| GRB10 is a novel factor associated with gastric cancer proliferation and prognosis. | GRB10 is a novel factor associated with gastric cancer proliferation and prognosis.
Ren LL, Wang ZW, Sen R, Dai ZT, Liao XH, Shen LJ., Free PMC Article | 05/30/2023 |
| Circ_0009910 shuttled by exosomes regulates proliferation, cell cycle and apoptosis of acute myeloid leukemia cells by regulating miR-5195-3p/GRB10 axis. | Circ_0009910 shuttled by exosomes regulates proliferation, cell cycle and apoptosis of acute myeloid leukemia cells by regulating miR-5195-3p/GRB10 axis.
Wang D, Ming X, Xu J, Xiao Y. | 08/21/2021 |
| GRB10 sustains AR activity by interacting with PP2A in prostate cancer cells. | GRB10 sustains AR activity by interacting with PP2A in prostate cancer cells.
Hao J, Ci X, Wang Y, Choi SYC, Sullivan SE, Xue H, Wu R, Dong X, Haegert AM, Collins CC, Lin D, Wang Y. | 06/12/2021 |
| inhibition of mTORC1 with rapamycin blocked Grb10 Ser476 phosphorylation and repressed a negative-feedback loop on PI3K/Akt signaling that increased myotube responsiveness to insulin | Role of Grb10 in mTORC1-dependent regulation of insulin signaling and action in human skeletal muscle cells.
Edick AM, Auclair O, Burgos SA. | 05/9/2020 |
| results suggest that GRB10 acts as a major downstream effector of PI3K and has tumor-promoting effects in prostate cancer | Proproliferative function of adaptor protein GRB10 in prostate carcinoma.
Khan MI, Al Johani A, Hamid A, Ateeq B, Manzar N, Adhami VM, Lall RK, Rath S, Sechi M, Siddiqui IA, Choudhry H, Zamzami MA, Havighurst TC, Huang W, Ntambi JM, Mukhtar H., Free PMC Article | 11/23/2019 |
| Using state-of-the-art patient-derived hormone-naive prostate cancer xenograft models,we found and validated the growth factor receptor bound protein 10 gene as a driver of CRPC. | Patient-derived Hormone-naive Prostate Cancer Xenograft Models Reveal Growth Factor Receptor Bound Protein 10 as an Androgen Receptor-repressed Gene Driving the Development of Castration-resistant Prostate Cancer.
Hao J, Ci X, Xue H, Wu R, Dong X, Choi SYC, He H, Wang Y, Zhang F, Qu S, Zhang F, Haegert AM, Gout PW, Zoubeidi A, Collins C, Gleave ME, Lin D, Wang Y. | 03/16/2019 |
| Through syngeneic comparison, our study identifies for the first time that Grb10 is associated with the pluripotency state in nuclear transfer embryonic stem cells. | High throughput sequencing identifies an imprinted gene, Grb10, associated with the pluripotency state in nuclear transfer embryonic stem cells.
Li H, Gao S, Huang H, Liu W, Huang H, Liu X, Gao Y, Le R, Kou X, Zhao Y, Kou Z, Li J, Wang H, Zhang Y, Wang H, Cai T, Sun Q, Gao S, Han Z., Free PMC Article | 04/28/2018 |
| Study found FGFR3 gene mutation plus GRB10 gene duplication in a patient with achondroplasia plus growth delay with prenatal onset | FGFR3 gene mutation plus GRB10 gene duplication in a patient with achondroplasia plus growth delay with prenatal onset.
Yuan H, Huang L, Hu X, Li Q, Sun X, Xie Y, Kong S, Wang X., Free PMC Article | 11/11/2017 |
| Data suggest that GRB10 and GRB14 are both Ca2+-dependent CaM-binding proteins; more than one CaM-binding site and/or accessory CaM-binding sites appear to exist in GRB10 and GRB14, as compared to a single one present in GRB7. (GRB10 = growth factor receptor-bound protein 10; GRB14 = growth factor receptor-bound protein 14; CaM = calmodulin; GRB7 = growth factor receptor-bound protein 7) | The adaptors Grb10 and Grb14 are calmodulin-binding proteins.
García-Palmero I, Pompas-Veganzones N, Villalobo E, Gioria S, Haiech J, Villalobo A. | 08/12/2017 |
| GRB10 may regulate degradation of the IL-4 receptor-signaling complex through interactions with NEDD4.2. | The TORC1-activated Proteins, p70S6K and GRB10, Regulate IL-4 Signaling and M2 Macrophage Polarization by Modulating Phosphorylation of Insulin Receptor Substrate-2.
Warren KJ, Fang X, Gowda NM, Thompson JJ, Heller NM., Free PMC Article | 05/27/2017 |
| placental expression associated positively with placental weight, birth weight, and neonatal head circumference | Placental expression of the insulin receptor binding protein GRB10: Relation to human fetoplacental growth and fetal gender.
Mukhopadhyay A, Ravikumar G, Dwarkanath P, Meraaj H, Thomas A, Crasta J, Thomas T, Kurpad AV, Sridhar TS. | 09/17/2016 |
| Risk alleles for 6 loci increased glucose levels from birth to 5 years of age (ADCY5, ADRA2A, CDKAL1, CDKN2A/B, GRB10, and TCF7L2 | Risk Alleles in/near ADCY5, ADRA2A, CDKAL1, CDKN2A/B, GRB10, and TCF7L2 Elevate Plasma Glucose Levels at Birth and in Early Childhood: Results from the FAMILY Study.
Sohani ZN, Anand SS, Robiou-du-Pont S, Morrison KM, McDonald SD, Atkinson SA, Teo KK, Meyre D., Free PMC Article | 08/27/2016 |
| This study demonstrated that the most significant SNP (rs11770199; p = 0.0003) in single-site analysis was located on chromosome 7 in the GRB10 gene. | Genetic variation in imprinted genes is associated with risk of late-onset Alzheimer's disease.
Chaudhry M, Wang X, Bamne MN, Hasnain S, Demirci FY, Lopez OL, Kamboh MI., Free PMC Article | 10/31/2015 |
| Association of the intronic polymorphism rs12540874 A>G of the GRB10 gene with high birth weight. | Association of the intronic polymorphism rs12540874 A>G of the GRB10 gene with high birth weight.
González-Renteria SM, Sosa-Macías M, Rodríguez-Moran M, Chairez-Hernández I, Lares-Aseff IA, Guerrero-Romero F, Galaviz-Hernández C. | 06/6/2015 |
| Tissue-specific methylation and possibly imprinting of GRB10 can influence glucose metabolism. | A central role for GRB10 in regulation of islet function in man.
Prokopenko I, Poon W, Mägi R, Prasad B R, Salehi SA, Almgren P, Osmark P, Bouatia-Naji N, Wierup N, Fall T, Stančáková A, Barker A, Lagou V, Osmond C, Xie W, Lahti J, Jackson AU, Cheng YC, Liu J, O'Connell JR, Blomstedt PA, Fadista J, Alkayyali S, Dayeh T, Ahlqvist E, Taneera J, Lecoeur C, Kumar A, Hansson O, Hansson K, Voight BF, Kang HM, Levy-Marchal C, Vatin V, Palotie A, Syvänen AC, Mari A, Weedon MN, Loos RJ, Ong KK, Nilsson P, Isomaa B, Tuomi T, Wareham NJ, Stumvoll M, Widen E, Lakka TA, Langenberg C, Tönjes A, Rauramaa R, Kuusisto J, Frayling TM, Froguel P, Walker M, Eriksson JG, Ling C, Kovacs P, Ingelsson E, McCarthy MI, Shuldiner AR, Silver KD, Laakso M, Groop L, Lyssenko V., Free PMC Article | 11/29/2014 |
| Grb10 binds to both normal and oncogenic FLT3 and induces PI3K-Akt and STAT5 signaling pathways resulting in an enhanced proliferation, survival and colony formation of hematopoietic cells. | FLT3 signals via the adapter protein Grb10 and overexpression of Grb10 leads to aberrant cell proliferation in acute myeloid leukemia.
Kazi JU, Rönnstrand L., Free PMC Article | 12/28/2013 |
| Studies indicate that insulin receptor (IR) and IGF Type 1 Receptor (IGFR) have been identified as important partners of Grb10/14 and SH2B1/B2 adaptors. | Regulation of insulin and type 1 insulin-like growth factor signaling and action by the Grb10/14 and SH2B1/B2 adaptor proteins.
Desbuquois B, Carré N, Burnol AF. | 04/13/2013 |
| H19 and GRB10 methylation was normal in Albright's hereditary osteodystrophy patients. | Methylation defect in imprinted genes detected in patients with an Albright's hereditary osteodystrophy like phenotype and platelet Gs hypofunction.
Izzi B, Francois I, Labarque V, Thys C, Wittevrongel C, Devriendt K, Legius E, Van den Bruel A, D'Hooghe M, Lambrechts D, de Zegher F, Van Geet C, Freson K., Free PMC Article | 10/6/2012 |
| discovery of Grb10 as an mTORC1 substrate | The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.
Hsu PP, Kang SA, Rameseder J, Zhang Y, Ottina KA, Lim D, Peterson TR, Choi Y, Gray NS, Yaffe MB, Marto JA, Sabatini DM., Free PMC Article | 06/25/2011 |
| Grb10 interacts with Bim L and inhibits its proapoptotic activity in a phosphorylation-dependant manner. | Grb10 interacts with Bim L and inhibits apoptosis.
Hu ZQ, Zhang JY, Ji CN, Xie Y, Chen JZ, Mao YM. | 01/15/2011 |
| GRB10 gene is expressed from the paternal allele in the brain, but from the maternal allele in the placental trophoblasts. | Reciprocal imprinting of human GRB10 in placental trophoblast and brain: evolutionary conservation of reversed allelic expression.
Monk D, Arnaud P, Frost J, Hills FA, Stanier P, Feil R, Moore GE. | 10/20/2010 |
| Results illuminate the membrane-recruitment mechanisms of Grb7, Grb10 and Grb14. | Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14.
Depetris RS, Wu J, Hubbard SR., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesIdentification of novel candidate genes for type 2 diabetes from a genome-wide association scan in the Old Order Amish: evidence for replication from diabetes-related quantitative traits and from independent populations.
Rampersaud E, Damcott CM, Fu M, Shen H, McArdle P, Shi X, Shelton J, Yin J, Chang YP, Ott SH, Zhang L, Zhao Y, Mitchell BD, O'Connell J, Shuldiner AR. Lack of association of birth size with polymorphisms of two imprinted genes, IGF2R and GRB10.
Kukuvitis A, Georgiou I, Syrrou M, Andronikou S, Dickerman Z, Islam A, McCann J, Polychronakos C, Kukuvitis A, Georgiou I, Syrrou M, Andronikou S, Dickerman Z, Islam A, McCann J, Polychronakos C. | 03/13/2008 |
| GRB10 protein products are correlated with parameters of birth size. | Lack of association of birth size with polymorphisms of two imprinted genes, IGF2R and GRB10.
Kukuvitis A, Georgiou I, Syrrou M, Andronikou S, Dickerman Z, Islam A, McCann J, Polychronakos C, Kukuvitis A, Georgiou I, Syrrou M, Andronikou S, Dickerman Z, Islam A, McCann J, Polychronakos C. | 01/21/2010 |
| Grb10 acts as a positive regulator in VEGF-R2 signaling and protects VEGF-R2 from degradation by interacting with Nedd4, a component of the endocytic machinery | Grb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradation.
Murdaca J, Treins C, Monthouël-Kartmann MN, Pontier-Bres R, Kumar S, Van Obberghen E, Giorgetti-Peraldi S. | 01/21/2010 |