| Pan-cancer analysis reveals the pro-oncogenic role of N6-methyladenosine (m6A)-regulated NTMT1 in head and neck squamous cell carcinoma. | Pan-cancer analysis reveals the pro-oncogenic role of N6-methyladenosine (m6A)-regulated NTMT1 in head and neck squamous cell carcinoma.
Zhao C, Yu M, Li Y. | 01/26/2024 |
| Methyltransferase-like protein 11A promotes migration of cervical cancer cells via up-regulating ELK3. | Methyltransferase-like protein 11A promotes migration of cervical cancer cells via up-regulating ELK3.
Zhang J, Song H, Chen C, Chen L, Dai Y, Sun PH, Zou C, Wang X. | 03/5/2022 |
| Age-related neurodegeneration and cognitive impairments of NRMT1 knockout mice are preceded by misregulation of RB and abnormal neural stem cell development. | Age-related neurodegeneration and cognitive impairments of NRMT1 knockout mice are preceded by misregulation of RB and abnormal neural stem cell development.
Catlin JP, Marziali LN, Rein B, Yan Z, Feltri ML, Schaner Tooley CE., Free PMC Article | 02/5/2022 |
| Modulation of N-terminal methyltransferase 1 by an N(6)-methyladenosine-based epitranscriptomic mechanism. | Modulation of N-terminal methyltransferase 1 by an N(6)-methyladenosine-based epitranscriptomic mechanism.
Bade D, Cai Q, Li L, Yu K, Dai X, Miao W, Wang Y., Free PMC Article | 05/22/2021 |
| Probing the Plasticity in the Active Site of Protein N-terminal Methyltransferase 1 Using Bisubstrate Analogues. | Probing the Plasticity in the Active Site of Protein N-terminal Methyltransferase 1 Using Bisubstrate Analogues.
Chen D, Dong C, Dong G, Srinivasan K, Min J, Noinaj N, Huang R., Free PMC Article | 12/5/2020 |
| The NRMT2 expression activates NRMT1 activity, not through priming, but by increasing its stability and substrate affinity. | The N-terminal methyltransferase homologs NRMT1 and NRMT2 exhibit novel regulation of activity through heterotrimer formation.
Faughn JD, Dean WL, Schaner Tooley CE., Free PMC Article | 05/18/2019 |
| CENP-A undergoes alpha-amino trimethylation by the enzyme NRMT in vivo. | α-amino trimethylation of CENP-A by NRMT is required for full recruitment of the centromere.
Sathyan KM, Fachinetti D, Foltz DR., Free PMC Article | 11/10/2018 |
| NRMT1 mutants N209I (endometrial cancer) and P211S (lung cancer) alter its catalytic activity and decrease N-terminal trimethylation. | Select human cancer mutants of NRMT1 alter its catalytic activity and decrease N-terminal trimethylation.
Shields KM, Tooley JG, Petkowski JJ, Wilkey DW, Garbett NC, Merchant ML, Cheng A, Schaner Tooley CE., Free PMC Article | 08/26/2017 |
| These studies position the NRMT1 knockout mouse as a useful new system for studying the effects of genomic instability and defective DNA damage repair on organismal and tissue-specific aging. | NRMT1 knockout mice exhibit phenotypes associated with impaired DNA repair and premature aging.
Bonsignore LA, Tooley JG, Van Hoose PM, Wang E, Cheng A, Cole MP, Schaner Tooley CE., Free PMC Article | 03/5/2016 |
| NRMT1 adopts a core methyltransferase fold that resembles DOT1L and PRMT but not SET domain family histone methyltransferases. | Molecular basis for histone N-terminal methylation by NRMT1.
Wu R, Yue Y, Zheng X, Li H., Free PMC Article | 03/5/2016 |
| kinetic mechanism of NTMT1 | Kinetic mechanism of protein N-terminal methyltransferase 1.
Richardson SL, Mao Y, Zhang G, Hanjra P, Peterson DL, Huang R., Free PMC Article | 07/25/2015 |
| Concurrent expression of NRMT1 and NRMT2 accelerates the production of trimethylation, and we propose that NRMT2 activates NRMT1 by priming its substrates for trimethylation. | NRMT2 is an N-terminal monomethylase that primes for its homologue NRMT1.
Petkowski JJ, Bonsignore LA, Tooley JG, Wilkey DW, Merchant ML, Macara IG, Schaner Tooley CE., Free PMC Article | 02/14/2015 |
| Peptide methylation assays and substrate immunoprecipitations demonstrate that the canonical M-X-P-K methylation motif is not the only one recognized by NRMT. | Substrate specificity of mammalian N-terminal α-amino methyltransferase NRMT.
Petkowski JJ, Schaner Tooley CE, Anderson LC, Shumilin IA, Balsbaugh JL, Shabanowitz J, Hunt DF, Minor W, Macara IG., Free PMC Article | 12/8/2012 |
| discovery of the first alpha-N-methyltransferase, which we named N-terminal RCC1 methyltransferase (NRMT). | NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein.
Tooley CE, Petkowski JJ, Muratore-Schroeder TL, Balsbaugh JL, Shabanowitz J, Sabat M, Minor W, Hunt DF, Macara IG., Free PMC Article | 09/29/2010 |