| Exosomal EIF5A derived from Lewis lung carcinoma induced adipocyte wasting in cancer cachexia. | Exosomal EIF5A derived from Lewis lung carcinoma induced adipocyte wasting in cancer cachexia.
Xiong H, Ye J, Luo Q, Li W, Xu N, Yang H. | 11/8/2023 |
| Targeted inhibition of eIF5A[hpu] suppresses tumor growth and polarization of M2-like tumor-associated macrophages in oral cancer. | Targeted inhibition of eIF5A(hpu) suppresses tumor growth and polarization of M2-like tumor-associated macrophages in oral cancer.
Zeng J, Ye Z, Shi S, Liang Y, Meng Q, Zhang Q, Le AD., Free PMC Article | 11/2/2023 |
| Deoxyhypusine synthase mutations alter the post-translational modification of eukaryotic initiation factor 5A resulting in impaired human and mouse neural homeostasis. | Deoxyhypusine synthase mutations alter the post-translational modification of eukaryotic initiation factor 5A resulting in impaired human and mouse neural homeostasis.
Padgett LR, Shinkle MR, Rosario S, Stewart TM, Foley JR, Casero RA Jr, Park MH, Chung WK, Mastracci TL., Free PMC Article | 06/23/2023 |
| Combined inhibition of polyamine metabolism and eIF5A hypusination suppresses colorectal cancer growth through a converging effect on MYC translation. | Combined inhibition of polyamine metabolism and eIF5A hypusination suppresses colorectal cancer growth through a converging effect on MYC translation.
Coni S, Bordone R, Ivy DM, Yurtsever ZN, Di Magno L, D'Amico R, Cesaro B, Fatica A, Belardinilli F, Bufalieri F, Maroder M, De Smaele E, Di Marcotullio L, Giannini G, Agostinelli E, Canettieri G. | 04/4/2023 |
| Neuron-specific ablation of eIF5A or deoxyhypusine synthase leads to impairments in growth, viability, neurodevelopment, and cognitive functions in mice. | Neuron-specific ablation of eIF5A or deoxyhypusine synthase leads to impairments in growth, viability, neurodevelopment, and cognitive functions in mice.
Kar RK, Hanner AS, Starost MF, Springer D, Mastracci TL, Mirmira RG, Park MH., Free PMC Article | 12/18/2021 |
| The eIF5A (eIF5A(H)) promotes the efficient expression of a subset of mitochondrial proteins involved in the TCA cycle and oxidative phosphorylation (OXPHOS). | Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation.
Puleston DJ, Buck MD, Klein Geltink RI, Kyle RL, Caputa G, O'Sullivan D, Cameron AM, Castoldi A, Musa Y, Kabat AM, Zhang Y, Flachsmann LJ, Field CS, Patterson AE, Scherer S, Alfei F, Baixauli F, Austin SK, Kelly B, Matsushita M, Curtis JD, Grzes KM, Villa M, Corrado M, Sanin DE, Qiu J, Pällman N, Paz K, Maccari ME, Blazar BR, Mittler G, Buescher JM, Zehn D, Rospert S, Pearce EJ, Balabanov S, Pearce EL., Free PMC Article | 10/3/2020 |
| Klf5 down-regulation induces vascular senescence through eIF5a depletion and mitochondrial fission. | Klf5 down-regulation induces vascular senescence through eIF5a depletion and mitochondrial fission.
Ma D, Zheng B, Liu HL, Zhao YB, Liu X, Zhang XH, Li Q, Shi WB, Suzuki T, Wen JK., Free PMC Article | 09/19/2020 |
| our results provide the first genetic evidence that the hypusine modification in eIF-5A is crucial for homeostasis in mammals | Biological Relevance and Therapeutic Potential of the Hypusine Modification System.
Pällmann N, Braig M, Sievert H, Preukschas M, Hermans-Borgmeyer I, Schweizer M, Nagel CH, Neumann M, Wild P, Haralambieva E, Hagel C, Bokemeyer C, Hauber J, Balabanov S., Free PMC Article | 10/24/2015 |
| knockout of either the eIF5A-1 gene (Eif5a) or of the deoxyhypusine synthase gene (Dhps) caused early embryonic lethality in mice, indicating the essential nature of both eIF5A-1 and deoxyhypusine synthase in mammalian development | Essential role of eIF5A-1 and deoxyhypusine synthase in mouse embryonic development.
Nishimura K, Lee SB, Park JH, Park MH., Free PMC Article | 06/2/2012 |
| These results point to a new functional role for eIF5A, relating it to embryogenesis, development, and cell differentiation. | Evidences of a role for eukaryotic translation initiation factor 5A (eIF5A) in mouse embryogenesis and cell differentiation.
Parreiras-e-Silva LT, Luchessi AD, Reis RI, Oliver C, Jamur MC, Ramos RG, Oliveira EB, Curi R, Costa-Neto CM. | 10/23/2010 |
| Results indicate that the N-terminal extension of the eukaryotic eIF5A contributes in signaling this protein to nuclear localization, despite of bearing no structural similarity with classical nuclear localization signals. | The N-terminal region of eukaryotic translation initiation factor 5A signals to nuclear localization of the protein.
Parreiras-E-Silva LT, Gomes MD, Oliveira EB, Costa-Neto CM. | 01/21/2010 |
| a decrease in either active eIF5A or polyamines inhibits cell growth, indicating that eIF5A and polyamines are independently involved in cell growth | Independent roles of eIF5A and polyamines in cell proliferation.
Nishimura K, Murozumi K, Shirahata A, Park MH, Kashiwagi K, Igarashi K., Free PMC Article | 01/21/2010 |
| Eukaryotic initiation factor 5A (eIF5A) (eIF-4D, eIF-5A) stimulates ribosomal peptidyltransferase activity, transport of HIV-1-mRNAs and binds exportins 1 and 4. Contains hypusine at lys 50. Mouse EIF5A1 and EIF5A2 encode two isoforms: eIF5AI and eIF5AII. | Human eIF5A2 on chromosome 3q25-q27 is a phylogenetically conserved vertebrate variant of eukaryotic translation initiation factor 5A with tissue-specific expression.
Jenkins ZA, Hååg PG, Johansson HE. | 06/12/2003 |