| Kainate receptor subunit 1 (GRIK1) risk variants and GRIK1 deficiency were detected in the Indian ADHD probands. | Kainate receptor subunit 1 (GRIK1) risk variants and GRIK1 deficiency were detected in the Indian ADHD probands.
Chatterjee M, Saha S, Dutta N, Sinha S, Mukhopadhyay K., Free PMC Article | 11/12/2022 |
| In vivo hippocampal cornu ammonis 1-3 glutamatergic abnormalities are associated with temporal lobe epilepsy surgery outcomes. | In vivo hippocampal cornu ammonis 1-3 glutamatergic abnormalities are associated with temporal lobe epilepsy surgery outcomes.
Lam J, DuBois JM, Rowley J, Rousset OG, González-Otárula KA, Soucy JP, Massarweh G, Hall JA, Guiot MC, Zimmermann M, Minuzzi L, Rosa-Neto P, Kobayashi E. | 10/16/2021 |
| DRD2 A2/A1, DRD3 Ser9Gly, DbetaH -1021C>T, OPRM1 A118G and GRIK1 rs2832407C>A are not associated with alcoholism alone or in interaction. | Association study of DRD2 A2/A1, DRD3 Ser9Gly, DβH -1021C>T, OPRM1 A118G and GRIK1 rs2832407C>A polymorphisms with alcohol dependence.
Ragia G, Veresies I, Veresie L, Veresies K, Manolopoulos VG. | 11/11/2017 |
| The findings reported here suggest that, in participants with the GRIK1 rs2832407*CC genotype, topiramate treatment enhances self-efficacy and reduces heavy drinking. | Self-efficacy mediates the effects of topiramate and GRIK1 genotype on drinking.
Kranzler HR, Armeli S, Wetherill R, Feinn R, Tennen H, Gelernter J, Covault J, Pond T., Free PMC Article | 12/24/2016 |
| Findings indicate that SNPs in the GRIK1 gene is associated with altered cue-induced brain activation that is related to craving for alcohol and relapse risk. | The effects of single nucleotide polymorphisms in glutamatergic neurotransmission genes on neural response to alcohol cues and craving.
Bach P, Kirsch M, Hoffmann S, Jorde A, Mann K, Frank J, Charlet K, Beck A, Heinz A, Walter H, Rietschel M, Kiefer F, Vollstädt-Klein S. | 10/22/2016 |
| Results suggested that the extracellular N-terminal region including the two CUB domains was largely responsible for the distinct regulatory effects of Neto1 and Neto2 on the desensitization properties of GluK1 homomeric receptors | The auxiliary subunits Neto1 and Neto2 have distinct, subunit-dependent effects at recombinant GluK1- and GluK2-containing kainate receptors.
Fisher JL., Free PMC Article | 09/3/2016 |
| In the present study, we have shown that gene-gene interaction of components of different systems associated with nicotine reinforcing effects, such as OPRM1 and GRIK1, rather than one gene polymorphism, is associated with smoking behavior. | Gene-gene interaction of μ-opioid receptor and GluR5 kainate receptor subunit is associated with smoking behavior in a Greek population: presence of a dose allele effect.
Misailidis G, Ragia G, Ivanova DD, Tavridou A, Manolopoulos VG. | 02/27/2016 |
| This found that, among rs2832407*C of GRIK1 homozygotes, topiramate treatment produced the greatest reductions in the expected positive effects of drinking and desire to drink during the treatment period. | GRIK1 genotype moderates topiramate's effects on daily drinking level, expectations of alcohol's positive effects and desire to drink.
Kranzler HR, Armeli S, Feinn R, Tennen H, Gelernter J, Covault J., Free PMC Article | 06/6/2015 |
| These results suggest that the effect of topiramate on drinking behavior, in which the GluK1-containing kainate receptor appears to play a key role, can be dissociated from its effect on weight. | Topiramate's reduction of body mass index in heavy drinkers: lack of moderation by a GRIK1 polymorphism.
Kranzler HR, Feinn R, Gelernter J, Pond T, Covault J., Free PMC Article | 05/30/2015 |
| Topiramate treatment for alcohol dependence was significantly more effective in rs2832407 C-allele homozygotes. | Topiramate treatment for heavy drinkers: moderation by a GRIK1 polymorphism.
Kranzler HR, Covault J, Feinn R, Armeli S, Tennen H, Arias AJ, Gelernter J, Pond T, Oncken C, Kampman KM., Free PMC Article | 05/17/2014 |
| Reduced Homer binding to mGluR5 supports an inhibitory role for Homer interactions with mGluR5 in mediating neuropathy. | Nerve injury-induced changes in Homer/glutamate receptor signaling contribute to the development and maintenance of neuropathic pain.
Obara I, Goulding SP, Hu JH, Klugmann M, Worley PF, Szumlinski KK., Free PMC Article | 05/3/2014 |
| Using the SNaPshot assay, we present evidence for allelic nondisjunction at rs363506 in the GRIK1 gene and rs2834235 and rs7283354 in the GARS-AIRS-GART gene in Down syndrome in India. | SNaPshot Assay in Quantitative Detection of Allelic Nondisjunction in Down Syndrome.
Ghosh D, Gochhait S, Banerjee D, Chatterjee A, Sinha S, Nandagopal K., Free PMC Article | 04/13/2013 |
| The association at rs455804 implicates GRIK1 as a novel susceptibility gene for HBV-related HCC, suggesting the involvement of glutamate signaling in the development of HBV-related HCC. | GWAS identifies novel susceptibility loci on 6p21.32 and 21q21.3 for hepatocellular carcinoma in chronic hepatitis B virus carriers.
Li S, Qian J, Yang Y, Zhao W, Dai J, Bei JX, Foo JN, McLaren PJ, Li Z, Yang J, Shen F, Liu L, Yang J, Li S, Pan S, Wang Y, Li W, Zhai X, Zhou B, Shi L, Chen X, Chu M, Yan Y, Wang J, Cheng S, Shen J, Jia W, Liu J, Yang J, Wen Z, Li A, Zhang Y, Zhang G, Luo X, Qin H, Chen M, Wang H, Jin L, Lin D, Shen H, He L, de Bakker PI, Wang H, Zeng YX, Wu M, Hu Z, Shi Y, Liu J, Zhou W., Free PMC Article | 01/5/2013 |
| GRIK1 rs469472 to be possibly associated with schizophrenia in our independent case-control and family samples | Association study of GRIK1 gene polymorphisms in schizophrenia: case-control and family-based studies.
Hirata Y, Zai CC, Souza RP, Lieberman JA, Meltzer HY, Kennedy JL. | 01/5/2013 |
| Presynaptic Gluk1 kainate receptors that reduce transmitter release downstream are independent of divalent calcium ion Ca2+ influx. | GluK1 inhibits calcium dependent and independent transmitter release at associational/commissural synapses in area CA3 of the hippocampus.
Salmen B, Beed PS, Ozdogan T, Maier N, Johenning FW, Winterer J, Breustedt J, Schmitz D. | 09/8/2012 |
| The amino acid sequence of the GluK1 kainate receptor near or within the carboxyl-terminal endoplasmic reticulum retention signal sequence, which affects receptor trafficking and/or expression, does not affect channel gating properties. | Channel-opening kinetic mechanism of wild-type GluK1 kainate receptors and a C-terminal mutant.
Han Y, Wang C, Park JS, Niu L., Free PMC Article | 03/10/2012 |
| The GRIK1 promoter is activated by Trichostatin A (TSA) treatment and by serum depletion according to promoter reporter assays in HEK 293 cells. | Functional analysis and identification of cis-regulatory elements of human chromosome 21 gene promoters.
Warnatz HJ, Querfurth R, Guerasimova A, Cheng X, Haas SA, Hufton AL, Manke T, Vanhecke D, Nietfeld W, Vingron M, Janitz M, Lehrach H, Yaspo ML., Free PMC Article | 09/14/2011 |
| Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) | Gene-environment interaction in the etiology of mathematical ability using SNP sets.
Docherty SJ, Kovas Y, Plomin R., Free PMC Article | 12/5/2010 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Glutamatergic gene variants impact the clinical profile of efficacy and side effects of haloperidol.
Giegling I, Drago A, Dolžan V, Plesničar BK, Schäfer M, Hartmann AM, Sander T, Toliat MR, Möller HJ, Stassen HH, Rujescu D, Serretti A. | 12/5/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| findings show GluR5 was upregulated in the hippocampus, but not in the temporal neocortex, of patients with temporal lobe epilepsy (TLE)compared to controls; mossy fiber sprouting in the hippocampus of TLE patients was correlated with GluR5 upregulation | Aberrant glutamate receptor 5 expression in temporal lobe epilepsy lesions.
Li JM, Zeng YJ, Peng F, Li L, Yang TH, Hong Z, Lei D, Chen Z, Zhou D. | 04/12/2010 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | Human variation in alcohol response is influenced by variation in neuronal signaling genes.
Joslyn G, Ravindranathan A, Brush G, Schuckit M, White RL. | 04/7/2010 |
| Variation in the 3' portion of the gene encoding the GluR5 kainate receptor subunit contributes to the risk for alcohol dependence. | Association of markers in the 3' region of the GluR5 kainate receptor subunit gene to alcohol dependence.
Kranzler HR, Gelernter J, Anton RF, Arias AJ, Herman A, Zhao H, Burian L, Covault J., Free PMC Article | 01/21/2010 |
| GluK1 kainate receptor polymorphisms are associated with Down syndrome. | A study of GluK1 kainate receptor polymorphisms in Down syndrome reveals allelic non-disjunction at 1173(C/T).
Ghosh D, Sinha S, Chatterjee A, Nandagopal K., Free PMC Article | 01/21/2010 |
| Clinical trial and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Molecular genetics of successful smoking cessation: convergent genome-wide association study results.
Uhl GR, Liu QR, Drgon T, Johnson C, Walther D, Rose JE, David SP, Niaura R, Lerman C., Free PMC Article | 12/2/2009 |