| SIGLEC15, negatively correlated with PD-L1 in HCC, could induce CD8+ T cell apoptosis to promote immune evasion. | SIGLEC15, negatively correlated with PD-L1 in HCC, could induce CD8+ T cell apoptosis to promote immune evasion.
Chen Z, Yu M, Zhang B, Jin L, Yu Q, Liu S, Zhou B, Yan J, Zhang W, Li X, Xu Y, Xiao Y, Zhou J, Fan J, Hung MC, Ye Q, Li H, Guo L., Free PMC Article | 08/1/2024 |
| Siglec-15 regulates cell proliferation, migration and invasion in bladder cancer. | Siglec-15 regulates cell proliferation, migration and invasion in bladder cancer.
Gao HY, Liu GJ, Qiu YR. | 04/4/2024 |
| Siglec-15 on macrophages suppress the immune microenvironment in patients with PD-L1 negative non-metastasis lung adenocarcinoma. | Siglec-15 on macrophages suppress the immune microenvironment in patients with PD-L1 negative non-metastasis lung adenocarcinoma.
Huang Z, Guo Y, Li B, Shen M, Yi Y, Li L, Zhao X, Yang L., Free PMC Article | 03/18/2024 |
| Siglec 15 as a biomarker or a druggable molecule for non-small cell lung cancer. | Siglec 15 as a biomarker or a druggable molecule for non-small cell lung cancer.
Moreira RS, da Silva MM, de Melo Vasconcelos CF, da Silva TD, Cordeiro GG, Mattos-Jr LAR, da Rocha Pitta MG, de Melo Rêgo MJB, Pereira MC. | 12/15/2023 |
| Non-spatial and spatial heterogeneity revealed a suppressive immune feature of Siglec-15 in lung adenocarcinomas. | Non-spatial and spatial heterogeneity revealed a suppressive immune feature of Siglec-15 in lung adenocarcinomas.
Li B, Guo Y, Yi Y, Huang Z, Ren Y, Wang H, Yang L., Free PMC Article | 09/8/2023 |
| Siglec-15 Promotes Evasion of Adaptive Immunity in B-cell Acute Lymphoblastic Leukemia. | Siglec-15 Promotes Evasion of Adaptive Immunity in B-cell Acute Lymphoblastic Leukemia.
Pillsbury CE, Dougan J, Rabe JL, Fonseca JA, Zhou C, Evans AN, Abukharma H, Ichoku O, Gonzalez-Flamenco G, Park SI, Aljudi A, DeRyckere D, Castellino SM, Rafiq S, Langermann S, Liu LN, Henry CJ, Porter CC., Free PMC Article | 07/24/2023 |
| Siglec15 promotes the migration of thyroid carcinoma cells by enhancing the EGFR protein stability. | Siglec15 promotes the migration of thyroid carcinoma cells by enhancing the EGFR protein stability.
Huang S, Ji Z, Xu J, Yang Y, Wu B, Chen Q, Geng S, Si Y, Chen J, Wei Y, Wang C, Ai Z, Jiang J. | 06/28/2023 |
| Siglec15 is a prognostic indicator and a potential tumor-related macrophage regulator that is involved in the suppressive immunomicroenvironment in gliomas. | Siglec15 is a prognostic indicator and a potential tumor-related macrophage regulator that is involved in the suppressive immunomicroenvironment in gliomas.
Wang J, Xu L, Ding Q, Li X, Wang K, Xu S, Liu B., Free PMC Article | 06/24/2023 |
| Structural insights into Siglec-15 reveal glycosylation dependency for its interaction with T cells through integrin CD11b. | Structural insights into Siglec-15 reveal glycosylation dependency for its interaction with T cells through integrin CD11b.
Lenza MP, Egia-Mendikute L, Antoñana-Vildosola A, Soares CO, Coelho H, Corzana F, Bosch A, Manisha P, Quintana JI, Oyenarte I, Unione L, Moure MJ, Azkargorta M, Atxabal U, Sobczak K, Elortza F, Sutherland JD, Barrio R, Marcelo F, Jiménez-Barbero J, Palazon A, Ereño-Orbea J., Free PMC Article | 06/22/2023 |
| Dynamic change in Siglec-15 expression in peritumoral macrophages confers an immunosuppressive microenvironment and poor outcome in glioma. | Dynamic change in Siglec-15 expression in peritumoral macrophages confers an immunosuppressive microenvironment and poor outcome in glioma.
Chen Q, Chen B, Wang C, Hu L, Wu Q, Zhu Y, Zhang Q., Free PMC Article | 05/30/2023 |
| Significance of Siglec-15 expression in colorectal cancer: association with advanced disease stage and fewer tumor-infiltrating lymphocytes. | Significance of Siglec-15 expression in colorectal cancer: association with advanced disease stage and fewer tumor-infiltrating lymphocytes.
Lu Z, Cheng P, Huang F, Li J, Wang B, Zou S, Zheng Z, Peng C., Free PMC Article | 02/13/2023 |
| Siglec-15 as multifunctional molecule involved in osteoclast differentiation, cancer immunity and microbial infection. | Siglec-15 as multifunctional molecule involved in osteoclast differentiation, cancer immunity and microbial infection.
Huang R, Zheng J, Shao Y, Zhu L, Yang T. | 02/10/2023 |
| Transcriptional Regulation of Siglec-15 by ETS-1 and ETS-2 in Hepatocellular Carcinoma Cells. | Transcriptional Regulation of Siglec-15 by ETS-1 and ETS-2 in Hepatocellular Carcinoma Cells.
Sheng K, Wu Y, Lin H, Fang M, Xue C, Lin X, Lin X., Free PMC Article | 01/28/2023 |
| Expression and function of Siglec-15 in RLPS and its correlation with PD-L1: Bioinformatics Analysis and Clinicopathological Evidence. | Expression and function of Siglec-15 in RLPS and its correlation with PD-L1: Bioinformatics Analysis and Clinicopathological Evidence.
Cui L, Tian X, Yan L, Guan X, Dong B, Zhao M, Lv A, Liu D, Wu J, Hao C., Free PMC Article | 12/10/2022 |
| Siglec-15 as a New Perspective Therapy Target in Human Giant Cell Tumor of Bone. | Siglec-15 as a New Perspective Therapy Target in Human Giant Cell Tumor of Bone.
Fan M, Zhang G, Xie M, Liu X, Zhang Q, Wang L., Free PMC Article | 11/5/2022 |
| Knocking down Siglec-15 in osteosarcoma cells inhibits proliferation while promoting apoptosis and pyroptosis by targeting the Siglec-15/STAT3/Bcl-2 pathway. | Knocking down Siglec-15 in osteosarcoma cells inhibits proliferation while promoting apoptosis and pyroptosis by targeting the Siglec-15/STAT3/Bcl-2 pathway.
Song K, Ma J, Gao Y, Qu Y, Ren C, Yan P, Zheng B, Yue B. | 10/29/2022 |
| Unveiling the molecular features, relevant immune and clinical characteristics of SIGLEC15 in thyroid cancer. | Unveiling the molecular features, relevant immune and clinical characteristics of SIGLEC15 in thyroid cancer.
Hou X, Chen C, Lan X, He X., Free PMC Article | 10/1/2022 |
| Siglec-15 Silencing Inhibits Cell Proliferation and Promotes Cell Apoptosis by Inhibiting STAT1/STAT3 Signaling in Anaplastic Thyroid Carcinoma. | Siglec-15 Silencing Inhibits Cell Proliferation and Promotes Cell Apoptosis by Inhibiting STAT1/STAT3 Signaling in Anaplastic Thyroid Carcinoma.
Hou X, Chen C, He X, Lan X., Free PMC Article | 07/9/2022 |
| Prognostic value of PD-L1 and Siglec-15 expression in patients with nasopharyngeal carcinoma. | Prognostic value of PD-L1 and Siglec-15 expression in patients with nasopharyngeal carcinoma.
Zhao J, Yang H, Hu H, Liu C, Wei M, Zhao Y, Chen Y, Cui Y, Chen P, Xiong K, Lu Y, Yang H, Yang L., Free PMC Article | 07/2/2022 |
| Long Noncoding RNA TUG1 Inhibits Tumor Progression through Regulating Siglec-15-Related Anti-Immune Activity in Hepatocellular Carcinoma. | Long Noncoding RNA TUG1 Inhibits Tumor Progression through Regulating Siglec-15-Related Anti-Immune Activity in Hepatocellular Carcinoma.
Ren Y, Lyu J, Guo Y, Yao Y, Hu L., Free PMC Article | 04/16/2022 |
| Identification and characterization of three Siglec15-related immune and prognostic subtypes of breast-invasive cancer. | Identification and characterization of three Siglec15-related immune and prognostic subtypes of breast-invasive cancer.
Cao X, Zhou Y, Mao F, Lin Y, Zhou X, Sun Q. | 04/16/2022 |
| Analysis of a novel immune checkpoint, Siglec-15, in pancreatic ductal adenocarcinoma. | Analysis of a novel immune checkpoint, Siglec-15, in pancreatic ductal adenocarcinoma.
Chen X, Mo S, Zhang Y, Ma H, Lu Z, Yu S, Chen J., Free PMC Article | 04/9/2022 |
| SIGLEC15 amplifies immunosuppressive properties of tumor-associated macrophages in pancreatic cancer. | SIGLEC15 amplifies immunosuppressive properties of tumor-associated macrophages in pancreatic cancer.
Li TJ, Jin KZ, Li H, Ye LY, Li PC, Jiang B, Lin X, Liao ZY, Zhang HR, Shi SM, Lin MX, Fei QL, Xiao ZW, Xu HX, Liu L, Yu XJ, Wu WD. | 03/12/2022 |
| Siglec-15 promotes progression of clear renal cell carcinoma. | Siglec-15 promotes progression of clear renal cell carcinoma.
Yang WB, Qin CP, Du YQ, Han SC, Xu T., Free PMC Article | 02/5/2022 |
| Siglec-15 recognition of sialoglycans on tumor cell lines can occur independently of sialyl Tn antigen expression. | Siglec-15 recognition of sialoglycans on tumor cell lines can occur independently of sialyl Tn antigen expression.
Murugesan G, Correia VG, Palma AS, Chai W, Li C, Feizi T, Martin E, Laux B, Franz A, Fuchs K, Weigle B, Crocker PR., Free PMC Article | 01/22/2022 |