JL, Liao WC, Lai YR, Chang KP, Li HP, Chang YS., Free PMC Article | 05/1/2021 |
| ASC, IL-18 and Galectin-3 as Biomarkers of Non-Alcoholic Steatohepatitis: A Proof of Concept Study. | ASC, IL-18 and Galectin-3 as Biomarkers of Non-Alcoholic Steatohepatitis: A Proof of Concept Study.
Cyr B, Keane RW, de Rivero Vaccari JP., Free PMC Article | 03/6/2021 |
| The Inflammasome Adaptor Protein ASC in Mild Cognitive Impairment and Alzheimer's Disease. | The Inflammasome Adaptor Protein ASC in Mild Cognitive Impairment and Alzheimer's Disease.
Scott XO, Stephens ME, Desir MC, Dietrich WD, Keane RW, de Rivero Vaccari JP., Free PMC Article | 02/27/2021 |
| Inhibition of NLRP3 inflammasome activation by cell-permeable stapled peptides. | Inhibition of NLRP3 inflammasome activation by cell-permeable stapled peptides.
Pal A, Neo K, Rajamani L, Ferrer FJ, Lane DP, Verma CS, Mortellaro A., Free PMC Article | 10/10/2020 |
| Genetic disruption of the inflammasome adaptor ASC has minimal impact on the pathogenesis of Duchenne muscular dystrophy in mdx mice. | Genetic disruption of the inflammasome adaptor ASC has minimal impact on the pathogenesis of Duchenne muscular dystrophy in mdx mice.
Lau YS, Zhao L, Zhang C, Li H, Han R., Free PMC Article | 09/19/2020 |
| Low ASC expression is associated with schwannoma. | Gene therapy with apoptosis-associated speck-like protein, a newly described schwannoma tumor suppressor, inhibits schwannoma growth in vivo.
Ahmed SG, Abdelnabi A, Maguire CA, Doha M, Sagers JE, Lewis RM, Muzikansky A, Giovannini M, Stemmer-Rachamimov A, Stankovic KM, Fulci G, Brenner GJ., Free PMC Article | 08/13/2020 |
| Our findings indicate that tumor released IL-1alpha and IL-1beta and ASC are key regulators of TSLP secretion by cancer associated fibroblasts and their targeting should ultimately dampen Th2 inflammation and improve overall survival in pancreatic cancer. | The IL-1/IL-1 receptor axis and tumor cell released inflammasome adaptor ASC are key regulators of TSLP secretion by cancer associated fibroblasts in pancreatic cancer.
Brunetto E, De Monte L, Balzano G, Camisa B, Laino V, Riba M, Heltai S, Bianchi M, Bordignon C, Falconi M, Bondanza A, Doglioni C, Protti MP., Free PMC Article | 04/4/2020 |
| Monocytes from chronic nonbacterial osteomyelitis patients over-express NLRP3, ASC, and IL-1beta. Gene expression is promoted by DNA hypomethylation at NLRP3 and PYCARD. | CD14(+) monocytes contribute to inflammation in chronic nonbacterial osteomyelitis (CNO) through increased NLRP3 inflammasome expression.
Brandt D, Sohr E, Pablik J, Schnabel A, Kapplusch F, Mäbert K, Girschick JH, Morbach H, Thielemann F, Hofmann SR, Hedrich CM. | 10/19/2019 |
| elevated in amniotic fluid concentrations of women with clinical chorioamnionitis | Clinical chorioamnionitis at term IX: in vivo evidence of intra-amniotic inflammasome activation.
Gomez-Lopez N, Romero R, Maymon E, Kusanovic JP, Panaitescu B, Miller D, Pacora P, Tarca AL, Motomura K, Erez O, Jung E, Hassan SS, Hsu CD., Free PMC Article | 09/7/2019 |
| These findings suggest that pyroptotic CD14CD16 classical monocytes of HIV-1-infected patients release ASC specks into the blood stream, a phenomenon that may contribute to HIV-1 induced inflammation and immune activation. | Evidence of inflammasome activation and formation of monocyte-derived ASC specks in HIV-1 positive patients.
Ahmad F, Mishra N, Ahrenstorf G, Franklin BS, Latz E, Schmidt RE, Bossaller L. | 07/27/2019 |
| increased in amniotic fluid in spontaneous labor at term | In vivo evidence of inflammasome activation during spontaneous labor at term.
Panaitescu B, Romero R, Gomez-Lopez N, Xu Y, Leng Y, Maymon E, Pacora P, Erez O, Yeo L, Hassan SS, Hsu CD., Free PMC Article | 06/23/2019 |