| Sustained pigmentation causes DNA damage and invokes translesion polymerase Polkappa for repair in melanocytes. | Sustained pigmentation causes DNA damage and invokes translesion polymerase Polκ for repair in melanocytes.
Ghazi M, Khanna S, Subramaniam Y, Rengaraju J, Sultan F, Gupta I, Sharma K, Chandna S, Gokhale RS, Natarajan VT., Free PMC Article | 11/1/2023 |
| A Role for Human DNA Polymerase lambda in Alternative Lengthening of Telomeres. | A Role for Human DNA Polymerase λ in Alternative Lengthening of Telomeres.
Mentegari E, Bertoletti F, Kissova M, Zucca E, Galli S, Tagliavini G, Garbelli A, Maffia A, Bione S, Ferrari E, Fagagna FDD, Francia S, Sabbioneda S, Chen LY, Lingner J, Bergoglio V, Hoffmann JS, Hübscher U, Crespan E, Maga G., Free PMC Article | 05/8/2021 |
| PAXX, XLF and XRCC4 synergise in the efficient DNA double-strand breaks recruitment, substrate recognition and stimulation of Pol lambda enzymatic activity during nonhomologous end joining DNA repair. | PAXX and its paralogs synergistically direct DNA polymerase λ activity in DNA repair.
Craxton A, Munnur D, Jukes-Jones R, Skalka G, Langlais C, Cain K, Malewicz M., Free PMC Article | 01/19/2019 |
| Bond formation and cleavage reactions catalyzed by base excision repair DNA polymerases beta and lambda has been described. | Uniform Free-Energy Profiles of the P-O Bond Formation and Cleavage Reactions Catalyzed by DNA Polymerases β and λ.
Klvaňa M, Bren U, Florián J., Free PMC Article | 04/28/2018 |
| When mutated or deregulated, DNA polymerase lambda can also be a source of genetic instability. Its multiple roles in DNA damage tolerance and its ability in promoting tumor progression make it also a possible target for novel anticancer approaches. [review] | Living on the Edge: DNA Polymerase Lambda between Genome Stability and Mutagenesis.
van Loon B, Hübscher U, Maga G. | 12/30/2017 |
| Data suggest that individuals who carry the rs3730477 POLL germline variant have an increased risk of estrogen-associated breast cancer. | Estrogen Drives Cellular Transformation and Mutagenesis in Cells Expressing the Breast Cancer-Associated R438W DNA Polymerase Lambda Protein.
Nemec AA, Bush KB, Towle-Weicksel JB, Taylor BF, Schulz V, Weidhaas JB, Tuck DP, Sweasy JB., Free PMC Article | 08/12/2017 |
| T204 was identified as a main target for ATM/DNA-PKcs phosphorylation on human POLL, and this phosphorylation may facilitate the repair of a subset of IR-induced DSBs and the efficient POLL-mediated gap-filling during NHEJ. POLL phosphorylation might favor POLL interaction with the DNA-PK complex at DSBs. | Regulation of human polλ by ATM-mediated phosphorylation during non-homologous end joining.
Sastre-Moreno G, Pryor JM, Moreno-Oñate M, Herrero-Ruiz AM, Cortés-Ledesma F, Blanco L, Ramsden DA, Ruiz JF., Free PMC Article | 07/29/2017 |
| The authors demonstrate that Pol lambda has a flexible active site that can tolerate 8-oxo-dG in either the anti- or syn-conformation. Importantly, we show that discrimination against the pro-mutagenic syn-conformation occurs at the extension step and identify the residue responsible for this selectivity. | A fidelity mechanism in DNA polymerase lambda promotes error-free bypass of 8-oxo-dG.
Burak MJ, Guja KE, Hambardjieva E, Derkunt B, Garcia-Diaz M., Free PMC Article | 07/1/2017 |
| Pol beta, to a greater extent than Pol lambda can incorporate rNMPs opposite normal bases or 8-oxo-G, and with a different fidelity. Further, the incorporation of rNMPs opposite 8-oxo-G delays repair by DNA glycosylases. | Impact of ribonucleotide incorporation by DNA polymerases β and λ on oxidative base excision repair.
Crespan E, Furrer A, Rösinger M, Bertoletti F, Mentegari E, Chiapparini G, Imhof R, Ziegler N, Sturla SJ, Hübscher U, van Loon B, Maga G., Free PMC Article | 07/16/2016 |
| Fen1 significantly stimulated trinucleotide repeats expansion by Pol beta, but not by the related enzyme Pol lambda. | Expansion of CAG triplet repeats by human DNA polymerases λ and β in vitro, is regulated by flap endonuclease 1 and DNA ligase 1.
Crespan E, Hübscher U, Maga G. | 02/13/2016 |
| DNA polymerase lamda catalyzes lesion bypass across benzo[a]pyrene-derived DNA adducts. | Human DNA polymerases catalyze lesion bypass across benzo[a]pyrene-derived DNA adduct clustered with an abasic site.
Starostenko LV, Rechkunova NI, Lebedeva NA, Kolbanovskiy A, Geacintov NE, Lavrik OI. | 10/24/2015 |
| pol lambda is responsible for a significant fraction of Fapy.dG-induced G --> T mutations. | Unlike catalyzing error-free bypass of 8-oxodGuo, DNA polymerase λ is responsible for a significant part of Fapy·dG-induced G → T mutations in human cells.
Pande P, Haraguchi K, Jiang YL, Greenberg MM, Basu AK., Free PMC Article | 05/16/2015 |
| Structural basis for the binding and incorporation of nucleotide analogs with L-stereochemistry by human DNA polymerase lambda. | Structural basis for the binding and incorporation of nucleotide analogs with L-stereochemistry by human DNA polymerase λ.
Vyas R, Zahurancik WJ, Suo Z., Free PMC Article | 11/8/2014 |
| A specific N-terminal extension of the 8 kDa domain of DNA polymerase lambda is important for the non-homologous end joining function. | A specific N-terminal extension of the 8 kDa domain is required for DNA end-bridging by human Polμ and Polλ.
Martin MJ, Garcia-Ortiz MV, Gomez-Bedoya A, Esteban V, Guerra S, Blanco L., Free PMC Article | 01/4/2014 |
| Inactivation of polymerase (DNA directed) lambda lyase activity by 5'-(2-phosphoryl-1,4-dioxobutane prevents the enzyme from conducting polymerization following preincubation of the protein and DNA. | DNA polymerase λ inactivation by oxidized abasic sites.
Stevens AJ, Guan L, Bebenek K, Kunkel TA, Greenberg MM., Free PMC Article | 03/30/2013 |
| The results provides evidence that DNA pol lambda is required for cell cycle progression and is functionally connected to the S phase DNA damage response machinery in cancer cells. | Silencing of human DNA polymerase λ causes replication stress and is synthetically lethal with an impaired S phase checkpoint.
Zucca E, Bertoletti F, Wimmer U, Ferrari E, Mazzini G, Khoronenkova S, Grosse N, van Loon B, Dianov G, Hübscher U, Maga G., Free PMC Article | 03/23/2013 |
| A structural study shows how a ribonucleotide can be accommodated in the DNA polymerase lambda active site. | The catalytic cycle for ribonucleotide incorporation by human DNA Pol λ.
Gosavi RA, Moon AF, Kunkel TA, Pedersen LC, Bebenek K., Free PMC Article | 11/17/2012 |
| Results reveal that DNA pol lambda and DNA ligase I are sufficient to promote efficient microhomology-mediated end-joining repair of broken DNA ends in vitro. | Microhomology-mediated DNA strand annealing and elongation by human DNA polymerases λ and β on normal and repetitive DNA sequences.
Crespan E, Czabany T, Maga G, Hübscher U., Free PMC Article | 10/6/2012 |
| Both Pol lambda- and (Pol kappa)-positive staining were associated with shorter survival in glioma patients. | Analysis of specialized DNA polymerases expression in human gliomas: association with prognostic significance.
Wang H, Wu W, Wang HW, Wang S, Chen Y, Zhang X, Yang J, Zhao S, Ding HF, Lu D., Free PMC Article | 09/1/2012 |
| Pollambda may play a specialized role in the process of repair of these kinds of lesions | Human DNA polymerase λ catalyzes lesion bypass across benzo[a]pyrene-derived DNA adduct during base excision repair.
Skosareva LV, Lebedeva NA, Rechkunova NI, Kolbanovskiy A, Geacintov NE, Lavrik OI. | 08/11/2012 |
| Studies indicate that pol lambda undergoes posttranslational modifications during the cell cycle that regulate its stability and possibly its subcellular localization. | Ubiquitylation of DNA polymerase λ.
Markkanen E, van Loon B, Ferrari E, Hübscher U. | 12/3/2011 |
| In vitro gap-directed translesion DNA synthesis of an abasic site involving human DNA polymerases epsilon, lambda, and beta. | In vitro gap-directed translesion DNA synthesis of an abasic site involving human DNA polymerases epsilon, lambda, and beta.
Villani G, Hubscher U, Gironis N, Parkkinen S, Pospiech H, Shevelev I, di Cicco G, Markkanen E, Syväoja JE, Tanguy Le Gac N., Free PMC Article | 11/26/2011 |
| Studies indicate that codon-based models of gene evolution yielded statistical support for the recurrent positive selection of five NHEJ genes during primate evolution: XRCC4, NBS1, Artemis, POLlambda, and CtIP. | Ancient and recent adaptive evolution of primate non-homologous end joining genes.
Demogines A, East AM, Lee JH, Grossman SR, Sabeti PC, Paull TT, Sawyer SL., Free PMC Article | 03/12/2011 |
| study found expression of PollambdaR438W sensitizes cells to camptothecin by affecting the homologous recombination pathway, whereas overexpression of pollambdaWT did not impact cell survival; this effect depends entirely on its DNA polymerase activity | The R438W polymorphism of human DNA polymerase lambda triggers cellular sensitivity to camptothecin by compromising the homologous recombination repair pathway.
Capp JP, Boudsocq F, Bergoglio V, Trouche D, Cazaux C, Blanco L, Hoffmann JS, Canitrot Y. | 01/8/2011 |
| both pol lambda and pol beta interact with the upstream DNA glycosylases for repair of alkylated and oxidized DNA bases | DNA polymerases beta and lambda mediate overlapping and independent roles in base excision repair in mouse embryonic fibroblasts.
Braithwaite EK, Kedar PS, Stumpo DJ, Bertocci B, Freedman JH, Samson LD, Wilson SH., Free PMC Article | 11/6/2010 |