| PCDH11X, expressed in brain is implicated in cell-cell communication, verbal ability, cerebral asymmetry, and dendritic synaptic plasticity, may be regarded as a new candidate gene for dyslexia. | Genome-wide copy number scan identifies disruption of PCDH11X in developmental dyslexia.
Veerappa AM, Saldanha M, Padakannaya P, Ramachandra NB. | 10/25/2014 |
| PCDH11X expression was detected in the fetal neocortex, ganglionic eminences, cerebellum, and inferior olive. In the adult brain, the cerebral cortex, hippocampal formation, and cerebellum and brain stem were immunoreactive. | Protocadherin 11X/Y a human-specific gene pair: an immunohistochemical survey of fetal and adult brains.
Priddle TH, Crow TJ., Free PMC Article | 03/1/2014 |
| the PCDH11X/Y gene pair determines cerebral asymmetry by initiating the right shift in Homo sapiens | The protocadherin 11X/Y (PCDH11X/Y) gene pair as determinant of cerebral asymmetry in modern Homo sapiens.
Priddle TH, Crow TJ., Free PMC Article | 08/10/2013 |
| our data...failed to confirm the association between PCDH11X polymorphisms and late-onset Alzheimer's disease | Lack of association between protocadherin 11-X/Y (PCDH11X and PCDH11Y) polymorphisms and late onset Alzheimer's disease.
Miar A, Alvarez V, Corao AI, Alonso B, Díaz M, Menéndez M, Martínez C, Calatayud M, Morís G, Coto E. | 08/6/2011 |
| An association between late-onset Alzheimer disease and the PCDH11X polymorphisms, was not detected. | PCDH11X variation is not associated with late-onset Alzheimer disease susceptibility.
Beecham GW, Naj AC, Gilbert JR, Haines JL, Buxbaum JD, Pericak-Vance MA, Beecham GW, Naj AC, Gilbert JR, Haines JL, Buxbaum JD, Pericak-Vance MA., Free PMC Articles: PMC2964434, PMC2964434 | 06/4/2011 |
| PCDH11X gene polymorphism does not play a major role in the genetic predisposition to late-onset Alzheimer disease in this Han Chinese population. | Lack of association between PCDH11X genetic variation and late-onset Alzheimer's disease in a Han Chinese population.
Wu ZC, Yu JT, Wang ND, Yu NN, Zhang Q, Chen W, Zhang W, Zhu QX, Tan L, Wu ZC, Yu JT, Wang ND, Yu NN, Zhang Q, Chen W, Zhang W, Zhu QX, Tan L. | 01/15/2011 |
| association not found for rs5984894 polymorphism in PCDH11X in Alzheimer's disease in Italy | Failure to replicate an association of rs5984894 SNP in the PCDH11X gene in a collection of 1,222 Alzheimer's disease affected patients.
Lescai F, Pirazzini C, D'Agostino G, Santoro A, Ghidoni R, Benussi L, Galimberti D, Federica E, Marchegiani F, Cardelli M, Olivieri F, Nacmias B, Sorbi S, Bagnoli S, Tagliavini F, Albani D, Martinelli Boneschi F, Binetti G, Forloni G, Quadri P, Scarpini E, Franceschi C, Lescai F, Pirazzini C, D'Agostino G, Santoro A, Ghidoni R, Benussi L, Galimberti D, Federica E, Marchegiani F, Cardelli M, Olivieri F, Nacmias B, Sorbi S, Bagnoli S, Tagliavini F, Albani D, Martinelli Boneschi F, Binetti G, Forloni G, Quadri P, Scarpini E, Franceschi C. | 01/1/2011 |
| The present article investigated the patterns of alternative splicing and expression of the PCDH11X/Y genes. | Quantitative analysis of alternative transcripts of human PCDH11X/Y genes.
Ahn K, Huh JW, Kim DS, Ha HS, Kim YJ, Lee JR, Kim HS. | 06/28/2010 |
| This paper proposes that the PCDH11X/Y gene pair generates epigenetic diversity relating to the species capacity for language including predisposition to psychosis. | The 'big bang' theory of the origin of psychosis and the faculty of language.
Crow TJ. | 12/28/2009 |
| a candidate for the evolution of hominid-specific characteristics including the sexual dimorphism of cerebral asymmetry, a putative correlate of language | Accelerated evolution of Protocadherin11X/Y: a candidate gene-pair for cerebral asymmetry and language.
Williams NA, Close JP, Giouzeli M, Crow TJ. | 12/28/2009 |
| We consider that a stronger case can be mounted for the Protocadherin11X/Y gene pair located in the hominid specific Xq21.3/Yp11.2 region of homology that was generated by a duplication from the X | Where and what is the right shift factor or cerebral dominance gene? A critique of Francks et al. (2007).
Crow TJ, Close JP, Dagnall AM, Priddle TH. | 01/21/2010 |
| Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease. | Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease.
Carrasquillo MM, Zou F, Pankratz VS, Wilcox SL, Ma L, Walker LP, Younkin SG, Younkin CS, Younkin LH, Bisceglio GD, Ertekin-Taner N, Crook JE, Dickson DW, Petersen RC, Graff-Radford NR, Younkin SG, Carrasquillo MM, Zou F, Pankratz VS, Wilcox SL, Ma L, Walker LP, Younkin SG, Younkin CS, Younkin LH, Bisceglio GD, Ertekin-Taner N, Crook JE, Dickson DW, Petersen RC, Graff-Radford NR, Younkin SG., Free PMC Articles: PMC2873177, PMC2873177 | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (5) articlesLack of association between PCDH11X genetic variation and late-onset Alzheimer's disease in a Han Chinese population.
Wu ZC, Yu JT, Wang ND, Yu NN, Zhang Q, Chen W, Zhang W, Zhu QX, Tan L, Wu ZC, Yu JT, Wang ND, Yu NN, Zhang Q, Chen W, Zhang W, Zhu QX, Tan L. Intermediate phenotypes identify divergent pathways to Alzheimer's disease.
Shulman JM, Chibnik LB, Aubin C, Schneider JA, Bennett DA, De Jager PL. Failure to replicate an association of rs5984894 SNP in the PCDH11X gene in a collection of 1,222 Alzheimer's disease affected patients.
Lescai F, Pirazzini C, D'Agostino G, Santoro A, Ghidoni R, Benussi L, Galimberti D, Federica E, Marchegiani F, Cardelli M, Olivieri F, Nacmias B, Sorbi S, Bagnoli S, Tagliavini F, Albani D, Martinelli Boneschi F, Binetti G, Forloni G, Quadri P, Scarpini E, Franceschi C, Lescai F, Pirazzini C, D'Agostino G, Santoro A, Ghidoni R, Benussi L, Galimberti D, Federica E, Marchegiani F, Cardelli M, Olivieri F, Nacmias B, Sorbi S, Bagnoli S, Tagliavini F, Albani D, Martinelli Boneschi F, Binetti G, Forloni G, Quadri P, Scarpini E, Franceschi C. PCDH11X variation is not associated with late-onset Alzheimer disease susceptibility.
Beecham GW, Naj AC, Gilbert JR, Haines JL, Buxbaum JD, Pericak-Vance MA, Beecham GW, Naj AC, Gilbert JR, Haines JL, Buxbaum JD, Pericak-Vance MA. Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease.
Carrasquillo MM, Zou F, Pankratz VS, Wilcox SL, Ma L, Walker LP, Younkin SG, Younkin CS, Younkin LH, Bisceglio GD, Ertekin-Taner N, Crook JE, Dickson DW, Petersen RC, Graff-Radford NR, Younkin SG, Carrasquillo MM, Zou F, Pankratz VS, Wilcox SL, Ma L, Walker LP, Younkin SG, Younkin CS, Younkin LH, Bisceglio GD, Ertekin-Taner N, Crook JE, Dickson DW, Petersen RC, Graff-Radford NR, Younkin SG. | 02/11/2009 |
| By confirming the suspected lack of X-Y homologous status for PCDH11 in non-human primates, our results reinforce the hypothesis of a hominid-specific role for this gene in brain development | PCDH11 is X/Y homologous in Homo sapiens but not in Gorilla gorilla and Pan troglodytes.
Wilson ND, Ross LJ, Crow TJ, Volpi EV. | 01/21/2010 |