| Hypoxic BMSC-derived exosomal miR-652-3p promotes proliferation and metastasis of hepatocarcinoma cancer cells via targeting TNRC6A. | Hypoxic BMSC-derived exosomal miR-652-3p promotes proliferation and metastasis of hepatocarcinoma cancer cells via targeting TNRC6A.
Li M, Zhai P, Mu X, Song J, Zhang H, Su J., Free PMC Article | 12/15/2023 |
| RNA helicase DDX6 and scaffold protein GW182 in P-bodies promote biogenesis of stress granules. | RNA helicase DDX6 and scaffold protein GW182 in P-bodies promote biogenesis of stress granules.
Majerciak V, Zhou T, Kruhlak MJ, Zheng ZM., Free PMC Article | 09/26/2023 |
| LINC01082 Inhibits Non-Small Cell Lung Cancer by Targeting the miR-543/TNRC6A Axis. | LINC01082 Inhibits Non-Small Cell Lung Cancer by Targeting the miR-543/TNRC6A Axis.
Yang R, Han J, Zhao S. | 07/27/2023 |
| MiR-652-3p promotes malignancy and metastasis of cancer cells via inhibiting TNRC6A in hepatocellular carcinoma. | MiR-652-3p promotes malignancy and metastasis of cancer cells via inhibiting TNRC6A in hepatocellular carcinoma.
Chen W, Ru J, Wu T, Man D, Wu J, Wu L, Sun Y, Yu H, Li M, Zhang G, Zhu X, Tong R, Xiao H, Li Y, Yang B. | 02/4/2023 |
| N-terminal Ago-binding domain of GW182 contains a tryptophan-rich region that confer binding to the CCR4-NOT complex. | N-terminal Ago-binding domain of GW182 contains a tryptophan-rich region that confer binding to the CCR4-NOT complex.
Wakiyama M, Takimoto K. | 09/17/2022 |
| Impact of scaffolding protein TNRC6 paralogs on gene expression and splicing. | Impact of scaffolding protein TNRC6 paralogs on gene expression and splicing.
Johnson ST, Chu Y, Liu J, Corey DR., Free PMC Article | 10/2/2021 |
| Acute necrotizing encephalopathy-linked mutations in Nup358 impair interaction of Nup358 with TNRC6/GW182 and miRNA function. | Acute necrotizing encephalopathy-linked mutations in Nup358 impair interaction of Nup358 with TNRC6/GW182 and miRNA function.
Deshmukh P, Singh A, Khuperkar D, Joseph J. | 08/28/2021 |
| DNA analysis of benign adult familial myoclonic epilepsy reveals associations between the pathogenic TTTCA repeat insertion in SAMD12 and the nonpathogenic TTTTA repeat expansion in TNRC6A. | DNA analysis of benign adult familial myoclonic epilepsy reveals associations between the pathogenic TTTCA repeat insertion in SAMD12 and the nonpathogenic TTTTA repeat expansion in TNRC6A.
Terasaki A, Nakamura M, Urata Y, Hiwatashi H, Yokoyama I, Yasuda T, Onuma T, Wada K, Kaneko S, Kan R, Niwa SI, Hashimoto O, Komure O, Goto YI, Yamagishi Y, Nakano M, Furusawa Y, Sano A. | 08/7/2021 |
| Identification of Phosphorylated Amino Acids in Human TNRC6A C-Terminal Region and Their Effects on the Interaction with the CCR4-NOT Complex. | Identification of Phosphorylated Amino Acids in Human TNRC6A C-Terminal Region and Their Effects on the Interaction with the CCR4-NOT Complex.
Munakata F, Suzawa M, Ui-Tei K., Free PMC Article | 07/31/2021 |
| Expression of TNRC6 (GW182) Proteins Is Not Necessary for Gene Silencing by Fully Complementary RNA Duplexes. | Expression of TNRC6 (GW182) Proteins Is Not Necessary for Gene Silencing by Fully Complementary RNA Duplexes.
Liu Z, Johnson ST, Zhang Z, Corey DR., Free PMC Article | 08/22/2020 |
| we report the important roles of GW182 and DDX6, but not Dicer, Ago2 and DCP1A, in PB formation, and that Kaposi's sarcoma-associated herpesvirus (KSHV) lytic infection reduces PB formation through several specific interactions with viral RNA-binding protein ORF57 | KSHV RNA-binding protein ORF57 inhibits P-body formation to promote viral multiplication by interaction with Ago2 and GW182.
Sharma NR, Majerciak V, Kruhlak MJ, Yu L, Kang JG, Yang A, Gu S, Fritzler MJ, Zheng ZM., Free PMC Article | 12/14/2019 |
| Study results demonstrate that TNRC6A regulates the biogenesis of the circRNA circ0006916, which regulates lung cancer cells proliferation by binding to miR-522-3p and inhibiting PHLPP1 activity. | RNA-binding protein trinucleotide repeat-containing 6A regulates the formation of circular RNA circ0006916, with important functions in lung cancer cells.
Dai X, Zhang N, Cheng Y, Yang T, Chen Y, Liu Z, Wang Z, Yang C, Jiang Y. | 11/23/2019 |
| The structure of GW182 protein silencing domain, including RNA recognition motif. | Structural Dynamics of the GW182 Silencing Domain Including its RNA Recognition motif (RRM) Revealed by Hydrogen-Deuterium Exchange Mass Spectrometry.
Cieplak-Rotowska MK, Tarnowski K, Rubin M, Fabian MR, Sonenberg N, Dadlez M, Niedzwiecka A., Free PMC Article | 08/24/2019 |
| Besides the role of GW182 as part of repressor complexes inside the cell, they function in wide variety of cellular processes including pathogenesis, circadian rhythm and cell cycle. (Review) | Role of GW182 protein in the cell.
Niaz S, Hussain MU. | 03/30/2019 |
| Functional analysis implicates TNRC6A, NAT10, MED14, and WDR5 in RNA-mediated transcriptional activation. | Human GW182 Paralogs Are the Central Organizers for RNA-Mediated Control of Transcription.
Hicks JA, Li L, Matsui M, Chu Y, Volkov O, Johnson KC, Corey DR., Free PMC Article | 04/28/2018 |
| that the interactions observed between TNRC6A and importin-alpha are conserved between mouse and human complexes. Our results highlight the ability of monopartite cNLS sequences to maximise contacts at the importin-alpha major binding site, as well as regions outside the main binding cavities | Structural characterisation of TNRC6A nuclear localisation signal in complex with importin-alpha.
Chaston JJ, Stewart AG, Christie M., Free PMC Article | 10/28/2017 |
| In miRNA-mediated gene silencing, the physical interaction between human Argonaute (hAgo) and GW182 (hGW182) is essential for facilitating the downstream silencing of the targeted mRNA. hGW182 can recruit up to three copies of hAgo via its three GW motifs. This may explain the observed cooperativity in miRNA-mediated gene silencing. | Multivalent Recruitment of Human Argonaute by GW182.
Elkayam E, Faehnle CR, Morales M, Sun J, Li H, Joshua-Tor L., Free PMC Article | 09/30/2017 |
| The results suggest that overexpressed Dcp1a and GW182 can form different cytoplasmic aggregates and play distinct biological roles in the miRNA pathway. | Dcp1a and GW182 Induce Distinct Cellular Aggregates and Have Different Effects on microRNA Pathway.
Wang X, Chang L, Wang H, Su A, Wu Z. | 09/23/2017 |
| miRNAs, AGOs, GW182, the CCR4-NOT complex, and DDX6/Me31B repress and degrade polyadenylated mRNA targets that are translated via scanning-independent mechanisms in both human and Drosophila melanogaster cells | miRISC and the CCR4-NOT complex silence mRNA targets independently of 43S ribosomal scanning.
Kuzuoğlu-Öztürk D, Bhandari D, Huntzinger E, Fauser M, Helms S, Izaurralde E., Free PMC Article | 06/3/2017 |
| The results indicate that TNRC6A subcellular localization is substantially controlled by the interaction with Argonaute proteins. | Control of the localization and function of a miRNA silencing component TNRC6A by Argonaute protein.
Nishi K, Takahashi T, Suzawa M, Miyakawa T, Nagasawa T, Ming Y, Tanokura M, Ui-Tei K., Free PMC Article | 04/2/2016 |
| TRIM65 relieves miRNA-driven suppression of mRNA expression through ubiquitination and subsequent degradation of TNRC6. | TRIM65 regulates microRNA activity by ubiquitination of TNRC6.
Li S, Wang L, Fu B, Berman MA, Diallo A, Dorf ME., Free PMC Article | 07/12/2014 |
| we have identified a new function of GW182 in protecting mature miRNA from being degraded by interacting with Argonaute (AGO) proteins | Defining a new role of GW182 in maintaining miRNA stability.
Yao B, La LB, Chen YC, Chang LJ, Chan EK., Free PMC Article | 06/1/2013 |
| HSP90 and GW182 are important factors in the pathomechanism of alcohol-induced augmentation of HCV replication. | Ethanol facilitates hepatitis C virus replication via up-regulation of GW182 and heat shock protein 90 in human hepatoma cells.
Bukong TN, Hou W, Kodys K, Szabo G., Free PMC Article | 03/9/2013 |
| Sinse Argonaute and GW182 are the core proteins of the RNA-silencing complex (RISC), it seems appropriate to suggest that the RISC is the main target of human autoantibodies. (Review) | Reflections on ten years of history of, and future prospects for, GW182 and GW/P body research.
Chan EK, Yao B, Fritzler MJ. | 03/2/2013 |
| 28.6% of patients containing autoantibodies to the trinucleotide repeat region of the TNRC6A were shown to have a single nucleotide polymorphism at c.344C>A in the CAG/CCA/G-rich region of TNRC6A. | An SNP in the trinucleotide repeat region of the TNRC6A gene maps to a major TNGW1 autoepitope in patients with autoantibodies to GW182.
Moser JJ, Chan EK, Fritzler MJ. | 03/2/2013 |