| Neuroanatomical, electrophysiological, and morphological characterization of melanin-concentrating hormone cells coexpressing cocaine- and amphetamine-regulated transcript. | Neuroanatomical, electrophysiological, and morphological characterization of melanin-concentrating hormone cells coexpressing cocaine- and amphetamine-regulated transcript.
Miller PA, Williams-Ikhenoba JG, Sankhe AS, Hoffe BH, Chee MJ. | 02/27/2024 |
| Demystifying functional role of cocaine- and amphetamine-related transcript (CART) peptide in control of energy homeostasis: A twenty-five year expedition. | Demystifying functional role of cocaine- and amphetamine-related transcript (CART) peptide in control of energy homeostasis: A twenty-five year expedition.
Singh A, de Araujo AM, Krieger JP, Vergara M, Ip CK, de Lartigue G., Free PMC Article | 01/29/2022 |
| Overcoming Stress, Hunger, and Pain: Cocaine- and Amphetamine-Regulated Transcript Peptide's Promise. | Overcoming Stress, Hunger, and Pain: Cocaine- and Amphetamine-Regulated Transcript Peptide's Promise.
Samson WK, Salvemini D, Yosten GLC., Free PMC Article | 10/23/2021 |
| Expression of TSHR and of CART is suppressed in response to lipopolysaccharides within the arcuate nucleus in the hypothalamus of the mouse. The present findings highlight hypothalamic TSH receptor mechanisms and CART as putative adaptive neuroendocrine components in the response to acute inflammation. Findings suggest that central and peripheral CART is affected by acute inflammation. | LPS immune challenge reduces arcuate nucleus TSHR and CART mRNA and elevates plasma CART peptides.
Burgos JR, Iresjö BM, Olsson L, Smedh U., Free PMC Article | 05/30/2020 |
| The potential mechanism of CART was determined to be associated with inflammatory cytokines and related apoptotic genes. CART therefore appears to be associated with DA in its effect on ischemic stroke and is protective against brain injury following ischemic stroke by reducing inflammation activation | Cocaine‑ and amphetamine‑regulated transcript (CART) is associated with dopamine and is protective against ischemic stroke.
Lin L, Sun D, Chang J, Ma M, Zhou X, Zhao M, Li J., Free PMC Article | 11/10/2018 |
| Study showed that the perikarya and central terminals of vagal afferents are invariably enriched in CART and devoid of melanin-concentrating hormone and that neuropeptidergic profile of the CART-positive vagal afferents is remarkably stable across the energy balance spectrum. | Levels of Cocaine- and Amphetamine-Regulated Transcript in Vagal Afferents in the Mouse Are Unaltered in Response to Metabolic Challenges.
Yuan X, Huang Y, Shah S, Wu H, Gautron L., Free PMC Article | 10/28/2017 |
| Study conclude that CART is a regulator of glucose homeostasis and could play an important role in the pathophysiology of type 2 diabetes. Based on the ability of CART to increase insulin secretion and reduce glucagon secretion, CART-based agents could be a therapeutic modality in type 2 diabetes. | CART is overexpressed in human type 2 diabetic islets and inhibits glucagon secretion and increases insulin secretion.
Abels M, Riva M, Bennet H, Ahlqvist E, Dyachok O, Nagaraj V, Shcherbina L, Fred RG, Poon W, Sörhede-Winzell M, Fadista J, Lindqvist A, Kask L, Sathanoori R, Dekker-Nitert M, Kuhar MJ, Ahrén B, Wollheim CB, Hansson O, Tengholm A, Fex M, Renström E, Groop L, Lyssenko V, Wierup N. | 09/2/2017 |
| Taken together, these results demonstrate that CART is a critical regulator of energy expenditure, energy partitioning and utilization dependent on the thermal environment. | Temperature dependence of the control of energy homeostasis requires CART signaling.
Lau J, Shi YC, Herzog H. | 02/18/2017 |
| Collectively, our main findings indicate that high-fat diet induced-hypertension and autonomic imbalance are associated to an upregulation of CART levels in the dorsomedial hypothalamus of mice. | High-fat diet-induced hypertension and autonomic imbalance are associated with an upregulation of CART in the dorsomedial hypothalamus of mice.
Chaar LJ, Coelho A, Silva NM, Festuccia WL, Antunes VR., Free PMC Article | 10/8/2016 |
| Leptin induced CART negatively affects intracellular cAMP levels, MAPK signaling, and aromatase mRNA expression, which leads to lower estradiol synthesis in granulosa cells and altered ovarian folliculogenesis. | Leptin-Induced CART (Cocaine- and Amphetamine-Regulated Transcript) Is a Novel Intraovarian Mediator of Obesity-Related Infertility in Females.
Ma X, Hayes E, Prizant H, Srivastava RK, Hammes SR, Sen A., Free PMC Article | 07/16/2016 |
| 100 mg/kg caffeine increased CART 2 h after administration in nucleus accumbens shell, dorsal bed nucleus of the stria terminalis, central nucleus of the amygdala, paraventricular hypothalamic nucleus, arcuate hypothalamic nucleus, and locus coeruleus. | Increase in cocaine- and amphetamine-regulated transcript (CART) in specific areas of the mouse brain by acute caffeine administration.
Cho JH, Cho YH, Kim HY, Cha SH, Ryu H, Jang W, Shin KH. | 01/16/2016 |
| The present study demonstrates a role for CART in ethanol consummatory behaviors. | Reduced ethanol consumption and preference in cocaine- and amphetamine-regulated transcript (CART) knockout mice.
Salinas AG, Nguyen CT, Ahmadi-Tehrani D, Morrisett RA., Free PMC Article | 11/29/2014 |
| CART exerts a neuroprotective effect via inhibition of post-spinal cord injury astrogliosis. | Neuroprotective effect of cocaine- and amphetamine-regulated transcript peptide in spinal cord injury in mice.
Bharne AP, Upadhya MA, Shelkar GP, Singru PS, Subhedar NK, Kokare DM. | 11/16/2013 |
| CART is an antioxidant peptide | CART peptide is a potential endogenous antioxidant and preferentially localized in mitochondria.
Mao P, Meshul CK, Thuillier P, Goldberg NR, Reddy PH., Free PMC Article | 05/19/2012 |
| CART expression is observed in loose clusters of spinocerebellar mossy fibers in the mouse anterior and posterior zones. | Patterned expression of a cocaine- and amphetamine-regulated transcript peptide reveals complex circuit topography in the rodent cerebellar cortex.
Reeber SL, Sillitoe RV. | 03/31/2012 |
| The lack of brain Ucn 1 immunoreactivity at birth and the gradual postnatal increase in Ucn 1 in the perioculomotor area suggests that this peptide plays a greater behavioral role in adulthood than during the early postnatal development of an organism. | Postnatal developmental profile of urocortin 1 and cocaine- and amphetamine-regulated transcript in the perioculomotor region of C57BL/6J mice.
Cservenka A, Spangler E, Cote DM, Ryabinin AE., Free PMC Article | 06/14/2010 |
| Ucn1, CART and nesfatin-1/NUCB2 are specifically involved in the response of Edinger-Westphal nucleus neurons to acute stress in the mouse | Restraint stress alters the secretory activity of neurons co-expressing urocortin-1, cocaine- and amphetamine-regulated transcript peptide and nesfatin-1 in the mouse Edinger-Westphal nucleus.
Okere B, Xu L, Roubos EW, Sonetti D, Kozicz T. | 05/31/2010 |
| While central, neuroendocrine regulation of bone mass via CART signaling may have effects on trabecular mass, absence of CART expression does not significantly alter cortical bone geometry, density, or strength. | CART deficiency increases body weight but does not alter bone strength.
Bartell SM, Isales CM, Baile CA, Kuhar MJ, Hamrick MW. | 01/21/2010 |
| Results suggest that CART (cocaine and amphetamine-regulated transcript) is an endogenous neuroprotective peptide against cerebral ischemia and it does so through the MAPK/ERK1/2 signaling pathway. | CART protects brain from damage through ERK activation in ischemic stroke.
Jia J, Chen X, Zhu W, Luo Y, Hua Z, Xu Y. | 01/21/2010 |
| The synergistic long-lasting effect of the CART peptide and CCK on food intake and their additive effect on Fos immunoreactivity in their common targets suggest cooperation of CART peptide and CCK possibly related to the effect of leptin on CCK satiety. | Synergistic effect of CART (cocaine- and amphetamine-regulated transcript) peptide and cholecystokinin on food intake regulation in lean mice.
Maletínská L, Maixnerová J, Matysková R, Haugvicová R, Pirník Z, Kiss A, Zelezná B., Free PMC Article | 01/21/2010 |
| The decrease of CART mRNA expression in Arc and PVN regions of DIO mice contributes to obesity. CART in the dorsomedial nucleus of hypothalamus and lateral hypothalamus are involved in the orexigenic effect. | Differential expression of hypothalamic CART mRNA in response to body weight change following different dietary interventions.
Yu Y, South T, Wang Q, Huang XF. | 01/21/2010 |
| In its capacity of a regulator of bone remodeling, CART may act more as a circulating molecule than a neuropeptide. | Cocaine and amphetamine-regulated transcript may regulate bone remodeling as a circulating molecule.
Singh MK, Elefteriou F, Karsenty G., Free PMC Article | 01/21/2010 |
| analysis of CART binding sites on HepG2 cells and mouse hypothalamic dissociated cells | Characterization and localization of cocaine- and amphetamine-regulated transcript (CART) binding sites.
Keller PA, Compan V, Bockaert J, Giacobino JP, Charnay Y, Bouras C, Assimacopoulos-Jeannet F. | 01/21/2010 |
| Review. The genetics of CART and its role in reward, stress, and feeding behavior are reviewed. | CART peptides.
Kuhar MJ, Adams S, Dominguez G, Jaworski J, Balkan B. | 01/21/2010 |
| observations are compatible with cocaine- and amphetamine-related transcript (CART) being a downstream mediator of the cannabinoid receptors (CB1) mediated orexigenic effect of endogenous anandamide | Cocaine- and amphetamine-related transcript is involved in the orexigenic effect of endogenous anandamide.
Osei-Hyiaman D, Depetrillo M, Harvey-White J, Bannon AW, Cravatt BF, Kuhar MJ, Mackie K, Palkovits M, Kunos G. | 01/21/2010 |