| Structural and functional fine mapping of cysteines in mammalian glutaredoxin reveal their differential oxidation susceptibility. | Structural and functional fine mapping of cysteines in mammalian glutaredoxin reveal their differential oxidation susceptibility.
Corteselli EM, Sharafi M, Hondal R, MacPherson M, White S, Lam YW, Gold C, Manuel AM, van der Vliet A, Schneebeli ST, Anathy V, Li J, Janssen-Heininger YMW., Free PMC Article | 08/14/2023 |
| Cytosolic glutaredoxin 1 is upregulated in AMD and controls retinal pigment epithelial cells proliferation via beta-catenin. | Cytosolic glutaredoxin 1 is upregulated in AMD and controls retinal pigment epithelial cells proliferation via β-catenin.
Hanschmann EM, Wilms C, Falk L, Holubiec MI, Mennel S, Lillig CH, Godoy JR. | 07/16/2022 |
| Glutaredoxin-1 levels in plasma can predict future events in patients with cardiovascular diseases. | Glutaredoxin-1 levels in plasma can predict future events in patients with cardiovascular diseases.
Watanabe Y, Nakamura T, Uematsu M, Fujioka D, Inomata D, Saito Y, Horikoshi T, Yoshizaki T, Kobayashi T, Nakamura K, Kugiyama K. | 12/11/2021 |
| Cellular S-denitrosylases: Potential role and interplay of Thioredoxin, TRP14, and Glutaredoxin systems in thiol-dependent protein denitrosylation. | Cellular S-denitrosylases: Potential role and interplay of Thioredoxin, TRP14, and Glutaredoxin systems in thiol-dependent protein denitrosylation.
Chatterji A, Sengupta R. | 09/4/2021 |
| Deficiency of Grx1 leads to high sensitivity of HeLaS3 cells to oxidative stress via excessive accumulation of intracellular oxidants including ROS. | Deficiency of Grx1 leads to high sensitivity of HeLaS3 cells to oxidative stress via excessive accumulation of intracellular oxidants including ROS.
Zhao T, Zhang-Akiyama QM. | 08/7/2021 |
| Redox Regulator GLRX Is Associated With Tumor Immunity in Glioma. | Redox Regulator GLRX Is Associated With Tumor Immunity in Glioma.
Chang Y, Li G, Zhai Y, Huang L, Feng Y, Wang D, Zhang W, Hu H., Free PMC Article | 06/26/2021 |
| Redox Regulation via Glutaredoxin-1 and Protein S-Glutathionylation. | Redox Regulation via Glutaredoxin-1 and Protein S-Glutathionylation.
Matsui R, Ferran B, Oh A, Croteau D, Shao D, Han J, Pimentel DR, Bachschmid MM., Free PMC Article | 05/15/2021 |
| Activation of 3-Mercaptopyruvate Sulfurtransferase by Glutaredoxin Reducing System. | Activation of 3-Mercaptopyruvate Sulfurtransferase by Glutaredoxin Reducing System.
Nagahara N., Free PMC Article | 04/13/2021 |
| Role of Glutaredoxin-1 and Glutathionylation in Cardiovascular Diseases. | Role of Glutaredoxin-1 and Glutathionylation in Cardiovascular Diseases.
Burns M, Rizvi SHM, Tsukahara Y, Pimentel DR, Luptak I, Hamburg NM, Matsui R, Bachschmid MM., Free PMC Article | 02/27/2021 |
| Research on Grx and its potential roles in Parkinson's disease (PD) presents a complex situation where Grx1 likely plays a primary neuroprotective role in dopaminergic neurons but a proinflammatory role in microglia. Midbrain PD samples showed decreased Grx1 specifically within dopaminergic neurons. Increased GLRX copy number in PD patients was associated with earlier onset.[review] | Critical Roles of Glutaredoxin in Brain Cells-Implications for Parkinson's Disease.
Gorelenkova Miller O, Mieyal JJ., Free PMC Article | 06/27/2020 |
| The glutaredoxin (Grx) is involved in the formation, transfer or isomerization of disulfide bonds through a characteristic thiol-disulfide exchange reaction. | Structural and mechanistic aspects of S-S bonds in the thioredoxin-like family of proteins.
Sousa SF, Neves RPP, Waheed SO, Fernandes PA, Ramos MJ. | 12/7/2019 |
| Patients who experienced a stroke or myocardial infarction at any time had a significantly higher increase in Grx during the 2 years of dialysis | Serum Glutaredoxin Activity as a Marker of Oxidative Stress in Chronic Kidney Disease: A Pilot Study.
Levin A, Nair D, Qureshi AR, Bárány P, Heimburger O, Anderstam B, Stenvinkel P, Bruchfeld A, Ungerstedt JS. | 10/5/2019 |
| GLRX inhibition enhanced the effects of geftinib in gefitinib-resistant cell proliferation in vitro and in vivo and promoted apoptosis and cell cycle arrest via the EGFR/Forkhead Box M1 (FoxM1) signaling pathway, indicating that combined inhibition of GLRX could enhance growth-inhibitory effects of gefitinib in gefitinib-resistant NSCLC cells. | GLRX inhibition enhances the effects of geftinib in EGFR-TKI-resistant NSCLC cells through FoxM1 signaling pathway.
Wang L, Liu J, Liu J, Chen X, Chang M, Li J, Zhou J, Bai C, Song Y. | 04/20/2019 |
| Trx and Grx have both, common and specific protein Cys redox targets and that down regulation of either redoxin has markedly different metabolic outcomes. They reflect the delicate sensitivity of redox equilibrium to changes in any of the elements involved and the difficulty of forecasting metabolic responses to redox environmental changes. | Thioredoxin and glutaredoxin regulate metabolism through different multiplex thiol switches.
López-Grueso MJ, González-Ojeda R, Requejo-Aguilar R, McDonagh B, Fuentes-Almagro CA, Muntané J, Bárcena JA, Padilla CA., Free PMC Article | 04/6/2019 |
| Glutaredoxin-1 silencing induces cell senescence via p53/p21/p16 signaling axis. | Glutaredoxin-1 Silencing Induces Cell Senescence via p53/p21/p16 Signaling Axis.
Yang F, Yi M, Liu Y, Wang Q, Hu Y, Deng H. | 09/22/2018 |
| Overexpression of NOS3 increased the levels and activities of proteins of the redoxin systems, Trx1, Grx1, TrxR1 and TxnIP, and the levels of signaling proteins (Akt1, pAkt1(-)Ser473, MapK, pMapK, Stat3, Fas). | Redox Regulation Of Metabolic And Signaling Pathways By Thioredoxin And Glutaredoxin In Nitric Oxide Treated Hepatoblastoma Cells.
Peña CA, González R, López-Grueso MJ, Antonio Bárcena J. | 01/13/2018 |
| Based on the roGFP2-hGrx1 signals, glutathione-dependent redox potentials of -267mV and -328mV, respectively, were obtained. Employing these novel tools, initial studies on the effects of redox-active agents and clinically employed antimalarial drugs were carried out on both organelles. | Determination of glutathione redox potential and pH value in subcellular compartments of malaria parasites.
Mohring F, Rahbari M, Zechmann B, Rahlfs S, Przyborski JM, Meyer AJ, Becker K. | 12/16/2017 |
| Reduction potentials of protein disulfides and catalysis of glutathionylation and deglutathionylation by glutaredoxin enzymes | Reduction potentials of protein disulfides and catalysis of glutathionylation and deglutathionylation by glutaredoxin enzymes.
Ukuwela AA, Bush AI, Wedd AG, Xiao Z. | 11/26/2017 |
| GRX1 overexpression constrains oxidative stress and apoptosis in osteoarthritis chondrocytes by regulating CREB/HO-1, providing a novel insight into the molecular mechanism and potential treatment of osteoarthritis. | Glutaredoxin 1 (GRX1) inhibits oxidative stress and apoptosis of chondrocytes by regulating CREB/HO-1 in osteoarthritis.
Sun J, Wei X, Lu Y, Cui M, Li F, Lu J, Liu Y, Zhang X. | 11/11/2017 |
| Our results indicate that Grx1 upregulation promotes neuroinflammation and consequent neuronal cell death in vitro, and synergizes with proinflammatory insults to promote DA loss in vivo. | Upregulation of Glutaredoxin-1 Activates Microglia and Promotes Neurodegeneration: Implications for Parkinson's Disease.
Gorelenkova Miller O, Behring JB, Siedlak SL, Jiang S, Matsui R, Bachschmid MM, Zhu X, Mieyal JJ., Free PMC Article | 08/12/2017 |
| Glutaredoxin desensitizes lens to oxidative stress by connecting and integrating specific signaling and transcriptional regulation for antioxidant response. | Glutaredoxin Desensitizes Lens to Oxidative Stress by Connecting and Integrating Specific Signaling and Transcriptional Regulation for Antioxidant Response.
Fan Q, Zhang Y, Liu Y, Yang J, Li D, Tang Y, Cai L, Zhao Z, Zhou P, Lu Y. | 02/18/2017 |
| Glrx ablation stabilizes HIF-1alpha by increasing GSH adducts on Cys(520) promoting in vivo HIF-1alpha stabilization, VEGF-A production, and revascularization in the ischemic muscles. | Glutathione adducts induced by ischemia and deletion of glutaredoxin-1 stabilize HIF-1α and improve limb revascularization.
Watanabe Y, Murdoch CE, Sano S, Ido Y, Bachschmid MM, Cohen RA, Matsui R., Free PMC Article | 12/24/2016 |
| The results demonstrate that the antiproliferative effect of NO is hampered by Trx1 and Grx1 and support the strategy of weakening the thiolic antioxidant defenses when designing new antitumoral therapies. | Redox regulation of metabolic and signaling pathways by thioredoxin and glutaredoxin in NOS-3 overexpressing hepatoblastoma cells.
González R, López-Grueso MJ, Muntané J, Bárcena JA, Padilla CA., Free PMC Article | 09/3/2016 |
| Prx2 glutathionylation is a favorable reaction that can occur in cells under oxidative stress and may have a role in redox signaling. GSH/Grx1 provide an alternative mechanism to thioredoxin and thioredoxin reductase for Prx2 recycling. | Glutathionylation of the Active Site Cysteines of Peroxiredoxin 2 and Recycling by Glutaredoxin.
Peskin AV, Pace PE, Behring JB, Paton LN, Soethoudt M, Bachschmid MM, Winterbourn CC., Free PMC Article | 06/28/2016 |
| Glutaredoxin 1 protects human retinal pigment epithelial cells from oxidative damage by preventing AKT glutathionylation. | Glutaredoxin 1 (Grx1) Protects Human Retinal Pigment Epithelial Cells From Oxidative Damage by Preventing AKT Glutathionylation.
Liu X, Jann J, Xavier C, Wu H. | 09/26/2015 |