| [High expression of UBE2S promotes progression of hepatocellular carcinoma by increasing cancer cell stemness]. | [High expression of UBE2S promotes progression of hepatocellular carcinoma by increasing cancer cell stemness].
Chen H, Li Z, Wang M, Lu L, Tang Q, Luo L., Free PMC Article | 04/24/2024 |
| As a potential predictor of pan-cancer, UBE2S is related to tumor-associated macrophage infiltration. | As a potential predictor of pan-cancer, UBE2S is related to tumor-associated macrophage infiltration.
Yue H, Wang J, Hou S, Zhang M. | 11/2/2023 |
| UBE2S interacting with TRIM21 mediates the K11-linked ubiquitination of LPP to promote the lymphatic metastasis of bladder cancer. | UBE2S interacting with TRIM21 mediates the K11-linked ubiquitination of LPP to promote the lymphatic metastasis of bladder cancer.
Xiao K, Peng S, Lu J, Zhou T, Hong X, Chen S, Liu G, Li H, Huang J, Chen X, Lin T., Free PMC Article | 07/12/2023 |
| Knockout of UBE2S inhibits the proliferation of gastric cancer cells and induces apoptosis by FAS-mediated death receptor pathway. | Knockout of UBE2S inhibits the proliferation of gastric cancer cells and induces apoptosis by FAS-mediated death receptor pathway.
Zhao R, Yu Z, Mao X, Zheng Y, Wang Y, Zhou Y. | 09/3/2022 |
| UBE2S promotes the development of ovarian cancer by promoting PI3K/AKT/mTOR signaling pathway to regulate cell cycle and apoptosis. | UBE2S promotes the development of ovarian cancer by promoting PI3K/AKT/mTOR signaling pathway to regulate cell cycle and apoptosis.
Zhang M, Liu Y, Yin Y, Sun Z, Wang Y, Zhang Z, Li F, Chen X., Free PMC Article | 06/11/2022 |
| UBE2S as a novel ubiquitinated regulator of p16 and beta-catenin to promote bone metastasis of prostate cancer. | UBE2S as a novel ubiquitinated regulator of p16 and β-catenin to promote bone metastasis of prostate cancer.
Peng S, Chen X, Huang C, Yang C, Situ M, Zhou Q, Ling Y, Huang H, Huang M, Zhang Y, Cheng L, Zhang Q, Guo Z, Lai Y, Huang J., Free PMC Article | 06/11/2022 |
| UBE2S activates NF-kappaB signaling by binding with IkappaBalpha and promotes metastasis of lung adenocarcinoma cells. | UBE2S activates NF-κB signaling by binding with IκBα and promotes metastasis of lung adenocarcinoma cells.
Ho JY, Lu HY, Cheng HH, Kuo YC, Lee YA, Cheng CH. | 03/12/2022 |
| UBE2S interacting with TRIM28 in the nucleus accelerates cell cycle by ubiquitination of p27 to promote hepatocellular carcinoma development. | UBE2S interacting with TRIM28 in the nucleus accelerates cell cycle by ubiquitination of p27 to promote hepatocellular carcinoma development.
Zhang RY, Liu ZK, Wei D, Yong YL, Lin P, Li H, Liu M, Zheng NS, Liu K, Hu CX, Yang XZ, Chen ZN, Bian H., Free PMC Article | 03/5/2022 |
| Functional conservation and divergence of the helix-turn-helix motif of E2 ubiquitin-conjugating enzymes. | Functional conservation and divergence of the helix-turn-helix motif of E2 ubiquitin-conjugating enzymes.
Welsh KA, Bolhuis DL, Nederstigt AE, Boyer J, Temple BRS, Bonacci T, Gu L, Ordureau A, Harper JW, Steimel JP, Zhang Q, Emanuele MJ, Harrison JS, Brown NG., Free PMC Article | 02/19/2022 |
| UBE2S exerts oncogenic activities in urinary bladder cancer by ubiquitinating TSC1. | UBE2S exerts oncogenic activities in urinary bladder cancer by ubiquitinating TSC1.
Tang H, Fang T, Ji M, Wang JP, Song LL, Zhang QY, Wu JS. | 01/29/2022 |
| UBE2S promotes the progression and Olaparib resistance of ovarian cancer through Wnt/beta-catenin signaling pathway. | UBE2S promotes the progression and Olaparib resistance of ovarian cancer through Wnt/β-catenin signaling pathway.
Hu W, Li M, Chen Y, Gu X., Free PMC Article | 01/8/2022 |
| Dimerization regulates the human APC/C-associated ubiquitin-conjugating enzyme UBE2S. | Dimerization regulates the human APC/C-associated ubiquitin-conjugating enzyme UBE2S.
Liess AKL, Kucerova A, Schweimer K, Schlesinger D, Dybkov O, Urlaub H, Mansfeld J, Lorenz S., Free PMC Article | 10/30/2021 |
| Comprehensive Investigation into the Role of Ubiquitin-Conjugating Enzyme E2S in Melanoma Development. | Comprehensive Investigation into the Role of Ubiquitin-Conjugating Enzyme E2S in Melanoma Development.
Wang P, Li Y, Ma Y, Zhang X, Li Z, Yu W, Zhu M, Wang J, Xu Y, Xu A. | 09/18/2021 |
| Ubiquitin-Conjugating Enzyme 2S Enhances Viral Replication by Inhibiting Type I IFN Production through Recruiting USP15 to Deubiquitinate TBK1. | Ubiquitin-Conjugating Enzyme 2S Enhances Viral Replication by Inhibiting Type I IFN Production through Recruiting USP15 to Deubiquitinate TBK1.
Huang L, Liu H, Zhang K, Meng Q, Hu L, Zhang Y, Xiang Z, Li J, Yang Y, Chen Y, Cui S, Tang H, Pei H, Bu Z, Weng C. | 05/29/2021 |
| Ube2S regulates Wnt/beta-catenin signaling and promotes the progression of non-small cell lung cancer. | Ube2S regulates Wnt/β-catenin signaling and promotes the progression of non-small cell lung cancer.
Qin Y, Du J, Fan C., Free PMC Article | 11/21/2020 |
| Ubiquitin chain-elongating enzyme UBE2S activates the RING E3 ligase APC/C for substrate priming. | Ubiquitin chain-elongating enzyme UBE2S activates the RING E3 ligase APC/C for substrate priming.
Martinez-Chacin RC, Bodrug T, Bolhuis DL, Kedziora KM, Bonacci T, Ordureau A, Gibbs ME, Weissmann F, Qiao R, Grant GD, Cook JG, Peters JM, Wade Harper J, Emanuele MJ, Brown NG., Free PMC Article | 10/31/2020 |
| Data show that intramolecular transfer of ubiquitin from the catalytic cysteine to Lys+5 prevents the E1-mediated reloading of UBE2S with ubiquitin, thus conferring autoinhibition. Lys+5 ubiquitination of UBE2S is regulated in the context of the cell, with reduced levels during mitotic exit; however, this modification does not trigger proteasomal turnover of UBE2S. | Autoinhibition Mechanism of the Ubiquitin-Conjugating Enzyme UBE2S by Autoubiquitination.
Liess AKL, Kucerova A, Schweimer K, Yu L, Roumeliotis TI, Diebold M, Dybkov O, Sotriffer C, Urlaub H, Choudhary JS, Mansfeld J, Lorenz S. | 05/9/2020 |
| UBE2S mediates tumor progression via SOX6/beta-Catenin signaling in endometrial cancer | UBE2S mediates tumor progression via SOX6/β-Catenin signaling in endometrial cancer.
Lin M, Lei T, Zheng J, Chen S, Du L, Xie H. | 12/7/2019 |
| Ube2s-promoted beta-Catenin accumulation partially released the dependence on exogenous molecules for the process of embryonic stem (ES) cell differentiation into mesoendoderm lineages. | Ube2s stabilizes β-Catenin through K11-linked polyubiquitination to promote mesendoderm specification and colorectal cancer development.
Li Z, Wang Y, Li Y, Yin W, Mo L, Qian X, Zhang Y, Wang G, Bu F, Zhang Z, Ren X, Zhu B, Niu C, Xiao W, Zhang W., Free PMC Article | 11/9/2019 |
| Data demonstrated that UBE2S was downregulated by endoplasmic reticulum stress caused by HCV. UBE2S interacted with domain I of HCV NS5A and degraded NS5A protein through the Lys11-linked proteasome-dependent pathway. Its overexpression suppressed viral propagation, while its depletion increased viral infectivity. HCV-infected cells are more sensitive to DNA damage, and thus UBE2S may contribute to viral oncogenesis. | Hepatitis C Virus Downregulates Ubiquitin-Conjugating Enzyme E2S Expression To Prevent Proteasomal Degradation of NS5A, Leading to Host Cells More Sensitive to DNA Damage.
Pham HT, Nguyen TTT, Nguyen LP, Han SS, Lim YS, Hwang SB., Free PMC Article | 10/26/2019 |
| UBE2S expression was efficiently suppressed by lentivirus-mediated shRNA strategy in A549 cells, and UBE2S silencing led to reduced cell proliferation, colony formation, and enhanced apoptosis. | UBE2S promotes the proliferation and survival of human lung adenocarcinoma cells.
Liu Z, Xu L., Free PMC Article | 04/6/2019 |
| Ubiquitin-conjugating enzyme E2S (UBE2S) enhanced the ubiquitination of p53 protein to facilitate its degradation in hepatocellular carcinoma (HCC) cells. | UBE2S enhances the ubiquitination of p53 and exerts oncogenic activities in hepatocellular carcinoma.
Pan YH, Yang M, Liu LP, Wu DC, Li MY, Su SG. | 12/22/2018 |
| SAG/RBX2 E3 ligase complexes with UBCH10 and UBE2S ubiquitin-conjugating enzymes to ubiquitylate beta-TrCP1 via K11-linkage for degradation. | SAG/RBX2 E3 ligase complexes with UBCH10 and UBE2S E2s to ubiquitylate β-TrCP1 via K11-linkage for degradation.
Kuang P, Tan M, Zhou W, Zhang Q, Sun Y., Free PMC Article | 05/19/2018 |
| High UBE2S expression is associated with drug resistance in glioblastoma. | UBE2S, a novel substrate of Akt1, associates with Ku70 and regulates DNA repair and glioblastoma multiforme resistance to chemotherapy.
Hu L, Li X, Liu Q, Xu J, Ge H, Wang Z, Wang H, Wang Z, Shi C, Xu X, Huang J, Lin Z, Pieper RO, Weng C. | 09/16/2017 |
| RNF8- and Ube2S-dependent Lys11-linkage ubiquitin conjugation plays an important role in regulating DNA damage-induced transcriptional silencing, distinct from the role of Lys63-linkage ubiquitin in the recruitment of DNA damage repair proteins 53BP1 and BRCA1. | RNF8- and Ube2S-Dependent Ubiquitin Lysine 11-Linkage Modification in Response to DNA Damage.
Paul A, Wang B., Free PMC Article | 09/9/2017 |