| Knockdown of ADAMDEC1 ameliorates ox-LDL-induced endothelial cell injury and atherosclerosis progression. | Knockdown of ADAMDEC1 ameliorates ox-LDL-induced endothelial cell injury and atherosclerosis progression.
Wang X, Gao F, Cheng C, Zhang Y. | 01/11/2024 |
| ADAMDEC1 induces EMT and promotes colorectal cancer cells metastasis by enhancing Wnt/beta-catenin signaling via negative modulation of GSK-3beta. | ADAMDEC1 induces EMT and promotes colorectal cancer cells metastasis by enhancing Wnt/β-catenin signaling via negative modulation of GSK-3β.
Jia Y, Huang X, Shi H, Wang M, Chen J, Zhang H, Hou D, Jing H, Du J, Han H, Zhang J. | 07/4/2023 |
| Upregulation of ADAMDEC1 correlates with tumor progression and predicts poor prognosis in non-small cell lung cancer (NSCLC) via the PI3K/AKT pathway. | Upregulation of ADAMDEC1 correlates with tumor progression and predicts poor prognosis in non-small cell lung cancer (NSCLC) via the PI3K/AKT pathway.
Zhu W, Shi L, Gong Y, Zhuo L, Wang S, Chen S, Zhang B, Ke B., Free PMC Article | 04/9/2022 |
| Knockdown of ADAMDEC1 inhibits the progression of glioma in vitro. | Knockdown of ADAMDEC1 inhibits the progression of glioma in vitro.
Liu X, Huang H, Li X, Zheng X, Zhou C, Xue B, He J, Zhang Y, Liu L. | 08/14/2021 |
| ADAMDEC1 Maintains a Growth Factor Signaling Loop in Cancer Stem Cells. | ADAMDEC1 Maintains a Growth Factor Signaling Loop in Cancer Stem Cells.
Jimenez-Pascual A, Hale JS, Kordowski A, Pugh J, Silver DJ, Bayik D, Roversi G, Alban TJ, Rao S, Chen R, McIntyre TM, Colombo G, Taraboletti G, Holmberg KO, Forsberg-Nilsson K, Lathia JD, Siebzehnrubl FA., Free PMC Article | 08/22/2020 |
| The ADAMDEC1 plays a pro-inflammatory role in rosacea via modulating the M1 polarization of macrophages. | ADAMDEC1 promotes skin inflammation in rosacea via modulating the polarization of M1 macrophages.
Liu T, Deng Z, Xie H, Chen M, Xu S, Peng Q, Sha K, Xiao W, Zhao Z, Li J. | 07/11/2020 |
| ADAMDEC1 is a positive regulator of Epithelial Defense Against Cancer (EDAC) that promotes apical extrusion of RasV12-transformed cells | ADAM-like Decysin-1 (ADAMDEC1) is a positive regulator of Epithelial Defense Against Cancer (EDAC) that promotes apical extrusion of RasV12-transformed cells.
Yako Y, Hayashi T, Takeuchi Y, Ishibashi K, Kasai N, Sato N, Kuromiya K, Ishikawa S, Fujita Y., Free PMC Article | 10/19/2019 |
| Data show the critical pathways regulating the expression of ADAMDEC1 and the roles of enhancer RNAs and mechanistically links E1A binding protein p300 (p300) and enhancer RNAs, which is dependent on NF-kappa B (NFkappaB). | Enhancer RNA and NFκB-dependent P300 regulation of ADAMDEC1.
Shi L, Li S, Maurer K, Zhang Z, Petri M, Sullivan KE., Free PMC Article | 05/4/2019 |
| Data suggest that activated platelets release ADAMDEC1, which hydrolyzes pro-EGF (epidermal growth factor) to soluble, active HMW-EGF; proteolytic cleavage of pro-EGF first occurs at the C-terminal arginyl residue of the EGF domain; proteolysis is the regulated, rate-limiting step in generating soluble EGF from activated platelets. | The soluble protease ADAMDEC1 released from activated platelets hydrolyzes platelet membrane pro-epidermal growth factor (EGF) to active high-molecular-weight EGF.
Chen R, Jin G, McIntyre TM., Free PMC Article | 07/8/2017 |
| We hypothesize that these unique features of ADAMDEC1 may have evolved to escape from inhibition by endogenous metalloprotease inhibitors | Evidence for restricted reactivity of ADAMDEC1 with protein substrates and endogenous inhibitors.
Lund J, Troeberg L, Kjeldal H, Olsen OH, Nagase H, Sørensen ES, Stennicke HR, Petersen HH, Overgaard MT., Free PMC Article | 05/23/2015 |
| ADAMDEC1 functions as an active metalloprotease. | ADAMDEC1 is a metzincin metalloprotease with dampened proteolytic activity.
Lund J, Olsen OH, Sørensen ES, Stennicke HR, Petersen HH, Overgaard MT., Free PMC Article | 11/30/2013 |
| Gene expression profiling performed on tissues obtained from pulmonary sarcoidosis patients identified ADAMDEC1 as a potential pathogenic mediator of lung damage and/or remodeling and may serve as a marker for this disease. | Gene expression profiling identifies MMP-12 and ADAMDEC1 as potential pathogenic mediators of pulmonary sarcoidosis.
Crouser ED, Culver DA, Knox KS, Julian MW, Shao G, Abraham S, Liyanarachchi S, Macre JE, Wewers MD, Gavrilin MA, Ross P, Abbas A, Eng C., Free PMC Article | 01/21/2010 |
| The ADAMDEC 1 haplotype may indicate an underlying mechanism for high FVIII levels in venous thromboembolism. | Association of ADAMDEC1 haplotype with high factor VIII levels in venous thromboembolism.
Berger M, Moscatelli H, Kulle B, Luxembourg B, Blouin K, Spannagl M, Lindhoff-Last E, Schambeck CM, Berger M, Moscatelli H, Kulle B, Luxembourg B, Blouin K, Spannagl M, Lindhoff-Last E, Schambeck CM. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Association of ADAMDEC1 haplotype with high factor VIII levels in venous thromboembolism.
Berger M, Moscatelli H, Kulle B, Luxembourg B, Blouin K, Spannagl M, Lindhoff-Last E, Schambeck CM, Berger M, Moscatelli H, Kulle B, Luxembourg B, Blouin K, Spannagl M, Lindhoff-Last E, Schambeck CM. | 05/14/2008 |
| molecular evolution by duplication in a metalloprotease gene cluster on chromosome 8p12 | The ADAMDEC1 (decysin) gene structure: evolution by duplication in a metalloprotease gene cluster on chromosome 8p12.
Bates EE, Fridman WH, Mueller CG. | 01/21/2010 |