| Tweak/Fn14 system is involved in rhabdomyolysis-induced acute kidney injury. | Tweak/Fn14 system is involved in rhabdomyolysis-induced acute kidney injury.
Guerrero-Hue M, Vallejo-Mudarra M, García-Caballero C, Córdoba-David GM, Palomino-Antolín A, Herencia C, Vendrell-Casana B, Rubio-Navarro A, Egido J, Blanco-Colio LM, Moreno JA. | 12/15/2023 |
| Fn14 promotes myoblast fusion during regenerative myogenesis. | Fn14 promotes myoblast fusion during regenerative myogenesis.
Tomaz da Silva M, Joshi AS, Castillo MB, Koike TE, Roy A, Gunaratne PH, Kumar A., Free PMC Article | 10/12/2023 |
| Alpha-Ketoglutarate Regulates Tnfrsf12a/Fn14 Expression via Histone Modification and Prevents Cancer-Induced Cachexia. | Alpha-Ketoglutarate Regulates Tnfrsf12a/Fn14 Expression via Histone Modification and Prevents Cancer-Induced Cachexia.
Ruiz BI, Lowman XH, Yang Y, Fan Q, Wang T, Wu H, Hanse EA, Kong M., Free PMC Article | 10/6/2023 |
| TWEAK/FN14 promotes profibrogenic pathway activation in Prominin-1-expressing hepatic progenitor cells in biliary atresia. | TWEAK/FN14 promotes profibrogenic pathway activation in Prominin-1-expressing hepatic progenitor cells in biliary atresia.
Short C, Zhong A, Xu J, Mahdi E, Glazier A, Malkoff N, Noriega N, Yeo T, Asahina K, Wang KS. | 04/21/2023 |
| Conjugation of the Fn14 Ligand to a SMAC Mimetic Selectively Suppresses Experimental Squamous Cell Carcinoma in Mice. | Conjugation of the Fn14 Ligand to a SMAC Mimetic Selectively Suppresses Experimental Squamous Cell Carcinoma in Mice.
Wang X, Lu M, Gu H, Xiao T, Hu G, Luo M, Guo X, Xia Y. | 02/11/2023 |
| Targeted ablation of Fn14 receptor improves exercise capacity and inhibits neurogenic muscle atrophy. | Targeted ablation of Fn14 receptor improves exercise capacity and inhibits neurogenic muscle atrophy.
Tomaz da Silva M, Joshi AS, Koike TE, Roy A, Mathukumalli K, Sopariwala DH, Narkar VA, Kumar A., Free PMC Article | 12/3/2022 |
| Fn14 exacerbates acute lung injury by activating the NLRP3 inflammasome in mice. | Fn14 exacerbates acute lung injury by activating the NLRP3 inflammasome in mice.
Guan XX, Yang HH, Zhong WJ, Duan JX, Zhang CY, Jiang HL, Xiang Y, Zhou Y, Guan CX., Free PMC Article | 08/13/2022 |
| Dysregulation of Tweak and Fn14 in skeletal muscle of spinal muscular atrophy mice. | Dysregulation of Tweak and Fn14 in skeletal muscle of spinal muscular atrophy mice.
Meijboom KE, Sutton ER, McCallion E, McFall E, Anthony D, Edwards B, Kubinski S, Tapken I, Bünermann I, Hazell G, Ahlskog N, Claus P, Davies KE, Kothary R, Wood MJA, Bowerman M., Free PMC Article | 08/6/2022 |
| Inhibition of fibroblast growth factor-inducible 14 attenuates experimental tubulointerstitial fibrosis and profibrotic factor expression of proximal tubular epithelial cells. | Inhibition of fibroblast growth factor-inducible 14 attenuates experimental tubulointerstitial fibrosis and profibrotic factor expression of proximal tubular epithelial cells.
Luo M, Liu M, Liu W, Cui X, Zhai S, Gu H, Wang H, Wu K, Zhang W, Li K, Xia Y. | 11/13/2021 |
| TWEAK Signaling Pathway Blockade Slows Cyst Growth and Disease Progression in Autosomal Dominant Polycystic Kidney Disease. | TWEAK Signaling Pathway Blockade Slows Cyst Growth and Disease Progression in Autosomal Dominant Polycystic Kidney Disease.
Cordido A, Nuñez-Gonzalez L, Martinez-Moreno JM, Lamas-Gonzalez O, Rodriguez-Osorio L, Perez-Gomez MV, Martin-Sanchez D, Outeda P, Chiaravalli M, Watnick T, Boletta A, Diaz C, Carracedo A, Sanz AB, Ortiz A, Garcia-Gonzalez MA., Free PMC Article | 10/23/2021 |
| Fibroblast growth factor inducible 14 signaling facilitates anti-dsDNA IgG penetration into mesangial cells. | Fibroblast growth factor inducible 14 signaling facilitates anti-dsDNA IgG penetration into mesangial cells.
Li R, Jia F, Ren K, Luo M, Min X, Xiao S, Xia Y. | 09/4/2021 |
| Inhibition of suppressor of cytokine signaling 1 mediates the profibrotic effect of TWEAK/Fn14 signaling on kidney cells. | Inhibition of suppressor of cytokine signaling 1 mediates the profibrotic effect of TWEAK/Fn14 signaling on kidney cells.
Chen J, Jia F, Ren K, Luo M, Min X, Wang P, Xiao S, Xia Y. | 08/7/2021 |
| Remodeling of Neurotransmission, Chemokine, and PI3K-AKT Signaling Genomic Fabrics in Neuropsychiatric Systemic Lupus Erythematosus. | Remodeling of Neurotransmission, Chemokine, and PI3K-AKT Signaling Genomic Fabrics in Neuropsychiatric Systemic Lupus Erythematosus.
Iacobas D, Wen J, Iacobas S, Schwartz N, Putterman C., Free PMC Article | 07/24/2021 |
| MicroRNA-19a Targets Fibroblast Growth Factor-Inducible Molecule 14 and Prevents Tubular Damage in Septic AKI. | MicroRNA-19a Targets Fibroblast Growth Factor-Inducible Molecule 14 and Prevents Tubular Damage in Septic AKI.
Hong J, Hu BC, Xu L, Zheng Y, Shao ZQ, Zhang R, Yang XH, Sun RH, Mo SJ., Free PMC Article | 05/29/2021 |
| Norcantharidin protects against renal interstitial fibrosis by suppressing TWEAK-mediated Smad3 phosphorylation. | Norcantharidin protects against renal interstitial fibrosis by suppressing TWEAK-mediated Smad3 phosphorylation.
Zeng D, Xiao Z, Xu Q, Luo H, Wen L, Tang C, Shan Y, Tian J, Wei J, Li Y. | 11/28/2020 |
| The TNF-like weak inducer of the apoptosis/fibroblast growth factor-inducible molecule 14 axis mediates histamine and platelet-activating factor-induced subcutaneous vascular leakage and anaphylactic shock. | The TNF-like weak inducer of the apoptosis/fibroblast growth factor-inducible molecule 14 axis mediates histamine and platelet-activating factor-induced subcutaneous vascular leakage and anaphylactic shock.
Mendez-Barbero N, Yuste-Montalvo A, Nuñez-Borque E, Jensen BM, Gutiérrez-Muñoz C, Tome-Amat J, Garrido-Arandia M, Díaz-Perales A, Ballesteros-Martinez C, Laguna JJ, Beitia JM, Poulsen LK, Cuesta-Herranz J, Blanco-Colio LM, Esteban V. | 09/26/2020 |
| These results suggest that Fn14 deficiency protects mice from experimental atopic dermatitis, involving the attenuation of inflammatory responses and keratinocyte apoptosis. In the context of atopic dermatitis-like inflammation, TWEAK modulates keratinocytes via a TNFR1-mediated pathway. | Experimental atopic dermatitis is dependent on the TWEAK/Fn14 signaling pathway.
Liu Q, Wang H, Wang X, Lu M, Tan X, Peng L, Tan F, Xiao T, Xiao S, Xia Y., Free PMC Article | 07/25/2020 |
| FN14 deficiency resulted in better cardiac performance, less myocardial inflammation, fibrosis, and cardiac damage in a model of autoimmune myocarditis. | FN14 Signaling Plays a Pathogenic Role in a Mouse Model of Experimental Autoimmune Myocarditis.
Fischer A, Bockstahler M, Müller AM, Stroikova V, Leib C, Pfitzer G, Katus HA, Kaya Z. | 07/25/2020 |
| Fn14 may be a potential target for the therapeutic treatment of peripheral neuropathic pain. | Fn14 Participates in Neuropathic Pain Through NF-κB Pathway in Primary Sensory Neurons.
Huang LN, Zou Y, Wu SG, Zhang HH, Mao QX, Li JB, Tao YX., Free PMC Article | 02/1/2020 |
| TLR4 regulates SCF(Fbxw7alpha)-dependent Fn14 stabilization during septic acute kidney injury. | Regulation of Fn14 stability by SCF(Fbxw7α) during septic acute kidney injury.
Mo SJ, Zhang W, Liu JQ, Chen MH, Xu L, Hong J, Li Q, Yang XH, Sun RH, Hu BC. | 02/1/2020 |
| TWEAK promoted the expression of interleukin 8, keratin 17, and epidermal growth factor receptor (EGFR) but inhibited the expression of involucrin in psoriatic keratinocytes in vitro. TWEAK also enhances the proliferation and interleukin-6 production of dermal microvascular endothelial cells under psoriatic condition. | Fn14 deficiency ameliorates psoriasis-like skin disease in a murine model.
Peng L, Li Q, Wang H, Wu J, Li C, Liu Y, Liu J, Xia L, Xia Y., Free PMC Article | 12/7/2019 |
| TWEAK/Fn14 mediates atrial-derived cardiomyocytes hypertrophy via JAK2/STAT3 signaling pathway. | TWEAK/Fn14 mediates atrial-derived HL-1 myocytes hypertrophy via JAK2/STAT3 signalling pathway.
Hao L, Ren M, Rong B, Xie F, Lin MJ, Zhao YC, Yue X, Han WQ, Zhong JQ., Free PMC Article | 11/2/2019 |
| TWEAK/Fn14 signals mediate the healing of burn wounds, possibly involving TWEAK regulation of the function of resident cells. | TWEAK/Fn14 Signals Mediate Burn Wound Repair.
Liu J, Liu Y, Peng L, Li J, Wu K, Xia L, Wu J, Wang S, Wang X, Liu Q, Zeng W, Xia Y. | 11/2/2019 |
| Confirming its critical role in TWEAK signaling, silencing TRAF3IP2 inhibited TWEAK autoregulation, TWEAKR upregulation, p38 MAPK, NF-kappaB and AP-1 activation, inflammatory cytokine expression, MMP and TIMP1 activation, collagen expression and secretion, and importantly, proliferation and migration | TRAF3IP2 mediates TWEAK/TWEAKR-induced pro-fibrotic responses in cultured cardiac fibroblasts and the heart.
Das NA, Carpenter AJ, Yoshida T, Kumar SA, Gautam S, Mostany R, Izadpanah R, Kumar A, Mummidi S, Siebenlist U, Chandrasekar B., Free PMC Article | 09/14/2019 |
| Fn14 was identified as a molecular link between sensory-driven gene expression and vision-sensitive refinement in the brain. | Visual Experience-Dependent Expression of Fn14 Is Required for Retinogeniculate Refinement.
Cheadle L, Tzeng CP, Kalish BT, Harmin DA, Rivera S, Ling E, Nagy MA, Hrvatin S, Hu L, Stroud H, Burkly LC, Chen C, Greenberg ME., Free PMC Article | 08/3/2019 |