| Neovascularization directed by CAVIN1/CCBE1/VEGFC confers TMZ-resistance in glioblastoma. | Neovascularization directed by CAVIN1/CCBE1/VEGFC confers TMZ-resistance in glioblastoma.
Wang M, Xia D, Xu D, Yin Y, Xu F, Zhang B, Li K, Yang Z, Zou J. | 01/16/2024 |
| Cavin1 activates the Wnt/beta-catenin pathway to influence the proliferation and migration of hepatocellular carcinoma. | Cavin1 activates the Wnt/β-catenin pathway to influence the proliferation and migration of hepatocellular carcinoma.
Hao X, Li J, Liu B, Jing W, Guo Y, Liu F, Li X, Chen X, Yuan Y, Ma W. | 01/11/2024 |
| Molecular and clinical characterization of PTRF in glioma via 1,022 samples. | Molecular and clinical characterization of PTRF in glioma via 1,022 samples.
Sun S, Yang C, Wang K, Huang R, Zhang KN, Liu Y, Cao Z, Zhao Z, Jiang T., Free PMC Article | 06/24/2023 |
| PTRF/Cavin-1 as a Novel RNA-Binding Protein Expedites the NF-kappaB/PD-L1 Axis by Stabilizing lncRNA NEAT1, Contributing to Tumorigenesis and Immune Evasion in Glioblastoma. | PTRF/Cavin-1 as a Novel RNA-Binding Protein Expedites the NF-κB/PD-L1 Axis by Stabilizing lncRNA NEAT1, Contributing to Tumorigenesis and Immune Evasion in Glioblastoma.
Yi K, Cui X, Liu X, Wang Y, Zhao J, Yang S, Xu C, Yang E, Xiao M, Hong B, Fang C, Kang C, Tan Y, Wang Q., Free PMC Article | 02/26/2022 |
| A role for caveola-forming proteins caveolin-1 and CAVIN1 in the pro-invasive response of glioblastoma to osmotic and hydrostatic pressure. | A role for caveola-forming proteins caveolin-1 and CAVIN1 in the pro-invasive response of glioblastoma to osmotic and hydrostatic pressure.
Pu W, Qiu J, Nassar ZD, Shaw PN, McMahon KA, Ferguson C, Parton RG, Riggins GJ, Harris JM, Parat MO., Free PMC Article | 09/11/2021 |
| Caveolin-1 and cavin1 act synergistically to generate a unique lipid environment in caveolae. | Caveolin-1 and cavin1 act synergistically to generate a unique lipid environment in caveolae.
Zhou Y, Ariotti N, Rae J, Liang H, Tillu V, Tee S, Bastiani M, Bademosi AT, Collins BM, Meunier FA, Hancock JF, Parton RG., Free PMC Article | 09/11/2021 |
| Stromal CAVIN1 Controls Prostate Cancer Microenvironment and Metastasis by Modulating Lipid Distribution and Inflammatory Signaling. | Stromal CAVIN1 Controls Prostate Cancer Microenvironment and Metastasis by Modulating Lipid Distribution and Inflammatory Signaling.
Low JY, Brennen WN, Meeker AK, Ikonen E, Simons BW, Laiho M., Free PMC Article | 08/14/2021 |
| Homotrimer cavin1 interacts with caveolin1 to facilitate tumor growth and activate microglia through extracellular vesicles in glioma. | Homotrimer cavin1 interacts with caveolin1 to facilitate tumor growth and activate microglia through extracellular vesicles in glioma.
Wang L, Yang C, Wang Q, Liu Q, Wang Y, Zhou J, Li Y, Tan Y, Kang C., Free PMC Article | 05/22/2021 |
| CAV1-CAVIN1-LC3B-mediated autophagy regulates high glucose-stimulated LDL transcytosis. | CAV1-CAVIN1-LC3B-mediated autophagy regulates high glucose-stimulated LDL transcytosis.
Bai X, Yang X, Jia X, Rong Y, Chen L, Zeng T, Deng X, Li W, Wu G, Wang L, Li Y, Zhang J, Xiong Z, Xiong L, Wang Y, Zhu L, Zhao Y, Jin S., Free PMC Article | 05/15/2021 |
| PTRF/CAVIN1, regulated by SHC1 through the EGFR pathway, is found in urine exosomes as a potential biomarker of ccRCC. | PTRF/CAVIN1, regulated by SHC1 through the EGFR pathway, is found in urine exosomes as a potential biomarker of ccRCC.
Zhao Y, Wang Y, Zhao E, Tan Y, Geng B, Kang C, Li X. | 08/22/2020 |
| The p.Glu176Argfs mutation imparts high positive charge to the cavin-1 LZD2 domain. The mutation imparts high membrane-binding propensity to this region. The peptide stretch displays preferential binding to the negatively-charged liposomes. Binding to the cholesterol/sphingomyelin-rich domain is also enhanced. | Interaction of cavin-1/PTRF leucine zipper domain 2 and its congenital generalized lipodystrophy mutant with model membranes.
Mohapatra A, Lokappa SB, Chaudhary N. | 08/1/2020 |
| Overexpression of PTRF led to MAPK inhibitors (MAPKi) resistance in melanoma, increased cell adhesion and sphere formation. In addition, immunohistochemistry of patient samples showed that PTRF expression levels were a significant biomarker of poor progression-free survival. | Proteomic identification of a marker signature for MAPKi resistance in melanoma.
Paulitschke V, Eichhoff O, Gerner C, Paulitschke P, Bileck A, Mohr T, Cheng PF, Leitner A, Guenova E, Saulite I, Freiberger SN, Irmisch A, Knapp B, Zila N, Chatziisaak TP, Stephan J, Mangana J, Kunstfeld R, Pehamberger H, Aebersold R, Dummer R, Levesque MP., Free PMC Article | 12/28/2019 |
| Data evaluate the interaction between one candidate interactor protein, protein phosphatase 1 alpha (PP1alpha), and Cavin-1 and -3 and show that UV treatment causes release of Cavin3 from caveolae allowing interaction with, and inhibition of, PP1alpha. | Identification of intracellular cavin target proteins reveals cavin-PP1alpha interactions regulate apoptosis.
McMahon KA, Wu Y, Gambin Y, Sierecki E, Tillu VA, Hall T, Martel N, Okano S, Moradi SV, Ruelcke JE, Ferguson C, Yap AS, Alexandrov K, Hill MM, Parton RG., Free PMC Article | 12/21/2019 |
| High CAVIN1 expression is associated with glioblastoma. | Correlation of the invasive potential of glioblastoma and expression of caveola-forming proteins caveolin-1 and CAVIN1.
Pu W, Nassar ZD, Khabbazi S, Xie N, McMahon KA, Parton RG, Riggins GJ, Harris JM, Parat MO. | 12/14/2019 |
| Overexpressing PTRF induced the malignancy of nearby cells in vivo, suggesting that PTRF alters the microenvironment through intercellular communication via exosomes in glioblastoma. | The role of PTRF/Cavin1 as a biomarker in both glioma and serum exosomes.
Huang K, Fang C, Yi K, Liu X, Qi H, Tan Y, Zhou J, Li Y, Liu M, Zhang Y, Yang J, Zhang J, Li M, Kang C., Free PMC Article | 02/2/2019 |
| Data suggest that PTRF is present in the bloodstream and associates with exosomes; visceral adipose tissue may be a source of plasma PTRF; PTRF is rapidly processed inside adipocytes and promotes glucose absorption in adipocytes. | PTRF acts as an adipokine contributing to adipocyte dysfunctionality and ectopic lipid deposition.
Perez-Diaz S, Garcia-Sobreviela MP, Gonzalez-Irazabal Y, Garcia-Rodriguez B, Espina S, Arenaz I, Arbones-Mainar JM. | 01/12/2019 |
| PTRF inhibits the proliferation, migration, and invasion of colorectal cancer cells. Future studies need to define the role of PTRF in the regulation of chemo-resistance in colorectal cancer cells and in colorectal cancer stem cells. | PTRF suppresses the progression of colorectal cancers.
Wang F, Zheng Y, Orange M, Yang C, Yang B, Liu J, Tan T, Ma X, Chen T, Yin X, Tang X, Zhu H., Free PMC Article | 04/28/2018 |
| Purified Cavin1 60S complexes were analyzed structurally in solution and after liposome reconstitution by electron cryotomography. Cavin1 adopted a flexible, net-like protein mesh able to form polyhedral lattices on phosphatidylserine-containing vesicles. Mutating the two coiled-coil domains in Cavin1 revealed that they mediate distinct assembly steps during 60S complex formation. | Model for the architecture of caveolae based on a flexible, net-like assembly of Cavin1 and Caveolin discs.
Stoeber M, Schellenberger P, Siebert CA, Leyrat C, Helenius A, Grünewald K., Free PMC Article | 04/7/2018 |
| Data suggest that the predominant plasmalemmal anionic lipid phosphatidylserine is essential for proper caveolin/cavin clustering, caveola formation, and caveola dynamics; membrane scrambling (by using other phospholipids) can perturb caveolar stability; these studies involved caveolin-1 and cavin-1 as models of caveolin/cavin clustering. | Phosphatidylserine dictates the assembly and dynamics of caveolae in the plasma membrane.
Hirama T, Das R, Yang Y, Ferguson C, Won A, Yip CM, Kay JG, Grinstein S, Parton RG, Fairn GD., Free PMC Article | 09/16/2017 |
| DNA methylation profiling identifies PTRF/Cavin-1 as a novel tumor suppressor in Ewing sarcoma when co-expressed with caveolin-1, which PTRF, disrupts the MDM2/p53 complex, leading to apoptosis. | DNA methylation profiling identifies PTRF/Cavin-1 as a novel tumor suppressor in Ewing sarcoma when co-expressed with caveolin-1.
Huertas-Martínez J, Court F, Rello-Varona S, Herrero-Martín D, Almacellas-Rabaiget O, Sáinz-Jaspeado M, Garcia-Monclús S, Lagares-Tena L, Buj R, Hontecillas-Prieto L, Sastre A, Azorin D, Sanjuan X, López-Alemany R, Moran S, Roma J, Gallego S, Mora J, García Del Muro X, Giangrande PH, Peinado MA, Alonso J, de Alava E, Monk D, Esteller M, Tirado OM. | 08/12/2017 |
| Results show that PTRF is a direct target of miR-187. PTRF plays crucial roles in miR-187-induced epithelial-mesenchymal transition and migration of non-small cell lung cancer cells. | MicroRNA-187 modulates epithelial-mesenchymal transition by targeting PTRF in non-small cell lung cancer.
Cai Y, Ruan J, Yao X, Zhao L, Wang B. | 07/1/2017 |
| The expression of the PTRF protein was significantly weaker than that in the adjacent normal lung tissues using immunohistochemical staining. The findings revealed that miR187 promotes cell growth and invasion by targeting PTRF and miR187 may be a new prognostic factor for nonsmall cell lung cancer | MicroRNA‑187 is an independent prognostic factor in lung cancer and promotes lung cancer cell invasion via targeting of PTRF.
Peng J, Liu HZ, Zhong J, Deng ZF, Tie CR, Rao Q, Xu W, You T, Li J, Cai CB, Lu Q, Liu W, Zhang Y, Lei ZY. | 03/11/2017 |
| A homozygous PTRF mutation was identified in patient-1. Congenital generalized lipodystrophy type 4 was caused by homozygous PTRF c.481-482insGTGA (p.Lys161Serfs*41) mutation in patient-2. | Spectrum of clinical manifestations in two young Turkish patients with congenital generalized lipodystrophy type 4.
Akinci G, Topaloglu H, Akinci B, Onay H, Karadeniz C, Ergul Y, Demir T, Ozcan EE, Altay C, Atik T, Garg A., Free PMC Article | 02/18/2017 |
| This study reports an unanticipated function of ROR1 as a scaffold of cavin-1 and caveolin-1, two essential structural components of caveolae. | ROR1 sustains caveolae and survival signalling as a scaffold of cavin-1 and caveolin-1.
Yamaguchi T, Lu C, Ida L, Yanagisawa K, Usukura J, Cheng J, Hotta N, Shimada Y, Isomura H, Suzuki M, Fujimoto T, Takahashi T., Free PMC Article | 06/11/2016 |
| Cavin-1 and cavin-2 are strongly expressed within caveolae-like structures within liver sinusoidal endothelial cells of the hepatitis C-related cirrhotic liver and cavin-1 would play a critical role in regulating aspects of caveolin-1. | Increases in endothelial caveolin-1 and cavins correlate with cirrhosis progression.
Yokomori H, Ando W, Yoshimura K, Yamazaki H, Takahashi Y, Oda M. | 04/2/2016 |