| Oxidation shuts down an auto-inhibitory mechanism of von Willebrand factor. | Oxidation shuts down an auto-inhibitory mechanism of von Willebrand factor.
Tsai R, Interlandi G., Free PMC Article | 01/1/2022 |
| Case Report: suggest that alloantibodies directed against Cab4b, the first human platelet antigen carried by glycoprotein IX, can induce severe neonatal thrombocytopenia. | Cab4b, the first human platelet antigen carried by glycoprotein IX discovered in a context of severe neonatal thrombocytopenia.
Jallu V, Beranger T, Bianchi F, Casale C, Chenet C, Ferre N, Philippe S, Quesne J, Martageix C, Petermann R. | 05/5/2018 |
| ERK5 associates with CKII to play essential roles in GPIb-IX-mediated platelet activation via the PTEN/PI3K/Akt pathway. | Extracellular signal-regulated kinase 5 associates with casein kinase II to regulate GPIb-IX-mediated platelet activation via the PTEN/PI3K/Akt pathway.
Cheng Z, Gao W, Fan X, Chen X, Mei H, Liu J, Luo X, Hu Y. | 05/5/2018 |
| Data show that localization of the GP Ib-IX complex to the lipid domain is mediated by GP Ibbeta and GP IX transmembrane domains. | The Transmembrane Domains of β and IX Subunits Mediate the Localization of the Platelet Glycoprotein Ib-IX Complex to the Glycosphingolipid-enriched Membrane Domain.
Xu G, Shang D, Zhang Z, Shaw TS, Ran Y, López JA, Peng Y., Free PMC Article | 02/6/2016 |
| genetic association study in population in western India: Data suggest novel mutations in platelet glycoprotein Ib (GP1BA, GP1BB) and GP9 are associated with Bernard-Soulier syndrome in subjects studies; of 12 mutations identified, ten were novel. | Novel genetic abnormalities in Bernard-Soulier syndrome in India.
Ali S, Ghosh K, Shetty S. | 04/12/2014 |
| Studies indicate that platelets from Bernard-Soulier syndrome (BSS) are defective in glycoprotein (GP)Ib-IX-V, a platelet-specific adhesion-signaling complex, composed of GPIbalpha disulfide linked to GPIbbeta, and noncovalently associated with GPIX and GPV. | Bernard-Soulier syndrome: an update.
Andrews RK, Berndt MC. | 03/22/2014 |
| GPIX increased the expression of GPIba by promoting the formation of a disulfide bond between GPIba and GPIbb in transfected CHO-K1 cells. | Platelets with a W127X mutation in GPIX express sufficient residual amounts of GPIbα to support adhesion to von Willebrand factor and collagen.
Takata Y, Kanaji T, Moroi M, Seki R, Sano M, Nakazato S, Sueoka E, Imamura Y, Okamura T. | 03/23/2013 |
| GPIbbeta missense mutations from Bernard-Soulier syndrome were examined for changes to GPIb-IX complex surface expression. Mutations A108P and P74R were found to maintain normal secretion/folding of GPIbbeta(E) but were unable to support GPIX surface expression | Quaternary organization of GPIb-IX complex and insights into Bernard-Soulier syndrome revealed by the structures of GPIbβ and a GPIbβ/GPIX chimera.
McEwan PA, Yang W, Carr KH, Mo X, Zheng X, Li R, Emsley J., Free PMC Article | 11/24/2012 |
| Report glycoprotein Ib/IX complex mutations found in Bernard-Soulier syndrome in Indian patients. | Molecular basis of Bernard-Soulier syndrome in 27 patients from India.
Sumitha E, Jayandharan GR, David S, Jacob RR, Sankari Devi G, Bargavi B, Shenbagapriya S, Nair SC, Abraham A, George B, Viswabandya A, Mathews V, Chandy M, Srivastava A. | 02/4/2012 |
| GPIIb/IIIa is the primary receptor set involved in platelet adhesion to adsorbed fibrinogen and serum albumin irrespective of their degree of adsorption-induced unfolding, while the GPIb-IX-V receptor complex plays an insignificant role. | Delineating the roles of the GPIIb/IIIa and GP-Ib-IX-V platelet receptors in mediating platelet adhesion to adsorbed fibrinogen and albumin.
Sivaraman B, Latour RA., Free PMC Article | 09/24/2011 |
| GP Ibbeta/GP IX mediates the disulfide-linked GP Ibalpha localization to the GEMs, which is critical for vWf interaction at high shear | Platelet glycoprotein Ib beta/IX mediates glycoprotein Ib alpha localization to membrane lipid domain critical for von Willebrand factor interaction at high shear.
Geng H, Xu G, Ran Y, López JA, Peng Y., Free PMC Article | 09/3/2011 |
| Raft association and cytoskeletal linkage of the platelet GPIb-IX-V complex are interrelated and are required for optimal receptor function, by attracting signaling proteins and membrane skeletal association allows proteins to move to new locations. | The platelet glycoprotein Ib-IX-V complex anchors lipid rafts to the membrane skeleton: implications for activation-dependent cytoskeletal translocation of signaling molecules.
Munday AD, Gaus K, López JA. | 05/31/2010 |
| the putative convex surface of the LRR domain in GPIX is sufficient, in the context of full-length subunit, to mediate its association with GPIbbeta | Binding of platelet glycoprotein Ibbeta through the convex surface of leucine-rich repeats domain of glycoprotein IX.
Mo X, Nguyen NX, McEwan PA, Zheng X, López JA, Emsley J, Li R., Free PMC Article | 01/21/2010 |
| 14-3-3beta, 14-3-3gamma, 14-3-3epsilon, 14-3-3eta and 14-3-3theta isoforms interact with the GPIb-IX complex in platelets | Identification of five novel 14-3-3 isoforms interacting with the GPIb-IX complex in platelets.
Mangin PH, Receveur N, Wurtz V, David T, Gachet C, Lanza F. | 01/21/2010 |
| Findings point to a role of the GPIb-V-IX complex intrinsic to megakaryocytes at the stage of proplatelet formation and suggest a functional link with the underlying microtubular cytoskeleton in platelet biogenesis. | Intrinsic impaired proplatelet formation and microtubule coil assembly of megakaryocytes in a mouse model of Bernard-Soulier syndrome.
Strassel C, Eckly A, Léon C, Petitjean C, Freund M, Cazenave JP, Gachet C, Lanza F., Free PMC Article | 01/21/2010 |
| Homozygous missense mutation in position 1829 (A(R)G) of the GPIX gene causes Bernard-Soulier syndrome in a Swiss family. | A large Swiss family with Bernard-Soulier syndrome - Correlation phenotype and genotype.
Zieger B, Jenny A, Tsakiris DA, Bartsch I, Sandrock K, Schubart C, Schäfer S, Busse A, Wuillemin WA. | 01/21/2010 |
| glycoprotein Ib-IX-V complex contributes to tissue factor-independent thrombin generation by recombinant factor VIIa on the activated platelet surface | The glycoprotein Ib-IX-V complex contributes to tissue factor-independent thrombin generation by recombinant factor VIIa on the activated platelet surface.
Weeterings C, de Groot PG, Adelmeijer J, Lisman T. | 01/21/2010 |
| Data demonstrate the native-like heteromeric interaction among the isolated Ibalpha, Ib beta and IX TM peptides, which provides support for the four-helix bundle model of the TM domains in the glycoprotein Ib-IX complex. | Specific heteromeric association of four transmembrane peptides derived from platelet glycoprotein Ib-IX complex.
Luo SZ, Li R., Free PMC Article | 01/21/2010 |
| laminin supports platelet adhesion depending on the interaction of VWF and GPIb-IX-V under pathophysiological high shear flow | Redundant mechanism of platelet adhesion to laminin and collagen under flow: involvement of von Willebrand factor and glycoprotein Ib-IX-V.
Inoue O, Suzuki-Inoue K, Ozaki Y. | 01/21/2010 |
| Polymorphisms in human platelet alloantigen (HPA)-1 and HPA-3 (GPIIb/IIIa), HPA-2 (GPIb/IX), HPA-4 (GPIIIa) and HPA-5 (GPIa/IIa) were found to be associated with the symptoms and recurrence of ischemic stroke. | Association of human platelet alloantigen 1 through 5 polymorphisms with ischemic stroke.
Saidi S, Mahjoub T, Slamia LB, Ammou SB, Al-Subaie AM, Almawi WY, Saidi S, Mahjoub T, Slamia LB, Ammou SB, Al-Subaie AM, Almawi WY. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesHuman platelet antigens polymorphisms and susceptibility of thrombosis in hemodialysis patients.
Gorgi Y, Sfar I, Ben Aabdallah T, Aouadi H, Abderrahim E, Bardi R, Jendoubi-Ayed S, Ayed K. Association of human platelet alloantigen 1 through 5 polymorphisms with ischemic stroke.
Saidi S, Mahjoub T, Slamia LB, Ammou SB, Al-Subaie AM, Almawi WY, Saidi S, Mahjoub T, Slamia LB, Ammou SB, Al-Subaie AM, Almawi WY. | 03/13/2008 |
| Observational study of genetic testing. (HuGE Navigator) | Application of a diagnostic algorithm for inherited thrombocytopenias to 46 consecutive patients.
Noris P, Pecci A, Di Bari F, Di Stazio MT, Di Pumpo M, Ceresa IF, Arezzi N, Ambaglio C, Savoia A, Balduini CL. | 03/13/2008 |
| The transmembrane domain of GPIX plays an important role in expression and assembly of the GPIb-IX complex by interacting with its counterparts of GPIb. | Role of the transmembrane domain of glycoprotein IX in assembly of the glycoprotein Ib-IX complex.
Luo SZ, Mo X, López JA, Li R., Free PMC Article | 01/21/2010 |
| the first non-Caucasian Turkish Bernard-Soulier syndrome case due to GPIX N45S and is likely the result of a recurrent mutational event. | First Turkish case of Bernard-Soulier syndrome associated with GPIX N45S.
Dağistan N, Kunishima S. | 01/21/2010 |
| 3 families from Iran with Bernard-Soulier syndrome were investigated; the presence of the same GpIX Phe55Ser missense mutation in two families and of a single base insertion (GP1BA C3221 ins) in the third family were demonstrated | Genetic characterization of patients with Bernard-Soulier syndrome and their relatives from Southern Iran.
Afrasiabi A, Lecchi A, Artoni A, Karimi M, Ashouri E, Peyvandi F, Mannucci PM. | 01/21/2010 |