| RAGE-TLR4 Crosstalk Is the Key Mechanism by Which High Glucose Enhances the Lipopolysaccharide-Induced Inflammatory Response in Primary Bovine Alveolar Macrophages. | RAGE-TLR4 Crosstalk Is the Key Mechanism by Which High Glucose Enhances the Lipopolysaccharide-Induced Inflammatory Response in Primary Bovine Alveolar Macrophages.
Yan L, Li Y, Tan T, Qi J, Fang J, Guo H, Ren Z, Gou L, Geng Y, Cui H, Shen L, Yu S, Wang Z, Zuo Z., Free PMC Article | 05/5/2023 |
| Lipopolysaccharide (LPS) exposure causes an acute increase in TLR4 gene expression in cultured primary ruminal epithelial cells | Effects of lipopolysaccharide exposure in primary bovine ruminal epithelial cells.
Kent-Dennis C, Aschenbach JR, Griebel PJ, Penner GB. | 10/11/2022 |
| Toll-like receptors and high mobility group box 1 in granulosa cells during bovine follicle maturation. | Toll-like receptors and high mobility group box 1 in granulosa cells during bovine follicle maturation.
Xie Y, Zhang K, Zhang K, Zhang J, Wang L, Wang X, Hu X, Liang Z, Li J. | 02/6/2021 |
| Single-nucleotide polymorphisms in CLEC7A, CD209 and TLR4 gene and their association with susceptibility to paratuberculosis in Indian cattle. | Single-nucleotide polymorphisms in CLEC7A, CD209 and TLR4 gene and their association with susceptibility to paratuberculosis in Indian cattle.
Gopi B, Singh RV, Kumar S, Kumar S, Chauhan A, Kumar A, Singh SV. | 01/16/2021 |
| SNPs rs8193046 and rs8193060 are likely a potential marker against Mycobacterium avium subspecies paratuberculosis and a selection programme eliminating AG genotype for rs8193046 and CT genotype for rs8193060 might be beneficial in conferring resistance to Mycobacterium avium subspecies paratuberculosis in Indian cattle population | Genetic association of polymorphisms in bovine TLR2 and TLR4 genes with Mycobacterium avium subspecies paratuberculosis infection in Indian cattle population.
Kumar S, Kumar S, Singh RV, Chauhan A, Kumar A, Sulabh S, Bharati J, Singh SV. | 06/1/2019 |
| This research reveals the effectiveness of LTF/EcoRI and TLR4/AluI loci as candidates for reproductive performance assessment in Holstein cattle. | Genetic Polymorphisms in LTF/EcoRI and TLR4/AluI loci as candidates for milk and reproductive performance assessment in Holstein cattle.
El-Domany WB, Radwan HA, Ateya AI, Ramadan HH, Marghani BH, Nasr SM. | 06/1/2019 |
| Two single nucleotide polymorphisms had significant effects on the milk production for Chinese Holstein, and these SNP could be used for molecular marker-assisted selection of milk production. | Toll-like receptor 4 gene polymorphisms influence milk production traits in Chinese Holstein cows.
Wang M, Song H, Zhu X, Xing S, Zhang M, Zhang H, Wang X, Yang Z, Ding X, Karrow NA, König S, Mao Y. | 01/19/2019 |
| PGE2 downregulates LPS-induced inflammatory responses via the TLR4-NF-kappaB signaling pathway in bovine endometrial epithelial cells. | PGE(2) downregulates LPS-induced inflammatory responses via the TLR4-NF-κB signaling pathway in bovine endometrial epithelial cells.
Shen Y, Liu B, Mao W, Gao R, Feng S, Qian Y, Wu J, Zhang S, Gao L, Fu C, Li Q, Deng Y, Cao J. | 12/1/2018 |
| Based on the impact of both candidate genes,TLR4 and CACNA2D1, on udder health, linear or generalized linear mixed models was applied for testing the associations of SNPs located in the genes and clinical mastitis | Dominance effects estimation of TLR4 and CACNA2D1 genes for health and production traits using logistic regression.
Bagheri M, Zahmatkesh A. | 08/4/2018 |
| a single nucleotide polymorphism of the bovine toll like receptor 4 gene (TLR4) in New Zealand (NZ) Holstein-Friesian x Jersey (HF x J) cross dairy cows was associated with milk production traits | Variation in the Toll-like Receptor 4 (TLR4) gene affects milk traits in dairy cows.
Zhou H, Cheng L, Gong H, Byun SO, Edwards GR, Hickford JGH. | 02/24/2018 |
| STA3 facilitates TLR4-dependent IL-6 and IL-8 production via IL-6 receptor-positive feedback in endometrial cells. | Signal transducer and activator of transcription-3 licenses Toll-like receptor 4-dependent interleukin (IL)-6 and IL-8 production via IL-6 receptor-positive feedback in endometrial cells.
Cronin JG, Kanamarlapudi V, Thornton CA, Sheldon IM., Free PMC Article | 10/28/2017 |
| Studied genetic diversity of the Toll-like receptor gene TLR4 in Czech Red and Czech Red Pied cattle. Found 8 SNPs, which were grouped into 18 haplotypes. | Diversity of the TLR4 Immunity Receptor in Czech Native Cattle Breeds Revealed Using the Pacific Biosciences Sequencing Platform.
Novák K, Pikousová J, Czerneková V, Mátlová V. | 10/14/2017 |
| TLR4 polymorphisms are associated with lower reproductive Performance. | Effect of Single Nucleotide Polymorphisms of Toll-Like Receptor 4 (TLR 4) on Reproductive Performance and Immune Function in Dairy Cows.
Shimizu T, Kawasaki Y, Aoki Y, Magata F, Kawashima C, Miyamoto A. | 06/24/2017 |
| As a pilot study, the present results revealed that identified SNPs in IL8 and TLR4 genes can be used as a genetic marker and predisposing factor for resistance/susceptibility to digital dermatitis in dairy cows. However, TLR4 gene may be a potential candidate for such disease. | Single Nucleotide Polymorphisms in IL8 and TLR4 Genes as Candidates for Digital Dermatitis Resistance/Susceptibility in Holstein Cattle.
El-Shafaey ES, Ateya A, Ramadan H, Saleh R, Elseady Y, Abo El Fadl E, El-Khodery S. | 06/24/2017 |
| Transcription levels of TLR2, TLR4, and CD14 in Holstein cows with retained placenta significantly decreased between the first and the seventh day postpartum. | Changes in endometrial transcription of TLR2, TLR4, and CD14 during the first-week postpartum in dairy cows with retained placenta.
Martins TM, Muniz CS, Andrade VB, Paixão TA, Santos RL, Borges ÁM. | 12/24/2016 |
| Bovine viral diarrhea virus type 2 infection modulates TLR4 responsiveness in differentiated myeloid cells. | Bovine viral diarrhea virus type 2 in vivo infection modulates TLR4 responsiveness in differentiated myeloid cells which is associated with decreased MyD88 expression.
Schaut RG, McGill JL, Neill JD, Ridpath JF, Sacco RE. | 05/28/2016 |
| TLR2 and TLR4 mediate innate response against Cryptosporidium parvum in bovine intestinal epithelial cells. | Bovine TLR2 and TLR4 mediate Cryptosporidium parvum recognition in bovine intestinal epithelial cells.
Yang Z, Fu Y, Gong P, Zheng J, Liu L, Yu Y, Li J, Li H, Yang J, Zhang X. | 04/16/2016 |
| TLR4 polymorphisms are associated with susceptibility to Mycobacterium avium ssp. paratuberculosis infection in Holsteins | Association of TLR4 polymorphisms with Mycobacterium avium subspecies paratuberculosis infection status in Canadian Holsteins.
Sharma BS, Abo-Ismail MK, Schenkel FS, You Q, Verschoor CP, Pant SD, Karrow NA. | 12/26/2015 |
| positive correlation between lower neutrophil apoptosis and higher expression of TLR2 and TLR4 with the formation of NETs and change in surface architecture. | Formation of NET, phagocytic activity, surface architecture, apoptosis and expression of toll like receptors 2 and 4 (TLR2 and TLR4) in neutrophils of mastitic cows.
Swain DK, Kushwah MS, Kaur M, Patbandha TK, Mohanty AK, Dang AK. | 02/7/2015 |
| Studied SNPs in the bovine toll-like receptor 4 (TLR4) and monocyte chemo attractant protein-1(CCL2) genes. | Genetic polymorphisms in the bovine toll-like receptor 4 (TLR4) and monocyte chemo attractant protein-1(CCL2) genes: SNPs distribution analysis in Bos indicus Sahiwal cattle breed.
Behl JD, Sharma A, Kataria RS, Verma NK, Kimothi SP, Bhatia AK, Sodhi M, Behl R, Joshi BK. | 12/20/2014 |
| Studied bovine TLR4 gene in mastitis resistance by association as well as expression profiling analysis in crossbred cattle. | Molecular characterization and expression profile of partial TLR4 gene in association to mastitis in crossbred cattle.
Panigrahi M, Sharma A, Bhushan B. | 11/22/2014 |
| Findings indicate that intervertebral disc (IVD) cells constitutively express TLR4. | Toll-Like Receptor 4 (TLR4) expression and stimulation in a model of intervertebral disc inflammation and degeneration.
Rajan NE, Bloom O, Maidhof R, Stetson N, Sherry B, Levine M, Chahine NO. | 02/15/2014 |
| Data suggest that granulosa cells from dominant follicles express functional TLR2 and TLR4; granulosa cells appear to participate in innate immunity by responding to bacterial lipopolysaccharides/lipopeptides via TLR2 and TLR4 signaling pathways. | Pathogen-associated molecular patterns initiate inflammation and perturb the endocrine function of bovine granulosa cells from ovarian dominant follicles via TLR2 and TLR4 pathways.
Price JC, Bromfield JJ, Sheldon IM. | 11/16/2013 |
| The expressions of host TLR2 and 4 genes were significantly higher in acidosis-resistant steers compared to those in acidosis-susceptible steers. | Variation of bacterial communities and expression of Toll-like receptor genes in the rumen of steers differing in susceptibility to subacute ruminal acidosis.
Chen Y, Oba M, Guan LL. | 08/31/2013 |
| TLR4 and downstream adaptor molecules, transcription factors and cytokines were up-regulated when endometrial epithelial cells were stimulated with LPS | Lipopolysaccharide increases Toll-like receptor 4 and downstream Toll-like receptor signaling molecules expression in bovine endometrial epithelial cells.
Fu Y, Liu B, Feng X, Liu Z, Liang D, Li F, Li D, Cao Y, Feng S, Zhang X, Zhang N, Yang Z. | 06/8/2013 |