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    IL1B interleukin 1 beta [ Bos taurus (domestic cattle) ]

    Gene ID: 281251, updated on 4-Oct-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Expression of IL1beta Gene in the Placentas from Humans and Cows during Brucella Infection.

    Expression of IL1β Gene in the Placentas from Humans and Cows during Brucella Infection.
    Al-Rahman Riyadh H, Abdullah FA, Al-Saad KM., Free PMC Article

    05/19/2023
    IL1B triggers inflammatory cytokine production in bovine oviduct epithelial cells and induces neutrophil accumulation via CCL2.

    IL1B triggers inflammatory cytokine production in bovine oviduct epithelial cells and induces neutrophil accumulation via CCL2.
    Nakamura Y, Aihara R, Iwata H, Kuwayama T, Shirasuna K.

    11/22/2021
    Mycoplasma bovis induces matrix metalloproteinase-3 expression in bovine synovial cells via up-regulation of interleukin-1beta expression in mononuclear cells.

    Mycoplasma bovis induces matrix metalloproteinase-3 expression in bovine synovial cells via up-regulation of interleukin-1β expression in mononuclear cells.
    Nishi K, Gondaira S, Okamoto M, Watanabe R, Hirano Y, Fujiki J, Iwano H, Higuchi H.

    06/5/2021
    The NADL strain of bovine viral diarrhea virus induces the secretion of IL-1beta through caspase 1 in bovine macrophages.

    The NADL strain of bovine viral diarrhea virus induces the secretion of IL-1β through caspase 1 in bovine macrophages.
    Morales-Aguilar A, López-Reyes Y, Regalado-Huitrón M, Sarmiento-Silva RE, Arriaga-Pizano L, Benitez-Guzman A.

    10/31/2020
    Mycobacterium bovis infected animals have a higher frequency of IFN-gamma producing CD4(+) T cells and elevated plasma IL-1beta levels.

    Evaluation of antigen specific interleukin-1β as a biomarker to detect cattle infected with Mycobacterium bovis.
    Elnaggar MM, Abdellrazeq GS, Elsisy A, Mahmoud AH, Shyboub A, Sester M, Khaliel SA, Singh M, Torky HA, Davis WC.

    04/7/2018
    The presence of embryos increased endometrial IL1B protein locally, while no differences regarding IL1R1 protein and IL1B and IL1R1 mRNA were detected.

    Expression and localization of interleukin 1 beta and interleukin 1 receptor (type I) in the bovine endometrium and embryo.
    Correia-Álvarez E, Gómez E, Martín D, Carrocera S, Pérez S, Otero J, Peynot N, Giraud-Delville C, Caamaño JN, Sandra O, Duranthon V, Muñoz M.

    03/19/2016
    For the inflammasome-dependent IL-1beta release, bovine monocytes require ATP in addition to a primary stimulus. This IL-1beta release depends on potassium efflux, but, in contrast to human and murine monocytes, does not require calcium influx or generation of reaction oxygen and is independent of the P2X7 receptor.

    Inflammasome activation in bovine monocytes by extracellular ATP does not require the purinergic receptor P2X7.
    Hussen J, Düvel A, Koy M, Schuberth HJ.

    12/22/2012
    Role of TGF-beta1 and TNF-alpha in IL-1beta mediated activation of proMMP-9 in pulmonary artery smooth muscle cells: involvement of an aprotinin sensitive protease.

    Role of TGF-β1 and TNF-α in IL-1β mediated activation of proMMP-9 in pulmonary artery smooth muscle cells: involvement of an aprotinin sensitive protease.
    Roy S, Samanta K, Chakraborti T, Chowdhury A, Chakraborti S.

    10/1/2011
    Testicular IL-1 alpha and IL-1 beta concentrations were highest in the early post-natal period; however, IL-1 bioactivity and IL-6 concentrations were greatest in the immediate pre-pubertal period.

    Post-natal changes in testicular concentrations of interleukin-1 alpha and beta and interleukin-6 during sexual maturation in bulls.
    Bagu ET, Gordon JR, Rawlings NC.

    02/26/2011
    Data describe the expression of IL-8, IL-1beta and their respective receptors, CXCR1 and IL-1R1 in bovine theca cells, and suggest that VEGF is associated with the IL system in theca cells in ovary.

    Effect of VEGF (vascular endothelial growth factor) on expression of IL-8 (interleukin-8), IL-1beta and their receptors in bovine theca cells.
    Murayama C, Kaji A, Miyauchi K, Matsui M, Miyamoto A, Shimizu T.

    10/23/2010
    These results suggest that IL-1alpha and IL-1beta are produced by the stromal cells, that IL-1beta is produced by the epithelial cells, and that IL-1alpha is a more potent stimulator of prostaglandin and plasminogen activator in bovine endometrial cells.

    Cell-type specificity of interleukins 1alpha and 1beta on prostaglandin and plasminogen activator production in bovine endometrial cells.
    Tanikawa M, Kim TS, Okuda K, Ryoo ZY, Park SB, Shin JH, Park CK, Lee DS.

    01/21/2010
    Data suggest an important regulatory mechanism of interleukin-1beta production, associated with microglial migration and proliferation, driven by ECM degradation and/or synthesis in an injured brain.

    Adhesion to fibronectin regulates interleukin-1 beta expression in microglial cells.
    Summers L, Kielty C, Pinteaux E.

    01/21/2010
    the low friction of articular cartilage can be modified by TGF-beta1 and IL-1beta treatment and that the friction coefficient depends on multiple factors, including superficial zone protein localization and surface roughness

    Regulation of the friction coefficient of articular cartilage by TGF-beta1 and IL-1beta.
    DuRaine G, Neu CP, Chan SM, Komvopoulos K, June RK, Reddi AH.

    01/21/2010
    dynamic compression stimulates cell proliferation and proteoglycan synthesis in the presence of IL-1beta and/or inhibitors of the MAPKs and NFkappaB and AP-1 signalling pathways

    Signal transduction pathways involving p38 MAPK, JNK, NFkappaB and AP-1 influences the response of chondrocytes cultured in agarose constructs to IL-1beta and dynamic compression.
    Chowdhury TT, Salter DM, Bader DL, Lee DA.

    01/21/2010
    These results indicate that activation of the intrinsic antistaphylococcal response in bovine endothelial cells (BEC), enhanced by TNF-alpha and IL-1beta, is effective to eliminate S. aureus and S. epidermidis.

    The capacity of bovine endothelial cells to eliminate intracellular Staphylococcus aureus and Staphylococcus epidermidis is increased by the proinflammatory cytokines TNF-alpha and IL-1beta.
    Oviedo-Boyso J, Cardoso-Correa BI, Cajero-Juárez M, Bravo-Patiño A, Valdez-Alarcón JJ, Baizabal-Aguirre VM.

    01/21/2010
    Lipopolysaccharide stimulation up-regulates the secretion of cytokines by bovine polymorphonuclear neutrophil leukocytes.

    Bacterial lipopolysaccharide stimulates bovine neutrophil production of TNF-alpha, IL-1beta, IL-12 and IFN-gamma.
    Sohn EJ, Paape MJ, Connor EE, Bannerman DD, Fetterer RH, Peters RR.

    01/21/2010
    non-metalloproteinase mechanisms participate in IL-1-induced matrix degradation and loss of tissue material properties

    Selective and non-selective metalloproteinase inhibitors reduce IL-1-induced cartilage degradation and loss of mechanical properties.
    Wilson CG, Palmer AW, Zuo F, Eugui E, Wilson S, Mackenzie R, Sandy JD, Levenston ME., Free PMC Article

    01/21/2010
    Genes for IL-1alpha and IL-1beta are expressed and a functional IL-1R is present in bovine corpora lutea throughout luteal phase. IL-1alpha and IL-1beta may have different roles as regulating PGF(2alpha) and PGE(2) production during luteal phase.

    Possible role of interleukin-1 in the regulation of bovine corpus luteum throughout the luteal phase.
    Nishimura R, Bowolaksono A, Acosta TJ, Murakami S, Piotrowska K, Skarzynski DJ, Okuda K.

    01/21/2010
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