| Identification of Selenoprotein H Isoforms and Impact of Selenoprotein H Overexpression on Protein But Not mRNA Levels of 2 Other Selenoproteins in 293T Cells. | Identification of Selenoprotein H Isoforms and Impact of Selenoprotein H Overexpression on Protein But Not mRNA Levels of 2 Other Selenoproteins in 293T Cells.
Cao L, Pechan T, Lee S, Cheng WH., Free PMC Article | 03/5/2022 |
| The high levels of SELENOH in tumors as well as in undifferentiated, proliferative cells together with its inhibitory effects on proliferation and G1/S phase transition suggest SELENOH as a key regulator for cell cycle progression and for prevention of uncontrolled proliferation | Selenoprotein H controls cell cycle progression and proliferation of human colorectal cancer cells.
Bertz M, Kühn K, Koeberle SC, Müller MF, Hoelzer D, Thies K, Deubel S, Thierbach R, Kipp AP. | 09/28/2019 |
| the obtained results clearly illustrate Sec residue plays an important role to restore functionally active conformation of SELENOH. The present study broadened our current understanding regarding the role of selenocysteine in protein structure and function. | Characterization of structural and functional role of selenocysteine in selenoprotein H and its impact on DNA binding.
Barage SH, Deobagkar DD, Baladhye VB. | 02/2/2019 |
| Transcriptome analysis revealed that SepH deficiency induces an inflammatory response and activates the p53 pathway. Consequently, loss of seph renders larvae susceptible to oxidative stress and DNA damage. Finally, we demonstrate that seph interacts with p53 deficiency in adulthood to accelerate gastrointestinal tumor development | Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis.
Cox AG, Tsomides A, Kim AJ, Saunders D, Hwang KL, Evason KJ, Heidel J, Brown KK, Yuan M, Lien EC, Lee BC, Nissim S, Dickinson B, Chhangawala S, Chang CJ, Asara JM, Houvras Y, Gladyshev VN, Goessling W., Free PMC Article | 01/27/2018 |
| Selenoprotein H suppresses cellular senescence through genome maintenance and redox regulation. | Selenoprotein H suppresses cellular senescence through genome maintenance and redox regulation.
Wu RT, Cao L, Chen BP, Cheng WH., Free PMC Article | 03/7/2015 |
| We conclude that the effects of selenoprotein H on mitochondrial biogenesis and mitochondrial function are probably mediated through protein kinase A-CREB-PGC-1alpha and Akt/protein kinase B-CREB-PGC-1alpha pathways. | Overexpression of human selenoprotein H in neuronal cells enhances mitochondrial biogenesis and function through activation of protein kinase A, protein kinase B, and cyclic adenosine monophosphate response element-binding protein pathway.
Mehta SL, Mendelev N, Kumari S, Andy Li P., Free PMC Article | 09/14/2013 |
| Overexpression of SelH promotes mitochondrial biogenesis and improves mitochondrial functional performance. | Upregulation of human selenoprotein H in murine hippocampal neuronal cells promotes mitochondrial biogenesis and functional performance.
Mendelev N, Mehta SL, Witherspoon S, He Q, Sexton JZ, Li PA., Free PMC Article | 04/2/2011 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.
Casabonne D, Reina O, Benavente Y, Becker N, Maynadié M, Foretová L, Cocco P, González-Neira A, Nieters A, Boffetta P, Middeldorp JM, de Sanjose S., Free PMC Article | 12/5/2010 |
| t SelH protects neurons against UVB-induced damage by inhibiting apoptotic cell death pathways | Overexpression of human selenoprotein H in neuronal cells ameliorates ultraviolet irradiation-induced damage by modulating cell signaling pathways.
Mendelev N, Witherspoon S, Li PA., Free PMC Article | 01/21/2010 |
| selenoprotein H is a redox-responsive DNA-binding protein of the AT-hook family and functions in regulating expression levels of genes involved in de novo glutathione synthesis and phase II detoxification in response to redox status. | Selenoprotein H is a redox-sensing high mobility group family DNA-binding protein that up-regulates genes involved in glutathione synthesis and phase II detoxification.
Panee J, Stoytcheva ZR, Liu W, Berry MJ. | 01/21/2010 |
| hSelH overexpression protects cells from UVB irradiation-induced murine hippocampal neuronal cell death by reducing the superoxide formation. | Overexpression of selenoprotein H reduces Ht22 neuronal cell death after UVB irradiation by preventing superoxide formation.
Ben Jilani KE, Panee J, He Q, Berry MJ, Li PA., Free PMC Article | 01/21/2010 |
| SelH is a novel nucleolar oxidoreductase that may have functions which are regulated by redox and dependent on the trace element selenium | Selenoprotein H is a nucleolar thioredoxin-like protein with a unique expression pattern.
Novoselov SV, Kryukov GV, Xu XM, Carlson BA, Hatfield DL, Gladyshev VN. | 01/21/2010 |