| Gustavson syndrome is caused by an in-frame deletion in RBMX associated with potentially disturbed SH3 domain interactions. | Gustavson syndrome is caused by an in-frame deletion in RBMX associated with potentially disturbed SH3 domain interactions.
Johansson J, Lidéus S, Frykholm C, Gunnarsson C, Mihalic F, Gudmundsson S, Ekvall S, Molin AM, Pham M, Vihinen M, Lagerstedt-Robinson K, Nordgren A, Jemth P, Ameur A, Annerén G, Wilbe M, Bondeson ML., Free PMC Article | 03/13/2024 |
| [RBMX overexpression inhibits proliferation, migration, invasion and glycolysis of human bladder cancer cells by downregulating PKM2]. | [RBMX overexpression inhibits proliferation, migration, invasion and glycolysis of human bladder cancer cells by downregulating PKM2].
Yan Q, Zeng P, Huang S, Tan C, Zhou X, Qiao J, Zhao X, Feng L, Zhu Z, Zhang G, Hu H, Chen C., Free PMC Article | 02/8/2024 |
| Aberrant RBMX expression is relevant for cancer prognosis and immunotherapy response. | Aberrant RBMX expression is relevant for cancer prognosis and immunotherapy response.
Sheng Y, Lei K, Sun C, Liu J, Tu Z, Zhu X, Huang K., Free PMC Article | 01/29/2024 |
| RBMX involves in telomere stability maintenance by regulating TERRA expression. | RBMX involves in telomere stability maintenance by regulating TERRA expression.
Liu J, Zheng T, Chen D, Huang J, Zhao Y, Ma W, Liu H., Free PMC Article | 09/29/2023 |
| The Role of Alternative Splicing Factors hnRNP G and Fox-2 in the Progression and Prognosis of Esophageal Cancer. | The Role of Alternative Splicing Factors hnRNP G and Fox-2 in the Progression and Prognosis of Esophageal Cancer.
Zheng Y, Niu X, Xue W, Li L, Geng Q, Fan Z, Zhao J., Free PMC Article | 12/10/2022 |
| Transcriptional control of CBX5 by the RNA binding proteins RBMX and RBMXL1 maintains chromatin state in myeloid leukemia. | Transcriptional control of CBX5 by the RNA binding proteins RBMX and RBMXL1 maintains chromatin state in myeloid leukemia.
Prieto C, Nguyen DTT, Liu Z, Wheat J, Perez A, Gourkanti S, Chou T, Barin E, Velleca A, Rohwetter T, Chow A, Taggart J, Savino AM, Hoskova K, Dhodapkar M, Schurer A, Barlowe TS, Vu LP, Leslie C, Steidl U, Rabadan R, Kharas MG., Free PMC Article | 04/23/2022 |
| Deletion of RBMX RGG/RG motif in Shashi-XLID syndrome leads to aberrant p53 activation and neuronal differentiation defects. | Deletion of RBMX RGG/RG motif in Shashi-XLID syndrome leads to aberrant p53 activation and neuronal differentiation defects.
Cai T, Cinkornpumin JK, Yu Z, Villarreal OD, Pastor WA, Richard S. | 02/12/2022 |
| RBMX is required for activation of ATR on repetitive DNAs to maintain genome stability. | RBMX is required for activation of ATR on repetitive DNAs to maintain genome stability.
Zheng T, Zhou H, Li X, Peng D, Yang Y, Zeng Y, Liu H, Ren J, Zhao Y., Free PMC Article | 11/22/2021 |
| RBMX suppresses tumorigenicity and progression of bladder cancer by interacting with the hnRNP A1 protein to regulate PKM alternative splicing. | RBMX suppresses tumorigenicity and progression of bladder cancer by interacting with the hnRNP A1 protein to regulate PKM alternative splicing.
Yan Q, Zeng P, Zhou X, Zhao X, Chen R, Qiao J, Feng L, Zhu Z, Zhang G, Chen C., Free PMC Article | 10/23/2021 |
| hnRNPG associates co-transcriptionally with RNAPII and regulates alternative splicing transcriptome-wide. m(6)A near splice sites in nascent pre-mRNA modulates hnRNPG binding, which influences RNAPII occupancy patterns and promotes exon inclusion. | Regulation of Co-transcriptional Pre-mRNA Splicing by m(6)A through the Low-Complexity Protein hnRNPG.
Zhou KI, Shi H, Lyu R, Wylder AC, Matuszek Ż, Pan JN, He C, Parisien M, Pan T., Free PMC Article | 02/22/2020 |
| PUM binding is required for maintenance of genomic stability by NORAD whereas binding of RBMX is dispensable for this function. | PUMILIO, but not RBMX, binding is required for regulation of genomic stability by noncoding RNA NORAD.
Elguindy MM, Kopp F, Goodarzi M, Rehfeld F, Thomas A, Chang TC, Mendell JT., Free PMC Article | 02/1/2020 |
| Study demonstrates a novel role for the splice factor hnRNPG in the pregnant myometrium. hnRNPG is required for the exclusion of exon 7 in the derivation of the dominant negative myometrial ERDelta7 isoform and is negatively regulated in an E2 dependent manner. | Estrogen receptor alpha isoform ERdelta7 in myometrium modulates uterine quiescence during pregnancy.
Anamthathmakula P, Kyathanahalli C, Ingles J, Hassan SS, Condon JC, Jeyasuria P., Free PMC Article | 06/15/2019 |
| These results suggest that satellite I RNA plays a role in stabilizing RBMX and Sororin in the ncRNP complex to maintain proper sister chromatid cohesion. | RBMX is a component of the centromere noncoding RNP complex involved in cohesion regulation.
Cho Y, Ideue T, Nagayama M, Araki N, Tani T. | 09/29/2018 |
| HNRNPG binds m6A-methylated RNAs through its C-terminal low-complexity region, which self-assembles into large particles in vitro. The Arg-Gly-Gly repeats within the low-complexity region are required for binding to the RNA motif exposed by m6A methylation. | N6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein.
Liu N, Zhou KI, Parisien M, Dai Q, Diatchenko L, Pan T., Free PMC Article | 10/7/2017 |
| A sequence deletion within RBMX is identified as associated with with Shashi X-linked intellectual disability syndrome. | The RBMX gene as a candidate for the Shashi X-linked intellectual disability syndrome.
Shashi V, Xie P, Schoch K, Goldstein DB, Howard TD, Berry MN, Schwartz CE, Cronin K, Sliwa S, Allen A, Need AC. | 07/2/2016 |
| Host RBMX is required for the maintenance of Borna disease virus nuclear viral factories. | X-linked RNA-binding motif protein (RBMX) is required for the maintenance of Borna disease virus nuclear viral factories.
Hirai Y, Honda T, Makino A, Watanabe Y, Tomonaga K. | 05/21/2016 |
| Results showed that HNRNPG and HTRA2-BETA1 were specific antagonistic regulators of ERa exon7 splicing and increased HNRNPG levels were associated with improved clinical outcome of endometrial cancer through up-regulation of ERaD7 expression. | HNRNP G and HTRA2-BETA1 regulate estrogen receptor alpha expression with potential impact on endometrial cancer.
Hirschfeld M, Ouyang YQ, Jaeger M, Erbes T, Orlowska-Volk M, Zur Hausen A, Stickeler E., Free PMC Article | 01/16/2016 |
| RBMX is a cohesion regulator that maintains the proper cohesion of sister chromatids. | RBMX: a regulator for maintenance and centromeric protection of sister chromatid cohesion.
Matsunaga S, Takata H, Morimoto A, Hayashihara K, Higashi T, Akatsuchi K, Mizusawa E, Yamakawa M, Ashida M, Matsunaga TM, Azuma T, Uchiyama S, Fukui K. | 03/23/2013 |
| Data show that RBMX accumulated at DNA lesions through multiple domains in a poly(ADP-ribose) polymerase 1-dependent manner and promoted HR by facilitating proper BRCA2 expression. | A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response.
Adamson B, Smogorzewska A, Sigoillot FD, King RW, Elledge SJ., Free PMC Article | 05/12/2012 |
| studied the genetic and expression states of hnRNP G in normal, premalignant and malignant human oral tissues to further understand the relationship between the hnRNP G alterations and the development of human oral cancer | Expression and mutation analysis of heterogeneous nuclear ribonucleoprotein G in human oral cancer.
Shin KH, Kim RH, Yu B, Kang MK, Elashoff D, Christensen R, Pucar A, Park NH., Free PMC Article | 02/4/2012 |
| These studies indicate that hnRNP G promotes the expression of Txnip and mediates its tumor-suppressive effect. | hnRNP G elicits tumor-suppressive activity in part by upregulating the expression of Txnip.
Shin KH, Kim RH, Kim RH, Kang MK, Park NH., Free PMC Article | 01/21/2010 |
| This identifies RBMX as an ARTS-1-associated protein that regulates both the constitutive release of TNFR1 exosome-like vesicles and the inducible proteolytic cleavage of TNFR1 ectodomains. | An association between RBMX, a heterogeneous nuclear ribonucleoprotein, and ARTS-1 regulates extracellular TNFR1 release.
Adamik B, Islam A, Rouhani FN, Hawari FI, Zhang J, Levine SJ., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Associations of homologous RNA-binding motif gene on the X chromosome (RBMX) and its like sequence on chromosome 9 (RBMXL9) with non-obstructive azoospermia.
Tsujimura A, Fujita K, Komori K, Tanjapatkul P, Miyagawa Y, Takada S, Matsumiya K, Sada M, Katsuyama Y, Ota M, Okuyama A. | 03/13/2008 |
| From these results, it seems that the X-chromosome, through its RBM genes, plays a formerly unknown role in the regulation of programmed cell death (apoptosis) in breast cancer. | Positive correlation between the expression of X-chromosome RBM genes (RBMX, RBM3, RBM10) and the proapoptotic Bax gene in human breast cancer.
Martínez-Arribas F, Agudo D, Pollán M, Gómez-Esquer F, Díaz-Gil G, Lucas R, Schneider J. | 01/21/2010 |
| p53 modulates DNA DSB repair by, in part, inducing hnRNP G | p53 promotes the fidelity of DNA end-joining activity by, in part, enhancing the expression of heterogeneous nuclear ribonucleoprotein G.
Shin KH, Kim RH, Kang MK, Kim RH, Kim SG, Lim PK, Yochim JM, Baluda MA, Park NH., Free PMC Article | 01/21/2010 |