| Pan-cancer analysis of the oncogenic effects of G-protein-coupled receptor kinase-interacting protein-1 and validation on liver hepatocellular carcinoma. | Pan-cancer analysis of the oncogenic effects of G-protein-coupled receptor kinase-interacting protein-1 and validation on liver hepatocellular carcinoma.
Wang T, Su K, Wang L, Shi Y, Niu Y, Zhou Y, Wang A, Wu T. | 11/1/2023 |
| GIT1 protects against breast cancer growth through negative regulation of Notch. | GIT1 protects against breast cancer growth through negative regulation of Notch.
Zhang S, Miyakawa A, Wickström M, Dyberg C, Louhivuori L, Varas-Godoy M, Kemppainen K, Kanatani S, Kaczynska D, Ellström ID, Elfman L, Kronqvist P, Repo H, Mikoshiba K, Sahlgren C, Johnsen JI, Uhlén P., Free PMC Article | 04/23/2022 |
| Exosomal miR-122-5p inhibits tumorigenicity of gastric cancer by downregulating GIT1. | Exosomal miR-122-5p inhibits tumorigenicity of gastric cancer by downregulating GIT1.
Jiao Y, Zhang L, Li J, He Y, Zhang X, Li J. | 11/27/2021 |
| GIT1 overexpression promotes epithelial-mesenchymal transition and predicts poor prognosis in hepatocellular carcinoma. | GIT1 overexpression promotes epithelial-mesenchymal transition and predicts poor prognosis in hepatocellular carcinoma.
Wang G, Bai X, Jiang G, Jin S, Wang Q, Wang A, Peng R, Ke A, Bai D., Free PMC Article | 11/22/2021 |
| mir760 targets GIT1 to inhibit cell growth and promote apoptosis in gastric cancer cells | MicroRNA-760 acts as a tumor suppressor in gastric cancer development via inhibiting G-protein-coupled receptor kinase interacting protein-1 transcription.
Ge L, Wang Y, Duan QH, Liu SS, Liu GJ., Free PMC Article | 06/6/2020 |
| a positive role for GIT1 by modulating the Notch/NF-kappaB signals which promoting paracrine of bone mesenchymal stem cells to enhance angiogenesis and fracture healing | GIT1 regulates angiogenic factor secretion in bone marrow mesenchymal stem cells via NF-κB/Notch signalling to promote angiogenesis.
Li L, Tang P, Zhou Z, Wang Q, Xu T, Zhao S, Huang Y, Kong F, Liu W, Cheng L, Zhou Z, Zhao X, Gu C, Luo Y, Tao G, Qian D, Chen J, Fan J, Yin G., Free PMC Article | 12/21/2019 |
| Induced association of beta-PIX with GIT1 is essential for the stimulation of intestinal epithelial restitution by activating Rac1, and this signaling pathway is tightly regulated by cellular polyamines. | β-PIX plays an important role in regulation of intestinal epithelial restitution by interacting with GIT1 and Rac1 after wounding.
Rathor N, Chung HK, Wang SR, Qian M, Turner DJ, Wang JY, Rao JN., Free PMC Article | 03/2/2019 |
| Alternative RNA splicing of the G protein-coupled receptor kinase-interacting protein 1 (GIT1) gene is associated with treatment-induced neuroendocrine prostate cancer (t-NEPC) and reprograms its function involving focal adhesions (FA)-mediated signaling and cell processes, which may contribute to t-NEPC development. | Alternative RNA splicing of the GIT1 gene is associated with neuroendocrine prostate cancer.
Lee AR, Gan Y, Xie N, Ramnarine VR, Lovnicki JM, Dong X., Free PMC Article | 01/19/2019 |
| There is significant interaction effects of the GIT1 and DRD4 gene variants on impulsivity in Attention Deficit Hyperactivity Disorder. | Interaction effects of GIT1 and DRD4 gene variants on continuous performance test variables in patients with ADHD.
Kim H, Kim JI, Kim H, Kim JW, Kim BN., Free PMC Article | 07/21/2018 |
| We show that GIT1, which also contains an ANK domain, inhibits the Notch1-Dll4 signaling pathway by competing with Notch1 ANK domain for binding to RBP-J in stalk cells | G-Protein-Coupled Receptor-2-Interacting Protein-1 Controls Stalk Cell Fate by Inhibiting Delta-like 4-Notch1 Signaling.
Majumder S, Zhu G, Xu X, Senchanthisai S, Jiang D, Liu H, Xue C, Wang X, Coia H, Cui Z, Smolock EM, Libby RT, Berk BC, Pang J., Free PMC Article | 11/26/2017 |
| we discuss recent findings in key physiological systems that exemplify current understanding of the function of this important regulatory complex. Further, we draw attention to gaps in crucial information that remain to be filled to allow a better understanding of the many roles of the GIT-PIX complex in health and disease | Expanding functions of GIT Arf GTPase-activating proteins, PIX Rho guanine nucleotide exchange factors and GIT-PIX complexes.
Zhou W, Li X, Premont RT., Free PMC Article | 08/5/2017 |
| interactions between Cat-1 and its binding partner paxillin are necessary to ensure sufficient Akt activation so that cancer cells are able to grow under anchorage-independent conditions | Cool-associated Tyrosine-phosphorylated Protein 1 Is Required for the Anchorage-independent Growth of Cervical Carcinoma Cells by Binding Paxillin and Promoting AKT Activation.
Yoo SM, Latifkar A, Cerione RA, Antonyak MA., Free PMC Article | 07/10/2017 |
| In astrocytes and neural stem cells, we identified G-protein-coupled receptor kinase-interacting protein 1 (GIT1) as a novel mTOR-binding protein, creating a unique mTOR complex lacking Raptor and Rictor | Proteomic analysis reveals GIT1 as a novel mTOR complex component critical for mediating astrocyte survival.
Smithson LJ, Gutmann DH., Free PMC Article | 05/13/2017 |
| miR-195 inhibits chondrocyte migration through targeted regulation of GIT1 expression. | miR-195 inhibits the proliferation and migration of chondrocytes by targeting GIT1.
Gu YL, Rong XX, Wen LT, Zhu GX, Qian MQ. | 04/8/2017 |
| MiR-491 has a role in attenuating cancer stem cells-like properties of hepatocellular carcinoma by inhibition of GIT-1/NF-kappaB-mediated EMT | MiR-491 attenuates cancer stem cells-like properties of hepatocellular carcinoma by inhibition of GIT-1/NF-κB-mediated EMT.
Yang X, Ye J, Yan H, Tang Z, Shen J, Zhang J, Yang L. | 02/18/2017 |
| Data show that G-protein-coupled receptor kinase-interacting protein 1 (GIT1) and semaphorin 4C (SEMA4C) were found to have putative microRNA miR-138 binding sites in their 3' untranslated region (3'UTRs). | MiR-138 inhibits cell proliferation and reverses epithelial-mesenchymal transition in non-small cell lung cancer cells by targeting GIT1 and SEMA4C.
Li J, Wang Q, Wen R, Liang J, Zhong X, Yang W, Su D, Tang J., Free PMC Article | 12/17/2016 |
| Data show association of G protein-coupled receptor kinase-interacting protein 1 (GIT1), p21-activated kinase interacting exchange factor (betaPIX), and p21 protein (Cdc42/Rac)-activated kinase 1 (PAK1) with centrosomes. | GIT1/βPIX signaling proteins and PAK1 kinase regulate microtubule nucleation.
Černohorská M, Sulimenko V, Hájková Z, Sulimenko T, Sládková V, Vinopal S, Dráberová E, Dráber P. | 07/30/2016 |
| Results suggested that cyclic phosphorylation-dephosphorylation at Tyr- 554 of Git1 was crucial for dynamic interactions between Git1 and paxillin/Hic-5 in order to ensure coordinated cell motility. | Specific dephosphorylation at tyr-554 of git1 by ptprz promotes its association with paxillin and hic-5.
Fujikawa A, Matsumoto M, Kuboyama K, Suzuki R, Noda M., Free PMC Article | 01/23/2016 |
| Interaction between MAT2B and GIT1 serves as a scaffold and facilitates signaling in multiple steps of the Ras/Raf/MEK/ERK pathway | Methionine adenosyltransferase 2B-GIT1 complex serves as a scaffold to regulate Ras/Raf/MEK1/2 activity in human liver and colon cancer cells.
Peng H, Li TW, Yang H, Moyer MP, Mato JM, Lu SC., Free PMC Article | 12/12/2015 |
| GIT1/betaPIX/Rac1/PAK pathway plays a crucial role in regulating GABA(A)R synaptic stability and hence inhibitory synaptic transmission with important implications for inhibitory plasticity and information processing in the brain. | GIT1 and βPIX are essential for GABA(A) receptor synaptic stability and inhibitory neurotransmission.
Smith KR, Davenport EC, Wei J, Li X, Pathania M, Vaccaro V, Yan Z, Kittler JT., Free PMC Article | 07/25/2015 |
| Results show that GIT1 is targeted by miR-149 to suppress breast cancer cell migration/invasion and metastasis. | MicroRNA-149 targets GIT1 to suppress integrin signaling and breast cancer metastasis.
Chan SH, Huang WC, Chang JW, Chang KJ, Kuo WH, Wang MY, Lin KY, Uen YH, Hou MF, Lin CM, Jang TH, Tu CW, Lee YR, Lee YH, Tien MT, Wang LH., Free PMC Article | 11/8/2014 |
| miRNA-491-5p and GIT1 serve as modulators and biomarkers for oral squamous cell carcinoma invasion and metastasis. | miRNA-491-5p and GIT1 serve as modulators and biomarkers for oral squamous cell carcinoma invasion and metastasis.
Huang WC, Chan SH, Jang TH, Chang JW, Ko YC, Yen TC, Chiang SL, Chiang WF, Shieh TY, Liao CT, Juang JL, Wang HC, Cheng AJ, Lu YC, Wang LH. | 04/19/2014 |
| GIT1-cortactin association through GIT1-Spa homology domain is required for cortactin localization to the leading edge and is essential for endothelial cell directional migration and tumor angiogenesis. | G-protein-coupled receptor-2-interacting protein-1 is required for endothelial cell directional migration and tumor angiogenesis via cortactin-dependent lamellipodia formation.
Majumder S, Sowden MP, Gerber SA, Thomas T, Christie CK, Mohan A, Yin G, Lord EM, Berk BC, Pang J., Free PMC Article | 03/22/2014 |
| MAT2B and GIT1 form a scaffold, which recruits and activates MEK and ERK to promote growth and tumorigenesis. | MAT2B-GIT1 interplay activates MEK1/ERK 1 and 2 to induce growth in human liver and colon cancer.
Peng H, Dara L, Li TW, Zheng Y, Yang H, Tomasi ML, Tomasi I, Giordano P, Mato JM, Lu SC., Free PMC Article | 08/31/2013 |
| GIT1 SNP rs550818 is not associated with ADHD in the Brazilian sample. | Association study of GIT1 gene with attention-deficit hyperactivity disorder in Brazilian children and adolescents.
Salatino-Oliveira A, Genro JP, Chazan R, Zeni C, Schmitz M, Polanczyk G, Roman T, Rohde LA, Hutz MH. | 03/16/2013 |