| Secreted EMC10 is upregulated in human obesity and its neutralizing antibody prevents diet-induced obesity in mice. | Secreted EMC10 is upregulated in human obesity and its neutralizing antibody prevents diet-induced obesity in mice.
Wang X, Li Y, Qiang G, Wang K, Dai J, McCann M, Munoz MD, Gil V, Yu Y, Li S, Yang Z, Xu S, Cordoba-Chacon J, De Jesus DF, Sun B, Chen K, Wang Y, Liu X, Miao Q, Zhou L, Hu R, Ding Q, Kulkarni RN, Gao D, Blüher M, Liew CW., Free PMC Article | 12/10/2022 |
| Membrane-Bound EMC10 Is Required for Sperm Motility via Maintaining the Homeostasis of Cytoplasm Sodium in Sperm. | Membrane-Bound EMC10 Is Required for Sperm Motility via Maintaining the Homeostasis of Cytoplasm Sodium in Sperm.
Liu L, Mao S, Chen K, Dai J, Jin S, Chen L, Wang Y, Guo L, Yang Y, Zhan C, Xiong Z, Diao H, Zhou Y, Ding Q, Wang X., Free PMC Article | 09/17/2022 |
| Biallelic loss of EMC10 leads to mild to severe intellectual disability. | Biallelic loss of EMC10 leads to mild to severe intellectual disability.
Kaiyrzhanov R, Rocca C, Suri M, Gulieva S, Zaki MS, Henig NZ, Siquier K, Guliyeva U, Mounir SM, Marom D, Allahverdiyeva A, Megahed H, van Bokhoven H, Cantagrel V, Rad A, Pourkeramti A, Dehghani B, Shao DD, Markus-Bustani K, Sofrin-Drucker E, Orenstein N, Salayev K, Arrigoni F, Houlden H, Maroofian R., Free PMC Article | 07/16/2022 |
| The phenotype of homozygous EMC10 variant: A new syndrome with intellectual disability and language impairment. | The phenotype of homozygous EMC10 variant: A new syndrome with intellectual disability and language impairment.
Haddad-Eid E, Gur N, Eid S, Pilowsky-Peleg T, Straussberg R. | 04/16/2022 |
| An engineered transcriptional reporter of protein localization identifies regulators of mitochondrial and ER membrane protein trafficking in high-throughput CRISPRi screens. | An engineered transcriptional reporter of protein localization identifies regulators of mitochondrial and ER membrane protein trafficking in high-throughput CRISPRi screens.
Coukos R, Yao D, Sanchez MI, Strand ET, Olive ME, Udeshi ND, Weissman JS, Carr SA, Bassik MC, Ting AY., Free PMC Article | 10/23/2021 |
| EMC10 homozygous variant identified in a family with global developmental delay, mild intellectual disability, and speech delay. | EMC10 homozygous variant identified in a family with global developmental delay, mild intellectual disability, and speech delay.
Umair M, Ballow M, Asiri A, Alyafee Y, Al Tuwaijri A, Alhamoudi KM, Aloraini T, Abdelhakim M, Althagafi AT, Kafkas S, Alsubaie L, Alrifai MT, Hoehndorf R, Alfares A, Alfadhel M., Free PMC Article | 08/21/2021 |
| A recurrent, homozygous EMC10 frameshift variant is associated with a syndrome of developmental delay with variable seizures and dysmorphic features. | A recurrent, homozygous EMC10 frameshift variant is associated with a syndrome of developmental delay with variable seizures and dysmorphic features.
Shao DD, Straussberg R, Ahmed H, Khan A, Tian S, Hill RS, Smith RS, Majmundar AJ, Ameziane N, Neil JE, Yang E, Al Tenaiji A, Jamuar SS, Schlaeger TM, Al-Saffar M, Hovel I, Al-Shamsi A, Basel-Salmon L, Amir AZ, Rento LM, Lim JY, Ganesan I, Shril S, Evrony G, Barkovich AJ, Bauer P, Hildebrandt F, Dong M, Borck G, Beetz C, Al-Gazali L, Eyaid W, Walsh CA., Free PMC Article | 08/7/2021 |
| Sperm EMC10 levels are positively associated with sperm motility in human. | EMC10 governs male fertility via maintaining sperm ion balance.
Zhou Y, Wu F, Zhang M, Xiong Z, Yin Q, Ru Y, Shi H, Li J, Mao S, Li Y, Cao X, Hu R, Liew CW, Ding Q, Wang X, Zhang Y., Free PMC Article | 09/21/2019 |
| hHSS1-overexpression modulates signaling pathways involved in tumorigenesis. | Human Hematopoietic Signal peptide-containing Secreted 1 (hHSS1) modulates genes and pathways in glioma: implications for the regulation of tumorigenicity and angiogenesis.
Junes-Gill KS, Lawrence CE, Wheeler CJ, Cordner R, Gill TG, Mar V, Shiri L, Basile LA., Free PMC Article | 07/25/2015 |
| High-expression of hHSS1 is associated high-grade gliomas. | hHSS1: a novel secreted factor and suppressor of glioma growth located at chromosome 19q13.33.
Junes-Gill KS, Gallaher TK, Gluzman-Poltorak Z, Miller JD, Wheeler CJ, Fan X, Basile LA., Free PMC Article | 07/16/2011 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| as a novel secreted protein, INM02 is associated with functions of pancreatic islets, especially of beta-cells | Molecular cloning of a novel secreted peptide, INM02, and regulation of its expression by glucose.
Wang X, Gong W, Liu Y, Yang Z, Zhou W, Wang M, Yang Z, Wen J, Hu R. | 01/21/2010 |