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    ANPEP alanyl aminopeptidase, membrane [ Homo sapiens (human) ]

    Gene ID: 290, updated on 3-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    ANPEP/CD13 Expression as a Marker of Lymphovascular Invasion and Survival in Esophageal Adenocarcinoma.

    ANPEP/CD13 Expression as a Marker of Lymphovascular Invasion and Survival in Esophageal Adenocarcinoma.
    Goltsov AA, Maru DM, Katkhuda R, Duose DY, Luthra R, Correa AM, Wang F, Futreal PA, Hofstetter WL.

    07/11/2024
    CD13 expression affects glioma patient survival and influences key functions of human glioblastoma cell lines in vitro.

    CD13 expression affects glioma patient survival and influences key functions of human glioblastoma cell lines in vitro.
    Zhang W, Blank A, Kremenetskaia I, Nitzsche A, Acker G, Vajkoczy P, Brandenburg S., Free PMC Article

    03/28/2024
    CD13 facilitates immune cell migration and aggravates acute injury but promotes chronic post-stroke recovery.

    CD13 facilitates immune cell migration and aggravates acute injury but promotes chronic post-stroke recovery.
    Nguyen JN, Mohan EC, Pandya G, Ali U, Tan C, Kofler JK, Shapiro L, Marrelli SP, Chauhan A., Free PMC Article

    11/2/2023
    Aminopeptidase N/CD13 Crosslinking Promotes the Activation and Membrane Expression of Integrin CD11b/CD18.

    Aminopeptidase N/CD13 Crosslinking Promotes the Activation and Membrane Expression of Integrin CD11b/CD18.
    Díaz-Alvarez L, Martínez-Sánchez ME, Gray E, Pérez-Figueroa E, Ortega E., Free PMC Article

    11/1/2023
    Altered serum levels of platelet-derived growth factor receptor beta and cluster of differentiation 13 suggest a role for pericytes in West syndrome.

    Altered serum levels of platelet-derived growth factor receptor β and cluster of differentiation 13 suggest a role for pericytes in West syndrome.
    Watanabe Y, Yamanaka G, Morichi S, Hayashi K, Suzuki S, Takeshita M, Morishita N, Ishida Y, Oana S, Takata F, Kawashima H.

    08/30/2023
    Reduced expression of alanyl aminopeptidase is a robust biomarker of non-familial adenomatous polyposis and non-hereditary nonpolyposis colorectal cancer syndrome early-onset colorectal cancer.

    Reduced expression of alanyl aminopeptidase is a robust biomarker of non-familial adenomatous polyposis and non-hereditary nonpolyposis colorectal cancer syndrome early-onset colorectal cancer.
    Ha YJ, Shin YJ, Tak KH, Park JL, Kim JH, Lee JL, Yoon YS, Kim CW, Kim SY, Kim JC., Free PMC Article

    05/12/2023
    Soluble ANPEP Released From Human Astrocytes as a Positive Regulator of Microglial Activation and Neuroinflammation: Brain Renin-Angiotensin System in Astrocyte-Microglia Crosstalk.

    Soluble ANPEP Released From Human Astrocytes as a Positive Regulator of Microglial Activation and Neuroinflammation: Brain Renin-Angiotensin System in Astrocyte-Microglia Crosstalk.
    Kim JH, Afridi R, Cho E, Yoon JH, Lim YH, Lee HW, Ryu H, Suk K., Free PMC Article

    12/3/2022
    Abnormal CD13/HLA-DR Expression Pattern on Myeloblasts Predicts Development of Myeloid Neoplasia in Patients With Clonal Cytopenia of Undetermined Significance.

    Abnormal CD13/HLA-DR Expression Pattern on Myeloblasts Predicts Development of Myeloid Neoplasia in Patients With Clonal Cytopenia of Undetermined Significance.
    Jevremovic D, Nanaa A, Geyer SM, Timm M, Azouz H, Hengel C, Reberg A, He R, Viswanatha D, Salama ME, Shi M, Olteanu H, Horna P, Otteson G, Greipp PT, Xie Z, Alkhateeb HB, Hogan W, Litzow M, Patnaik MM, Shah M, Al-Kali A, Nguyen PL., Free PMC Article

    10/15/2022
    [The Relationship between the Expressions of CD33 and CD13 and the Prognosis of Patients with Multiple Myeloma].

    [The Relationship between the Expressions of CD33 and CD13 and the Prognosis of Patients with Multiple Myeloma].
    Li DD, Xia HL, Sun XM, Liu ZQ, Zhang SY, Liu Q.

    02/12/2022
    CD13 is a critical regulator of cell-cell fusion in osteoclastogenesis.

    CD13 is a critical regulator of cell-cell fusion in osteoclastogenesis.
    Ghosh M, Kelava T, Madunic IV, Kalajzic I, Shapiro LH., Free PMC Article

    11/13/2021
    CD13 orients the apical-basal polarity axis necessary for lumen formation.

    CD13 orients the apical-basal polarity axis necessary for lumen formation.
    Wang LT, Rajah A, Brown CM, McCaffrey L., Free PMC Article

    08/21/2021
    The role of LNPEP and ANPEP gene polymorphisms in the pathogenesis of pre-eclampsia.

    The role of LNPEP and ANPEP gene polymorphisms in the pathogenesis of pre-eclampsia.
    Khaliq OP, Konoshita T, Moodley J, Naicker T.

    07/3/2021
    Synthesis and Inhibitory Studies of Phosphonic Acid Analogues of Homophenylalanine and Phenylalanine towards Alanyl Aminopeptidases.

    Synthesis and Inhibitory Studies of Phosphonic Acid Analogues of Homophenylalanine and Phenylalanine towards Alanyl Aminopeptidases.
    Wanat W, Talma M, Dziuk B, Kafarski P., Free PMC Article

    06/26/2021
    In Vivo Molecular Imaging of the Efficacy of Aminopeptidase N (APN/CD13) Receptor Inhibitor Treatment on Experimental Tumors Using (68)Ga-NODAGA-c(NGR) Peptide.

    In Vivo Molecular Imaging of the Efficacy of Aminopeptidase N (APN/CD13) Receptor Inhibitor Treatment on Experimental Tumors Using (68)Ga-NODAGA-c(NGR) Peptide.
    Kis A, Dénes N, Szabó JP, Arató V, Beke L, Matolay O, Enyedi KN, Méhes G, Mező G, Bai P, Kertész I, Trencsényi G., Free PMC Article

    05/29/2021
    APN-mediated phosphorylation of BCKDK promotes hepatocellular carcinoma metastasis and proliferation via the ERK signaling pathway.

    APN-mediated phosphorylation of BCKDK promotes hepatocellular carcinoma metastasis and proliferation via the ERK signaling pathway.
    Zhai M, Yang Z, Zhang C, Li J, Jia J, Zhou L, Lu R, Yao Z, Fu Z., Free PMC Article

    03/13/2021
    Can aminopeptidase N determined in the meconium be a candidate for biomarker of fetal intrauterine environment?

    Can aminopeptidase N determined in the meconium be a candidate for biomarker of fetal intrauterine environment?
    Lisowska-Myjak B, Wilczyńska P, Bartoszewicz Z, Jakimiuk A, Skarżyńska E.

    10/31/2020
    ACO2 and ANPEP as novel prognostic markers for gallbladder squamous cell/adenosquamous carcinomas and adenocarcinomas.

    ACO2 and ANPEP as novel prognostic markers for gallbladder squamous cell/adenosquamous carcinomas and adenocarcinomas.
    Liu Z, Yang Z, Xiong L, Li D, Zou Q, Yuan Y.

    09/19/2020
    Nonglucuronidated Ezetimibe Disrupts CD13- and CD64-Coassembly in Membrane Microdomains and Decreases Cellular Cholesterol Content in Human Monocytes/Macrophages.

    Nonglucuronidated Ezetimibe Disrupts CD13- and CD64-Coassembly in Membrane Microdomains and Decreases Cellular Cholesterol Content in Human Monocytes/Macrophages.
    Orsó E, Robenek H, Boettcher A, Wolf Z, Liebisch G, Kramer W, Schmitz G.

    08/22/2020
    ANPEP could be involved in the regulation of endometrial receptivity

    Aminopeptidase N expression in the endometrium could affect endometrial receptivity.
    Shui LJ, Meng Y, Huang C, Qian Y, Liu JY.

    07/11/2020
    Findings indicate a role for cell surface antigen CD13 (CD13) in the fundamental cellular processes of receptor recycling cell-ECM interactions, and cell migration.

    CD13 tethers the IQGAP1-ARF6-EFA6 complex to the plasma membrane to promote ARF6 activation, β1 integrin recycling, and cell migration.
    Ghosh M, Lo R, Ivic I, Aguilera B, Qendro V, Devarakonda C, Shapiro LH., Free PMC Article

    07/4/2020
    The structures show that common core interactions define the specificity of human coronavirus 229E surface glycoprotein for human APN and that the peripheral receptor binding domain sequence variation is accommodated by loop plasticity.

    The human coronavirus HCoV-229E S-protein structure and receptor binding.
    Li Z, Tomlinson AC, Wong AH, Zhou D, Desforges M, Talbot PJ, Benlekbir S, Rubinstein JL, Rini JM., Free PMC Article

    05/30/2020
    These results suggest that testing for CD13 expression in routine flow cytometry panels could help to discriminate Waldenstrom Macroglobulinaemia (WM)/lymphoplasmacytic lymphoma from other B-cell lymphoproliferative disorders.

    CD13 expression in B cell malignancies is a hallmark of plasmacytic differentiation.
    Raimbault A, Machherndl-Spandl S, Itzykson R, Clauser S, Chapuis N, Mathis S, Lauf J, Alary AS, Burroni B, Kosmider O, Fontenay M, Béné MC, Durrieu F, Bettelheim P, Bardet V.

    12/28/2019
    Crosslinking of CD13 by mAb C or E is required to inhibit adhesion, as monovalent Fab fragments are not sufficient. Thus, C and E antibodies recognize a distinct epitope on CD13, and binding to this epitope interferes with both CD13-mediated cell adhesion and enzymatic activity.

    Distinct Epitopes on CD13 Mediate Opposite Consequences for Cell Adhesion.
    Garay-Canales CA, Licona-Limón I, Ortega E., Free PMC Article

    09/29/2018
    Data indicate the expression of aminopeptidase N (CD13) in small cell lung cancer (SCLC) tumor and suggest pre-therapeutic CD13 analysis for testing as investigational predictive biomarker for patient selection.

    CD13 as target for tissue factor induced tumor vascular infarction in small cell lung cancer.
    Schmidt LH, Stucke-Ring J, Brand C, Schliemann C, Harrach S, Muley T, Herpel E, Kessler T, Mohr M, Görlich D, Kreuter M, Lenz G, Wardelmann E, Thomas M, Berdel WE, Schwöppe C, Hartmann W.

    06/30/2018
    CD13 may be a marker for onychofibroblasts within nail matrix onychodermis

    CD13 is a marker for onychofibroblasts within nail matrix onychodermis: Comparison of its expression patterns in the nail unit and in the hair follicle.
    Park JH, Lee DY, Jang KT, Ha SY, Kwon GY, Lee KH, Shim JS, Kwon EJ.

    06/2/2018
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