| Thrombogenic potential of picomolar coagulation factor XIa is mediated by thrombin wave propagation. | Thrombogenic potential of picomolar coagulation factor XIa is mediated by thrombin wave propagation.
Parunov LA, Liang Y, Lu Q, Shibeko AM, Tucker EI, Lee TK, Ataullakhanov FI, Scott DE, Ovanesov MV., Free PMC Article | 06/16/2023 |
| Functional Characterization of Antithrombin Mutations by Monitoring of Thrombin Inhibition Kinetics. | Functional Characterization of Antithrombin Mutations by Monitoring of Thrombin Inhibition Kinetics.
Reda S, Müller J, Pavlova A, Pezeshkpoor B, Oldenburg J, Pötzsch B, Rühl H., Free PMC Article | 04/17/2021 |
| the weaker rapid interaction between prothrombin and membranes is the most important in vivo when considering the activation of prothrombin at the cell surface. | Kinetic regulation of the binding of prothrombin to phospholipid membranes.
Smith E, Vekaria R, Brown KA, Longstaff C., Free PMC Article | 09/27/2014 |
| novel pyranosic sulfated arabinan Ab1 exerts its anticoagulant activity on thrombin by a mechanism different from those found previously for other sulfated polysaccharides and glycosaminoglycans | Anticoagulant activity of a unique sulfated pyranosic (1->3)-β-L-arabinan through direct interaction with thrombin.
Fernández PV, Quintana I, Cerezo AS, Caramelo JJ, Pol-Fachin L, Verli H, Estevez JM, Ciancia M., Free PMC Article | 03/2/2013 |
| Exogenous delivery of thrombin enhances microvascular collateral development in response to ischemic insult, and accelerates tissue reperfusion. | Exogenous thrombin delivery promotes collateral capillary arterialization and tissue reperfusion in the murine spinotrapezius muscle ischemia model.
Bruce AC, Peirce SM., Free PMC Article | 06/16/2012 |
| the signaling pathways of MAPK, MSK1, and NF-kappaB play important roles in thrombin-induced iNOS expression in alveolar macrophages | Thrombin induces inducible nitric oxide synthase expression via the MAPK, MSK1, and NF-κB signaling pathways in alveolar macrophages.
Lin CC, Shih CH, Yang YL, Bien MY, Lin CH, Yu MC, Sureshbabu M, Chen BC. | 03/10/2012 |
| High glucose enhances smooth muscle cell responsiveness to thrombin through transcriptional upregulation of PAR-4, mediated via PKC and NFkappaB. | High glucose enhances thrombin responses via protease-activated receptor-4 in human vascular smooth muscle cells.
Dangwal S, Rauch BH, Gensch T, Dai L, Bretschneider E, Vogelaar CF, Schrör K, Rosenkranz AC. | 04/9/2011 |
| Thrombin induces a sustained contraction in the normal pulmonary artery, by activating PAR(1) and thereby increasing the sensitivity of the myofilament to Ca(2+). | Thrombin activation of proteinase-activated receptor 1 potentiates the myofilament Ca2+ sensitivity and induces vasoconstriction in porcine pulmonary arteries.
Maki J, Hirano M, Hoka S, Kanaide H, Hirano K., Free PMC Article | 07/12/2010 |
| ERK-dependent IKKalpha/beta/NF-kappaB signaling pathway plays an important role in thrombin-induced COX-2 expression in human lung fibroblasts. | Thrombin induces cyclooxygenase-2 expression via the ERK and NF-kappaB pathways in human lung fibroblasts.
Shih CH, Bien MY, Chiang LL, Su CL, Lin CH, Chen BC. | 01/21/2010 |
| These studies illustrate that GpIbalpha and gamma' target thrombin binding sites with similar consequences on thrombin dynamics, albeit with differing structural features. | Biophysical investigation of GpIbalpha binding to thrombin anion binding exosite II.
Sabo TM, Maurer MC., Free PMC Article | 01/21/2010 |
| Examination of a dipalmitoylphosphatidylcholine membrane-bound prothrombin 1 fragment reveals another well-defined carboxyglutamic acid (Gla domain)-binding site for phosphatidylserine. | The PT1-Ca2+ Gla domain binds to a membrane through two dipalmitoylphosphatidylserines. A computational study.
Rodríguez Y, Mezei M, Osman R. | 01/21/2010 |
| Thrombomoduln not only binds to HMGB1 but also aids the proteolytic cleavage of HMGB1 by thrombin. | Proteolytic cleavage of high mobility group box 1 protein by thrombin-thrombomodulin complexes.
Ito T, Kawahara K, Okamoto K, Yamada S, Yasuda M, Imaizumi H, Nawa Y, Meng X, Shrestha B, Hashiguchi T, Maruyama I. | 01/21/2010 |
| thrombin and factor Xa diffusion along the heparin molecule explains the effects of extended heparin chain lengths | Linear diffusion of thrombin and factor Xa along the heparin molecule explains the effects of extended heparin chain lengths.
Wagenvoord R, Al Dieri R, van Dedem G, Béguin S, Hemker HC. | 01/21/2010 |
| A comparison of recombinant thrombin to bovine thrombin as a hemostatic ancillary in patients undergoing peripheral arterial bypass and arteriovenous graft procedures. | A comparison of recombinant thrombin to bovine thrombin as a hemostatic ancillary in patients undergoing peripheral arterial bypass and arteriovenous graft procedures.
Weaver FA, Lew W, Granke K, Yonehiro L, Delange B, Alexander WA, Study Investigators. | 01/21/2010 |
| crystal structure | Crystallization and preliminary x-ray studies of the unliganded wild-type bovine thrombin.
Iyaguchi D, Yao M, Watanabe N, Tanaka I, Toyota E. | 01/21/2010 |
| analysis of staphylocoagulase-mediated bovine prothrombin activation | Structural basis for reduced staphylocoagulase-mediated bovine prothrombin activation.
Friedrich R, Panizzi P, Kawabata S, Bode W, Bock PE, Fuentes-Prior P., Free PMC Article | 01/21/2010 |
| kinetic and structural analysis of interactions between thrombin and the Factor XIII activation peptide | V34I and V34A substitutions within the factor XIII activation peptide segment (28-41) affect interactions with the thrombin active site.
Trumbo TA, Maurer MC. | 01/21/2010 |