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    TOR2A torsin family 2 member A [ Homo sapiens (human) ]

    Gene ID: 27433, updated on 18-Sep-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Salusin-alpha alleviates lipid metabolism disorders via regulation of the downstream lipogenesis genes through the LKB1/AMPK pathway.

    Salusin‑α alleviates lipid metabolism disorders via regulation of the downstream lipogenesis genes through the LKB1/AMPK pathway.
    Pan J, Yang C, Xu A, Zhang H, Fan Y, Zeng R, Chen L, Liu X, Wang Y., Free PMC Article

    07/29/2024
    Use of salusin beta for predicting atherosclerosis and components of the metabolic syndrome.

    Use of salusin β for predicting atherosclerosis and components of the metabolic syndrome.
    Janecka A, Stefanowicz J.

    03/1/2024
    Overexpression of salusin-beta downregulates adipoR1 expression to prevent fatty acid oxidation in HepG2 cells.

    Overexpression of salusin‑β downregulates adipoR1 expression to prevent fatty acid oxidation in HepG2 cells.
    Xu A, Wang L, Luo M, Zhang H, Ning M, Pan J, Duan X, Wang Y, Liu X., Free PMC Article

    01/10/2024
    TOR2A Variants in Blepharospasm.

    TOR2A Variants in Blepharospasm.
    Saeirad S, LeDoux MS., Free PMC Article

    12/20/2023
    Downregulation of Salusin-beta protects renal tubular epithelial cells against high glucose-induced inflammation, oxidative stress, apoptosis and lipid accumulation via suppressing miR-155-5p.

    Downregulation of Salusin-β protects renal tubular epithelial cells against high glucose-induced inflammation, oxidative stress, apoptosis and lipid accumulation via suppressing miR-155-5p.
    Chen H, Jin G., Free PMC Article

    12/18/2021
    Evaluation of salusin-alpha and salusin-beta levels in patients with type 2 diabetes mellitus and determination of the impact of severity of hyperglycemia on salusin levels.

    Evaluation of salusin-α and salusin-β levels in patients with type 2 diabetes mellitus and determination of the impact of severity of hyperglycemia on salusin levels.
    Argun D, Argun F, Borku Uysal B.

    10/23/2021
    Serum salusin-beta in relation to atherosclerosis and ventricular dysfunction in patients with type 2 diabetes mellitus.

    Serum salusin-β in relation to atherosclerosis and ventricular dysfunction in patients with type 2 diabetes mellitus.
    Yassien M, Fawzy O, Mahmoud E, Khidr EG.

    10/9/2021
    The importance of circulating levels of salusin-alpha, salusin-beta, and heregulin-beta1 in atherosclerotic coronary arterial disease.

    The importance of circulating levels of salusin-α, salusin-β, and heregulin-β1 in atherosclerotic coronary arterial disease.
    Arkan A, Atukeren P, Ikitimur B, Simsek G, Koksal S, Gelisgen R, Ongen Z, Uzun H.

    05/29/2021
    Assessment of salusin alpha and salusin beta levels in patients with newly diagnosed dipper and non-dipper hypertension.

    Assessment of salusin alpha and salusin beta levels in patients with newly diagnosed dipper and non-dipper hypertension.
    Alpsoy S, Dogan B, Ozkaramanli Gur D, Akyüz A, Fidan Ç, Guzel S, Ozkoyuncu B.

    05/8/2021
    Salusin-beta mediates tubular cell apoptosis in acute kidney injury: Involvement of the PKC/ROS signaling pathway.

    Salusin-β mediates tubular cell apoptosis in acute kidney injury: Involvement of the PKC/ROS signaling pathway.
    Lu QB, Du Q, Wang HP, Tang ZH, Wang YB, Sun HJ., Free PMC Article

    04/17/2021
    Salusin-beta is superior to salusin-alpha as a marker for evaluating coronary atherosclerosis.

    Salusin-β is superior to salusin-α as a marker for evaluating coronary atherosclerosis.
    Wang Y, Wang S, Zhang J, Zhang M, Zhang H, Gong G, Luo M, Wang T, Mao X., Free PMC Article

    12/12/2020
    results demonstrate the novel role of salusin-beta in the central nervous system and salusin-beta can be used as a novel therapeutic to effectively treat Parkinson's disease

    Salusin-β mediate neuroprotective effects for Parkinson's disease.
    Chang Y, Yoo J, Kim H, Park HJ, Jeon S, Kim J.

    02/23/2019
    Increased expression of salusin-beta is associated with Diabetes Mellitus-Induced Endothelial Dysfunction.

    Salusin-β Is Involved in Diabetes Mellitus-Induced Endothelial Dysfunction via Degradation of Peroxisome Proliferator-Activated Receptor Gamma.
    Sun HJ, Chen D, Wang PY, Wan MY, Zhang CX, Zhang ZX, Lin W, Zhang F., Free PMC Article

    08/18/2018
    the effects of salusin-alpha on the expression of some pro- and anti-inflammatory cytokines and on TNF-alpha-induced inflammatory responses in human umbilical vein endothelial cells (HUVECs) were examined

    Salusin-α Attenuates Inflammatory Responses in Vascular Endothelial Cells.
    Esfahani M, Saidijam M, Goodarzi MT, Movahedian A, Najafi R.

    01/6/2018
    Salusin-beta mediates high glucose-induced endothelial injury via disruption of AMPK signaling pathway.

    Salusin-β mediates high glucose-induced endothelial injury via disruption of AMPK signaling pathway.
    Zhu X, Zhou Y, Cai W, Sun H, Qiu L.

    09/2/2017
    Overexpression of salusin-beta is associated with ovarian cancer.

    Overexpression of salusin-β is associated with poor prognosis in ovarian cancer.
    Zhang Q, Chen WM, Zhang XX, Zhang HX, Wang HC, Zheng FY, Zhu FF.

    07/15/2017
    Study provides evidence results that salusin-beta induces foam formation and monocyte adhesion via miR155/NOX2/NFkappaB-mediated ACAT-1 and VCAM-1 expressions in vascular smooth muscle cells.

    Salusin-β induces foam cell formation and monocyte adhesion in human vascular smooth muscle cells via miR155/NOX2/NFκB pathway.
    Sun HJ, Zhao MX, Liu TY, Ren XS, Chen Q, Li YH, Kang YM, Zhu GQ., Free PMC Article

    02/4/2017
    These results demonstrate contrasting actions of salusin-beta in the control of water intake via the central and peripheral systems and highlight it as a potent endogenous antidipsogenic neuropeptide.

    Salusin-β as a powerful endogenous antidipsogenic neuropeptide.
    Suzuki-Kemuriyama N, Nakano-Tateno T, Tani Y, Hirata Y, Shichiri M., Free PMC Article

    12/31/2016
    salusin-alpha might serve as a potential biomarker for predicting the development and progression of coronary artery disease.

    Serum salusin-α levels are inversely correlated with the presence and severity of coronary artery disease.
    Du SL, Wang WJ, Wan J, Wang YG, Wang ZK, Zhang Z.

    12/17/2016
    Plasma salusin-alpha and salusin-beta levels are increased in endometrioma patients and positively correlated with endometrioma size.

    Serum salusins levels are increased and correlated positively with cyst size in ovarian endometrioma.
    Sahin L, Bozkurt M, Celik O, Çelik N, Aydin S, Gencdal S.

    07/2/2016
    Serum salusin-Beta levels were associated with the presence and severity of coronary artery disease.

    Serum salusin-β levels are associated with the presence and severity of coronary artery disease.
    Liu J, Ren YG, Zhang LH, Tong YW, Kang L.

    04/2/2016
    Salusin-beta but not saluin-alpha is able to promote inflammatory responses in human umbilical vein endothelial cells.

    Salusin-β, but not salusin-α, promotes human umbilical vein endothelial cell inflammation via the p38 MAPK/JNK-NF-κB pathway.
    Zhou CH, Pan J, Huang H, Zhu Y, Zhang M, Liu L, Wu Y., Free PMC Article

    10/31/2015
    circulating salusin-beta levels are suppressed following physiological parasympathetic stimulation and appear to constitute a negative feedback relationship with the parasympathetic nervous system

    Physiological fluctuations of human plasma total salusin-β, an endogenous parasympathomimetic/proatherosclerotic peptide.
    Ogawa A, Fujimoto K, Hayashi A, Chida S, Sato K, Takai K, Masaki T, Suzuki A, Kamata Y, Takano K, Koyama T, Shichiri M.

    06/6/2015
    the mechanism of salusins in atherosclerosis

    Salusin-β not salusin-α promotes vascular inflammation in ApoE-deficient mice via the I-κBα/NF-κB pathway.
    Zhou CH, Liu L, Liu L, Zhang MX, Guo H, Pan J, Yin XX, Ma TF, Wu YQ., Free PMC Article

    05/30/2015
    Salusin-beta is an antimicrobial peptide with potent antibacterial activity against Gram-positive microorganisms.

    Salusin-β, an antimicrobially active peptide against Gram-positive bacteria.
    Kimura M, Shindo M, Moriizumi T, Tagawa N, Fujinami A, Kato I, Uchida Y.

    11/20/2014
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