| Bioinformatics analysis identifies GLUD1 as a prognostic indicator for clear cell renal cell carcinoma. | Bioinformatics analysis identifies GLUD1 as a prognostic indicator for clear cell renal cell carcinoma.
Liu S., Free PMC Article | 02/1/2024 |
| Hyperinsulinism/hyperammonemia syndrome caused by biallelic SLC25A36 mutation. | Hyperinsulinism/hyperammonemia syndrome caused by biallelic SLC25A36 mutation.
Safran A, Proskorovski-Ohayon R, Eskin-Schwartz M, Yogev Y, Drabkin M, Eremenko E, Aharoni S, Freund O, Jean MM, Agam N, Hadar N, Loewenthal N, Staretz-Chacham O, Birk OS. | 10/28/2023 |
| Glutamate dehydrogenase1 supports HIF-1alpha stability to promote colorectal tumorigenesis under hypoxia. | Glutamate dehydrogenase1 supports HIF-1α stability to promote colorectal tumorigenesis under hypoxia.
Hu K, Ding Y, Zhu H, Jing X, He W, Yu H, Wang X., Free PMC Article | 06/19/2023 |
| Mosaic GLUD1 Mutations Associated with Hyperinsulinism Hyperammonemia Syndrome. | Mosaic GLUD1 Mutations Associated with Hyperinsulinism Hyperammonemia Syndrome.
Boodhansingh KE, Rosenfeld E, Lord K, Adzick NS, Bhatti T, Ganguly A, De Leon DD, Stanley CA., Free PMC Article | 11/26/2022 |
| Oncogenic circTICRR suppresses autophagy via binding to HuR protein and stabilizing GLUD1 mRNA in cervical cancer. | Oncogenic circTICRR suppresses autophagy via binding to HuR protein and stabilizing GLUD1 mRNA in cervical cancer.
Zhu T, Cen Y, Chen Z, Zhang Y, Zhao L, Wang J, Lu W, Xie X, Wang X., Free PMC Article | 06/11/2022 |
| Cytosolic GDH1 degradation restricts protein synthesis to sustain tumor cell survival following amino acid deprivation. | Cytosolic GDH1 degradation restricts protein synthesis to sustain tumor cell survival following amino acid deprivation.
Shao J, Shi T, Yu H, Ding Y, Li L, Wang X, Wang X., Free PMC Article | 12/18/2021 |
| Mapping the Intramolecular Communications among Different Glutamate Dehydrogenase States Using Molecular Dynamics. | Mapping the Intramolecular Communications among Different Glutamate Dehydrogenase States Using Molecular Dynamics.
Basith S, Manavalan B, Shin TH, Lee G., Free PMC Article | 09/25/2021 |
| miR30a5p inhibits hypoxia/reoxygenationinduced oxidative stress and apoptosis in HK2 renal tubular epithelial cells by targeting glutamate dehydrogenase 1 (GLUD1). | miR‑30a‑5p inhibits hypoxia/reoxygenation‑induced oxidative stress and apoptosis in HK‑2 renal tubular epithelial cells by targeting glutamate dehydrogenase 1 (GLUD1).
He Y, Lang X, Cheng D, Zhang T, Yang Z, Xiong R., Free PMC Article | 07/10/2021 |
| Hyperinsulinism associated with GLUD1 mutation: allosteric regulation and functional characterization of p.G446V glutamate dehydrogenase. | Hyperinsulinism associated with GLUD1 mutation: allosteric regulation and functional characterization of p.G446V glutamate dehydrogenase.
Luczkowska K, Stekelenburg C, Sloan-Béna F, Ranza E, Gastaldi G, Schwitzgebel V, Maechler P., Free PMC Article | 07/10/2021 |
| Hyperinsulinism hyperammonaemia (HI/HA) syndrome due to GLUD1 mutation: phenotypic variations ranging from late presentation to spontaneous resolution. | Hyperinsulinism hyperammonaemia (HI/HA) syndrome due to GLUD1 mutation: phenotypic variations ranging from late presentation to spontaneous resolution.
Brandt A, Agarwal N, Giri D, Yung Z, Didi M, Senniappan S. | 05/15/2021 |
| EGFR activates GDH1 transcription to promote glutamine metabolism through MEK/ERK/ELK1 pathway in glioblastoma. | EGFR activates GDH1 transcription to promote glutamine metabolism through MEK/ERK/ELK1 pathway in glioblastoma.
Yang R, Li X, Wu Y, Zhang G, Liu X, Li Y, Bao Y, Yang W, Cui H. | 11/21/2020 |
| our data support the utility of serum GLDH as a liver-specific biomarker of liver injury that has a potential to improve diagnosis of hepatocellular injury in patients with underlying muscle impairments | Serum glutamate dehydrogenase activity enables early detection of liver injury in subjects with underlying muscle impairments.
Schomaker S, Potter D, Warner R, Larkindale J, King N, Porter AC, Owens J, Tomlinson L, Sauer JM, Johnson K, Aubrecht J., Free PMC Article | 07/25/2020 |
| Clinically, XLOC_006390 was positively correlated with the mRNA level of GDH1, and c-Myc positively regulated GDH1 gene expression, which was tightly associated with PC patient prognosis. The dysregulated lncRNA/c-Myc axis increased glutamate metabolism, promoting PC progression to a higher stage. | LncRNA XLOC_006390 promotes pancreatic carcinogenesis and glutamate metabolism by stabilizing c-Myc.
He J, Li F, Zhou Y, Hou X, Liu S, Li X, Zhang Y, Jing X, Yang L. | 06/20/2020 |
| Low expression of GDH can significantly inhibit gastric cancer cell migration, invasion and proliferation, and decrease in the expression levels of Notch1, Notch2, Notch3 and Notch4 in vitro. GDH suppressed tumor growth and metastasis by mediating the Notch signaling pathway in mice with gastric cancer. Therefore, GDH-Notch signaling pathway is considered an important target of anti-tumor growth and metastasis. | Glutamate dehydrogenase inhibits tumor growth in gastric cancer through the Notch signaling pathway.
Wu YJ, Hu ZL, Hu SD, Li YX, Xing XW, Yang Y, Du XH. | 04/11/2020 |
| GluD1 defines a trans-synaptic interaction regulating postsynaptic signaling pathways for the proper establishment of cortical inhibitory connectivity | Trans-Synaptic Signaling through the Glutamate Receptor Delta-1 Mediates Inhibitory Synapse Formation in Cortical Pyramidal Neurons.
Fossati M, Assendorp N, Gemin O, Colasse S, Dingli F, Arras G, Loew D, Charrier C., Free PMC Article | 03/28/2020 |
| We provide comprehensive data indicating GLUD1 plays an important role in luminal/ER + breast cancer | Glutamate dehydrogenase (GLUD1) expression in breast cancer.
Craze ML, El-Ansari R, Aleskandarany MA, Cheng KW, Alfarsi L, Masisi B, Diez-Rodriguez M, Nolan CC, Ellis IO, Rakha EA, Green AR. | 07/13/2019 |
| Both GDH1 and GDH2 were overexpressed in the HEK293 cell line and found to be co-localized in subcellular fractions. | Localization of Human Glutamate Dehydrogenases Provides Insights into Their Metabolic Role and Their Involvement in Disease Processes.
Mathioudakis L, Bourbouli M, Daklada E, Kargatzi S, Michaelidou K, Zaganas I. | 03/16/2019 |
| GLUD1 may play an important role in osteogenic differentiation of human dental pulp stem cells | [Effect of GLUD1 on proliferation, osteogenic differentiation and mineralization of human dental pulp stem cells].
Lu X, Liu SF, Zhao SL. | 02/16/2019 |
| This study provides insight into the molecular mechanism by which GDH1-mediated metabolic reprogramming of glutaminolysis mediates lung cancer metastasis and offers a therapeutic strategy for patients with LKB1-deficient lung cancer. | The PLAG1-GDH1 Axis Promotes Anoikis Resistance and Tumor Metastasis through CamKK2-AMPK Signaling in LKB1-Deficient Lung Cancer.
Jin L, Chun J, Pan C, Kumar A, Zhang G, Ha Y, Li D, Alesi GN, Kang Y, Zhou L, Yu WM, Magliocca KR, Khuri FR, Qu CK, Metallo C, Owonikoko TK, Kang S., Free PMC Article | 12/22/2018 |
| Phenotypic heterogeneity of GDH-hyperinsulinemia patients was observed within the Chinese cohort in the present study. The fact that most patients had a GLUD1 p. S445L mutation implies that this site could be a hotspot in Chinese patients. | Clinical and Molecular Spectrum of Glutamate Dehydrogenase Gene Defects in 26 Chinese Congenital Hyperinsulinemia Patients.
Su C, Liang XJ, Li WJ, Wu D, Liu M, Cao BY, Chen JJ, Qin M, Meng X, Gong CX., Free PMC Article | 12/22/2018 |
| structural model of a complex of human Sirt4 and GDH in order to elucidate the molecular mechanism underlying the ADP-ribosylation of GDH by Sirt4 | A ternary complex model of Sirtuin4-NAD(+)-Glutamate dehydrogenase.
Kato Y, Kihara H, Fukui K, Kojima M. | 07/14/2018 |
| Upregulation of GLUD1 and SLC25A13 was associated with tumor aggressiveness and poorer prognosis in colorectal cancer patients. | Metabolic Adaptation to Nutritional Stress in Human Colorectal Cancer.
Miyo M, Konno M, Nishida N, Sueda T, Noguchi K, Matsui H, Colvin H, Kawamoto K, Koseki J, Haraguchi N, Nishimura J, Hata T, Gotoh N, Matsuda F, Satoh T, Mizushima T, Shimizu H, Doki Y, Mori M, Ishii H., Free PMC Article | 06/2/2018 |
| This study showed that SIRT5 supports the anaplerotic entry of glutamine into the TCA cycle in malignant phenotypes of CRC via activating GLUD1. | Sirtuin5 contributes to colorectal carcinogenesis by enhancing glutaminolysis in a deglutarylation-dependent manner.
Wang YQ, Wang HL, Xu J, Tan J, Fu LN, Wang JL, Zou TH, Sun DF, Gao QY, Chen YX, Fang JY., Free PMC Article | 03/10/2018 |
| the present study shows that the GDHS445L enzyme is highly sensitive to the allosteric activator ADP, explaining the hyperactivity of this mutant. INS-1E beta-cells expressing GDHS445L responded to glutamine stimulation by increasing the mitochondrial respiration and ATP production, as well as by a rise in cytosolic calcium. | Identification of the molecular dysfunction caused by glutamate dehydrogenase S445L mutation responsible for hyperinsulinism/hyperammonemia.
Grimaldi M, Karaca M, Latini L, Brioudes E, Schalch T, Maechler P. | 01/20/2018 |
| We have shown that alpha-ketoglutarate substrate inhibition kinetics of GDH, which include both random and obligatory ordered association/dissociation reactions, robustly control the ratio between glutamate and ammonium under a wide range of intracellular substrate variation. Dysregulation of this activity under pericentral nitrogen insufficiency contributes to the breaking down of ammonia homeostasis and thereby can s... | Robust regulation of hepatic pericentral amination by glutamate dehydrogenase kinetics.
Bera S, Lamba S, Rashid M, Sharma AK, Medvinsky AB, Acquisti C, Chakraborty A, Li BL. | 12/9/2017 |