| StkP- and PhpP-Mediated Posttranslational Modifications Modulate the S. pneumoniae Metabolism, Polysaccharide Capsule, and Virulence. | StkP- and PhpP-Mediated Posttranslational Modifications Modulate the S. pneumoniae Metabolism, Polysaccharide Capsule, and Virulence.
Kant S, Sun Y, Pancholi V., Free PMC Article | 08/11/2023 |
| Pivotal Roles for Ribonucleases in Streptococcus pneumoniae Pathogenesis. | Pivotal Roles for Ribonucleases in Streptococcus pneumoniae Pathogenesis.
Sinha D, Frick JP, Clemons K, Winkler ME, De Lay NR., Free PMC Article | 02/12/2022 |
| Microvesicles released from pneumolysin-stimulated lung epithelial cells carry mitochondrial cargo and suppress neutrophil oxidative burst. | Microvesicles released from pneumolysin-stimulated lung epithelial cells carry mitochondrial cargo and suppress neutrophil oxidative burst.
Letsiou E, Teixeira Alves LG, Fatykhova D, Felten M, Mitchell TJ, Müller-Redetzky HC, Hocke AC, Witzenrath M., Free PMC Article | 10/30/2021 |
| S1 Domain RNA-Binding Protein CvfD Is a New Posttranscriptional Regulator That Mediates Cold Sensitivity, Phosphate Transport, and Virulence in Streptococcus pneumoniae D39. | S1 Domain RNA-Binding Protein CvfD Is a New Posttranscriptional Regulator That Mediates Cold Sensitivity, Phosphate Transport, and Virulence in Streptococcus pneumoniae D39.
Sinha D, Zheng JJ, Tsui HT, Richardson JD, De Lay NR, Winkler ME., Free PMC Article | 04/3/2021 |
| The Pneumococcal Iron Uptake Protein A (PiuA) Specifically Recognizes Tetradentate Fe(III)bis- and Mono-Catechol Complexes. | The Pneumococcal Iron Uptake Protein A (PiuA) Specifically Recognizes Tetradentate Fe(III)bis- and Mono-Catechol Complexes.
Zhang Y, Edmonds KA, Raines DJ, Murphy BA, Wu H, Guo C, Nolan EM, VanNieuwenhze MS, Duhme-Klair AK, Giedroc DP., Free PMC Article | 03/13/2021 |
| These data revealed that TprA expression is modulated by a complex regulatory network, where the master regulators CcpA and GlnR are involved in a sugar dependent manner. Mutants in the TprA/PhrA system are highly attenuated in their survival in nasopharynx and lungs after intranasal infection, and growth in blood after intravenous infection.[GlnR, TprA, PhrA] | TprA/PhrA Quorum Sensing System Has a Major Effect on Pneumococcal Survival in Respiratory Tract and Blood, and Its Activity Is Controlled by CcpA and GlnR.
Motib AS, Al-Bayati FAY, Manzoor I, Shafeeq S, Kadam A, Kuipers OP, Hiller NL, Andrew PW, Yesilkaya H., Free PMC Article | 06/13/2020 |
| The variability in susceptibility to neutrophil extracellular traps-mediated killing of pneumococcal strains is attributed to PspA, as strains lacking the surface expression of PspA were significantly more sensitive to NETs-mediated killing compared to the wild-type strains.[PspA] | PspA facilitates evasion of pneumococci from bactericidal activity of neutrophil extracellular traps (NETs).
Martinez PJ, Farhan A, Mustafa M, Javaid N, Darkoh C, Garrido-Sanabria E, Fisher-Hoch SP, Briles DE, Kantarci A, Mirza S. | 03/28/2020 |
| In vitro activation of transcription read-through of mgtA by Mn2+ is much greater than by Ca2+. mgtA mRNA and protein levels increase approximately 5-fold during cellular Mn stress, but only in genetic backgrounds that exhibit Mn2+ sensitivity. This riboswitch functions as a failsafe 'on' signal to prevent Mn2+ toxicity in the presence of high cellular Mn2+. mgtA. | A Mn-sensing riboswitch activates expression of a Mn2+/Ca2+ ATPase transporter in Streptococcus.
Martin JE, Le MT, Bhattarai N, Capdevila DA, Shen J, Winkler ME, Giedroc DP., Free PMC Article | 01/11/2020 |
| The choline-binding protein CbpI was crystallized and X-ray crystallographic analysis showed that the crystals belonged to the tetragonal space group P4 [CbpI protein] | Overexpression, purification and crystallization of a choline-binding protein CbpI from Streptococcus pneumoniae.
Paterson NG, Riboldi-Tunicliffe A, Mitchell TJ, Isaacs NW., Free PMC Article | 10/22/2019 |
| A c-di-AMP effector protein, CabP, affects c-di-AMP homeostasis. [CabP] | Stress Suppressor Screening Leads to Detection of Regulation of Cyclic di-AMP Homeostasis by a Trk Family Effector Protein in Streptococcus pneumoniae.
Zarrella TM, Metzger DW, Bai G., Free PMC Article | 08/31/2019 |
| The authors conclude that Streptococcus pneumoniae PspA and PspC help the pneumococcus to evade complement attack by binding C4BP and so inactivating C4b.[PspA, PspC] | The Pneumococcal Surface Proteins PspA and PspC Sequester Host C4-Binding Protein To Inactivate Complement C4b on the Bacterial Surface.
Haleem KS, Ali YM, Yesilkaya H, Kohler T, Hammerschmidt S, Andrew PW, Schwaeble WJ, Lynch NJ., Free PMC Article | 07/6/2019 |
| the biophysical interaction between SpAdK and Cps2D plays an important role in enhancing Cps2D phosphorylation, which results in increased capsular polysaccharide synthesis.[SpAdK, Cps2D] | Adenylate kinase potentiates the capsular polysaccharide by modulating Cps2D in Streptococcus pneumoniae D39.
Ghosh P, Luong TT, Shah M, Thach TT, Choi S, Lee S, Rhee DK., Free PMC Article | 05/18/2019 |
| Here, the authors show that PspC is a pneumococcal plasminogen receptor and that plasmin generated on the surface of hemolytic uremic syndrome pneumococci damages endothelial cells, causing endothelial retraction and exposure of the underlying matrix.[PspC] | Streptococcus pneumoniae From Patients With Hemolytic Uremic Syndrome Binds Human Plasminogen via the Surface Protein PspC and Uses Plasmin to Damage Human Endothelial Cells.
Meinel C, Spartà G, Dahse HM, Hörhold F, König R, Westermann M, Coldewey SM, Cseresnyés Z, Figge MT, Hammerschmidt S, Skerka C, Zipfel PF. | 04/13/2019 |
| The structure of the large extracellular loop 1 of FtsX reveals an upper extended beta-hairpin and a lower alpha-helical lobe, each extending from a mixed alpha-beta core. The helical lobe mediates a physical interaction with the peptidoglycan hydrolase PcsB via the coiled-coil domain of PcsB.[FtsX, PcsB] | Structure of the Large Extracellular Loop of FtsX and Its Interaction with the Essential Peptidoglycan Hydrolase PcsB in Streptococcus pneumoniae.
Rued BE, Alcorlo M, Edmonds KA, Martínez-Caballero S, Straume D, Fu Y, Bruce KE, Wu H, Håvarstein LS, Hermoso JA, Winkler ME, Giedroc DP., Free PMC Article | 04/6/2019 |
| Study results support that GpsB functions as an adaptor protein that mediates the interaction between membrane proteins, scaffolding proteins, signaling proteins and enzymes to generate larger protein complexes at specific sites in a bacterial cell cycle-dependent manner.(GpsB) | The cell cycle regulator GpsB functions as cytosolic adaptor for multiple cell wall enzymes.
Cleverley RM, Rutter ZJ, Rismondo J, Corona F, Tsui HT, Alatawi FA, Daniel RA, Halbedel S, Massidda O, Winkler ME, Lewis RJ., Free PMC Article | 02/23/2019 |
| Here, the authors describe the regulation of capsular polysaccharide, one of the most important pneumococcal virulence factor by a GntR family regulator, CpsR.[CspR] | CpsR, a GntR family regulator, transcriptionally regulates capsular polysaccharide biosynthesis and governs bacterial virulence in Streptococcus pneumoniae.
Wu K, Xu H, Zheng Y, Wang L, Zhang X, Yin Y., Free PMC Article | 05/26/2018 |
| These results indicate that CozE is a member of the MreCD complex of Streptococcus pneumoniae that directs the activity of PBP1a to the midcell plane where it promotes zonal cell elongation and normal morphology.[CozE] | CozE is a member of the MreCD complex that directs cell elongation in Streptococcus pneumoniae.
Fenton AK, El Mortaji L, Lau DT, Rudner DZ, Bernhardt TG., Free PMC Article | 01/27/2018 |
| The transcriptomic comparison of Streptococcus pneumoniae D39 DeltaniaR to D39 wild-type revealed that the transcriptional regulator NiaR acts as a transcriptional repressor of niaX, pnuC, and nadC.[NiaR, niaX, pnuC, and nadC] | Niacin-mediated Gene Expression and Role of NiaR as a Transcriptional Repressor of niaX, nadC, and pnuC in Streptococcus pneumoniae.
Afzal M, Kuipers OP, Shafeeq S., Free PMC Article | 09/23/2017 |
| These results suggested that Streptococcus pneuomoniae PLY induces the influx of calcium in Streptococcus pneumoniae-infected macrophages, followed by calpain activation and subsequent IL-1alpha maturation and secretion. | Pneumolysin-Dependent Calpain Activation and Interleukin-1α Secretion in Macrophages Infected with Streptococcus pneumoniae.
Fang R, Wu R, Du H, Jin M, Liu Y, Lei G, Jiang B, Lei Z, Peng Y, Nie K, Tsuchiya K., Free PMC Article | 09/9/2017 |
| Importantly, AI-2 signaling via FruA enables the bacterium to utilize galactose as a carbon source and upregulates the Leloir pathway, thereby leading to increased production of capsular polysaccharide and a hypervirulent phenotype.[FruA] | Autoinducer 2 Signaling via the Phosphotransferase FruA Drives Galactose Utilization by Streptococcus pneumoniae, Resulting in Hypervirulence.
Trappetti C, McAllister LJ, Chen A, Wang H, Paton AW, Oggioni MR, McDevitt CA, Paton JC., Free PMC Article | 07/1/2017 |
| The results of this study suggest that DprA has a significant effect on virulence characteristics of Streptococcus pneumoniae by influencing the expression of choline-binding protein and PsaA.[DprA] | The virulence of Streptococcus pneumoniae partially depends on dprA.
Yu Y, Chang D, Xu H, Zhang X, Pan L, Xu C, Huang B, Zhou H, Li J, Guo J, Liu C., Free PMC Article | 04/15/2017 |
| Most of the variation in the ability of human apo-hLf to kill Streptococcus pneumoniae is dependent on the variation in the binding of apo-hLf to surface PspA and this binding is dependent on variation in PspA as well as variation in capsule which may enhance killing by reducing the binding of apo-hLf to PspA.[PspA] | The effects of differences in pspA alleles and capsular types on the resistance of Streptococcus pneumoniae to killing by apolactoferrin.
Mirza S, Benjamin WH Jr, Coan PA, Hwang SA, Winslett AK, Yother J, Hollingshead SK, Fujihashi K, Briles DE. | 04/1/2017 |
| CupA and CopA may interact and filling of the CupA S2 site with Cu(i) results in stimulation of cellular copper efflux by CopA.[CupA] | The S2 Cu(i) site in CupA from Streptococcus pneumoniae is required for cellular copper resistance.
Fu Y, Bruce KE, Wu H, Giedroc DP., Free PMC Article | 10/22/2016 |
| the ZnuA domain of AdcA was crystallized.[AdcA] | Heterogeneous nucleation is required for crystallization of the ZnuA domain of pneumococcal AdcA.
Luo Z, Morey JR, McDevitt CA, Kobe B., Free PMC Article | 09/24/2016 |
| Ni(2+) is directly involved in the derepression of the AdcR regulon via the Zn(2+)-dependent repressor AdcR, and has an opposite effect on the expression of the AdcR regulon compared to Zn(2+).[AdcR] | The Regulation of the AdcR Regulon in Streptococcus pneumoniae Depends Both on Zn(2+)- and Ni(2+)-Availability.
Manzoor I, Shafeeq S, Afzal M, Kuipers OP., Free PMC Article | 06/28/2016 |