| Post-transcriptional silencing of Bos taurus prion family genes and its impact on granulosa cell steroidogenesis. | Post-transcriptional silencing of Bos taurus prion family genes and its impact on granulosa cell steroidogenesis.
Pimenta JMBGA, Pires VMR, Nolasco S, Castelo-Branco P, Marques CC, Apolónio J, Azevedo R, Fernandes MT, Lopes-da-Costa L, Prates J, Pereira RMLN. | 03/19/2022 |
| Prion protein modulates endothelial to mesenchyme-like transition in trabecular meshwork cells: Implications for primary open angle glaucoma. | Prion protein modulates endothelial to mesenchyme-like transition in trabecular meshwork cells: Implications for primary open angle glaucoma.
Ashok A, Kang MH, Wise AS, Pattabiraman P, Johnson WM, Lonigro M, Ravikumar R, Rhee DJ, Singh N., Free PMC Article | 10/31/2020 |
| Deletion/insertion polymorphisms of the PRNP gene is associated with bovine spongiformencephalopathy. | Deletion/insertion polymorphisms of the prion protein gene (PRNP) in gayal (Bos frontalis).
Memon S, Li G, Xiong H, Wang L, Liu XY, Yuan M, Deng W, Xi D. | 02/16/2019 |
| Data suggest that the E211K prion protein provides the opportunity for future analysis of physiological changes over time. | Effects of a naturally occurring amino acid substitution in bovine PrP: a model for inherited prion disease in a natural host species.
Vrentas CE, Greenlee JJ, Foster GH, West J, Jahnke MM, Schmidt MT, Nicholson EM., Free PMC Article | 08/11/2018 |
| Disparate Modes of Evolution Shaped Modern Prion (PRNP) and Prion-Related Doppel (PRND) Variation in Domestic Cattle | Disparate Modes of Evolution Shaped Modern Prion (PRNP) and Prion-Related Doppel (PRND) Variation in Domestic Cattle.
Brunelle BW, O'Grady AM, Nicholson EM, Seabury CM., Free PMC Article | 07/8/2017 |
| the data indicate a four-rung beta-solenoid structure as a key feature for the architecture of infectious mammalian prions. | The Structural Architecture of an Infectious Mammalian Prion Using Electron Cryomicroscopy.
Vázquez-Fernández E, Vos MR, Afanasyev P, Cebey L, Sevillano AM, Vidal E, Rosa I, Renault L, Ramos A, Peters PJ, Fernández JJ, van Heel M, Young HS, Requena JR, Wille H., Free PMC Article | 06/24/2017 |
| Insights into Chronic Wasting Disease and Bovine Spongiform Encephalopathy Species Barriers by Use of Real-Time Conversion | Insights into Chronic Wasting Disease and Bovine Spongiform Encephalopathy Species Barriers by Use of Real-Time Conversion.
Davenport KA, Henderson DM, Bian J, Telling GC, Mathiason CK, Hoover EA., Free PMC Article | 11/7/2015 |
| Misfolded structures, with nonnative beta-strands formed in the flexible N-terminal domain of PRNP were found in acidic pH simulations. | Molecular dynamics simulations capture the misfolding of the bovine prion protein at acidic pH.
Cheng CJ, Daggett V., Free PMC Article | 06/6/2015 |
| This work demonstrates that this isolate is transmissible, has a BSE-H phenotype when transmitted to cattle with the K211 polymorphism, and has molecular features that distinguish it from other cases of BSE-H described in the literature. | Clinical and pathologic features of H-type bovine spongiform encephalopathy associated with E211K prion protein polymorphism.
Greenlee JJ, Smith JD, West Greenlee MH, Nicholson EM., Free PMC Article | 02/14/2015 |
| Genetic characterization of PRNP promoter indel variations and the polymorphism of open reading frames (ORFs) of PRNP and bovine prion-like Shadoo (SPRN) genes, are reported. | PRNP and SPRN genes polymorphism in atypical bovine spongiform encephalopathy cases diagnosed in Polish cattle.
Gurgul A, Polak MP, Larska M, Słota E. | 06/29/2013 |
| data showed a differential timing of PrPC expression during early bovine development; the cell-specific expression of PrPC in bovine embryos was revealed to included the developing brain and spinal cord, peripheral nervous system, liver, and mesonephros | Developmental expression of the cellular prion protein (PrP(C) ) in bovine embryos.
Peralta OA, Huckle WR, Eyestone WH., Free PMC Article | 01/26/2013 |
| The centripetal spread of bovine spongiform encephalopathy prions along the autonomic nervous system to the central nervous system, starting already halfway in the incubation time, is reported. | Spread of classic BSE prions from the gut via the peripheral nervous system to the brain.
Kaatz M, Fast C, Ziegler U, Balkema-Buschmann A, Hammerschmidt B, Keller M, Oelschlegel A, McIntyre L, Groschup MH. | 12/8/2012 |
| The results indicate that certain negative feedback response elements are located in the 5' flanking region and intron1 of the PRNP gene, suggesting that regulation by transcription factors such as Sp1 and RP58 may contribute to the negative feedback mechanism of PRNP. | The 5' flanking region and intron1 of the bovine prion protein gene (PRNP) are responsible for negative feedback regulation of the prion protein.
Xue G, Aida Y, Onodera T, Sakudo A., Free PMC Article | 11/24/2012 |
| allele and haplotype segregation at the polymorphic sites within the promoter (23indel) and intron 1 (12indel) regions of the PRNP | Abnormal segregation of alleles and haplotypes at the polymorphic site of the PRNP gene within promoter and intron 1 regions in Polish Holstein-Friesian cattle.
Strychalski J, Czarnik U, Zabolewicz T., Free PMC Article | 11/17/2012 |
| PRNP gene variation in Pakistani cattle and buffaloes. | PRNP gene variation in Pakistani cattle and buffaloes.
Imran M, Mahmood S, Babar ME, Hussain R, Yousaf MZ, Abid NB, Lone KP. | 09/29/2012 |
| The Japanese and Canadian L-type bovine spongiform encephalopathy prions are identical to those from the European cases. | Comparative analysis of Japanese and foreign L-type BSE prions.
Masujin K, Miwa R, Okada H, Mohri S, Yokoyama T., Free PMC Article | 08/11/2012 |
| A significant relation between the investigated PRNP indel polymorphisms (23 and 12 bp indels), and susceptibility of Polish Holstein-Friesian cattle to classical bovine spongiform encephalopathy, is reported. | Polymorphism of the prion protein gene (PRNP) in Polish cattle affected by classical bovine spongiform encephalopathy.
Gurgul A, Czarnik U, Larska M, Polak MP, Strychalski J, Słota E. | 07/14/2012 |
| fibrils formed by the rabbit protein contain less beta-sheet structure and more alpha-helix structure than those formed by the proteins from human and cow | Fibril formation of the rabbit/human/bovine prion proteins.
Zhou Z, Yan X, Pan K, Chen J, Xie ZS, Xiao GF, Yang FQ, Liang Y., Free PMC Article | 07/7/2012 |
| these results identify a novel PrP(C)-interacting protein KCTD1 and suggest a new approach to investigating the unidentified physiological cellular function of PrP(C). | PrPC interacts with potassium channel tetramerization domain containing 1 (KCTD1) protein through the PrP(51-136) region containing octapeptide repeats.
Huang T, Xu J, Xiang J, Lu Y, Chen R, Huang L, Xiao G, Sun G. | 03/24/2012 |
| Different overall sensitivities of prion protein toward urea denaturation occurs with stabilities in the following species order: hamster </= mouse < rabbit < bovine prion protein | Relative and regional stabilities of the hamster, mouse, rabbit, and bovine prion proteins toward urea unfolding assessed by nuclear magnetic resonance and circular dichroism spectroscopies.
Julien O, Chatterjee S, Bjorndahl TC, Sweeting B, Acharya S, Semenchenko V, Chakrabartty A, Pai EF, Wishart DS, Sykes BD, Cashman NR. | 10/22/2011 |
| The polymorphisms of PRNP gene, including SNP in exon 3, 23-bp indel in promoter region, 12-bp indel in intron 1 in 2 Chinese indigenous cattle breeds of northeast China, were investigated. | Polymorphism of the prion protein gene (PRNP) in two Chinese indigenous cattle breeds.
Qin LH, Zhao YM, Bao YH, Bai WL, Chong J, Zhang GL, Zhang JB, Zhao ZH. | 10/15/2011 |
| The del/del genotype or at least its del allele may modulate the expression of PRNP at the 23-bp locus in the medulla oblongata of the cattle breeds studied. | Evaluation of PRNP expression based on genotypes and alleles of two indel loci in the medulla oblongata of Japanese Black and Japanese Brown cattle.
Msalya G, Shimogiri T, Ohno S, Okamoto S, Kawabe K, Minezawa M, Maeda Y., Free PMC Article | 09/17/2011 |
| PRNP haplotype is associated with classical bovine spongiform encephalopathy incidence in European Holstein cattle. | PRNP haplotype associated with classical BSE incidence in European Holstein cattle.
Murdoch BM, Clawson ML, Yue S, Basu U, McKay S, Settles M, Capoferri R, Laegreid WW, Williams JL, Moore SS., Free PMC Article | 02/26/2011 |
| The present study demonstrated that vector-based siRNA expression systems is an efficient approach to knockdown the PRNP gene expression in bovine fibroblast cells. | Knockdown of the prion gene expression by RNA interference in bovine fibroblast cells.
Wang S, Lv X, Zhang K, Lin T, Liu X, Yuan J, Dai Y, Li N. | 01/15/2011 |
| The interaction of the molecular chaperone Hsc70 (HSPA8) with recombinant PrP was investigated. | The binding of the molecular chaperone Hsc70 to the prion protein PrP is modulated by pH and copper.
Wilkins S, Choglay AA, Chapple JP, van der Spuy J, Rhie A, Birkett CR, Cheetham ME. | 10/4/2010 |