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    VSTM1 V-set and transmembrane domain containing 1 [ Homo sapiens (human) ]

    Gene ID: 284415, updated on 28-Oct-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    New insights into the role of the immune inhibitory receptor VSTM1 in autoimmune disease.

    New insights into the role of the immune inhibitory receptor VSTM1 in autoimmune disease.
    Miao N, Wang J.,

    01/13/2024
    Oxidized galectin-1 in SLE fails to bind the inhibitory receptor VSTM1 and increases reactive oxygen species levels in neutrophils.

    Oxidized galectin-1 in SLE fails to bind the inhibitory receptor VSTM1 and increases reactive oxygen species levels in neutrophils.
    Jiang X, Xiao X, Li H, Gong Y, Wang M, Yang H, Zhao L, Jiang Y, Wei Y, Zhao C, Li J, Chen Y, Feng S, Deng H, Ma S, Xu Y, Liu Y, Tsokos GC, Jiang M, Zhang X.,

    11/1/2023
    VSTM1-v2 does not drive human Th17 cell differentiation: A replication study.

    VSTM1-v2 does not drive human Th17 cell differentiation: A replication study.
    von Richthofen HJ, Hafkamp FMJ, van Haperen A, de Jong EC, Meyaard L., Free PMC Article

    04/17/2023
    Recognition of S100 proteins by Signal Inhibitory Receptor on Leukocytes-1 negatively regulates human neutrophils.

    Recognition of S100 proteins by Signal Inhibitory Receptor on Leukocytes-1 negatively regulates human neutrophils.
    Rumpret M, von Richthofen HJ, van der Linden M, Westerlaken GHA, Talavera Ormeño C, Low TY, Ovaa H, Meyaard L., Free PMC Article

    11/22/2021
    Signal Inhibitory Receptor on Leukocytes-1 is highly expressed on lung monocytes, but absent on mononuclear phagocytes in skin and colon.

    Signal Inhibitory Receptor on Leukocytes-1 is highly expressed on lung monocytes, but absent on mononuclear phagocytes in skin and colon.
    von Richthofen HJ, Gollnast D, van Capel TMM, Giovannone B, Westerlaken GHA, Lutter L, Oldenburg B, Hijnen D, van der Vlist M, de Jong EC, Meyaard L.

    03/13/2021
    Signal inhibitory receptor on leukocytes (SIRL)-1 and leukocyte- associated immunoglobulin-like receptor (LAIR)-1 regulate neutrophil function in infants.

    Signal inhibitory receptor on leukocytes (SIRL)-1 and leukocyte- associated immunoglobulin-like receptor (LAIR)-1 regulate neutrophil function in infants.
    Besteman SB, Callaghan A, Hennus MP, Westerlaken GHA, Meyaard L, Bont LL.

    08/13/2020
    VSTM1 rs612529T is associated with a complete demethylation of the VSTM1 promoter and allele-specific upregulation of SIRL-1 expression in monocytes.

    A functional SNP associated with atopic dermatitis controls cell type-specific methylation of the VSTM1 gene locus.
    Kumar D, Puan KJ, Andiappan AK, Lee B, Westerlaken GH, Haase D, Melchiotti R, Li Z, Yusof N, Lum J, Koh G, Foo S, Yeong J, Alves AC, Pekkanen J, Sun LD, Irwanto A, Fairfax BP, Naranbhai V, Common JE, Tang M, Chuang CK, Jarvelin MR, Knight JC, Zhang X, Chew FT, Prabhakar S, Jianjun L, Wang Y, Zolezzi F, Poidinger M, Lane EB, Meyaard L, Rötzschke O., Free PMC Article

    08/12/2017
    findings show that SIRL-1 attenuates neutrophil extracellular traps (NET) release by neutrophils in response to distinct triggers, including opsonized Staphylococcus aureus and inflammatory danger signals; define SIRL-1 as an intervention point of benefit to suppress neutrophil extracellular trap formation in disease while preserving intracellular antimicrobial defense

    Signal Inhibitory Receptor on Leukocytes-1 Limits the Formation of Neutrophil Extracellular Traps, but Preserves Intracellular Bacterial Killing.
    Van Avondt K, van der Linden M, Naccache PH, Egan DA, Meyaard L.

    07/29/2017
    VSTM1-v2 might be a biomarker of rheumatoid arthritis (RA) and a novel factor in the pathogenesis of RA.

    Expression of VSTM1-v2 Is Increased in Peripheral Blood Mononuclear Cells from Patients with Rheumatoid Arthritis and Is Correlated with Disease Activity.
    Wang D, Li Y, Liu Y, He Y, Shi G., Free PMC Article

    07/16/2016
    we report a potential leukocyte differentiation antigen gene VSTM1 (V-set and transmembrane domain-containing 1) that was downregulated in bone marrow cells from leukemia patients and exhibited a higher degree of promoter methylation

    VSTM-v1, a potential myeloid differentiation antigen that is downregulated in bone marrow cells from myeloid leukemia patients.
    Xie M, Li T, Li N, Li J, Yao Q, Han W, Ruan G., Free PMC Article

    01/23/2016
    Signaling via the inhibitory receptor SIRL-1 was induced by ligation with anti-SIRL-1 specific antibodies.

    Ligation of signal inhibitory receptor on leukocytes-1 suppresses the release of neutrophil extracellular traps in systemic lupus erythematosus.
    Van Avondt K, Fritsch-Stork R, Derksen RH, Meyaard L., Free PMC Article

    02/28/2015
    SIRL-1 negatively regulates the oxidative burst in human phagocytes.

    Signal inhibitory receptor on leukocytes-1 (SIRL-1) negatively regulates the oxidative burst in human phagocytes.
    Steevels TA, van Avondt K, Westerlaken GH, Stalpers F, Walk J, Bont L, Coffer PJ, Meyaard L.

    06/22/2013
    Signal inhibitory receptor on leukocytes-1 is a member of immunoglobulin superfamily ITIM; expressed by myeloid but not lymphoid cells; requires both of its ITIMs for full inhibition of Fc epsilon receptor type I-mediated mast cell degranulation.

    Signal inhibitory receptor on leukocytes-1 is a novel functional inhibitory immune receptor expressed on human phagocytes.
    Steevels TA, Lebbink RJ, Westerlaken GH, Coffer PJ, Meyaard L.

    07/5/2010
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