| Human MCTS1-dependent translation of JAK2 is essential for IFN-gamma immunity to mycobacteria. | Human MCTS1-dependent translation of JAK2 is essential for IFN-γ immunity to mycobacteria.
Bohlen J, Zhou Q, Philippot Q, Ogishi M, Rinchai D, Nieminen T, Seyedpour S, Parvaneh N, Rezaei N, Yazdanpanah N, Momenilandi M, Conil C, Neehus AL, Schmidt C, Arango-Franco CA, Voyer TL, Khan T, Yang R, Puchan J, Erazo L, Roiuk M, Vatovec T, Janda Z, Bagarić I, Materna M, Gervais A, Li H, Rosain J, Peel JN, Seeleuthner Y, Han JE, L'Honneur AS, Moncada-Vélez M, Martin-Fernandez M, Horesh ME, Kochetkov T, Schmidt M, AlShehri MA, Salo E, Saxen H, ElGhazali G, Yatim A, Soudée C, Sallusto F, Ensser A, Marr N, Zhang P, Bogunovic D, Cobat A, Shahrooei M, Béziat V, Abel L, Wang X, Boisson-Dupuis S, Teleman AA, Bustamante J, Zhang Q, Casanova JL., Free PMC Article | 11/14/2023 |
| MCTS1 enhances the proliferation of laryngeal squamous cell carcinoma via promoting OTUD6B-1 mediated LIN28B deubiquitination. | MCTS1 enhances the proliferation of laryngeal squamous cell carcinoma via promoting OTUD6B-1 mediated LIN28B deubiquitination.
Ma B, Wei X, Zhou S, Yang M. | 09/19/2023 |
| MCTS1 promotes laryngeal squamous cell carcinoma cell growth via enhancing LARP7 stability. | MCTS1 promotes laryngeal squamous cell carcinoma cell growth via enhancing LARP7 stability.
Yang M, Ma B, Liu X. | 05/28/2022 |
| Prognostic value of malignant T cell-amplified sequence 1 in head and neck squamous cell carcinoma. | Prognostic value of malignant T cell-amplified sequence 1 in head and neck squamous cell carcinoma.
Zhu J, Wang X, Shao Z, Sun W, Wu T. | 03/26/2022 |
| MCT1 expression is independently related to shorter cancer-specific survival in clear cell renal cell carcinoma. | MCT1 expression is independently related to shorter cancer-specific survival in clear cell renal cell carcinoma.
de Carvalho PA, Bonatelli M, Cordeiro MD, Coelho RF, Reis S, Srougi M, Nahas WC, Pinheiro C, Leite KRM. | 02/26/2022 |
| These results suggest MCT-1/miR-34a/IL-6/IL-6R axis is responsible for MCT-1-mediated effects on non-small cell lung cance cell stemness. | Multiple Copies in T-Cell Malignancy 1 (MCT-1) Promotes the Stemness of Non-Small Cell Lung Cancer Cells via Activating Interleukin-6 (IL-6) Signaling through Suppressing MiR-34a Expression.
Li Y, Wang B, Gui S, Ji J., Free PMC Article | 06/20/2020 |
| High MCT-1 expression is associated with M2-like polarization and triple-negative breast cancer cell invasion. | MCT-1/miR-34a/IL-6/IL-6R signaling axis promotes EMT progression, cancer stemness and M2 macrophage polarization in triple-negative breast cancer.
Weng YS, Tseng HY, Chen YA, Shen PC, Al Haq AT, Chen LM, Tung YC, Hsu HL., Free PMC Article | 08/3/2019 |
| Present the crystal structure of MCTS1 bound to a fragment of DENR. Based on this structure, we identify and experimentally validate that DENR residues Glu42, Tyr43, and Tyr46 are important for MCTS1 binding and that MCTS1 residue Phe104 is important for tRNA binding. Mutation of these residues reveals that DENR-MCTS1 dimerization and tRNA binding are both necessary for DENR and MCTS1 to promote translation reinitiation. | DENR-MCTS1 heterodimerization and tRNA recruitment are required for translation reinitiation.
Ahmed YL, Schleich S, Bohlen J, Mandel N, Simon B, Sinning I, Teleman AA., Free PMC Article | 04/27/2019 |
| findings elucidate further the mechanism of regulation of DENR-MCT-1 activities in unconventional translation initiation, reinitiation, and recycling. | Crystal structure of the DENR-MCT-1 complex revealed zinc-binding site essential for heterodimer formation.
Lomakin IB, Dmitriev SE, Steitz TA., Free PMC Article | 03/16/2019 |
| PKC inhibitor sotrastaurin induced cell apoptosis and cell cycle arrest in DLBCL cells potentially through regulating the expression of MCT-1 | PKC inhibition of sotrastaurin has antitumor activity in diffuse large B-cell lymphoma via regulating the expression of MCT-1.
Chang G, Zheng J, Xiao W, Chang S, Wei Q, Wu H, Tao Y, Yang G, Xie B, Lan X, Wang Y, Yu D, Hu L, Xie Y, Bu W, Kong Y, Dai B, Hou J, Shi J. | 11/3/2018 |
| findings elucidate how the DENR-MCT-1 dimer interacts with the ribosome and have functional implications for the mechanism of unconventional translation initiation and reinitiation. | Crystal Structure of the Human Ribosome in Complex with DENR-MCT-1.
Lomakin IB, Stolboushkina EA, Vaidya AT, Zhao C, Garber MB, Dmitriev SE, Steitz TA, Lomakin IB, Stolboushkina EA, Vaidya AT, Zhao C, Garber MB, Dmitriev SE, Steitz TA., Free PMC Articles: PMC5551485, PMC5551485 | 04/7/2018 |
| DENR binds to the P-site of the 40S ribosomal subunit and together with MCTS1 forms a tRNA binding surface and interferes with eIF1/eIF2/eIF3 binding, thus operating in post-termination ribosome recycling and translation re-initiation | Crystal Structure of the Human Ribosome in Complex with DENR-MCT-1.
Lomakin IB, Stolboushkina EA, Vaidya AT, Zhao C, Garber MB, Dmitriev SE, Steitz TA, Lomakin IB, Stolboushkina EA, Vaidya AT, Zhao C, Garber MB, Dmitriev SE, Steitz TA., Free PMC Articles: PMC5551485, PMC5551485 | 01/2/2018 |
| Reinitiation complexes involving initiation factors eIF2D, MCT-1, and DENR controls the translation of a large fraction of mammalian cellular mRNAs. | Structural and Functional Insights into Human Re-initiation Complexes.
Weisser M, Schäfer T, Leibundgut M, Böhringer D, Aylett CHS, Ban N. | 09/30/2017 |
| Overexpression of MCT1 is associated with gliomas. | Monocarboxylate transporters (MCTs) in gliomas: expression and exploitation as therapeutic targets.
Miranda-Gonçalves V, Honavar M, Pinheiro C, Martinho O, Pires MM, Pinheiro C, Cordeiro M, Bebiano G, Costa P, Palmeirim I, Reis RM, Baltazar F., Free PMC Article | 07/6/2013 |
| MCT-1 is a new centrosomal-associated oncoprotein, and that it plays a novel role in the regulation of mitosis signifies its important function in the process of tumorigenesis. | The involvement of MCT-1 oncoprotein in inducing mitotic catastrophe and nuclear abnormalities.
Shih HJ, Chu KL, Wu MH, Wu PH, Chang WW, Chu JS, Wang LH, Takeuchi H, Ouchi T, Hsu HL. | 01/5/2013 |
| The present study indicates possible involvement of a protein kinase (PK)C- and PKA-mediated pathway associated with expression of MCT1 and lactate transport in rhabdomyosarcoma cells. | Regulation of monocarboxylate transporter 1 in skeletal muscle cells by intracellular signaling pathways.
Narumi K, Furugen A, Kobayashi M, Otake S, Itagaki S, Iseki K. | 07/23/2011 |
| The oppositions between MCT-1 and p53 are firstly confirmed at multistage processes that include transcription control, mRNA metabolism, and protein expression | The antagonism between MCT-1 and p53 affects the tumorigenic outcomes.
Kasiappan R, Shih HJ, Wu MH, Choy C, Lin TD, Chen L, Hsu HL., Free PMC Article | 03/26/2011 |
| The result suggest that co-expression of CD147 and MCT1/MCT4 is related to drug resistance during EOC metastasis and could be useful therapeutic targets to prevent the development of incurable, recurrent and drug resistance EOC. | Co-expression of CD147/EMMPRIN with monocarboxylate transporters and multiple drug resistance proteins is associated with epithelial ovarian cancer progression.
Chen H, Wang L, Beretov J, Hao J, Xiao W, Li Y. | 01/1/2011 |
| Results describe the expression and purification of MCT-1 in insect cells using a baculovirus expression system. | Expression and purification of recombinant human MCT-1 oncogene in insect cells.
Pérez-Arellano I, Gozalbo-Rovira R, Martínez AI, Cervera J. | 06/14/2010 |
| Loss of p53 and MCT-1 overexpression synergistically promote chromosome instability and tumorigenicity. | Loss of p53 and MCT-1 overexpression synergistically promote chromosome instability and tumorigenicity.
Kasiappan R, Shih HJ, Chu KL, Chen WT, Liu HP, Huang SF, Choy CO, Shu CL, Din R, Chu JS, Hsu HL. | 01/21/2010 |
| role of the MCT-1 in lymphomagenesis | Targeted suppression of MCT-1 attenuates the malignant phenotype through a translational mechanism.
Mazan-Mamczarz K, Hagner P, Dai B, Corl S, Liu Z, Gartenhaus RB. | 01/21/2010 |
| tumor cell lines overexpressing MCT-1 exhibited increased growth rates and displayed increased protection against apoptosis induced by serum starvation | Expression of the candidate MCT-1 oncogene in B- and T-cell lymphoid malignancies.
Shi B, Hsu HL, Evens AM, Gordon LI, Gartenhaus RB. | 01/21/2010 |
| demonstrated the presence of sequence-specific DNA-binding protein in nuclear extracts designated as LMBF; the 26-mer oligonucleotide containing the LMBF binding site is required for maximum transcriptional activity of the MCT-1 promoter | Identification and characterization of a novel enhancer for the human MCT-1 oncogene promoter.
Shi B, Levenson V, Gartenhaus RB. | 01/21/2010 |