| GNAI3 mediated by Lin28A regulates lipopolysaccharide-induced inflammation and osteogenic differentiation in periodontal stem cells by mediating the NF-kappaB/NLRP3 inflammasome pathway. | GNAI3 mediated by Lin28A regulates lipopolysaccharide-induced inflammation and osteogenic differentiation in periodontal stem cells by mediating the NF-κB/NLRP3 inflammasome pathway.
Guo L, Sun H, Pu J. | 05/31/2024 |
| Integrins regulate hERG1 dynamics by girdin-dependent Galphai3: signaling and modeling in cancer cells. | Integrins regulate hERG1 dynamics by girdin-dependent Gαi3: signaling and modeling in cancer cells.
Duranti C, Iorio J, Bagni G, Chioccioli Altadonna G, Fillion T, Lulli M, D'Alessandro FN, Montalbano A, Lastraioli E, Fanelli D, Coppola S, Schmidt T, Piazza F, Becchetti A, Arcangeli A., Free PMC Article | 11/14/2023 |
| Galphai1/3 mediate Netrin-1-CD146-activated signaling and angiogenesis. | Gαi1/3 mediate Netrin-1-CD146-activated signaling and angiogenesis.
Li Y, Chai JL, Shi X, Feng Y, Li JJ, Zhou LN, Cao C, Li KR., Free PMC Article | 05/12/2023 |
| A novel missense variant of the GNAI3 gene and recognisable morphological characteristics of the mandibula in ARCND1. | A novel missense variant of the GNAI3 gene and recognisable morphological characteristics of the mandibula in ARCND1.
Yanagi K, Morimoto N, Iso M, Abe Y, Okamura K, Nakamura T, Matsubara Y, Kaname T., Free PMC Article | 01/22/2022 |
| A highly conserved delta-opioid receptor region determines RGS4 interaction. | A highly conserved δ-opioid receptor region determines RGS4 interaction.
Karoussiotis C, Marti-Solano M, Stepniewski TM, Symeonof A, Selent J, Georgoussi Z. | 10/24/2020 |
| The CpG-SNP rs11810577 in GNAI3 in the gastric acid secretion pathway was significantly associated with susceptibility to gastric cancer. | Novel CpG-SNPs in the gastric acid secretion pathway GNAI3 and susceptibility to gastric cancer.
Liu M, Li S, Du M, Chu H, Wang M, Zhang Z. | 03/21/2020 |
| We found that the inhibitory Galphai3 protein selectively bound to the G-protein-binding domain on the C-terminus of PC1. The dissociation of Galphai3 upon cleavage of PC1 increased TRPC4 activity. | Gα(i)-mediated TRPC4 activation by polycystin-1 contributes to endothelial function via STAT1 activation.
Kwak M, Hong C, Myeong J, Park EYJ, Jeon JH, So I., Free PMC Article | 09/14/2019 |
| These results provide mechanistic insights into the critical role played by Galphai1/3 proteins in VEGF-induced VEGFR2 endocytosis, signaling and angiogenesis. | Gαi1 and Gαi3mediate VEGF-induced VEGFR2 endocytosis, signaling and angiogenesis.
Sun J, Huang W, Yang SF, Zhang XP, Yu Q, Zhang ZQ, Yao J, Li KR, Jiang Q, Cao C., Free PMC Article | 09/7/2019 |
| direct binding of GATA4 to the GNAI3 promoter, both in vitro and in vivo, is reported. | Role of GATA binding protein 4 (GATA4) in the regulation of tooth development via GNAI3.
Guo S, Zhang Y, Zhou T, Wang D, Weng Y, Wang L, Ma J., Free PMC Article | 12/22/2018 |
| magnetic field-dependent nuclear magnetic resonance relaxation analyses were used to investigate the structural and dynamic properties of GDP bound Galpha on a microsecond timescale. | Dynamic regulation of GDP binding to G proteins revealed by magnetic field-dependent NMR relaxation analyses.
Toyama Y, Kano H, Mase Y, Yokogawa M, Osawa M, Shimada I., Free PMC Article | 11/10/2018 |
| Results show that Galphai3 nuclear translocation causes irradiation resistance in human glioma cells through its complexation with DNA-PKcs leading to DNA repair. | Gαi3 nuclear translocation causes irradiation resistance in human glioma cells.
Cai S, Li Y, Bai JY, Zhang ZQ, Wang Y, Qiao YB, Zhou XZ, Yang B, Tian Y, Cao C., Free PMC Article | 03/10/2018 |
| GNAI3 is identified a second gene possibly responsible for X-linked ocular albinism. | GNAI3: Another Candidate Gene to Screen in Persons with Ocular Albinism.
Young A, Dandekar U, Pan C, Sader A, Zheng JJ, Lewis RA, Farber DB., Free PMC Article | 08/5/2017 |
| These data indicate that, unlike in taste cells, TAS2Rs couple to the prevalent G proteins, Galphai1, Galphai2, and Galphai3, with no evidence for functional coupling to Galphagust. | Coupling of Airway Smooth Muscle Bitter Taste Receptors to Intracellular Signaling and Relaxation Is via G(αi1,2,3).
Kim D, Woo JA, Geffken E, An SS, Liggett SB., Free PMC Article | 08/5/2017 |
| Data show that auriculo-condylar syndrome (ACS)-associated mutations in G protein subunit alpha i3 (GNAI3) produce dominant-negative Galpha(i3) mutant proteins that couple to endothelin type A receptor (ET(A)R). | Dominant-negative Gα subunits are a mechanism of dysregulated heterotrimeric G protein signaling in human disease.
Marivin A, Leyme A, Parag-Sharma K, DiGiacomo V, Cheung AY, Nguyen LT, Dominguez I, Garcia-Marcos M., Free PMC Article | 01/14/2017 |
| In postmortem human prefrontal cortex, adenosine A1 receptor is coupled preferentially, if not exclusively, to Galphai-3. | Adenosine A1( )receptors are selectively coupled to Gα(i-3) in postmortem human brain cortex: Guanosine-5'-O-(3-[(35)S]thio)triphosphate ([(35)S]GTPγS) binding/immunoprecipitation study.
Odagaki Y, Kinoshita M, Ota T, Javier Meana J, Callado LF, García-Sevilla JA. | 07/30/2016 |
| transcriptional upregulation of Girdin expression and Girdin-Galphai3 signaling play crucial roles in regulating epithelial apicobasal polarity through the PAR complex. | Regulation of epithelial cell polarity by PAR-3 depends on Girdin transcription and Girdin-Gαi3 signaling.
Sasaki K, Kakuwa T, Akimoto K, Koga H, Ohno S. | 04/2/2016 |
| GIV and its substrate Galphai3 are recruited to active integrin complexes | Integrins activate trimeric G proteins via the nonreceptor protein GIV/Girdin.
Leyme A, Marivin A, Perez-Gutierrez L, Nguyen LT, Garcia-Marcos M., Free PMC Article | 12/26/2015 |
| We demonstrate that the GNAI3 variant is the likely cause of auriculocondylar syndrome in the original ACS1 family. | Novel variants in GNAI3 associated with auriculocondylar syndrome strengthen a common dominant negative effect.
Romanelli Tavares VL, Gordon CT, Zechi-Ceide RM, Kokitsu-Nakata NM, Voisin N, Tan TY, Heggie AA, Vendramini-Pittoli S, Propst EJ, Papsin BC, Torres TT, Buermans H, Capelo LP, den Dunnen JT, Guion-Almeida ML, Lyonnet S, Amiel J, Passos-Bueno MR., Free PMC Article | 12/19/2015 |
| Both SH2 and GEF domains of GIV are required for the formation of a ligand-activated ternary complex between GIV, Galphai3, and EGFR. | Structural basis for activation of trimeric Gi proteins by multiple growth factor receptors via GIV/Girdin.
Lin C, Ear J, Midde K, Lopez-Sanchez I, Aznar N, Garcia-Marcos M, Kufareva I, Abagyan R, Ghosh P., Free PMC Article | 06/27/2015 |
| Low GNAI3 expression is associated with hepatocellular carcinoma. | GNAI3 inhibits tumor cell migration and invasion and is post-transcriptionally regulated by miR-222 in hepatocellular carcinoma.
Zhang Y, Yao J, Huan L, Lian J, Bao C, Li Y, Ge C, Li J, Yao M, Liang L, He X. | 03/7/2015 |
| We observed increased expression of Galphai1/3 in wounded human skin and keloid skin tissues, suggesting the possible involvement of Galphai1/3 in wound healing and keloid formation. | Requirement of Gαi1/3-Gab1 signaling complex for keratinocyte growth factor-induced PI3K-AKT-mTORC1 activation.
Zhang YM, Zhang ZQ, Liu YY, Zhou X, Shi XH, Jiang Q, Fan DL, Cao C. | 02/28/2015 |
| Data indicate that dynein- and astral microtubule-mediated transport of Galphai/LGN/nuclear mitotic apparatus (NuMA) complex from cell cortex to spindle poles. | Evidence for dynein and astral microtubule-mediated cortical release and transport of Gαi/LGN/NuMA complex in mitotic cells.
Zheng Z, Wan Q, Liu J, Zhu H, Chu X, Du Q., Free PMC Article | 09/21/2013 |
| The phenotypic variability of auriculocondylar syndrome suggests that mutations in this pathway, especially those affecting core signaling molecules such as PLCB4 and GNAI3, should be considered as potential candidates for other ear and jaw malformations. | A human homeotic transformation resulting from mutations in PLCB4 and GNAI3 causes auriculocondylar syndrome.
Rieder MJ, Green GE, Park SS, Stamper BD, Gordon CT, Johnson JM, Cunniff CM, Smith JD, Emery SB, Lyonnet S, Amiel J, Holder M, Heggie AA, Bamshad MJ, Nickerson DA, Cox TC, Hing AV, Horst JA, Cunningham ML., Free PMC Article | 06/30/2012 |
| These results identify the Oa1 transducer Galphai3 as the first downstream component in the Oa1 signaling pathway. | Specific interaction of Gαi3 with the Oa1 G-protein coupled receptor controls the size and density of melanosomes in retinal pigment epithelium.
Young A, Jiang M, Wang Y, Ahmedli NB, Ramirez J, Reese BE, Birnbaumer L, Farber DB., Free PMC Article | 02/4/2012 |
| The mechanisms of regulation of GIRK by Galpha(i/o) using wild-type Galpha(i3) (Galpha(i3)WT) and Galpha(i3), were investigated. | Two distinct aspects of coupling between Gα(i) protein and G protein-activated K+ channel (GIRK) revealed by fluorescently labeled Gα(i3) protein subunits.
Berlin S, Tsemakhovich VA, Castel R, Ivanina T, Dessauer CW, Keren-Raifman T, Dascal N., Free PMC Article | 11/26/2011 |